Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan high-end foam product OEM/ODM factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia insole ODM design and production

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China sustainable material ODM solutions

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow for sleep brands Indonesia

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China anti-odor insole OEM service

Researchers studying the European olm, and other cave dwellers, believe these strange creatures can provide important answers about evolution and even human eye diseases. Credit: © Javier Ábalos Alvarez from Madrid, España, CC BY-SA 2.0 In watery underground caverns, there are strange creatures that live in an eternal midnight. Over the course of generations, these animals have adapted to their isolated and unique environments, and scientists believe their pasty skin and blind eyes may hold secrets to evolution – and to genetic adaptations that could reveal insights on longevity, surviving starvation, and eye diseases in humans. “These caves are isolated worlds,” said Professor Peter Trontelj, a zoologist at the University of Ljubljana in Slovenia. “If you go a couple of meters (below the surface), you enter a new world with totally different ecological conditions.” Certain animals are able to adapt to these dark habitats where no plants grow, making lightless caves, like those found in Slovenia, natural laboratories of evolutionary biology. Trontelj heads up the GENEVOLCAV project, which is investigating the European olm. These unusual cave salamanders resemble small ghostly swimming snakes with four spindly legs and a crocodile’s snout. Long ago, the olm’s ancestors lived above ground, but once stuck in these caves, they underwent dramatic physical changes to cope with their new environment. The olm is not the only creature able to evolve in this way. Scientists dive deep to collect DNA from one of the world’s last unexplored frontiers. Credit: © Alejandro Martínez, Juan Valenciano and Enrique Domínguez, 2010 Historically, evolutionary biologists thought that if we were to go back in time and replay the timeline of evolution, we could just as likely take different evolutionary paths and the world and creatures in it would look completely different. But caves show us that this is not the case. Animals’ adaptations to light- and nutrient-poor environments, like underground caves, are “usually quite predictable”, said Trontelj. “We now know that every time it will go the same way.” Trontelj and his colleagues have shown that this is true within European olms, which are found in central and South-Eastern Europe. GENEVOLCAV has overturned our understanding of these rare cave salamanders. Instead of just one species, as was previously thought, they have discovered nine potentially different species of olm, each of which evolved similar characteristics independently in the eternal watery dark. “If you go a couple of meters (below the surface), you enter a new world with totally different ecological conditions.” Professor Peter Trontelj, GENEVOLCAV project coordinator While all have the same bleached skin, sightless eyes, and elongated snouts, these species descended from different individual ancestors which found their ways into these midnight caves. “Everything happened independently, but in a more or less parallel way,” said Trontelj. DNA Diving The project aims to assemble the olm genome, which is about 16 times larger than the human genome, and identify the genetic changes that have allowed olms to adapt to their unique environments. “The (physical) changes are the same or very similar, but the question is: ‘Are they caused by the same genes (and) are they the same mutations?’” Trontelj asked. To answer these questions, he and colleagues cave dive into the dark recesses underground, sometimes descending into pits 400 meters (1,300 feet) deep, to measure olms and swab their skins to collect DNA. They will need hundreds of samples to investigate these questions, which could have important implications for human medicine. “There are several traits of (olms) that are interesting from a wider perspective,” said Trontelj. These milky amphibians can live for more than hundreds of years, 10 times longer than their surface-based ancestors, and are able to survive years of starvation. In the dark, olms also lose their color and go blind. “It’s already known that this pigment loss and eye degeneration in cave fishes can be caused by several different genes, some of which are linked,” he said. Scientists have also linked this group of genes to “some pathological states in human eye degeneration and albinism.” “Understanding these mechanisms that happen in a predictable way might also help our understanding of some degenerative diseases in humans,” he said. But olms, which are now only able to survive in these niche habitats, are vulnerable. “These caves and subterranean waters are quite endangered, and sometimes even very threatened by pollution,” said Trontelj. “If we don’t describe the new species, if they don’t have names, they will not receive the conservation attention that a fully-fledged species might.” The same holds true for the worms, crustaceans, and sometimes even fish that inhabit the dark recesses of the Earth. Underground Database Alejandro Martínez, lead on the ANCAVE project, is working to create a database of such creatures. His database, which already has more than 330,000 entries, draws on all references to underground cave fauna published in scientific literature in every written language. “They resemble things that we know from the fossil record, but which are now extinct.” Alejandro Martínez, ANCAVE It is called the “Stygofauna Mundi” database, in reference to a book by naturalist Lazare Botosaneanu, who pioneered the study of these subterranean creatures. “We are working on making all of this information publicly available,” Martínez said. Of that database, about 10% of entries are animals that particularly interest Martínez: those that live in coastal aquifers, also known as anchialine environments. What makes these underground caverns special is that their water is salty, fed through underground cracks and fissures by the nearby ocean, with a mix of freshwater seeping in from above. These environments are found all over the world, including in the Canary Islands where Martínez grew up. And the animals in them are unique. “Many of those animals are exclusive to this type of habitat, they are not found elsewhere,” said Martínez. They look “weird” and somehow “primitive,” he said. “They resemble things that we know from the fossil record, but which are now extinct.” Others share ancestors with animals in the ocean, but their seclusion in the caverns means they cannot interbreed, and this allows scientists to compare cave-dwellers with their kin in the sunshine. “(Some) are similar to other animals found in the deep ocean nowadays,” he said. “They are genetically close to each other, but morphologically (physically), they are very different… By comparing these types of species across the world, we can try to better understand how animals change shape to adapt to a new environment.” He has added species to the database himself, and as part of the ANCAVE project has sampled about 50 caves in the Mediterranean, the Caribbean, and several Atlantic oceanic archipelagos. In these caverns, he gauged the relative abundance of animals within them, captured some, and then described them morphologically and genetically. Midnight Caves However, the database is just the first step. “We can see the generalities that happen across all these lineages,” he explained. “We can get rid of these confounding effects of phylogeny (how a species or group evolves) and understand morphological change.” By documenting the breadth of biodiversity in the midnight caves underground, scientists can illuminate the nature of evolution and how animals change. But Martinez also recognizes that the database and research into the subterranean world will only raise more questions. In fact, that is why he keeps returning to these dark watery caverns. The research in this article was funded by the EU. This article was originally published in Horizon, the EU Research & Innovation Magazine.

Tyrannosaurus Rex Skull Theropod dinosaurs evolved more robust jaws through time allowing them to consume tougher food, a new study reveals. Researchers used digital modeling and computer simulation to uncover a common trend of jaw strengthening in theropods — expanding the rear jaw portion in all groups, as well as evolving an upturned jaw in carnivores and a downturned jaw in herbivores. Publishing their findings today (December 16, 2021) in the journal Current Biology, scientists revealed that biomechanical analysis showed these form changes made jaws mechanically more stable when biting — minimizing the chance of bone fracture. The international team, led by scientists at the University of Birmingham, created digital models of more than 40 lower jaws from five different theropod dinosaur groups, including typical carnivores like Tyrannosaurus and Velociraptor, and lesser-known herbivores like ornithomimosaurs, therizinosaurs, and oviraptorosaurs. Fion Waisum Ma, PhD researcher at the University of Birmingham, who led the study, said: “Although theropod dinosaurs are always depicted as fearsome predators in popular culture, they are in fact very diverse in terms of diets. It is interesting to observe the jaws becoming structurally stronger over time, in both carnivores and herbivores. This gives them the capacity to exploit a wider range of food items. Life reconstruction of the Late Cretaceous Iren Dabasu Formation fauna, showing theropod dinosaurs of various diets. Such dietary niche partitioning could have contributed to the diversification of theropod dinosaurs, which eventually led to the evolution of modern birds. Depicted species: Gigantoraptor, Garudimimus, Neimongosaurus and Velociraptor. Credit: Gabriel Ugueto “Theropod dinosaurs underwent extreme dietary changes during their evolutionary history of 165 million years. They started off as carnivores, later on evolved into more specialized carnivores, omnivores, and herbivores. Studying how their feeding mechanics changed is key to understanding the dietary transitions in other vertebrate animals too.” For example, in carnivores like tyrannosauroids, an early form like Guanlong had a relatively slender and straight jaw. But later forms such as Tarbosaurus and Tyrannosaurus evolved deeper jaws with the front portion bending upward, which increased jaw strength. Having a strengthened jaw is especially important to herbivorous theropods, as their jaws experience considerable stress from repetitive plant cropping. Herbivores like Erlikosaurus and Caudipteryx have extremely downward-bending jaws that could help dissipate such stress. Dr. Stephan Lautenschlager, Senior Lecturer at the University of Birmingham and senior author of the study, said: “It is fascinating to see how theropod dinosaurs had evolved different strategies to increase jaw stability depending on their diet. This was achieved through bone remodeling — a mechanism where bone is deposited in regions of the jaw that experience high stresses during feeding.” The researchers studied the feeding mechanics of tyrannosaurids through growth and observed that the deeper and more upturned jaws of adult theropods, such as Tyrannosaurus and Tarbosaurus, are structurally stronger compared to those of their juvenile forms. Dr. Lautenschlager further explained: “The similarity between jaw strengthening through growth and through time suggests that developmental patterns in juvenile dinosaurs ultimately affected the evolution of the whole group. This likely facilitated the jaw evolution of theropod dinosaurs and their overall success for over 150 million years.” Reference: “Macroevolutionary trends in theropod dinosaur feeding mechanics” by Waisum Ma, Michael Pittman, Richard J. Butler and Stephan Lautenschlager, 16 December 2021, Current Biology. DOI: 10.1016/j.cub.2021.11.060

More than a million individuals in Japan are believed to suffer from hikikomori, and research over the last ten years has suggested that the disease is “spreading” internationally. Some worry that the COVID-19 pandemic may result in an international surge of hikikomori patients. Credit: Kyushu University Researchers find multiple important biomarkers in people with Hikikomori (pathological social withdrawal), and they demonstrate their potential for predicting the severity of the disorder. Key blood biomarkers for the pathological social withdrawal disorder called Hikikomori have been discovered by researchers at Kyushu University. The team’s research enabled them to distinguish between healthy people and hikikomori sufferers, as well as to gauge the severity of the disease. Hikikomori is a condition in which people isolate themselves from society and family for a time longer than six months, according to the Ministry of Health, Labour, and Welfare of Japan. Hikikomori, also called “pathological social withdrawal,” is said to affect over a million individuals in Japan as of 2022. Although it has traditionally been thought of as a syndrome specific to the Japanese culture, evidence over the past few decades has shown that it is increasingly becoming a global phenomenon. Some fear that the COVID-19 pandemic will cause a wave of hikikomori patients to spread throughout the world. The Kyushu University Hospital opened the first outpatient clinic in the world for hikikomori research in 2013 with the goal of creating patient support systems through biological, psychological, and social understanding of the condition. As outlined in this figure, researchers from Kyushu University used blood metabolome and clinical data to clarify the components characteristic of hikikomori, and machine learning models were created for the classification, prediction of the severity, and stratification of hikikomori. Credit: Kyushu University/Kato’s Hikikomori Lab Biological Aspects of Hikikomori In a report published in Dialogues in Clinical Neuroscience, lead researcher Takahiro A. Kato of Kyushu University’s Faculty of Medical Sciences explains that while the sociological underpinnings of the condition are carefully studied, major gaps remain in the understanding of the biological aspects of hikikomori. “Mental illnesses such as depression, schizophrenia, and social anxiety disorder are occasionally observed in hikikomori individuals. However, our past research shows that it is not that simple, and that it is a complex condition with overlaps of different psychiatric and non-psychiatric elements,” explains Kato. “Understanding what happens biologically will help us greatly in identifying and treating hikikomori.” The team conducted blood biochemical tests and collected data on the plasma metabolome—small molecules found in the blood such as sugars, amino acids, and proteins—from 42 unmedicated hikikomori individuals and compared it with data from 41 healthy volunteers. In total, data for 127 molecules were analyzed. Elevated Ornithine, Acylcarnitine, and Disturbed Arginine Metabolism “Some of our key findings showed that in the blood of men with hikikomori, ornithine levels, and serum arginase activity were higher while bilirubin and arginine levels were lower,” states first author of the paper Daiki Setoyama. “In both men and women patients, long-chain acylcarnitine levels were higher. Moreover, when this data was further analyzed and categorized, we were able to distinguish between healthy and hikikomori individuals, and even predict its severity.” Ornithine is an amino acid produced from the amino acid arginine with the help of the enzyme arginase. These molecules are vital in many bodily functions, including blood pressure regulation and the urea cycle. Bilirubin is made when the liver breaks down red blood cells and is often used as a marker for proper liver function. Patients with major depression and seasonal affective disorder have been reported to have lower blood bilirubin levels. Differences in Acylcarnitines Between Hikikomori and Depression Finally, acylcarnitines play an important role in supplying energy to the brain. Its levels decrease when patients with depression take selective serotonin reuptake inhibitors. However, patients with hikikomori differ from patients with depression in that only the long-chain acylcarnitines are elevated in hikikomori whereas short-chain acylcarnitines remain the same. Says Kato, “Identifying the biomarkers of hikikomori is the first step in uncovering the biological roots of the condition and connecting them to its severity. We hope these findings will lead to better-specialized treatments and support for hikikomori.” “Many questions remain, including understanding the root causes behind these biomarkers. Today, hikikomori is spreading worldwide, thus, we must conduct international investigations to understand the similarities and differences between patients with hikikomori globally,” he concludes. Reference: “Blood metabolic signatures of hikikomori, pathological social withdrawal” by Daiki Setoyamaa, Toshio Matsushima, Kohei Hayakawa, Tomohiro Nakao, Shigenobu Kanba, Dongchon Kang and Takahiro A. Kato, 1 June 2022, Dialogues in Clinical Neuroscience. DOI: 10.1080/19585969.2022.2046978 The study was funded by the Japan Society for the Promotion of Science and the Japan Agency for Medical Research and Development.

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