Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Memory foam pillow OEM factory Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam orthopedic insole OEM manufacturer

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam insole ODM for global brands

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene insole manufacturer in Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia custom product OEM/ODM services

Formins are made of two identical parts (red, orange) that encircle the actin (grey) filament in a ring-like conformation. Credit: MPI of Molecular Physiology Max Plank researchers from Dortmund have revealed the molecular mechanisms by which ring-shaped formin proteins facilitate the growth of actin filaments in cells. Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time. The proteins of the formin family are pivotal partners in this process: positioned at the filament end, formins recruit new actin subunits and stay associated with the end by ‘stepping’ with the growing filament. There are as many as 15 different formins in our cells that drive actin filament growth at different speeds and for different purposes. Yet, the exact mechanism of action of formins and the basis for their different inherent speeds have remained elusive. Now, for the first time, researchers from the groups of Stefan Raunser and Peter Bieling at the Max Planck Institute of Molecular Physiology in Dortmund have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing filament. Furthermore, they elucidated the reasons for the different speeds at which the different formins promote this process. The MPI researchers used a combination of biochemical strategies and electron cryo-microscopy (cryo-EM). The breakthrough, published in the journal Science, can help us explain why certain mutations in formins can lead to neurological, immune, and cardiovascular diseases. Joining forces “Our discovery allows us to interpret decades of biochemical studies on formins through new lenses, which answers many long-standing, open questions in this field,” says Peter Bieling. Previous structures from X-ray crystallization revealed that formins are made of two identical parts that encircle the actin filament in a ring-like conformation and step along it as it grows. In the speculative models suggested so far, formins interact through all their four binding domains with actin, while slow and fast-moving formin would adopt different shapes at the filament. Micaela Boiero Sanders and Wout Oosterheert at the electron cryo-microscope. Credit: MPI of Molecular Physiology “But those studies lacked high-resolution structures of formins bound to their relevant sites of activity, the barbed end of actin filaments,” says Wout Oosterheert, postdoc in the group of Stefan Raunser at the MPI Dortmund and co-first author of the publication. Formins are highly dynamic proteins that assemble filaments rapidly, hence it is difficult to obtain enough filament ends for detailed structure determination. The MPI scientists analyzed not just one, but three distinct formins originating from fungi, mice, and humans, which all elongate actin filaments at highly different speeds. “One of the formins that we studied is very fast and can be considered the Ferrari among formins, while another formin behaves more like a tractor”, says Stefan Raunser. The scientists tested and optimized a wide variety of conditions that ultimately gave them a high number of formin-bound filaments. “We built on the experience that we gained from our previous studies. The iterative optimization of both the biochemistry and cryo-EM sample preparation was key for obtaining these structures,” says Micaela Boiero Sanders, the other co-first author of the study. A new paradigm The new structures, with resolutions around 3.5 Ångstrom, show that formins encircle actin like an asymmetric ring: One half of the ring is stably bound, while the other half is loosely associated with the filament and is free to capture a new subunit. “Analyzing the structures gave us a true ‘Eureka’ moment regarding the mechanism,” say Oosterheert and Boiero Sanders. When the new actin subunit arrives, its incorporation onto the filament destabilizes the formin arrangement and requires the stable half-ring to step onto the new subunit and become loose, while the other half-ring becomes stable. Thanks to this concerted mechanism, formins stay associated with the growing actin filament end over long distances. Contrary to previous hypotheses, the structures are similar for all three analyzed formins, with only three binding domains being engaged with actin at the same time. By introducing mutations into formins, the MPI scientists also explained the speed differences among actin-formin complexes: if the formin ring is bound more tightly to the actin filament end, it is more difficult for the ring to let go and step onto a new, incoming actin subunit. As a result, filament growth is slower. “We now understand how a formin that behaves like a tractor can be made faster by giving it some Ferrari-like features,” says Peter Bieling. The MPI team expects that their results will be useful for the many scientists around the world that study the actin cytoskeleton. “Our new insights open up a large number of possibilities for elucidating the specific roles of the fifteen human formins at the cellular level, which can increase our understanding of how mutations in formin genes lead to severe diseases,” concludes Raunser. Reference: “Molecular mechanism of actin filament elongation by formins” by Wout Oosterheert, Micaela Boiero Sanders, Johanna Funk, Daniel Prumbaum, Stefan Raunser and Peter Bieling, 12 April 2024, Science. DOI: 10.1126/science.adn9560

A new study reveals that coral reefs in the Gulf of Eilat/Aqaba stopped growing for 3,000 years, likely due to a temporary sea-level drop caused by global cooling. While the reef eventually recovered, scientists warn that modern threats like climate change and pollution pose greater risks, making conservation efforts crucial. Coral reefs in the Gulf of Eilat paused growth for 3,000 years due to sea-level changes but later recovered. Scientists warn that today’s environmental threats could prevent future recovery. A new study reveals that coral reefs in the Gulf of Eilat experienced a surprising 3,000-year “shutdown” in growth—from about 4,400 to 1,000 years ago—likely due to a temporary drop in sea level possibly triggered by global cooling. This interruption, which mirrors similar events observed in reefs off Mexico, Brazil, and Australia, points to a widespread environmental shift during that time. Although the reefs experienced a long pause, they eventually recovered, with coral species reestablishing from deeper waters, a testament to their natural resilience. However, researchers caution that modern challenges—such as climate change, pollution, and ocean acidification—present far greater risks, underscoring the urgent need for conservation to protect these essential marine ecosystems. Led by Prof. Adi Torfstein from the Hebrew University and Prof. Oren Levy from Bar-Ilan University, in collaboration with an international team of researchers, the study uncovered this significant pause in coral reef growth in the Gulf of Eilat/Aqaba in the northern Red Sea during the late Holocene period. Published in Global Change Biology, the findings offer critical insights into the historical resilience of coral reef ecosystems and how they have responded to environmental changes over time. Coral reefs play a vital role in marine biodiversity, supporting the oceanic carbon cycle and acting as natural barriers against coastal erosion and storm surges. Despite their importance, our understanding of how reefs have long responded to temperature fluctuations, sea-level shifts, and human influences remains limited. Key Findings A noticeable hiatus in reef growth between 4,400 and 1,000 years Before Present (BP) was observed, coinciding with similar events recorded in Mexico, Brazil, and Australia. Coral diversity and abundance displayed remarkable consistency before and after the hiatus, suggesting that the reef ecosystem recovered by recolonizing from deeper coral communities. The study attributes this temporary “shutdown” to a combination of tectonic activity and glacio-eustatic sea-level changes. A temporary sea-level drop, possibly caused by a cooling event, exposed the reef and halted its growth. Additional analyses of coral skeletons in the modern era revealed a significant shift in the carbon isotopic composition, reflecting the increasing influence of human activity on the global carbon balance. Innovative Research Methods The research team included Dr. Bar Feldman from Bar-Ilan University, Prof. Aldo Shemesh from the Weizmann Institute, Dr. Yonathan Shaked from the Inter-University Institute of Marine Sciences (IUI), Prof. Mick O’Leary from the University of Western Australia and Prof. Huang Dunwei from the National University of Singapore, conducted extensive sampling of coral cores up to three meters long. These samples provided an unprecedented window into the growth history of the reef over the past 10,000 years. Implications for Future Coral Conservation Despite the historical “switch-off,” the findings highlight the resilience of coral reef ecosystems in the face of environmental challenges. However, they also underscore the pressing need for conservation efforts to address the modern threats posed by climate change, ocean acidification, and human-induced disturbances. “Understanding how reefs have responded to past sea-level changes helps us predict their future resilience and informs conservation strategies,” said Dr. Torfstein. “While our research shows that coral communities can recover after major disruptions, today’s climate crisis presents unprecedented challenges that demand urgent action.” Reference: “Late Holocene “Turn-Off” of Coral Reef Growth in the Northern Red Sea and Implications for a Sea-Level Fall” by B. Feldman, A. Torfstein, M. O’Leary, N. Simon Blecher, R. Yam, Y. Shaked, A. Shemesh, D. Huang and O. Levy, 12 February 2025, Global Change Biology. DOI: 10.1111/gcb.70073 Supported by the Israel Nature and Parks Authority, this study enhances our understanding of coral reef dynamics and contributes to global efforts to protect these fragile marine ecosystems.

Tyrannosaurus Rex Skeleton Research suggests that Tyrannosaurus rex may consist of three species based on differences in femur robustness and dental structures. A new analysis of Tyrannosaurus skeletal remains reveals physical differences in the femur, other bones, and dental structures across specimens that could suggest Tyrannosaurus rex specimens need to be re-categorized into three distinct groups or species, reports a study published in Evolutionary Biology. Tyrannosaurus rex is the only recognized species of the group of dinosaurs, or genus, Tyrannosaurus to date. Previous research has acknowledged variation across Tyrannosaurus skeletal remains in the femur (thighbone) and specimens with either one or two slender incisor teeth on each side of front ends of the jaw. Gregory Paul and colleagues analyzed the bones and dental remains of 37 Tyrannosaurus specimens. The authors compared the robustness of the femur in 24 of the specimens, a measure calculated from the length and circumference that gives an indication of the strength of the bone. They also measured the diameter of the base of teeth or space in the gums to assess if specimens had one or two slender incisiform teeth. Femur Robustness and Growth Analysis The authors observed that the femur varied across specimens, some with more robust femurs and others with more gracile femurs. The authors found there were two times more robust femurs than gracile ones across specimens, which suggests that this is not a difference caused by sex, which would likely result in a more even split. The authors also suggest that the variation in femurs is not related to growth of the specimen as robust femurs were found in some juvenile specimens two thirds the size of an adult and gracile femurs were found in some specimens that were full adult size. Dental structure also varied across specimens, although those with both femur measurements and dental remains was low (12 specimens). Specimens with one incisor tooth were correlated with often having higher femur gracility. Of the Tyrannosaurus specimens, 28 could be identified in distinct layers of sediment (stratigraphy) at the Lancian upper Masstrichtian formations in North America (estimated to be from between 67.5 to 66 million years ago). The authors compared Tyrannosaurus specimens with other theropod species found in lower layers of sediment. Only robust Tyrannosaurus femurs were found in the lower layer of sediment (six femurs). The variation of femur robustness in the lower layer was not different to that of other theropod species, which indicates that likely only one species of Tyrannosaurus existed at this point. Only one gracile Tyrannosaurus femur was identified in the middle layer with five other gracile femurs in the upper layer, alongside other robust femurs. The variation in Tyrannosaurus femur robustness in the top layer of the sediments was higher than what was observed in some earlier theropod specimens. This suggests that the Tyrannosaurus specimens found at higher layers of sediment physically developed into more distinct forms compared to specimens from lower layers, and other dinosaur species. Gregory Paul, lead author, said: “We found that the changes in Tyrannosaurus femurs are likely not related to the sex or age of the specimen. We propose that the changes in the femur may have evolved over time from a common ancestor who displayed more robust femurs to become more gracile in later species. The differences in femur robustness across layers of sediment may be considered distinct enough that the specimens could potentially be considered separate species.” Proposed New Tyrannosaurus Species: T. imperator and T. regina The authors nominate two potential new species of Tyrannosaurus based on their analysis. The first, Tyrannosaurus imperator (tyrant lizard emperor), relates to specimens found at the lower and middle layers of sediment, characterized with more robust femurs and usually two incisor teeth. The authors argue these features have been retained from earlier ancestors (tyrannosaurids). The second, Tyrannosaurus regina (tyrant lizard queen), is linked to specimens from the upper and possibly middle layers of sediment, characterized with slenderer femurs and one incisor tooth. The recognized species Tyrannosaurus rex (tyrant lizard king) was identified in the upper and possibly middle layer of sediment with specimens classed as retaining more robust femurs while having only one incisor tooth. Some specimens could not be identified based on their remains so were not assigned to a species. The authors acknowledge that they cannot rule out that the observed variation is due to extreme individual differences, or atypical sexual dimorphism, rather than separate groups, and they also caution that the location within sediment layers is not known for some specimens. The authors discuss the difficulties of assigning fossil vertebrates to a potential new species. The authors conclude that the physical variation found in Tyrannosaurus specimens combined with their stratigraphy are indicative of three potential groups that could be nominated as two new species, T. imperator and T. regina, alongside the only recognized species to date, T. rex. Reference: “The Tyrant Lizard King, Queen and Emperor: Multiple Lines of Morphological and Stratigraphic Evidence Support Subtle Evolution and Probable Speciation Within the North American Genus Tyrannosaurus” by Gregory S. Paul, W. Scott Persons IV and Jay Van Raalte, 1 March 2022, Evolutionary Biology. DOI: 10.1007/s11692-022-09561-5

DVDV1551RTWW78V