Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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PU insole OEM production in Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ODM service for ergonomic pillows Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia insole ODM design and production

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China ODM expert for comfort products

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China pillow OEM manufacturer

A new study at the University of Maryland School of Medicine (UMSOM) has shed light on the frustrating experience of forgetting a person’s face after only speaking with them hours earlier. This type of memory decline is common with age, but the reason for it is still not fully understood. The study, published in Aging Cell, offers some valuable insights into this dysfunction. Research identifies target for potentially developing new therapies to treat age-related cognitive decline. One of the most upsetting aspects of age-related memory decline is not being able to remember the face that accompanies the name of a person you just talked with hours earlier. While researchers don’t understand why this dysfunction occurs, a new study conducted at the University of Maryland School of Medicine (UMSOM) has provided some important new clues. The study was published recently in the journal Aging Cell. Using aging mice, researchers have identified a new mechanism in neurons that causes memories associated with these social interactions to decline with age. In addition, they were able to reverse this memory loss in the lab. The researchers report that their findings identified a specific target in the brain that may one day be used to develop therapies that could prevent or reverse memory loss due to typical aging. Aging memory problems are distinct from those caused by diseases like Alzheimer’s or dementia. At this time, there are no medications that can prevent or reverse cognitive decline due to typical aging. PDE11A memory enzyme (green) in the brains of young (left) and old (right) mice. Credit: University of Maryland School of Medicine “If an older adult attends a cocktail party, afterward they would most likely recognize the names or the faces of the other attendees, but they might struggle with remembering which name went with which face,” said the study leader Michy Kelly, PhD, Associate Professor of Anatomy and Neurobiology at UMSOM.   These kinds of memories that associate multiple pieces of information within a personal interaction, so-called social associative memories, require an enzyme, known as PDE11A, in a part of the brain responsible for memory involving life experiences. Last year, Dr. Kelly published research on PDE11A demonstrating that mice with genetically similar versions of the PDE11 enzyme were more likely to interact than those mice with a different type of PDE11A. In this new study, Dr. Kelly and her team sought to determine PDE11A’s role in social associative memory in the aging brain and whether manipulating this enzyme could be used to prevent this memory loss. Researchers can study mouse “social interactions” with their neighbors by seeing whether they will be willing to try a new food, based on their memories of encountering that food on the breath of another mouse.  Mice do not like to eat new foods to avoid getting sick or even dying from them. When they smell food on another mouse’s breath, mice make an association between the food odor and the smell of the other mouse’s pheromones, the memory of which serves as a safety signal that any food with that odor is safe to eat in the future. PDE11A Levels Increase with Age Dr. Kelly and her colleagues found that although old mice could recognize both food odors and social odors separately, they were not able to remember the association between the two, similar to the cognitive decline in older people. They also discovered that levels of PDE11A increased with age in both people and mice, specifically in a brain region responsible for many types of learning and memory known as the hippocampus. This extra PDE11A in the hippocampus was not simply found where it was normally located in young mice; instead, it preferentially accumulated as little filaments in compartments of neurons. Genetic Deletion of PDE11A Restores Memory The researchers wondered if having too much PDE11A in these filaments was why the older mice forgot their social associative memories and would no longer eat the safe food they smelled on another mouse’s breath. To answer this question, they prevented these age-related increases in PDE11A by genetically deleting the PDE11A gene in mice. Without PDE11A, the older mice no longer forgot the social associative memory, meaning they ate the safe food they smelled on another mouse’s breath. When the researchers added the PDE11A back into the hippocampus of these old mice, the mice once again forgot the social associative memory and would no longer eat the safe food. One potential pathway to drug development to prevent this memory loss in people lies in an additional finding: The researchers learned that the concentrated filaments of PDE11A had an extra chemical modification in a specific place on the enzyme that the other PDE11 diffused throughout the neuron did not have. When they prevented this chemical modification, it reduced PDE11 levels and also prevented it from accumulating as filaments. “PDE11 is involved in more things than just memory, including preferences for who you prefer to be around. So, if we are to develop a therapy to help with cognitive decline, we would not want to get rid of it entirely or it could cause other negative side effects,” said Dr. Kelly. She and her colleagues joke that any drug that eliminated PDE11 would ensure you would remember your friends and family, but you may no longer like them. “Thus, our goal is to figure out a way to target the bad form of PDE11A specifically, in order to not interfere with the normal, healthy function of the enzyme.” Dean Mark T. Gladwin, MD, Executive Vice President for Medical Affairs, UM Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor at UMSOM, said, “We are at the tip of the iceberg when it comes to understanding how the brain ages, so it’s crucial to have basic research studies such as these to help us further our understanding and eventually find ways to prevent cognitive decline.” Reference: “Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories” by Katy Pilarzyk, Latarsha Porcher, William R. Capell, Steven D. Burbano, Jeff Davis, Janet L. Fisher, Nicole Gorny, Siena Petrolle and Michy P. Kelly, 8 September 2022, Aging Cell. DOI: 10.1111/acel.13687 Additional authors on the study include students Nicole Gorny, MS, and Siena Petrolle of UMSOM, as well as co-authors from the University of South Carolina. Funding for this study was provided by grants from the National Institute of General Medical Sciences (P20GM109091), the National Institute of Mental Health (R01MH101130), the National Institute on Aging (R01AG061200), and the National Science Foundation.

The scientific study used satellite transmitters, population counts, and DNA analyses of tissue samples to describe the special Kangia ringed seal in Ilulissat Icefjord. Here, a seal has just had a satellite transmitter mounted on its back. Credit: Pinngortitaleriffik – Greenland Nature Institute Local hunters in the Icefjord near Ilulissat are familiar with a special variety of ringed seal known as the Kangia seal. Distinct in size and appearance, the Kangia seal is considerably larger and boasts a notably different fur color and pattern compared to the common Arctic ringed seals. Recent scientific research has revealed that this distinctive seal has been genetically isolated from its Arctic counterparts for a long period of time – more than 100,000 years. Exploring the Arctic’s natural wonders can be difficult. The extreme weather and vast distances often hinder researchers in their quest to uncover nature’s mysteries. However, a research project, led by Greenlandic and Danish researchers, has now succeeded in describing a new type of ringed seal that lives in the Icefjord near Ilulissat in West Greenland; a unique natural area on the UNESCO World Heritage List. The results have recently been published in the renowned scientific journal Molecular Ecology. The Kangia ringed seal is larger than the typical Arctic ringed seal and its fur color is different with more distinctive patterns. Credit: Pinngortitaleriffik – Greenland Nature Institute A small population Over a number of years, the researchers together with local hunters captured seals in nets and mounted a small satellite transmitter on the seals’ backs. When the seals were up for air, the satellite transmitter sent a message about their location. ”We could see that the Kangia seals primarily stay inside the Icefjord. We were able to count the seals from a plane and therefore able to estimate that there are only approx. 3,000 of these special Kangia ringed seals,” says Aqqalu Rosing-Asvid, Senior Researcher at the Pinngortitaleriffik – Greenland Institute of Nature, and one of the researchers behind the study. Fur color and patterns of the Kangia ringed seal (left) and a typical Arctic ringed seal (right). Credit: Pinngortitaleriffik – Greenland Nature Institute The small resident population is highly unusual compared to the typical Arctic ringed seal, which has an enormous population size and often travels thousands of kilometers around the Arctic in search of food. Isolated for thousands of years The researchers also took small tissue samples from the captured seals. The samples were sent for genetic analyses to uncover the seals’ DNA profile, and the results revealed that the Kangia ringed seals are genetically different from the typical Arctic ringed seals. The Kangia ringed seal lives in the Ilulissat Icefjord, which is on the UNESCO World Heritage List because of its magnificent and unique nature. Credit: Pinngortitaleriffik – Greenland Nature Institute But where and how the Kangia ringed seal was isolated from the other Arctic ringed seals and why it acquired its new special biological characteristics is still a mystery. Perhaps also special seals in other Arctic fjords The study emphasizes that there is still much we do not know about the diversity of organisms in the Arctic and thus their possibilities to adapt to climate change and human activities. “There are many other fjords in the Arctic that have not yet been studied in detail, and where the ringed seals may also have locally developed new genetic variants,” points out Rune Dietz, Professor at the Department of Ecoscience at Aarhus University, who also participated in the study. Reference: “An evolutionarily distinct ringed seal in the Ilulissat Icefjord” by Aqqalu Rosing-Asvid, Ari Löytynoja, Paolo Momigliano, Rikke Guldborg Hansen, Camilla Hjorth Scharff-Olsen, Mia Valtonen, Juhana Kammonen, Rune Dietz, Frank Farsø Rigét, Steve H. Ferguson, Christian Lydersen, Kit M. Kovacs, David M. Holland, Jukka Jernvall, Petri Auvinen and Morten Tange Olsen, 19 October 2023, Molecular Ecology. DOI: 10.1111/mec.17163

The spectacular structure of the protective armor of superbug C. difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail. This assembly prevents molecules from getting in and provides a new target for future treatments, according to the scientists at Newcastle, Sheffield, and Glasgow Universities who have uncovered it. Credit: Newcastle University, UK Spectacular structure of chain-mail may explain the success of C.diff at defending itself against antibiotics and immune system molecules. The spectacular structure of the protective armor of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail. This assembly prevents molecules from getting in and provides a new target for future treatments, according to the scientists who have uncovered it. Publishing in Nature Communications, the team of scientists from Newcastle, Sheffield, and Glasgow Universities together with colleagues from Imperial College and Diamond Light Source, outline the structure of the main protein, SlpA, that forms the links of the chain mail and how they are arranged to form a pattern and create this flexible armor. This opens the possibility of designing C. diff specific drugs to break the protective layer and create holes to allow molecules to enter and kill the cell. Protective Armor One of the many ways that diarrhea-causing superbug Clostridioides difficile has to protect itself from antibiotics is a special layer that covers the cell of the whole bacteria — the surface layer or S-layer. This flexible armor protects against the entry of drugs or molecules released by our immune system to fight bacteria. The team determined the structure of the proteins and how they arranged using a combination of X-ray and electron crystallography. Corresponding author Dr. Paula Salgado, Senior Lecturer in Macromolecular Crystallography who led the research at Newcastle University said: “I started working on this structure more than 10 years ago, it’s been a long, hard journey but we got some really exciting results! Surprisingly, we found that the protein forming the outer layer, SlpA, packs very tightly, with very narrow openings that allow very few molecules to enter the cells. S-layer from other bacteria studied so far tend to have wider gaps, allowing bigger molecules to penetrate. This may explain the success of C.diff at defending itself against the antibiotics and immune system molecules sent to attack it. “Excitingly, it also opens the possibility of developing drugs that target the interactions that make up the chain mail. If we break these, we can create holes that allow drugs and immune system molecules to enter the cell and kill it.” One of the current challenges in our fight against infections is the growing ability bacteria have to resist the antibiotics that we use to try to kill them. Antibiotic or more generally, antimicrobial resistance (AMR), was declared by WHO as one of the top 10 global public health threats facing humanity. Different bacteria have different mechanisms to resist antibiotics and some have multiple ways to avoid their action – the so-called superbugs. Included in these superbugs is C. diff, a bacteria that infects the human gut and is resistant to all but three current drugs. Not only that, it actually becomes a problem when we take antibiotics, as the good bacteria in the gut are killed alongside those causing an infection and, as C. diff is resistant, it can grow and cause diseases ranging from diarrhea to death due to massive lesions in the gut. Another problem is the fact that the only way to treat C.diff is to take antibiotics, so we restart the cycle and many people get recurrent infections. Determining the structure allows the possibility of designing C. diff-specific drugs to break the S-layer, the chainmail, and create holes to allow molecules to enter and kill the cell. Colleagues, Dr. Rob Fagan and Professor Per Bullough at the University of Sheffield carried out the electron crystallography work. Dr. Fagan said: “We’re now looking at how our findings could be used to find new ways to treat C. diff infections such as using bacteriophages to attach to and kill C. diff cells — a promising potential alternative to traditional antibiotic drugs.” From Dr. Salgado’s team at Newcastle University, PhD student Paola Lanzoni-Mangutchi and Dr. Anna Barwinska-Sendra unraveled the structural and functional details of the building blocks and determined the overall X-ray crystal structure of SlpA. Paola said: “This has been a challenging project and we spent many hours together, culturing the difficult bug and collecting X-ray data at the Diamond Light Source synchrotron.” Dr. Barwinska-Sendra added: “Working together was key to our success, it is very exciting to be part of this team and to be able to finally share our work.” The work is illustrated in the stunning image by Newcastle-based science Artist and Science Communicator, Dr. Lizah van der Aart. Reference: “Structure 1 and assembly of the S-layer in C. difficile” by Paola Lanzoni-Mangutchi, Oishik Banerji, Jason Wilson, Anna Barwinska-Sendra, Joseph A. Kirk, Filipa Vaz, Shauna O’Beirne, Arnaud Baslé, Kamel El Omari, Armin Wagner, Neil F. Fairweather, Gillian R. Douce, Per A. Bullough, Robert P. Fagan and Paula S. Salgado, 25 February 2022, Nature Communications. DOI: 10.1038/s41467-022-28196-w

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