Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Private label insole and pillow OEM China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene-infused pillow ODM Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Soft-touch pillow OEM service in Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance insole OEM Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan graphene material ODM factory

The giant clam (Tridacna gigas) is critically endangered, with its population falling by over 80% in the last century, largely due to overfishing and climate change. Credit: Ruiqi Li/CU Boulder Giant clams are critically endangered, with populations down 80% due to overfishing and climate change. Conservationists are pushing for legal protections to prevent extinction, given the clams’ essential role in tropical ecosystems. The giant clam, recognized for its vibrant, cape-like mantle, wavy shell, and remarkable size, faces the threat of extinction after its population has dropped by over 80% in the past century, according to a recent assessment by a biologist from the University of Colorado Boulder and colleagues. The assessment, led by Ruiqi Li, a postdoctoral researcher at the CU Museum of Natural History, prompted the International Union for Conservation of Nature (IUCN) today to update the conservation status of this animal from “vulnerable” to “critically endangered,” the highest level before a species becomes extinct in the wild. It also adjusted the statuses of 11 other related species, all from the group of animals known as giant clams. Many giant clam species have colorful mantles. Credit: Ruin Li/CU Boulder Overfishing and climate change are the major threats endangering these marine invertebrates, Li said. “Along with coral reefs, these clams provide important habitats for other creatures living in the reefs,” Li said. “They are also important nutrient producers in shallow ocean water, which is generally deprived of food. If the giant clam becomes extinct, it will have significant ecological impacts on tropical oceans.” The IUCN announcement comes as representatives from 175 countries meet in Colombia for the 2024 United Nations Biodiversity Conference (COP16). Countries are discussing ways to stop what is known as the “sixth mass extinction,” a rapid decline in biodiversity due to human activity. The fifth mass extinction, 66 million years ago, wiped out the dinosaurs. The World Wildlife Fund estimated this month that global marine wildlife has declined by 56% since 1970. The Giant Clam: An Ecological Marvel The giant clam, or Tridacna gigas, is the best-known species of giant clams. It is the world’s largest marine bivalve mollusk, a group of invertebrate animals with two-part shells. It can grow up to 4.5 feet in length and weigh more than 700 pounds. These clams live in the shallow water of the tropical Indo-Pacific Ocean, off the coasts of Malaysia, Australia, and Fiji. Scientists are unsure how T. gigas grow so big. Similar to corals, these massive clams live in a mutually beneficial relationship with algae inside their bodies. While T. gigas provide shelter for the algae, the algae produce additional nutrients that help feed the clams. The last time scientists assessed the T. gigas population was in 1996, when the IUCN listed the species as “vulnerable” on its Red List of Threatened Species, the global reference for assessing extinction risks for wildlife. The previous Red List version also failed to include many other giant clam species due to a lack of research. “This is a major issue in the conservation world. People, even scientists, tend to pay more attention to mammals and birds, because they are big, cute, and familiar. So there’s a good chance you can find these animals on the Red List. But marine invertebrates are very neglected,” Li said. Giant clam meat for sale at a fish market in Malaysia. Credit: Ruiqi Li/CU Boulder Working with the Senckenberg Natural History Museum in Germany, Li and his collaborator, Neo Mei Lin from the National University of Singapore, collected data from previous research and biodiversity databases on all 12 giant clam species for a reassessment. The team found that T. gigas has already become locally extinct in many regions where it used to exist, such as near Taiwan, and its overall population has declined by 84% over the past century. In addition to updating the status of T. gigas, IUCN also upgraded other giant clam species, including Tridacna mbalavuana, or the tevoro clam, from “vulnerable” to “endangered,” as well as Hippopus hippopus, or horse’s hoof clam, from “least concern” to “vulnerable.” Li said many giant clam species have beautiful mantles—the exposed flesh that lines the shell. Even among individuals of the same species, the mantles’ color patterns vary widely, from turquoise with yellow spots to emerald green with black specks. Some resemble ink flowing through a sky-blue river. Human Impact: Overharvesting and Climate Change In many parts of the world, fishers harvest giant clams for food or their shells for decoration. Climate change also poses a major threat to giant clams. When the ocean water becomes too warm, the clams expel the algae living in their tissues, similar to what happens to corals during coral bleaching. Without the algae, giant clams can starve. The Red List update also includes some recently discovered species under the “data deficiency” category. Li said that adding these species could pave the way for future research by highlighting what is missing. “Invertebrates, like insects and mollusks, account for more than 95% of total animal biodiversity in the world, but people are not paying enough attention to them. There’re still a lot of undiscovered or undescribed species out there,” Li said. While the IUCN Red List has no legal implications, efforts to protect giant clams are growing. In July, the National Oceanic and Atmospheric Administration (NOAA) proposed listing 10 giant clam species —including T. gigas—under the Endangered Species Act. If approved, these giant clams will receive legal protection in the U.S., barring harvesting and trade of wild individuals. Li has submitted his assessment to NOAA in support of this effort. “As a biologist, I’m working on translating findings from my research into policy changes, but not enough biologists are doing this. I hope to encourage more biologists to devote time into population assessment and conservation,” Li said.

A study by CUNY ASRC researchers, using X-ray crystallography under different conditions, revealed various shapes of a disease-related protein, offering new avenues for drug development. Credit: SciTechDaily.com New crystallography experiments using high pressure and heat to reveal how proteins change shape could advance the development of novel drugs. Proteins do the heavy lifting of performing biochemical functions in our bodies by binding to metabolites or other proteins to complete tasks. To do this successfully, protein molecules often shape-shift to allow specific binding interactions that are needed to perform complex, precise chemical processes. Research on Protein Structures A better understanding of the shapes proteins take on would give researchers important insight into stopping or treating diseases, but current methods for revealing these dynamic, three-dimensional forms offer scientists limited information. To address this knowledge gap, a team from the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) designed an experiment to test whether performing X-ray crystallography imaging using elevated temperature versus elevated pressure would reveal distinct shapes. The results of the team’s work will be published today (January 12) in the journal Communications Biology. The positions of these water molecules are often important for understanding protein flexibility and the ability of drug-like molecules to influence protein structure and function. In this study, different unique waters appeared at the surface of the protein under different experimental perturbations such as high temperature (red), high pressure (green), or default conditions (blue), offering complementary insights into these questions. Credit: Ali Ebrahim & Liliana Guerrero Study Insights by Dr. Daniel Keedy “Protein structures don’t sit still; they shift between several similar shapes much like a dancer,” said the study’s principal investigator Daniel Keedy, Ph.D., a professor with the CUNY ASRC’s Structural Biology Initiative and a chemistry and biochemistry professor at The City College of New York and the CUNY Graduate Center. “Unfortunately, existing approaches for viewing proteins only reveal one shape, or suggest the presence of multiple shapes without providing specific details. We wanted to see if different ways of poking at a protein could give a us a more detailed view of how it shape-shifts.” Experimentation and Observations For their experiment, the team obtained crystals of STEP, also known as PTPN5—a drug target protein for the treatment of several diseases, including Alzheimer’s—and agitated them using either high pressure (2,000 times the Earth’s atmospheric pressure) or high temperature (body temperature), both of which are very different from typical crystallography experiments at atmospheric pressure and cryogenic temperature (-280 °F, -173 °C). The researchers viewed the samples using X-ray crystallography and observed that high temperature and high pressure had different effects on the protein, revealing distinct shapes. Implications for Drug Development While high pressure isn’t a condition that proteins experience inside the body, Keedy said the agitation method exposed different structural states of the protein that may be relevant to its activity in human cells. “Having the ability to use perturbations such as heat and pressure to elucidate these different states could give drug developers tools for determining how they can trap a protein in a particular shape using a small-molecule drug to diminish its function,” Keedy added. Reference: “Pushed to extremes: distinct effects of high temperature versus pressure on the structure of STEP” by Liliana Guerrero, Ali Ebrahim, Blake T. Riley, Minyoung Kim, Qingqiu Huang, Aaron D. Finke and Daniel A. Keedy, 12 January 2024, Communications Biology. DOI: 10.1038/s42003-023-05609-0

African clawed frogs are known for their flat bodies, vocal organs, and claws on the first three toes of the hind feet. Credit: Adam Bewick Researchers at McMaster University discovered eight different sex chromosomes in 11 species of African clawed frogs, revealing surprising genetic diversity. The study found these chromosomes in genome regions with high genetic recombination, challenging existing theories about sex-determining gene evolution. This research highlights how crucial biological traits like sexual differentiation can evolve rapidly through newly developed genes. Genetic Diversity in African Clawed Frogs Researchers at McMaster University have discovered surprising genetic diversity in how sex is determined in the African clawed frog, one of the most extensively studied amphibians in the world. Through genomic analysis, scientists identified eight distinct sex chromosomes across 11 species of the frog. Many of these chromosomes may carry newly evolved genes responsible for triggering male or female development. Before this study, researchers were aware of only three sex chromosomes in the species, making this a groundbreaking discovery in the field of genetic evolution. The African clawed frog is used as a model organism for biological research because of its close evolutionary relationship to humans. Credit: Adam Bewick “In these frogs, we’ve discovered extraordinary variation even among closely related species, which allows us to explore how important things like sex determination evolve rapidly,” says Ben Evans, a professor in the Department of Biology at McMaster and lead author of a new study in the journal Molecular Biology and Evolution. Evans conducted the work with colleagues from the Czech Republic, France, the USA, and South Africa. The African clawed frog is used as a model organism for biological research because of its close evolutionary relationship to humans, and because early development occurs externally, allowing fundamental processes to be readily observed and manipulated. The frogs are found in sub-Saharan Africa and live in slow-moving or stagnant water. They are known for their flat bodies, vocal organs that can produce sound underwater, and claws on the first three toes of the hind feet, which they use to tear food apart. Surprising Locations of Sex-Determining Genes In this study, the researchers pinpointed the locations of the newly identified sex chromosomes, which added to their surprise. Prevailing theory had suggested that sex-determining genes might typically arise in regions of the genome with a low rate of recombination – the exchange of genetic material within each parent that creates new mixtures of traits in their offspring. Evolutionary Insights into Sex Determination Instead, they found these newly evolved genes were almost universally located in regions where genetic recombination is high, raising questions about how and why the genetic basis of very important biological traits – such as sexual differentiation – may evolve so quickly, and how new genes and genetic function arise. “If you conducted these same tests within some even older groups such as most mammals or all birds, you would find that their sex chromosomes are all the same,” explains Evans. “But this group of frogs — in sharp contrast — has incredible variation.” “It is very likely that new genes arose many times in these frogs to orchestrate sexual differentiation, by acting as an ‘on-off switch’ or a ‘male-female switch’ at the top of the developmental cascade,” he says. Historical Context and Ongoing Research In 2015, Evans—who has studied the African clawed frog for over two decades—led a team which discovered six new species and added another back to the list of known species, providing the foundational information for this current work. Reference: “Rapid Sex Chromosome Turnover in African Clawed Frogs (Xenopus) and the Origins of New Sex Chromosomes” by Ben J Evans, Václav Gvoždík, Martin Knytl, Caroline M S Cauret, Anthony Herrel, Eli Greenbaum, Jay Patel, Tharindu Premachandra, Theodore J Papenfuss, James Parente, Marko E Horb and John Measey, 12 December 2024, Molecular Biology and Evolution. DOI: 10.1093/molbev/msae234

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