Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China neck support pillow OEM

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan athletic insole OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Arch support insole OEM from Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China insole ODM design and production

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Custom foam pillow OEM production factory in Taiwan

Wild Takakia population on the Tibetan Plateau. Credit: Xuedong Li / Capital Normal University Beijing Takakia Has Adapted to Extreme Environments for Millions of Years but Now Faces Climate-Driven Extinction. The rare moss species Takakia has evolved over the course of millions of years to thrive in high-altitude environments. A collaborative research effort headed by Prof. Dr. Ralf Reski from the University of Freiburg and Prof. Dr. Yikun He from Capital Normal University in China has recently uncovered exactly how it has developed the ability to survive frost and life-threatening high UV radiation. Published in the prestigious journal Cell, the study outlines the genetic characteristics that arm the moss against extreme environmental factors. The researchers also report on how rapid climate change has significantly impacted the natural habitat of this highly specialized species within just a few years. The genus Takakia comprises only two species. Together, they are found only on the Tibetan Plateau, the “roof of the world,” a hotspot of biodiversity. There, Prof. Dr. Xuedong Li, one of the two first authors of the study, discovered populations of the species Takakia lepidozioides at an altitude of over four thousand meters in 2005. Since then, the team has studied Takakia in the mountains and in the laboratory for more than a decade. For example, the study’s other first author, Dr. Ruoyang Hu, has been on site more than twenty times during the study period. “It is difficult to work at this altitude. High altitude sickness is a problem and sometimes our instruments fail”, Li explains. “Still, I love working in this environment. There you truly understand how important it is to preserve and protect the environment,” Hu says. View of the region where the researchers studied moss populations. Gawalong East Glacier on the left. Credit: Ruoyang Hu / Capital Normal University Beijing On the Tibetan Plateau, Takakia is buried under snow for eight months of the year and otherwise exposed to high levels of UV radiation. To survive there, living creatures need special adaptations. For Takakia, these have evolved over the last 65 million years: Only since then has this region of the Earth been uplifted by continental drift, making the moss’s habitat increasingly extreme. “These geological time records help us to trace the gradual adaptation to a life at high altitudes in the Takakia genome,” explains Reski, who conducts research at the University of Freiburg and its Cluster of Excellence CIBSS. In the current study, his team investigated which biological signaling pathways protect the cells of the moss from freezing and mutagenic UV radiation, amongst other things. Takakia Is the Oldest Living Land Plant The moss, which is only a few millimeters in size, is of particular interest to researchers because its systematic affiliation was long unclear, as it combines features of green algae, liverworts, and mosses. “We have now been able to prove that Takakia is a moss that separated from the other mosses 390 million years ago, shortly after the emergence of the first land plants. We were surprised to find that Takakia has the highest known number of fast-evolving genes under positive selection”, says He. The Living Fossil Another surprise was that the special shape of Takakia could already be found in 165 million-year-old fossils from Inner Mongolia. The fossils thus provide biologists with another valuable time reference because they show that genetic changes affecting morphology evolved more than 165 million years ago under very different environmental conditions. Among these peculiarities is a mode of operation, atypical for plants, of the signaling molecule auxin, which controls growth and development in plants. “Although the Takakia genome is evolving so rapidly, the morphology has not changed recognizably for more than 165 million years. This makes Takakia a true living fossil. This apparent contrast between unchanged shape and rapidly changing genome is a scientific challenge for evolutionary biologists”, Reski describes. Changing Metabolic Processes Protect Against UV Radiation Genetic traits that influence the processing of stress signals and the regulation of certain metabolic processes, on the other hand, are younger, according to the current study, and emerged only after the uplift of the Tibetan Plateau. The researchers were able to reconstruct their gradual emergence within the last 50 million years and show how they protect the cells of the moss from harmful environmental influences. “For example, Takakia regulates its metabolism to accumulate molecules such as flavonoids and unsaturated fatty acids that protect against harmful UV radiation and free radicals,” He explains. “We see in the genome that signaling molecules that regulate DNA repair, photosynthesis and mechanisms against oxidative stress are under particularly strong positive selection and have changed greatly over the last few million years.” Climate Change May Put an End to Takakia’s Evolution After 390 Million Years While Takakia has had many millions of years to adapt to decreasing temperatures and increasing radiation intensities, its habitat is now changing within decades: Since the measurements began in 2010, the researchers found an average temperature increase of almost half a degree Celsius per year there. At the same time, the glaciers near the sample sites receded almost 50 meters per year. The highly specialized moss copes less well with this temperature rise than other species. Takakia populations became significantly smaller over the study period, while other plant species benefited from the warming. This trend is likely to continue, the researchers fear. “Our study shows how valuable Takakia is in tracing the evolution of land plants. The population decline we found is frightening”, He says. “Fortunately, knowing that the plant is threatened by extinction also gives us a chance to protect it, for example by growing it in the lab,” Hu points out. “Takakia has seen the dinosaurs come and go. It has seen us humans coming. Now we can learn something about resilience and extinction from this tiny moss,” Reski concludes. Reference: “Adaptive evolution of the enigmatic Takakia now facing climate change in Tibet” by Ruoyang Hu, Xuedong Li, Yong Hu, Runjie Zhang, Qiang Lv, Min Zhang, Xianyong Sheng, Feng Zhao, Zhijia Chen, Yuhan Ding, Huan Yuan, Xiaofeng Wu, Shuang Xing, Xiaoyu Yan, Fang Bao, Ping Wan, Lihong Xiao, Xiaoqin Wang, Wei Xiao, Eva L. Decker and Yikun He, 9 August 2023, Cell. DOI: 10.1016/j.cell.2023.07.003 The study was funded by National Natural Science Foundation of China, Science and Technology Department of Tibet Autonomous Region, New Interdisciplinary Construction of Bioinformatics and Statistics of Capital Normal University, Shenzhen Key Laboratory of South Subtropical Plant Diversity, German Research Foundation DFG as well as by the Freiburg Institute for Advanced Studies FRIAS and the University of Strasbourg Institute of Advanced Study USIAS (METABEVO).

Researchers have discovered a new biological mechanism involving Daam2 protein and CK2α kinase that regulates myelin repair and regeneration. This study has implications for treating neurological diseases like multiple sclerosis and cerebral palsy. A new discovery reveals how Daam2 and CK2α regulate myelin repair, opening doors to potential treatments for neurological disorders like MS and cerebral palsy. A study led by Dr. Hyun Kyoung Lee, associate professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, has identified a previously unknown biological mechanism for repairing and regenerating myelin. Myelin is the insulating layer around nerve fibers that is crucial for the fast and precise transmission of neural signals. The Duncan NRI team found novel roles for the Dishevelled associated activator of morphogenesis 2 (Daam2) protein and CK2α kinase in regulating myelin repair and regeneration. The study was recently published in the Proceedings of the National Academy of Science. Myelin is produced by a type of glial precursor cells called oligodendrocytes (OLs) which are among the most numerous cells in the nervous system. Damage or loss of myelin sheath is the hallmark of various neurological diseases in adults (e.g. multiple sclerosis) and infants (e.g. cerebral palsy) and is common after brain injuries. The Wingless (Wnt) signaling pathway is one of the key regulators of OL development and myelin regeneration. In certain diseased conditions and brain injury, its levels are elevated in the white matter, which impairs myelin production by forcing oligodendroctyes to remain in a “stalled/quiescent state”. A few years back, Dr. Lee and others found that a glial protein, Daam2 inhibits the differentiation of oligodendrocytes during development as well as myelin regeneration and repair. However, until now precise mechanisms underlying this process have remained a mystery. Deciphering Daam2’s Role in Myelin Formation To understand how Daam2 inhibits myelination, the team first needed to determine the regulation of Daam2 itself. Using biochemical approaches, they found two amino acid residues (Ser704 and Thr705) of Daam2 protein undergo phosphorylation – a common post-translational regulatory mechanism that turns on or off the activity of the proteins. To explore if Daam2 phosphorylation affected the progression of OL lineage, they analyzed differentially expressed genes (DEGs) in wild-type and mutant animals whose Daam2 is constitutively phosphorylated. DEGs downregulated in the mutant OLs were enriched in genes involved in lipid/cholesterol metabolism whereas DEGs upregulated in the mutant OLs were involved in multiple signaling processes, including the Wnt pathway. Since Daam2 is a known positive modulator of canonical Wnt signaling, they examined whether these DEGs were due to perturbations in Wnt signaling. They undertook a thorough developmental stage-specific analysis which revealed dynamic changes in the machinery and function of Wnt/β-catenin signaling in early versus late stages of OL development, and established that this signaling pathway is affected by Daam2 phosphorylation. “Intriguingly, we found Daam2 phosphorylation differentially impacts distinct stages of oligodendrocyte development – in early stages, it accelerates the conversion of precursor OLs to glial cells but in later stages, it slows down their maturation and their ability to produce myelin,” Dr. Lee said. CK2α Identified as the Key Regulator of Daam2 To identify the kinase(s) responsible for Daam2 phosphorylation, they conducted a motif analysis which found CK2, a Wnt/β-catenin signaling Ser/Thr kinase that was also one of the candidates in their biochemical and genetic screen. They further confirmed that its catalytic subunit, CK2α, interacted with Daam2 in lab-cultured OLs and also phosphorylated it. Moreover, both Daam2 and CK2α were sequentially upregulated in a manner that was concomitant with the progression of OL lineage. Using in vitro cultured OLs and in vivo mouse models, they found compelling evidence suggesting that CK2α promotes OL differentiation by phosphorylating Daam2. Further studies using an animal model of neonatal hypoxic injury model revealed a beneficial role for CK2α-mediated Daam2 phosphorylation. They found that it plays a protective role in developmental and behavioral recovery after neonatal hypoxia, a form of brain injury seen in cerebral palsy and other conditions, and additionally, it facilitates remyelination after white matter injury in adult animals. Together, these findings have identified a novel regulatory node in the Wnt pathway that regulates stage-specific oligodendrocyte development and offers insights into a new biological mechanism to regenerate myelin. “This study opens exciting therapeutic avenues we could develop in the future to repair and restore myelin, which has the potential to alleviate and treat several neurological that are currently untreatable,” Dr. Lee said. Reference: “Daam2 phosphorylation by CK2α negatively regulates Wnt activity during white matter development and injury” by Chih-Yen Wang, Zhongyuan Zuo, Juyeon Jo, Kyoung In Kim, Christine Madamba, Qi Ye, Sung Yun Jung, Hugo J. Bellen and Hyun Kyoung Lee, 22 August 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2304112120 The first author, Chih-Yen Wang is now an assistant professor in the National Cheng Kung University. Others involved in the study were Zhongyuan Zuo, Juyeon Jo, Kyoung In Kim, Christine Madamba, Qi Ye, Sung Yun Jung, and Hugo J. Bellen. They are affiliated with one or more of the following institutions: Baylor College of Medicine and Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. This work was supported by grants from NIH/NINDS, the National Multiple Sclerosis Society, the Cynthia and Anthony G. Petrello Endowment, and the Mark A. Wallace Endowment, the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health for the BCM IDDRC Neurobehavior and Neurovisualization Cores. GERM core at Baylor College of Medicine helped with mouse line generation, scRNA-sequencing was partially supported by the SCG core and GARP core.

The Atacama Desert, one of Earth’s harshest environments, contains surface soil with DNA from both living cells and external sources. A novel technique enables researchers to distinguish between internal and external DNA, revealing the microbes thriving in this extreme habitat. This method could also be adapted to study microbial communities in similarly hostile environments, including those on other planets. A novel technique separates living (iDNA) and dead (eDNA) microbial DNA, enabling precise analysis of microbial life in the Atacama Desert. This method reveals active microbes and offers new insights into extreme ecosystems. The Atacama Desert, stretching along the Pacific Coast of Chile, is the driest place on Earth and, due to its extreme aridity, inhospitable to most forms of life. Yet, not everything succumbs to its harsh conditions—studies of the desert’s sandy soil have uncovered diverse microbial communities. Investigating the roles of microorganisms in such environments is challenging, however, as it is difficult to distinguish genetic material from living microbes from that of dead ones. A new separation technique can help researchers focus on the living part of the community. In a paper recently published in the journal Applied and Environmental Microbiology, an international team of researchers describes a new way to separate extracellular (eDNA) from intracellular (iDNA) genetic material. The method provides better insights into microbial life in low-biomass environments, which was previously not possible with conventional DNA extraction methods, said Dirk Wagner, Ph.D., a geomicrobiologist at the GFZ German Research Centre for Geosciences in Potsdam, who led the study. Research in the Atacama Desert The microbiologists used the novel approach on Atacama soil samples collected from the desert along a west-to-east swath from the ocean’s edge to the foothills of the Andes mountains. Their analyses revealed a variety of living and possibly active microbes in the most arid areas. A better understanding of eDNA and iDNA, Wagner said, can help researchers probe all microbial processes. “Microbes are the pioneers colonizing this kind of environment and preparing the ground for the next succession of life,” Wagner said. These processes, he said, aren’t limited to the desert. “This could also apply to new terrain that forms after earthquakes or landslides where you have more or less the same situation, a mineral or rock-based substrate.” Most commercially available tools for extracting DNA from soils leave a mixture of living, dormant and dead cells from microorganisms, Wagner said. “If you extract all the DNA, you have DNA from living organisms and also DNA that can represent organisms that just died or that died a long time ago.” Metagenomic sequencing of that DNA can reveal specific microbes and microbial processes. However, it requires sufficient good-quality DNA, Wagner added, “which is often the bottleneck in low-biomass environments.” Challenges of Conventional DNA Extraction To remedy that problem, he and his collaborators developed a process for filtering intact cells out of a mixture, leaving behind eDNA genetic fragments left from dead cells in the sediment. It involves multiple cycles of gentle rinsing, he said. In lab tests they found that after 4 repetitions, nearly all the DNA in a sample had been divided into the 2 groups. When they tested soil from the Atacama Desert, they found Actinobacteria and Proteobacteria in all samples in both eDNA and iDNA groups. That’s not surprising, Wagner said, because the living cells constantly replenish the store of iDNA as they die and degrade. “If a community is really active, then a constant turnover is taking place, and that means the 2 pools should be more similar to each other,” he said. In samples collected from depths of less than 5 centimeters, they found that Chloroflexota bacteria dominated in the iDNA group. In future work, Wagner said he plans to conduct metagenomic sequencing on the iDNA samples to better understand the microbes at work, and to apply the same approach to samples from other hostile environments. By studying iDNA, he said, “you can get deeper insights into the real active part of the community.” Reference: “Inside the Atacama Desert: uncovering the living microbiome of an extreme environment” by Alexander Bartholomäus, Steffi Genderjahn, Kai Mangelsdorf, Beate Schneider, Pedro Zamorano, Samuel P. Kounaves, Dirk Schulze-Makuch and Dirk Wagner, 14 November 2024, Applied and Environmental Microbiology. DOI: 10.1128/aem.01443-24

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