Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan OEM factory for footwear and bedding solutions

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Smart pillow ODM manufacturer Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia ergonomic pillow OEM supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan high-end foam product OEM/ODM factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.PU insole OEM production in China

A sampling of snake diversity. Clockwise from upper left: rainbow boa (Epicrates cenchria), image credit Pascal Title, U-M Museum of Zoology; Amazon basin tree snake (Imantodes lentiferus), image credit Pascal Title, U-M Museum of Zoology; western worm snake (Carphophis vermis), image credit Alison Rabosky, U-M Museum of Zoology; two-striped forest pitviper (Bothrops bilineatus), image credit Dan Rabosky, U-M Museum of Zoology; parrot snake (Leptophis ahaetulla), image credit Ivan Prates, U-M Museum of Zoology; and green anaconda (Eunectes murinus), image credit Dan Rabosky, U-M Museum of Zoology. These species show considerable variability in their diets, ranging from generalist predators on vertebrates (rainbow boa, anaconda) to species that specialize on sleeping lizards (tree snake), earthworms (worm snake), and tree frogs (parrot snake). Modern snakes evolved from ancestors that lived side by side with the dinosaurs and that likely fed mainly on insects and lizards. Then a miles-wide asteroid wiped out nearly all the dinosaurs and roughly three-quarters of the planet’s plant and animal species 66 million years ago, setting the stage for the spectacular diversification of mammals and birds that followed in the early Cenozoic Era. A new University of Michigan study shows that early snakes capitalized on that ecological opportunity and the smorgasbord that it presented, rapidly and repeatedly evolving novel dietary adaptations and prey preferences. A blunt-headed tree snake (Imantodes inornatus) eating its way through a batch of treefrog eggs. Credit: John David Curlis, University of Michigan Museum of Zoology. The study, which combines genetic evidence with ecological information extracted from preserved museum specimens, was published on October 14, 2021, in the journal PLOS Biology. “We found a major burst of snake dietary diversification after the dinosaur extinction—species were evolving quickly and rapidly acquiring the ability to eat new types of prey,” said study lead author Michael Grundler, who did the work for his doctoral dissertation at U-M and who is now a postdoctoral researcher at UCLA. Mammals and birds, which were also diversifying in the wake of the extinction, began to appear in snake diets at that time. Specialized diets also emerged, such as snakes that feed only on slugs or snails, or snakes that eat only lizard eggs. A false boa (Pseudoboa nigra) eating a lava lizard (Tropidurus hispidus). Credit: Ivan Prates, University of Michigan Museum of Zoology Similar outbursts of dietary diversification were also seen when snakes arrived in new places, as when they colonized the New World. “What this suggests is that snakes are taking advantage of opportunities in ecosystems,” said U-M evolutionary biologist and study co-author Daniel Rabosky, who was Grundler’s doctoral adviser. “Sometimes those opportunities are created by extinctions and sometimes they are caused by an ancient snake dispersing to a new land mass.” X-ray of a bighead sea snake (Hydrophis annandalei) showing a prey item (fish) within its stomach. The fish skull is visible within the snake’s rib cage in the center-right of the image. Snake specimen from U-M’s Museum of Zoology. Credit: Jenna Crowe-Riddell / Randy Singer, University of Michigan Museum of Zoology Those repeated transformational shifts in dietary ecology were important drivers of what evolutionary biologists call adaptive radiation, the development of a variety of new forms adapted for different habitats and ways of life, according to Grundler and Rabosky. Modern snakes are impressively diverse, with more than 3,700 species worldwide. And they display a stunning variety of diets, from tiny leaf-litter snakes that feed only on invertebrates such as ants and earthworms to giant constrictors like boas and pythons that eat mammals as big as antelope. So, how did legless reptiles that can’t chew come to be such important predators on land and sea? To find out, Grundler and Rabosky first assembled a dataset on the diets of 882 modern-day snake species. CT scan of a cat-eyed snake (Leptodeira septentrionalis) reveals a frog (blue skeleton) in its digestive tract. Snake specimen from U-M’s Museum of Zoology. Credit: Ramon Nagesan, University of Michigan Museum of Zoology The dataset includes more than 34,000 direct observations of snake diets, from published accounts of scientists’ encounters with snakes in the field and from the analysis of the stomach contents of preserved museum specimens. Many of those specimens came from the U-M Museum of Zoology, home to the world’s second-largest collection of reptiles and amphibians. All species living today are descended from other species that lived in the past. But because snake fossils are rare, direct observation of the ancient ancestors of modern snakes—and the evolutionary relationships among them—is mostly hidden from view. Cat-eyed snake (Leptodeira semiannulata) in the Peruvian Amazon. Credit: Dan Rabosky, University of Michigan Museum of Zoolog However, those relationships are preserved in the DNA of living snakes. Biologists can extract that genetic information and use it to construct family trees, which biologists call phylogenies. Grundler and Rabosky merged their dietary dataset with previously published snake phylogenetic data in a new mathematical model that allowed them to infer what long-extinct snake species were like. A green vine snake (Oxybelis fulgidus) in Brazil. This mildly venomous species is known to eat frogs, lizards, and birds. Credit: Ivan Prates, University of Michigan Museum of Zoology “You might think it would be impossible to know things about species that lived long ago and for which we have no fossil information,” said Rabosky, an associate professor in the U-M Department of Ecology and Evolutionary Biology and an associate curator at the Museum of Zoology. “But provided that we have information about evolutionary relationships and data about species that are now living, we can use these sophisticated models to estimate what their long-ago ancestors were like.” An emerald tree boa (Corallus batesii) in the Amazonian rainforest, a specialized predator of small mammals. Credit: Dan Rabosky, University of Michigan Museum of Zoology In addition to showing a major burst of snake dietary diversification following the demise of the dinosaurs in what’s known as the K-Pg mass extinction, the new study revealed similar explosive dietary shifts when groups of snakes colonized new locations. For example, some of the fastest rates of dietary change—including an increase of roughly 200% for one subfamily—occurred when the Colubroidea superfamily of snakes made it to the New World. The colubroids account for most of the world’s current snake diversity, with representatives found on every continent except Antarctica. They include all venomous snakes and most other familiar snakes; the group does not include boas, pythons and several obscure snakes such as blind snakes and pipe snakes. The American pipe snake (Anilius scytale) is harmless but is frequently mistaken for dangerously venomous coral snakes. This species is a specialized predator of elongated vertebrates, such as snakes, legless lizards, and legless amphibians (caecilians). Credit: Dan Rabosky, University of Michigan Museum of Zoology Grundler and Rabosky also found a tremendous amount of variability in how fast snakes evolve new diets. Some groups, such as blind snakes, evolved more slowly and maintained similar diets—mostly ants and termite larvae—for tens of millions of years. On the other extreme are the dipsadine snakes, a large subfamily of colubroid snakes that includes more than 700 species. Since arriving in the New World roughly 20 million years ago, they have experienced a sustained burst of dietary diversification, according to the new study. The dipsadines include goo-eaters, false water cobras, forest flame snakes and hognose snakes. Many of them imitate deadly coral snakes to ward off predators and are known locally as false coral snakes. The American pipe snake (Anilius scytale) is harmless but is frequently mistaken for dangerously venomous coral snakes. This species is a specialized predator of elongated vertebrates, such as snakes, legless lizards, and legless amphibians (caecilians). Credit: Dan Rabosky, University of Michigan Museum of Zoology “In a relatively short period of time, they’ve had species evolve to specialize on earthworms, on fishes, on frogs, on slugs, on snakelike eels—even other snakes themselves,” Grundler said. “A lot of the stories of evolutionary success that make it into the textbooks—such as Darwin’s famous finches—are nowhere near as impressive as some groups of snakes. The dipsadines of South and Central America have just exploded in all aspects of their diversity, and yet they are almost completely unknown outside the community of snake biologists.” Rabosky and Grundler stressed that their study could not have been done without the information gleaned from preserved museum specimens. “Some people think that zoology collections are just warehouses for dead animals, but that stereotype is completely inaccurate,” Rabosky said. “Our results highlight what a tremendous, world-class resource these collections are for answering questions that are almost impossible to answer otherwise.” Reference: “Rapid increase in snake dietary diversity and complexity following the end-Cretaceous mass extinction” by Michael C. Grundler and Daniel L. Rabosky, 14 October 2021, PLOS Biology. DOI: 10.1371/journal.pbio.3001414 Funding for the study was provided by the National Science Foundation and the David and Lucile Packard Foundation.

A male and a female Aedes aegypti mosquito, taken in the researchers’ lab. A new study has shown that the eggs of this species, a carrier of the Zika virus, can endure prolonged desiccation due to metabolic changes.  Credit: Anjana Prasad Zika-carrying mosquito eggs can survive drying due to metabolic changes, offering potential control strategies. Eggs of the mosquito that carries Zika virus can tolerate extended desiccation by altering their metabolism, according to a new study published on October 24th in the open access journal PLOS Biology by Anjana Prasad, Sunil Laxman, and colleagues at the Institute for Stem Cell Science and Regenerative Medicine in Bengaluru, India and the Indian Institute of Technology in Mandi, India. The finding offers potential new ways to control the spread of this mosquito. Desiccation and Survival Cells are made mostly of water, and desiccation is a potentially fatal event for any organism, since the structures of many proteins and other cellular molecules are dependent on adequate hydration. While many types of microbes have evolved mechanisms to survive drying out, only a few animals have. Among them is the mosquito Aedes aegypti, the carrier of a variety of viral diseases, including, Zika, dengue, yellow fever, and Chikungunya. Originally found in North Africa, Ae. aegypti has expanded globally, and is now a threat in warm, moist regions throughout the world. Metabolic Adjustments and Protection Aedes eggs require from 48 to 72 hours to hatch into larvae, and the authors first showed that eggs must be at least 15 hours old to survive desiccation; eggs that were dried out before this stage failed to hatch when rehydrated. They then compared the proteomes of viable eggs that had and had not been desiccated, and found multiple major changes in metabolic pathways within the desiccated eggs. These included increases in the levels of those enzymes in the tricarboxylic acid (Krebs) cycle that promote lipid metabolism, and a decrease in enzymes of glycolysis and ATP-producing parts of the TCA cycle, which together shunted cellular metabolism toward the production and use of fatty acids. Overall, the level of metabolism was reduced, while the levels of the amino acids arginine and glutamine were increased. In addition, enzymes that reduce the damaging effects of oxidative stress, a known consequence of dehydration, were also increased. The Role of Polyamines When linked together, arginine molecules form polyamines, which are known to help protect nucleic acids, proteins, and membranes from a variety of insults. Here, the authors showed that the eggs accumulate polyamines, suggesting that they may be a key aspect of desiccation tolerance. To test this, they fed egg-laying female mosquitoes an inhibitor of polyamine synthesis. The eggs that they laid were significantly less able to survive desiccation than eggs from untreated females. A second inhibitor, this one of fatty acid metabolism, also reduced egg viability after desiccation. Finally, they showed that this fatty acid inhibitor reduced polyamine synthesis, indicating that one role of the increase in fatty acid breakdown is to supply the energy needed for production of protective polyamines. Implications and Future Directions “Given the importance of Ae. aegypti as a primary vector for numerous viral diseases that affect nearly half the world’s population,” Laxman said, “as well as the rapid geographical expansion of this mosquito vector, these results provide a foundation for reducing Aedes egg survival and global spread. Additionally, some of the specific inhibitors described here that reduce desiccation resistance in Ae. aegypti eggs, as well as new ones affecting other steps in the egg desiccation tolerance pathway, may prove useful as vector-control agents.” Laxman adds, “Aedes mosquito eggs can indefinitely survive after drying up completely, and hatch into viable larvae. The embryos rewire their metabolism upon drying, to protect themselves through desiccation, and revive after water becomes available again.” Reference: “Eggs of the mosquito Aedes aegypti survive desiccation by rewiring their polyamine and lipid metabolism” by Anjana Prasad, Sreesa Sreedharan, Baskar Bakthavachalu and Sunil Laxman, 24 October 2023, PLOS Biology. DOI: 10.1371/journal.pbio.3002342 Funding: No specific funding was obtained for this study. DST-INSPIRE (IF190149 to SS) and DBT/Wellcome Trust India Alliance (IA/I/19/1/504286 to BB) supported individual fellowships. These funders had no role in study design, data collection and analysis, support for experiments, decision to publish, or preparation of the manuscript. Intramural support was provided by the Tata Institute for Genetics and Society (to BB), and DBT-inStem (to SL).

A new study from the University of Surrey reveals that the human body can predict the timing of regular meals, and daily blood glucose rhythms may be influenced by both meal timing and size. The research suggests that there is a physiological drive for people to eat at certain times as their bodies have been trained to expect food. Circadian rhythms enable the body to predict meal times, aligning glucose levels and hunger cues with regular feeding schedules. According to a recent study from the University of Surrey, the human body has the ability to predict the timing of regular meals. The findings of the research team suggest that the daily rhythms of blood glucose levels may be influenced not only by the timing of meals but also by their portion sizes. A team of researchers at Surrey, led by Professor Jonathan Johnston, conducted a pioneering investigation to determine if the human circadian system is capable of anticipating large meals. Circadian rhythms, which refer to physiological changes that occur in a 24-hour cycle and are typically synchronized with environmental cues like light and darkness, encompass a variety of metabolic changes. Previous studies in this field have focussed on animal controls and until now it has been undetermined whether human physiology can predict mealtimes and food availability. Jonathan Johnston, Professor of Chronobiology, and Integrative Physiology at the University of Surrey said: “We often get hungry around the same time every day, but the extent to which our biology can anticipate mealtimes is unknown. It is possible that metabolic rhythms align to meal patterns and that regularity of meals will ensure that we eat at the time when our bodies are best adapted to deal with them.” To learn more, 24 male participants undertook an eight-day laboratory study with strict sleep-wake schedules, exposure to light-dark cycles, and food intake. For six days, 12 participants consumed small meals hourly throughout the waking period, with the remaining participants consuming two large daily meals (7.5 and 14.5 hours after waking). After six days, all participants were then put on the same feeding schedule for 37 hours and received small meals hourly in a procedure known to reveal internal circadian rhythms. Glucose was measured every 15 minutes during the study, and hunger levels were measured hourly during waking hours on days two four and six in the first stage of the study and then hourly for the final 37 hours. Analyzing results of the first six days of the study, researchers found the glucose concentration of participants in the small meal group increased upon waking and remained elevated throughout the day until declining after their last meal. In the large meal group, there was a similar increase in glucose concentration upon waking however there was a gradual decline leading up to the first meal. Glucose and Hunger Responses to Meal Patterns In the final 37 hours, when both groups were fed the same small meals hourly, all participants exhibited an initial rise in glucose concentration upon waking. However, in those who had previously received two large meals, glucose levels began to decline before the anticipated large meal (which they did not receive) whereas for participants who had always consumed small meals hourly, their glucose levels continued to rise as previously seen. In addition, in the large meal group, there was an increase in hunger preceding projected mealtimes which sharply declined after the anticipated mealtime had passed. Professor Johnston added: “What we have found is that the human body is rhythmically programmed to anticipate mealtimes particularly when food is not readily accessible. This suggests that there is a physiological drive for some people to eat at certain times as their body has been trained to expect food rather than it just being a psychological habit.” Reference: “Human glucose rhythms and subjective hunger anticipate meal timing” by Cheryl M. Isherwood, Daan R. van der Veen, Hana Hassanin, Debra J. Skene and Jonathan D. Johnston, 22 February 2023, Current Biology. DOI: 10.1016/j.cub.2023.02.005

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