Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Thailand graphene material ODM solution

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China graphene sports insole ODM

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole manufacturing factory in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam ergonomic pillow OEM supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene sheet OEM supplier Taiwan

Two views of the carbonate chimneys at the Point Dume methane seep off southern California are covered with colorful microbial mats and permeated by methane-eating microbes. Credit: Courtesy of Courtesy of the Schmidt Ocean Institute Methane-eating microbes help regulate Earth’s temperatures with remarkably high metabolic rates within seafloor carbonate rocks. Methane is a strong greenhouse gas that plays a key role in Earth’s climate. Anytime we use natural gas, whether we light up our kitchen stove or barbeque, we are using methane. Only three sources on Earth produce methane naturally: volcanoes, subsurface water-rock interactions, and microbes. Between these three sources, most is generated by microbes, which have deposited hundreds of gigatons of methane into the deep seafloor. At seafloor methane seeps, it percolates upwards toward the open ocean, and microbial communities consume the majority of this methane before it reaches the atmosphere. Over the years, researchers are finding more and more methane beneath the seafloor, yet very little ever leaves the oceans and gets into the atmosphere. Where is the rest going? A team of researchers led by Jeffrey J. Marlow, former postdoctoral researcher in Organismic and Evolutionary Biology at Harvard University, discovered microbial communities that rapidly consume the methane, preventing its escape into Earth’s atmosphere. The study published in Proceedings of the National Academy of Sciences collected and examined methane-eating microbes from seven geologically diverse seafloor seeps and found, most surprisingly, that the carbonate rocks from one site in particular hosts methane-oxidizing microbial communities with the highest rates of methane consumption measured to date. “The microbes in these carbonate rocks are acting like a methane bio filter consuming it all before it leaves the ocean,” said senior author Peter Girguis, Professor of Organismic and Evolutionary Biology, Harvard University. Researchers have studied microbes living in seafloor sediment for decades and know these microbes are consuming methane. This study, however, examined microbes that thrive in the carbonate rocks in great detail. Seafloor carbonate rocks are common, but in select locations, they form unusual chimney-like structures. These chimneys reach 12 to 60 inches in height and are found in groups along the seafloor resembling a stand of trees. Unlike many other types of rocks, these carbonate rocks are porous, creating channels that are home to a very dense community of methane-consuming microbes. In some cases, these microbes are found in much higher densities within the rocks than in the sediment. During a 2015 expedition funded by the Ocean Exploration Trust, Girguis discovered a carbonate chimney reef off the coast of southern California at the deep sea site Point Dume. Girguis returned in 2017 with funding from NASA to build a sea floor observatory. Upon joining Girguis’s lab, Marlow, currently Assistant Professor of Biology at Boston University, was studying microbes in carbonates. The two decided to conduct a community study and gather samples from the site. “We measured the rate at which the microbes from the carbonates eat methane compared to microbes in sediment,” said Girguis. “We discovered the microbes living in the carbonates consume methane 50 times faster than microbes in the sediment. We often see that some sediment microbes from methane-rich mud volcanoes, for example, may be five to ten times faster at eating methane, but 50 times faster is a whole new thing. Moreover, these rates are among the highest, if not the highest, we’ve measured anywhere.” “These rates of methane oxidation, or consumption, are really extraordinary, and we set out to understand why,” said Marlow. The team found that the carbonate chimney sets up an ideal home for the microbes to eat a lot of methane really fast. “These chimneys exists because some methane in fluid flowing out from the subsurface is transformed by the microbes into bicarbonate, which can then precipitate out of the seawater as carbonate rock,” said Marlow. “We’re still trying to figure out where that fluid — and its methane — is coming from.” The micro-environments within the carbonates may contain more methane than the sediment due to its porous nature. Carbonates have channels that are constantly irrigating the microbes with fresh methane and other nutrients allowing them to consume methane faster. In sediment, the supply of methane is often limited because it diffuses through smaller, winding channels between mineral grains. A startling find was that, in some cases, these microbes are surrounded by pyrite, which is electrically conductive. One possible explanation for the high rates of methane consumption is that the pyrite provides an electrical conduit that passes electrons back and forth, allowing the microbes to have higher metabolic rates and consume methane quickly. “These very high rates are facilitated by these carbonates which provide a framework for the microbes to grow,” said Girguis. “The system resembles a marketplace where carbonates allow a bunch of microbes to aggregate in one place and grow and exchange — in this case, exchange electrons — which allows for more methane consumption.” Marlow agreed, “When microbes work together they’re either exchanging building blocks like carbon or nitrogen, or they’re exchanging energy. And one kind of way to do that is through electrons, like an energy currency. The pyrite interspersed throughout these carbonate rocks could help that electron exchange happen more swiftly and broadly.” In the lab, the researchers put the collected carbonates into high pressure reactors and recreated conditions on the sea floor. They gave them isotopically labeled methane with added Carbon-14 or Deuterium (Hydrogen-2) in order to track methane production and consumption. The team next compared the data from Point Dume to six additional sites, from the Gulf of Mexico to the coast of New England. In all locations, carbonate rocks at methane seeps contained methane-eating microbes. “Next we plan to disentangle how each of these different parts of the carbonates — the structure, electrical conductivity, fluid flow, and dense microbial community — make this possible. As of now, we don’t know the exact contribution of each,” said Girguis. “First, we need to understand how these microbes sustain their metabolic rate, whether they’re in a chimney or in the sediment. And we need to know this in our changing world in order to build our predictive power,” said Marlow. “Once we clarify how these many interconnected factors come together to turn methane to rock, we can then ask how we might apply these anaerobic methane-eating microbes to other situations, like landfills with methane leaks.” Reference: “Carbonate-hosted microbial communities are prolific and pervasive methane oxidizers at geologically diverse marine methane seep sites” by Jeffrey J. Marlow, Daniel Hoer, Sean P. Jungbluth, Linda M. Reynard, Amy Gartman, Marko S. Chavez, Mohamed Y. El-Naggar, Noreen Tuross, Victoria J. Orphan and Peter R. Girguis, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2006857118

New research shows that sperm production is critical to how regions of the genome are re-organized within and between chromosomes during evolution. In particular, inherited chromosomal rearrangements are associated with physical and biochemical processes that are specific to the final stages of sperm production, after the meiotic cell divisions have completed. Researchers found that chromosomal rearrangements during sperm production play a key role in genome evolution, with male germ cells contributing more to these changes due to DNA compaction and repair processes. A study led by researchers at the Universitat Autònoma de Barcelona (UAB) and the University of Kent uncovers how the genome three-dimensional structure of male germ cells determines how genomes evolve over time. Published today (May 11, 2022) in Nature Communications and carried out in rodent species, these findings show that the distinctive events occurring during egg and sperm cell production have a different impact on genome evolution and open new research paths into the genetic origin of genome structure in all organisms. A comparison of genomes across many different mammalian species reveals that, while all species have a broadly similar catalog of genes, these are arranged in a different order for each species and can be turned off and on differently. These rearrangements may have an impact on gene function and regulation and, therefore, play a part in evolutionary changes and in defining species identity. Until now, the ultimate origin of these rearrangements has been a mystery: where (in which cell types) and when (during development) do they arise? Do they arise as a by-product of the normal reshuffling of genes between chromosome copies that occurs during meiosis, the cellular process to produce gametes (oocytes and sperm), or at some other stage in the life cycle? A genome is all of an organism’s genetic information. It is made up of DNA nucleotide sequences (or RNA in RNA viruses). The genome contains genes (coding regions) as well as noncoding DNA, mitochondrial DNA, and chloroplast DNA. The study of the genome is called genomics and is related to the fields of molecular biology and genetics. Now a research study led by scientists from the Universitat Autònoma de Barcelona (UAB) and the University of Kent shows that sperm production is key to how regions of the genome are re-organized within and between chromosomes during evolution. In particular, inherited chromosomal rearrangements are associated with physical and biochemical processes that are specific to the final stages of sperm production, after the meiotic cell divisions have been completed. Chromatin Remodeling and Genetic Recombination in Spermatogenesis The total sequence of DNA or genome of an individual is folded into a specifically tailored and dynamic 3D chromatin structure within the cell nuclei, that determines which genes are “turned on” and which are “turned off” in each cell type. Gametes are produced by all sexually reproducing organisms through a process called meiosis that involves one round of genome replication followed by two consecutive cell divisions, to leave haploid cells (gametes), carrying only one copy of each chromosome. During meiosis, genes are “shuffled” between the chromosome copies inherited from the mother and father, a process known as genetic recombination. These complex events imply that the genome must be packaged and unpackaged in a precise and highly regulated manner into chromatin. “Our work shows the dynamics of chromatin remodeling during the formation of male gametes is fundamental for understanding which parts of the genome are located close to each other inside the nucleus, and are therefore more likely to be involved in chromosomal rearrangements, in different moments throughout male spermatogenesis” throughout male spermatogenesis,” says Dr. Aurora Ruiz-Herrera, Associate Professor at the Department of Cell Biology, Physiology and Immunology of the Institute of Biotechnology and Biomedicine (IBB) at the UAB. Analyzing Genome Rearrangements in Rodents To study genome evolution, the team compared the genomes of 13 different rodent species and “unscrambled” the rearrangements that distinguish them. “This allowed us to work out the genome configuration of the rodent common ancestor and determine the locations of the evolutionary breakpoint regions (EBRs) participating in genome rearrangements,” explains Dr. Marta Farré, Lecturer in Genomics at the School of Biosciences in the University of Kent, and co-leader of the study. “Strikingly, EBRs were associated with regions that are active in later stages of spermatogenesis, when the developing male germ cells are called spermatids. Rearrangements occurring at EBRs were found to break and rejoin DNA stretches that are physically located close to each other in the spermatid nucleus,” says Dr. Peter Ellis, Senior Lecturer in Molecular Genetics and Reproduction at the School of Biosciences in the University of Kent and co-leader of the study. Furthermore, EBRs were not associated with meiotic recombination hotspots – indicating that these rearrangements most likely did not occur during meiosis in either males or females. Instead, EBRs were correlated with DNA damage locations in spermatids. Spermatids are cells undergoing the final stage of sperm development, after cell division has finished – and the events occurring during this process are male specific. This, therefore, carries the startling implication that males and females are not equal in terms of their impact on genome evolution. “Of all the rearrangements that distinguish a mouse from a rat, a squirrel, or a rabbit, the majority appear likely to have arisen in a sperm cell rather than an egg cell. For me, this shows that the male germline is the overall engine of genome structural evolution,” says Dr. Ellis. “We show that developing sperm cells retain a ‘memory’ of previous genome configurations. There are stretches of DNA that used to be part of a single chromosome in rodent common ancestor but are now located on different chromosomes in mouse – yet these still move close to each other and make physical contact specifically in developing sperm cells” says Dr. Marta Farré. Why in Male Germ Cells? The authors propose one explanation for their results is the different events that occur during egg and sperm cell production. While both sperm and egg cells reshuffle DNA during meiosis, the DNA breaks created during this process are repaired highly accurately. However, sperm cells also have to compact their DNA into a tiny volume to fit in the sperm head. This compaction causes DNA breaks and uses an error-prone method to repair the DNA. Some of these errors can generate genomic rearrangements – explaining why sperm development is a critical factor in genome evolution. On the other side, a current unsolved mystery is why some species have very stable genomes with few rearrangements, while others have highly dynamic genomes with multiple rearrangements. “Our work suggests that this may be due to the details of where and when DNA is broken and repaired during sperm production,” says Dr. Ruiz-Herrera. While the study was carried out in rodents, spermatogenesis is a highly conserved process and therefore this principle is likely to apply widely throughout the tree of life, researchers point out. Reference: “3D chromatin remodelling in the germ line modulates genome evolutionary plasticity” by Lucía Álvarez-González, Frances Burden, Dadakhalandar Doddamani, Roberto Malinverni, Emma Leach, Cristina Marín-García, Laia Marín-Gual, Albert Gubern, Covadonga Vara, Andreu Paytuví-Gallart, Marcus Buschbeck, Peter J. I. Ellis, Marta Farré and Aurora Ruiz-Herrera, 11 May 2022, Nature Communications. DOI: 10.1038/s41467-022-30296-6 Participating in this study led by the UAB and University of Kent were also the research teams from Josep Carreras Leukaemia Research Institute (IJC) and Sequentia Biotech.

Scientists characterize previously unknown gut reactions. Strictly speaking, humans cannot digest complex carbohydrates — that’s the job of bacteria in our large intestines. UC Riverside scientists have just discovered a new group of viruses that attack these bacteria. The viruses, and the way they evade counterattack by their bacterial hosts, are described in a paper published in Cell Reports. Bacterioides can constitute up to 60% of all the bacteria living in a human’s large intestine, and they’re an important way that people get energy. Without them, we’d have a hard time digesting bread, beans, vegetables, or other favorite foods. Given their significance, it is surprising that scientists know so little about viruses that prey on Bacteroides.  “This is largely unexplored territory,” said microbiologist Patrick Degnan, an assistant professor of microbiology and plant pathology, who led the research.  To find a virus that attacks Bacteroides, Degnan and his team analyzed a collection of bacterial genomes, where viruses can hide for numerous generations until something triggers them to replicate, attack, and leave their host. This viral lifestyle is not without risk as over time mutations could occur that prevent the virus from escaping its host. On analyzing the genome of Bacteroides vulgatus, Degnan’s team found DNA belonging to a virus they named BV01. However, determining whether the virus is capable of escaping, or re-infecting its host, proved challenging. Reconstructed microscopy image of a bacteriophage, which is a virus that attacks bacteria. Credit: Purdue University and Seyet LLC “We tried every trick we could think of. Nothing in the laboratory worked until we worked with a germ-free mouse model,” Degnan said. “Then, the virus jumped.”  This was possible due to Degnan’s collaboration with UCR colleague, co-author and fellow microbiologist Ansel Hsiao. This result suggests conditions in mammalian guts act as a trigger for BV01 activity. The finding underscores the importance of both in vitro and in vivo experiments for understanding the biology of microbes.  Looking for more information about the indirect effect of this bacterial virus might have on humans, Degnan’s team determined that when BV01 infects a host cell, it disrupts how that cell normally behaves.  “Over 100 genes change how they get expressed after infection,” Degnan said.  Two of the altered genes that stood out to the researchers are both responsible for deactivating bile acids, which are toxic to microbes. The authors speculate that while this possibly alters the sensitivity of the bacteria to bile acids, it also may influence the ability of the bacteria to be infected by other viruses. “This virus can go in and change the metabolism of these bacteria in human guts that are so key for our own metabolism,” Degnan said.  Though the full extent of BV01 infection is not yet known, scientists believe viruses that change the abundance and activity of gut bacteria contribute to human health and disease. One area for future studies will involve the effect of diet on BV01 and viruses like it, as certain foods can cause our bodies to release more bile. Degnan also notes that BV01 is only one of a group of viruses his team identified that function in similar ways. The group, Salyersviridae, is named after famed microbiologist Abigail Salyers whose work on intestinal bacteria furthered the science of antibiotic resistance. Further research is planned to understand the biology of these viruses.  “It’s been sitting in plain sight, but no one has characterized this important group of viruses that affect what’s in our guts until now,” Degnan said. Reference: “Infection with Bacteroides Phage BV01 Alters the Host Transcriptome and Bile Acid Metabolism in a Common Human Gut Microbe” by Danielle E. Campbell, Lindsey K. Ly and Jason M. R, 15 September 2020, Cell Reports. DOI: 10.1016/j.celrep.2020.108142

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