Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam insole ODM design and production

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow OEM for wellness brands Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia pillow ODM development service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia anti-odor insole OEM service

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole manufacturer in Indonesia

MIT biologists have found a possible explanation for the Warburg effect, first seen in cancer cells in the 1920s and named after Otto Warburg, pictured. Credit: Image: Digital collage by Jose-Luis Olivares; cancer image courtesy of Dr. Cecil Fox, NCI; Warburg photo courtesy of NIH MIT study sheds light on the longstanding question of why cancer cells get their energy from fermentation. In the 1920s, German chemist Otto Warburg discovered that cancer cells don’t metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient. MIT biologists have now found a possible answer to this longstanding question. In a study appearing in Molecular Cell, they showed that this metabolic pathway, known as fermentation, helps cells to regenerate large quantities of a molecule called NAD+, which they need to synthesize DNA and other important molecules. Their findings also account for why other types of rapidly proliferating cells, such as immune cells, switch over to fermentation.  “This has really been a hundred-year-old paradox that many people have tried to explain in different ways,” says Matthew Vander Heiden, an associate professor of biology at MIT and associate director of MIT’s Koch Institute for Integrative Cancer Research. “What we found is that under certain circumstances, cells need to do more of these electron transfer reactions, which require NAD+, in order to make molecules such as DNA.” Vander Heiden is the senior author of the new study, and the lead authors are former MIT graduate student and postdoc Alba Luengo PhD ’18 and graduate student Zhaoqi Li. Inefficient Metabolism Fermentation is one way that cells can convert the energy found in sugar to ATP, a chemical that cells use to store energy for all of their needs. However, mammalian cells usually break down sugar using a process called aerobic respiration, which yields much more ATP. Cells typically switch over to fermentation only when they don’t have enough oxygen available to perform aerobic respiration. MIT researchers have shown that cancer cells’ demand for NAD+ drives them to switch to a wasteful metabolic process called fermentation. Credit: Courtesy of the researchers Since Warburg’s discovery, scientists have put forth many theories for why cancer cells switch to the inefficient fermentation pathway. Warburg originally proposed that cancer cells’ mitochondria, where aerobic respiration occurs, might be damaged, but this turned out not to be the case. Other explanations have focused on the possible benefits of producing ATP in a different way, but none of these theories have gained widespread support. In this study, the MIT team decided to try to come up with a solution by asking what would happen if they suppressed cancer cells’ ability to perform fermentation. To do that, they treated the cells with a drug that forces them to divert a molecule called pyruvate from the fermentation pathway into the aerobic respiration pathway. They saw, as others have previously shown, that blocking fermentation slows down cancer cells’ growth. Then, they tried to figure out how to restore the cells’ ability to proliferate, while still blocking fermentation. One approach they tried was to stimulate the cells to produce NAD+, a molecule that helps cells to dispose of the extra electrons that are stripped out when cells make molecules such as DNA and proteins. When the researchers treated the cells with a drug that stimulates NAD+ production, they found that the cells started rapidly proliferating again, even though they still couldn’t perform fermentation. This led the researchers to theorize that when cells are growing rapidly, they need NAD+ more than they need ATP. During aerobic respiration, cells produce a great deal of ATP and some NAD+. If cells accumulate more ATP than they can use, respiration slows and production of NAD+ also slows. “We hypothesized that when you make both NAD+ and ATP together, if you can’t get rid of ATP, it’s going to back up the whole system such that you also cannot make NAD+,” Li says. Therefore, switching to a less efficient method of producing ATP, which allows the cells to generate more NAD+, actually helps them to grow faster. “If you step back and look at the pathways, what you realize is that fermentation allows you to generate NAD+ in an uncoupled way,” Luengo says. Solving the Paradox The researchers tested this idea in other types of rapidly proliferating cells, including immune cells, and found that blocking fermentation but allowing alternative methods of NAD+ production enabled cells to continue rapidly dividing. They also observed the same phenomenon in nonmammalian cells such as yeast, which perform a different type of fermentation that produces ethanol. “Not all proliferating cells have to do this,” Vander Heiden says. “It’s really only cells that are growing very fast. If cells are growing so fast that their demand to make stuff outstrips how much ATP they’re burning, that’s when they flip over into this type of metabolism. So, it solves, in my mind, many of the paradoxes that have existed.” The findings suggest that drugs that force cancer cells to switch back to aerobic respiration instead of fermentation could offer a possible way to treat tumors. Drugs that inhibit NAD+ production could also have a beneficial effect, the researchers say. Reference: “Increased demand for NAD+ relative to ATP drives aerobic glycolysis” by Alba Luengo, Zhaoqi Li, Dan Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, Raphael Ferreira, Adi Naamati, Ahmed Ali, Caroline A. Lewis, Craig J. Thomas, Stefani Spranger, Nicholas J. Matheson and Matthew G. Vander Heiden, 30 December 2020, Molecular Cell. DOI: 10.1016/j.molcel.2020.12.012 The research was funded by the Ludwig Center for Molecular Oncology, the National Science Foundation, the National Institutes of Health, the Howard Hughes Medical Institute, the Medical Research Council, NHS Blood and Transplant, the Novo Nordisk Foundation, the Knut and Alice Wallenberg Foundation, Stand Up 2 Cancer, the Lustgarten Foundation, and the MIT Center for Precision Cancer Medicine.

Intermale-competitions of giraffoid, foreground: Discokeryx xiezhi, background: Giraffa camelopardalis. Credit: WANG Yu and GUO Xiaocong The discovery of Discokeryx xiezhi fossils reveals that giraffes’ long necks likely evolved as a weapon in courtship battles, not just for feeding. Giraffes are quite distinctive due to their extremely long necks. In fact, their necks can be as long as 7.9 feet (2.4 m). Even though there have been various hypotheses as to the evolutionary origin of these long necks, they haven’t had sufficient proof, leaving it an unsolved mystery. Charles Darwin suggested the “competing browsers hypothesis,” which basically says that the elongated necks evolved because they enabled giraffes to reach food that competitors could not. It makes sense, but was this really what happened? Discovery of Discokeryx xiezhi: Key to Giraffe Evolution Now, fossils of a strange early giraffoid have revealed the key driving forces in giraffe evolution, according to a study led by researchers from the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences (CAS). The study was published in the journal Science on June 2, 2022. Modeling of high-speed head-butting in Discokeryx xiezhi using finite element analyses, with (A) and without (B) the complicated joints between cranium and vertebrae, showing the stable (A) or over-bending (B) head-neck articulation. Credit: IVPP How the giraffe’s long neck evolved has long been an evolutionary mystery. Although there have been different opinions about the process of giraffe neck elongation, scientists never doubted that the impetus for neck elongation was high foliage. However, as observation of giraffe behavior increased, scientists began to realize that the elegant, long neck of giraffes actually serves as a weapon in male courtship competition and this may be the key to the giraffe evolutionary mystery. Specifically, giraffes use their two-to-three-meter-long swinging necks to hurl their heavy skulls—equipped with small ossicones and osteomas—against the weak parts of competitors. As a result, the longer the neck, the greater the damage to the opponent. IVPP researchers and their collaborators conducted their study on Discokeryx xiezhi, a strange early giraffoid. This research contributes to understanding how the giraffe’s long neck evolved as well as to understanding the extensive integration of courtship struggles and feeding pressure. In fact, the neck size of male giraffes is directly related to social hierarchy, and courtship competition is the driving force behind the evolution of long necks. The fossil community in the Junggar Basin at ~17 million years ago. Discokeryx xiezhi are in the middle. Credit: GUO Xiaocong The fossils in this study were found in early Miocene strata from about 17 million years ago on the northern margin of the Junggar Basin, Xinjiang. A full skull and four cervical vertebrae were part of the find. “Discokeryx xiezhi featured many unique characteristics among mammals, including the development of a disc-like large ossicone in the middle of its head,” said Prof. DENG Tao from IVPP, a corresponding author of the study. DENG said the single ossicone resembles that of the xiezhi, a one-horned creature from ancient Chinese mythology—thus giving the fossil its name. Head-to-Head Combat and Neck Evolution According to the researchers, the cervical vertebrae of Discokeryx xiezhi are very stout and have the most complex joints between head and neck and between cervical vertebrae of any mammal. The team demonstrated that the complex articulations between the skull and cervical vertebrae of Discokeryx xiezhi was particularly adapted to high-speed head-to-head impact. They found this structure was far more effective than that of extant animals, such as musk oxen, that are adapted to head impact. In fact, Discokeryx xiezhi may have been the vertebrate best adapted to head impact ever. “Both living giraffes and Discokeryx xiezhi belong to the Giraffoidea, a superfamily. Although their skull and neck morphologies differ greatly, both are associated with male courtship struggles and both have evolved in an extreme direction,” said WANG Shiqi, first author of the study. Giraffoid Horn Morphology and Courtship Struggles The research team compared the horn morphology of several groups of ruminants, including giraffoids, cattle, sheep, deer and pronghorns. They found that horn diversity in giraffes is much greater than in other groups, with a tendency toward extreme differences in morphology, thus indicating that courtship struggles are more intense and diverse in giraffes than in other ruminants. The research team further analyzed the ecological environment of Discokeryx xiezhi and the niche it occupied. The Earth was in a warm period and generally densely forested, but the Xinjiang region, where Discokeryx xiezhi lived, was somewhat drier than other areas because the Tibetan Plateau to the south had been rising dramatically, thus blocking the transfer of water vapor. “Stable isotopes of tooth enamel have indicated that Discokeryx xiezhi was living in open grasslands and may have migrated seasonally,” said MENG Jin, another corresponding author of the study. For animals of the time, the grassland environment was more barren and less comfortable than the forest environment. The violent fighting behavior of Discokeryx xiezhi may have been related to survival-related stress caused by the environment. Evolution of Giraffa: Neck Elongation and Ecological Pressures At the beginning of the emergence of the genus Giraffa, a similar environment existed. Around seven million years ago, the East African Plateau also changed from a forested environment to open grassland, and the direct ancestors of giraffes had to adapt to new changes. It is possible that, among giraffe ancestors during this period, mating males developed a way of attacking their competitors by swinging their necks and heads. This extreme struggle, supported by sexual selection, thus led to the rapid elongation of the giraffe’s neck over a period of two million years to become the extant genus, Giraffa. Based on this elongation, Giraffa were well-suited for the niche of feeding on high foliage. However, their ecological status was necessarily less secure than that of bovids and cervids. As a result, Giraffa’s marginal ecological niche may have promoted extreme intraspecific courtship competition, which in turn may have promoted extreme morphological evolution. Reference: “Sexual selection promotes giraffoid head-neck evolution and ecological adaptation” by Shi-Qi Wang, Jie Ye, Jin Meng, Chunxiao Li, Loïc Costeur, Bastien Mennecart, Chi Zhang, Ji Zhang, Manuela Aiglstorfer, Yang Wang, Yan Wu, Wen-Yu Wu and Tao Deng, 3 June 2022, Science. DOI: 10.1126/science.abl8316

Quadruple-helix DNA structure. Credit: Imperial College London New probes allow scientists to see four-stranded DNA interacting with molecules inside living human cells, unraveling its role in cellular processes. DNA usually forms the classic double helix shape of two strands wound around each other. While DNA can form some more exotic shapes in test tubes, few are seen in real living cells. “G-quadruplexes play an important role in a wide variety of processes vital for life, and in a range of diseases, but the missing link has been imaging this structure directly in living cells.” Ben Lewis However, four-stranded DNA, known as G-quadruplex, has recently been seen forming naturally in human cells. Now, in new research published in Nature Communications, a team led by Imperial College London scientists have created new probes that can see how G-quadruplexes are interacting with other molecules inside living cells. G-quadruplexes are found in higher concentrations in cancer cells, so are thought to play a role in the disease. The probes reveal how G-quadruplexes are ‘unwound’ by certain proteins, and can also help identify molecules that bind to G-quadruplexes, leading to potential new drug targets that can disrupt their activity. Needle in a Haystack One of the lead authors, Ben Lewis, from the Department of Chemistry at Imperial, said: “A different DNA shape will have an enormous impact on all processes involving it – such as reading, copying, or expressing genetic information. “Evidence has been mounting that G-quadruplexes play an important role in a wide variety of processes vital for life, and in a range of diseases, but the missing link has been imaging this structure directly in living cells.” G-quadruplexes are rare inside cells, meaning standard techniques for detecting such molecules have difficulty detecting them specifically. Ben Lewis describes the problem as “like finding a needle in a haystack, but the needle is also made of hay”. To solve the problem, researchers from the Vilar and Kuimova groups in the Department of Chemistry at Imperial teamed up with the Vannier group from the Medical Research Council’s London Institute of Medical Sciences. Fluorescence lifetime imaging microscopy map of nuclear DNA in live cells stained with the new probe. Colours represent fluorescence lifetimes between 9 (red) and 13 (blue) nanoseconds. Credit: Imperial College London They used a chemical probe called DAOTA-M2, which fluoresces (lights up) in the presence of G-quadruplexes, but instead of monitoring the brightness of fluorescence, they monitored how long this fluorescence lasts. This signal does not depend on the concentration of the probe or of G-quadruplexes, meaning it can be used to unequivocally visualize these rare molecules. Dr. Marina Kuimova, from the Department of Chemistry at Imperial, said: “By applying this more sophisticated approach we can remove the difficulties which have prevented the development of reliable probes for this DNA structure.” Looking Directly in Live Cells The team used their probes to study the interaction of G-quadruplexes with two helicase proteins – molecules that ‘unwind’ DNA structures. They showed that if these helicase proteins were removed, more G-quadruplexes were present, showing that the helicases play a role in unwinding and thus breaking down G-quadruplexes. “Many researchers have been interested in the potential of G-quadruplex binding molecules as potential drugs for diseases such as cancers. Our method will help to progress our understanding of these potential new drugs.” Professor Ramon Vilar Dr. Jean-Baptiste Vannier, from the MRC London Institute of Medical Sciences and the Institute of Clinical Sciences at Imperial, said: “In the past we have had to rely on looking at indirect signs of the effect of these helicases, but now we take a look at them directly inside live cells.” They also examined the ability of other molecules to interact with G-quadruplexes in living cells. If a molecule introduced to a cell binds to this DNA structure, it will displace the DAOTA-M2 probe and reduce its lifetime, i.e. how long the fluorescence lasts. This allows interactions to be studied inside the nucleus of living cells, and for more molecules, such as those which are not fluorescent and can’t be seen under the microscope, to be better understood. Professor Ramon Vilar, from the Department of Chemistry at Imperial, explained: “Many researchers have been interested in the potential of G-quadruplex binding molecules as potential drugs for diseases such as cancers. Our method will help to progress our understanding of these potential new drugs.” Peter Summers, another lead author from the Department of Chemistry at Imperial, said: “This project has been a fantastic opportunity to work at the intersection of chemistry, biology, and physics. It would not have been possible without the expertise and close working relationship of all three research groups.” The three groups intend to continue working together to improve the properties of their probe and to explore new biological problems and shine further light on the roles G-quadruplexes play inside our living cells. The research was funded by Imperial’s Excellence Fund for Frontier Research. Reference: “Visualising G-quadruplex DNA dynamics in live cells by fluorescence lifetime imaging microscopy” by Peter A. Summers, Benjamin W. Lewis, Jorge Gonzalez-Garcia, Rosa M. Porreca, Aaron H. M. Lim, Paolo Cadinu, Nerea Martin-Pintado, David J. Mann, Joshua B. Edel, Jean Baptiste Vannier, Marina K. Kuimova and Ramon Vilar, 8 January 2021, Nature Communications. DOI: 10.1038/s41467-020-20414-7

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