Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Thailand sustainable material ODM solutions

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Breathable insole ODM innovation factory Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand insole ODM service provider

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Insole ODM factory in Taiwan

A camp on the South Col, where hundreds of adventurers pitch their final camp each year before attempting to scale the world’s tallest peak from the southeastern side. Photo was taken near the site of where soil samples were collected by Baker Perry. Credit: Baker Perry Human activity leaves a microbial footprint at Everest’s South Col. Resilient microbes highlight life’s adaptability and raise concerns about contamination during future space exploration. Located nearly 5 miles (8 kilometers) above sea level in the Himalayas, the barren, wind-swept depression between Mount Everest and its neighboring summit, Lhotse, remains devoid of snow. At the South Col, hundreds of thrill-seekers set up their final camp annually, preparing to ascend the world’s highest mountain from the southeast flank. New research led by the University of Colorado Boulder indicates that these adventurers are inadvertently leaving behind a frozen signature of resilient microbes. These microorganisms can endure extreme conditions at high altitudes and remain dormant in the soil for decades, or potentially even centuries. The research not only highlights an invisible impact of tourism on the world’s highest mountain, but could also lead to a better understanding of environmental limits to life on Earth, as well as where life may exist on other planets or cold moons. The findings were published last month in Arctic, Antarctic, and Alpine Research, a journal published on behalf of the Institute of Arctic and Alpine Research (INSTAAR) at CU Boulder. “There is a human signature frozen in the microbiome of Everest, even at that elevation,” said Steve Schmidt, senior author on the paper and professor of ecology and evolutionary biology. In decades past, scientists have been unable to conclusively identify human-associated microbes in samples collected above 26,000 feet (8,000 meters). This study marks the first time that next-generation gene sequencing technology has been used to analyze soil from such a high elevation on Mount Everest, enabling researchers to gain new insight into almost everything and anything that’s in them. The researchers weren’t surprised to find microorganisms left by humans. Microbes are everywhere, even in the air, and can easily blow around and land some distance away from nearby camps or trails. “If somebody even blew their nose or coughed, that’s the kind of thing that might show up,” said Schmidt. What they were impressed by, however, was that certain microbes which have evolved to thrive in warm and wet environments like our noses and mouths were resilient enough to survive in a dormant state in such harsh conditions. Life in the Cryosphere This team of CU Boulder scientists—including Schmidt, lead author Nicholas Dragone and Adam Solon, both graduate students in the Department of Ecology and Evolutionary Biology and the Cooperative Institute for Research in Environmental Science (CIRES)—study the cryobiosphere: Earth’s cold regions and the limits to life in them. They have sampled soils everywhere from Antarctica and the Andes to the Himalayas and the high Arctic. Usually, human-associated microbes don’t show up in these places to the extent they appeared in the recent Everest samples. Schmidt’s work over the years connected him with researchers who were headed to Everest’s South Col in May of 2019 to set up the planet’s highest weather station, established by the National Geographic and Rolex Perpetual Planet Everest Expedition. He asked his colleagues: Would you mind collecting some soil samples while you’re already there? So Baker Perry, co-author, professor of geography at Appalachian State University, and a National Geographic Explorer, hiked as far away from the South Col camp as possible to scoop up some soil samples to send back to Schmidt. Extremes on Earth, and Elsewhere Dragone and Solon then analyzed the soil in several labs at CU Boulder. Using next-generation gene sequencing technology and more traditional culturing techniques, they were able to identify the DNA of almost any living or dead microbes in the soils. They then carried out extensive bioinformatics analyses of the DNA sequences to determine the diversity of organisms, rather than their abundances. Most of the microbial DNA sequences they found were similar to hardy, or “extremophilic” organisms previously detected in other high-elevation sites in the Andes and Antarctica. The most abundant organism they found using both old and new methods was a fungus in the genus Naganishia that can withstand extreme levels of cold and UV radiation. But they also found microbial DNA for some organisms heavily associated with humans, including Staphylococcus, one of the most common skin and nose bacteria, and Streptococcus, a dominant genus in the human mouth. At high elevations, microbes are often killed by ultraviolet light, cold temperatures, and low water availability. Only the hardiest critters survive. Most—like the microbes carried up great heights by humans—go dormant or die, but there is a chance that organisms like Naganishia may grow briefly when water and the perfect ray of sunlight provides enough heat to help them momentarily prosper. But even for the toughest of microbes, Mount Everest is a Hotel California: “You can check out any time you like/ But you can never leave.” The researchers don’t expect this microscopic impact on Everest to significantly affect the broader environment. But this work does carry implications for the potential for life far beyond Earth, if one day humans step foot on Mars or beyond. “We might find life on other planets and cold moons,” said Schmidt. “We’ll have to be careful to make sure we’re not contaminating them with our own.” Reference: “Genetic analysis of the frozen microbiome at 7900 m a.s.l., on the South Col of Sagarmatha (Mount Everest)” by Nicholas B. Dragone, L. Baker Perry, Adam J. Solon, Anton Seimon, Tracie A. Seimon and Steven K. Schmidt, 16 February 2023, Arctic, Antarctic, and Alpine Research. DOI: 10.1080/15230430.2023.2164999 The study was funded by the National Geographic and Rolex Perpetual Planet Everest Expedition, the Department of Ecology and Evolutionary Biology, and the University of Colorado Boulder Libraries Open Access Fund

Neurons in Drosophila fruit flies were studied by The Picower Institute for Learning and Memory to understand the diversity in neuronal communication. They found that a protein, complexin, plays a vital role in controlling neurotransmitter release. The study showed that RNA editing of complexin results in different versions of the protein, affecting how neurons communicate and grow synapses. Credit: SciTechDaily.com Neurons stochastically generated up to eight different versions of a protein-regulating neurotransmitter release, which could vary how they communicate with other cells. Neurons are talkers. They each communicate with fellow neurons, muscles, or other cells by releasing neurotransmitter chemicals at “synapse” junctions, ultimately producing functions ranging from emotions to motions. But even neurons of the exact same type can vary in their conversational style. A new open-access study published in the journal Cell Reports by neurobiologists at The Picower Institute for Learning and Memory highlights a molecular mechanism that might help account for the nuanced diversity of neural discourse. The scientists made their findings in neurons that control muscles in Drosophila fruit flies. These cells are models in neuroscience because they exhibit many fundamental properties common to neurons in people and other animals, including communication via the release of the neurotransmitter glutamate. In the lab of Troy Littleton, Menicon Professor in MIT’s departments of Biology and Brain and Cognitive Sciences, which studies how neurons regulate this critical process, researchers frequently see that individual neurons vary in their release patterns. Some “talk” more than others. In a new study of a key protein that regulates how neurons communicate via the release of neurotransmitters, scientists tracked how RNA editing affected the protein’s distribution and performance. Here three different edits of complexin (yellow) resulted in different distributions of the protein in segments of motor neurons as well as different degrees of function. The left panel shows distribution of unedited complexin while the right two panels show distribution of two different edited variants. Credit: Littleton Lab/Picower Institute Complexin’s Role in Neuronal Communication In more than a decade of studies, Littleton’s lab has shown that a protein called complexin has the job of restraining spontaneous glutamate chatter. It clamps down on fusion of glutamate-filled vesicles at the synaptic membrane to preserve a supply of the neurotransmitter for when the neuron needs it for a functional reason, for instance to simulate a muscle to move. The lab’s studies have identified two different kinds of complexin in flies (mammals have four) and showed that the clamping effectiveness of the rare but potent 7B splice form is regulated by a molecular process called phosphorylation. How the much more abundant 7A version is regulated was not known, but scientists had shown that the RNA transcribed from DNA that instructs the formation of the protein is sometimes edited in the cell by an enzyme called ADAR. In the new study from Littleton’s team, led by Elizabeth Brija PhD ’23, the lab investigated whether RNA editing of complexin 7A affects how it regulates glutamate release. What she discovered was surprising. Not only does RNA editing of complexin 7A have a significant impact on how well the protein prevents glutamate release, but also this can vary widely among individual neurons because they can stochastically mix and match up to eight different editions of the protein. Some edits were much more common than others on average, but 96 percent of the 200 neurons the team examined had at least some editing, which affected the structure of an end of the protein called its C-terminus. Experiments to test some of the consequences of this structural variation showed that different complexin 7A edits can dramatically affect the level of electrical current measurable at different synapses. That varying level of activity can also affect the growth of the synapses the neurons make with muscle. RNA editing of the protein might therefore endow each neuron with fine degrees of communication control. “What this offers the nervous system is that you can take the same transcriptome and by alternatively editing various RNA transcripts, these neurons will behave differently,” Littleton says. Expanding the Scope: Editing of Other Proteins Additionally, Littleton and Brija’s team found that other key proteins involved in synaptic glutamate release, such as synapsin and Syx1A, are also sometimes edited at quite different levels among the same population of neurons. This suggests that other aspects of synaptic communication might also be tunable. “Such a mechanism would be a robust way to change multiple features of neuronal output,” Brija, Littleton, and colleagues wrote. The team tracked the different editing levels by meticulously extracting and sequencing RNA from the nuclei and cell bodies of 200 motor neurons. The work yielded a rich enough dataset to show that any of three adenosine nucleotides encoding two amino acids in the C-terminus could be swapped for another, yielding eight different editions of the protein. A slim majority of complexin 7A went unedited in the average neuron, while the seven edited versions composed the rest with widely varying degrees of frequency. To investigate the functional consequences of some of the different editions, the team knocked out complexin and then “rescued” flies by adding back in unedited or two different edited versions. The experiments showed a stark contrast between the two edited proteins. One, which occurs more commonly, proved to be a less effective clamp than unedited complexin, barely preventing spontaneous glutamate release and upticks in electrical current. The other turned out to be more effective at clamping than the unedited version, keeping a tight lid on glutamate release and synaptic output. And while both of the edited versions showed a tendency to drift away from synapses and into the neuron’s axon, the long branch that extends from the cell body, the edition that clamped well prevented any overgrowth of synapses while the one that clamped poorly provided only a meager curb. Because multiple editions are often present in neurons, Brija and the team did one more set of experiments in which they “rescued” complexin-less flies with a combination of unedited complexin and the weak-clamping edition. The result was a blend of the two: reduced spontaneous glutamate release than with just the weakly clamping edition alone. The findings suggest that not only does each edition potentially fine-tune glutamate release, but that combinations among them can act in a combinatorial fashion. Reference: “Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release” by Elizabeth A. Brija, Zhuo Guan, Suresh K. Jetti and J. Troy Littleton, 17 September 2023, Cell Reports. DOI: 10.1016/j.celrep.2023.113152 In addition to Brija and Littleton the paper’s other authors are Zhuo Guan and Suresh Jetti. The National Institutes of Health, The JPB Foundation, and The Picower Institute for Learning and Memory supported the research.

In a groundbreaking study reported in Current Biology, researchers have found the earliest-known fossil mosquitoes in Lebanese amber, revealing that ancient male mosquitoes likely fed on blood. Credit: Current Biology/Azar et al. Researchers have unearthed the oldest fossil mosquitoes in Lebanese amber, showing that ancient male mosquitoes were likely blood-feeders. This finding from the Lower Cretaceous period sheds new light on the evolution of mosquitoes and their relationship with flowering plants. Researchers reporting in the journal Current Biology on December 4 have found the earliest-known fossil mosquito in Lower Cretaceous amber from Lebanon. What’s more, the well-preserved insects are two males of the same species with piercing mouthparts, suggesting they likely sucked blood. That’s noteworthy because, among modern-day mosquitoes, only females are hematophagous, meaning that they use piercing mouthparts to feed on the blood of people and other animals. “Lebanese amber is, to date, the oldest amber with intensive biological inclusions, and it is a very important material as its formation is contemporaneous with the appearance and beginning of radiation of flowering plants, with all that follows of co-evolution between pollinators and flowering plants,” says Dany Azar of the Nanjing Institute of Geology and Palaeontology at the Chinese Academy of Sciences and the Lebanese University. Mosquito in amber. Credit: Dany Azar A New Perspective on Mosquito Evolution “Molecular dating suggested that the family Culicidae arose during the Jurassic, but previously the oldest record was mid-Cretaceous,” says André Nel of the National Museum of Natural History of Paris (Muséum National d’Histoire Naturelle de Paris). “Here we have one from the early Cretaceous, about 30 million years before.” The Culicidae family of arthropods includes more than 3,000 species of mosquitoes. The new findings suggest that male mosquitoes in the past fed on blood as well, according to the researchers. They also help to narrow the “ghost-lineage gap” for mosquitoes, they say. Implications and Future Research Female mosquitoes are notorious for their blood-feeding ways, which has made them a major vector for spreading infectious diseases. Hematophagy in insects is thought to have arisen as a shift from piercing-sucking mouthparts used to extract plant fluids. For example, blood-sucking fleas likely arose from nectar-feeding insects. But the evolution of blood feeding has been hard to study in part due to gaps in the insect fossil record. Head, ventral view; scale bar 100 mm Credit: Current Biology/Azar et al. In the new study, Azar, Nel, Diying Huang, and Michael S. Engel describe two male mosquitoes with piercing mouthparts, including an exceptionally sharp, triangular mandible and elongated structure with small, tooth-like denticles. They report that the mosquitoes’ preservation in amber extends the definitive occurrence of the mosquito family of insects into the early Cretaceous. It also suggests that the evolution of hematophagy was more complicated than had been suspected, with hematophagous males in the distant past. In future work, Nel says the team wants to learn more about the “utility” of having hematophagy in Cretaceous male mosquitoes. They’re also curious to explore “why this no longer exists,” he says. Reference: “The earliest fossil mosquito” by Dany Azar, André Nel, Diying Huang and Michael S. Engel, 4 December 2023, Current Biology. DOI: 10.1016/j.cub.2023.10.047 Funding: National Natural Science Foundation of China

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