Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Graphene sheet OEM supplier Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia foot care insole ODM expert

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Smart pillow ODM manufacturer Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan pillow OEM manufacturing factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene sheet OEM supplier Vietnam

New research indicates that generating new brain cells in adults supports verbal learning and memory, linking reduced neurogenesis with cognitive decline and highlighting potential therapeutic approaches to enhance cognitive health. Credit: SciTechDaily.com Researchers at USC have discovered that the formation of new brain cells in adults, known as neurogenesis, is essential for verbal learning and memory. This study, utilizing brain tissues from epilepsy patients, shows a direct correlation between decreased neurogenesis and cognitive decline, opening the door to therapies that could enhance cognitive function by promoting neurogenesis. Adult Neurogenesis and Cognitive Function Why do adults grow new brain cells? A groundbreaking study published today (December 5) in Cell Stem Cell offers the first direct evidence that the generation of new brain cells in adulthood supports verbal learning and memory. This ability helps people engage in conversations and retain what they hear. The findings may pave the way for innovative treatments to restore cognitive function. The research, conducted by scientists at USC Stem Cell and the USC Neurorestoration Center at the Keck School of Medicine, examined brain tissue from patients with drug-resistant mesial temporal lobe epilepsy (MTLE). This condition is characterized by seizures and accelerated cognitive decline. Newborn neuron (green and purple cell) in brain tissue from patients with epilepsy. Credit: Aswathy Ammothumkandy/Bonaguidi Lab/USC Stem Cell Exploring the Link Between Neurogenesis and Verbal Learning “Treating patients with epilepsy allows us to investigate the purpose of generating new neurons in our brains. We observe that one of reasons is to learn from the conversations we have” said co-corresponding author Michael Bonaguidi, an associate professor of stem cell biology and regenerative medicine, gerontology, biochemistry and molecular medicine, biomedical engineering, and neurological surgery, and assistant director of the USC Neurorestoration Center. “These findings are clearly important for all people who suffer from learning and cognitive decline, but they are also specifically relevant to the epilepsy patients who participated in the research,” added co-corresponding author Charles Liu, a professor of neurological surgery, neurology, and biomedical engineering, director of the USC Neurorestoration Center, and director of the USC Epilepsy Care Consortium. Research Methodology and Findings in Epilepsy Patients In the study, first authors Aswathy Ammothumkandy and Luis Corona from USC and their collaborators investigated how the process of making new brain cells—called neurogenesis—affects different types of cognitive decline during the progression of MTLE. The researchers found that MTLE patients experience cognitive decline in many areas including verbal learning and memory, intelligence, and visuospatial skills. For verbal learning and memory, as well as for intelligence, patients undergo a dramatic decline during the first 20 years of seizures. During those same two decades, neurogenesis slows to the point where immature brain cells became nearly undetectable. Implications of Neurogenesis on Cognitive Health Based on these observations, the scientists searched for links between the number of immature brain cells and the major areas of MTLE-related cognitive decline. They found the strongest association occurs between the declining number of immature brain cells and verbal learning and memory. This is a surprising finding because neurogenesis levels in rodents and other lab animals contribute to a different type of learning and memory using visuospatial skills. The role of neurogenesis in verbal learning and memory highlights the value of studying human brain tissue. These highly valuable surgical specimens were generously donated by patients of the Rancho Los Amigos Epilepsy Center- a unique resource in the public safety-net health system advancing health care and research equity for the underinsured population in the region. During the complex operations, the neurosurgeons carefully removed the affected hippocampus in one piece, curing the majority of the patients of their seizures. “Our study provides the first cellular evidence of how neurogenesis contributes to human cognition—in this case, verbal learning and memory,” said Bonaguidi. “This work opens a gateway for future studies exploring ways to improve verbal learning and memory by boosting neurogenesis, possibly through exercise or therapeutic drugs. Those approaches could help not only patients with MTLE, Alzheimer’s disease and dementia, but also all of us with aging brains.” Reference: “Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression” by Aswathy Ammothumkandy, Luis Corona, Kristine Ravina, Victoria Wolseley, Jeremy Nelson, Nadiya Atai, Aidin Abedi, Nora Jimenez, Michelle Armacost, Lina M. D’Orazio, Virginia Zuverza-Chavarria, Alisha Cayce, Carol McCleary, George Nune, Laura Kalayjian, Darrin J. Lee, Brian Lee, Robert H. Chow, Christianne Heck, Jonathan J. Russin and Michael A. Bonaguidi, 5 December 2024, Cell Stem Cell. DOI: 10.1016/j.stem.2024.11.002 Neuropsychologist Jason Smith from the Medical University of South Carolina is also a co-corresponding author. Additional authors are: Kristine Ravina, Victoria Wolseley, Jeremy Nelson, Nadiya Atai, Aidin Abedi, Lina D’Orazio, Alisha Cayce, Carol McClearly, George Nune, Laura Kalayjian, Darrin Lee, Brian Lee, Christianne Heck, Robert Chow, and Jonathan Russin from USC; Nora Jimenez from Los Angeles General Medical Center; Michelle Armacost from USC and Rancho Los Amigos National Rehabilitation Center; and Virginia Zuverza-Chavarria from Rancho Los Amigos National Rehabilitation Center. Thirty percent of this work was supported by federal funding from the National Institutes of Health (grants R56AG064077, R01AG076956, and U01MH098937). Additional support came from the Donald E. and Delia B.Baxter Foundation, L.K. Whittier Foundation, Simon-Strauss Foundation, Cure Alzheimer’s Fund, Eli and Edythe Broad Foundation, USC Neurorestoration Center, Rudi Schulte Research Institute, American Epilepsy Society, and California Institute for Regenerative Medicine.

New research has uncovered the genetic connections of the legendary killer whale, Old Tom, to modern New Zealand killer whales, suggesting the local extinction of his kind. The study also decolonizes the history of Eden’s whaling, emphasizing the historic bond between Indigenous Australians and killer whales. Credit: SciTechDaily.com Evolutionary biologists have successfully unraveled the genetic lineage of a renowned killer whale in Australia for the first time. For the first time, evolutionary biologists have unraveled the genetic history of a renowned killer whale and its group, which historically collaborated with whale hunters off the New South Wales coast. The leader of this pod, known as Old Tom, famous for helping whalers in hunting baleen whales during the 20th century, has been found to have genetic connections to present-day killer whales in New Zealand according to new DNA research. Old Tom also shared a common ancestor with killer whales from Australasia, the North Pacific, and North Atlantic Oceans, but is most similar to modern New Zealand killer whales. However, most of Tom’s DNA code is not found in other killer whales globally suggesting that the killer whales of Eden may have become extinct locally. Graphic depicting ancestry testing of “Old Tom”, a killer whale central to a cooperative hunting relationship with human whalers. Credit: Isabella Reeves at Flinders University Old Tom’s Unique History and Current Research Efforts Known as the killers of Eden, Old Tom, and his family would help whalers hunt their target and were rewarded with the lips and tongues from the whale carcass. This is known as the “Law of the Tongue.” This legendary relationship between the whalers and Old Tom’s family persisted and developed a strong bond across many generations of whalers. Measuring 6.7 meters in length and weighing six tonnes, Old Tom is now on display in the Eden Killer Whale Museum after washing up on shore in 1930. DNA testing of Old Tom at the Eden Killer Whale Museum in Australia. Credit: Charlie White Led by PhD Candidate Isabella Reeves at Flinders University and the Cetacean Research Centre, alongside a global research team that undertook an ambitious journey relying on ancient DNA techniques to attempt to trace Old Tom’s genetic lineage through DNA sequencing and comparing his DNA with killer whales globally. Through collaboration with Thaua Traditional Custodian Steven Holmes, the researchers have also revealed new insights in an attempt to decolonize the history of the Killers of Eden never officially documented before. Map of Twofold Bay, NSW Australia. Credit: Isabella Reeves Reeves’ Findings and the Indigenous Connection Lead researcher Isabella Reeves says that while the genetic comparisons didn’t find any direct descendants of Old Tom, the researchers did find that Tom shared much of his DNA variation with other killer whales, suggesting they are locally extinct today.   “The killers of Eden represent a rare partnership between people and whales. It was an exciting journey to trace the genetic ancestry of Old Tom, in order to provide the first insights into the genetic history of this group that captured the hearts of the community and whale lovers.” “Our research also delved into uncharted territory by unveiling a decolonized history. We collaborated with a Traditional Custodian, which gave us a fresh perspective on Eden’s whaling history to rectify historical inaccuracies and shed light on a crucial aspect of this unique story about the bond between their people and these whales. Importantly, we want to ensure this aspect of the story is acknowledged moving forward.” Ancient DNA lab work at Flinders University on Old Tom and the Killers of Eden. Credit: Andrew Foote In Twofold Bay, the coastal Thaua people, part of the Yuin nation, had a connection with the killer whales through the Dreaming, a relationship that was highly respected and relied upon due to the Thaua’s dependency on the ocean for resources. “It’s important that we recognize that Indigenous Australians initiated the relationship with the killer whales before European colonization and the advent of commercial whaling locally. This study rectifies discrepancies in local records and provides new insight into the origins of the killer whales in Eden and the history of Australasian killer whales,” says Ms Reeves. Old Tom skeleton at the Eden Killer Whale Museum. Credit: Charlie White Traditional Custodian, Steven Holmes, says the Thaua people had a long-lasting friendship with the whales in Eden, especially Old Tom. “We consider beowas (killer whales) to be our brothers. Our Dreamtime stories which connect us to the beowas, is that when a Thaua member dies, they are reincarnated as a beowa. The beowas remained part of the Thaua, even after passing. The beowas would help the men by herding the other whales in the bay of Turembulerrer (Twofold Bay) for the whalers to kill. The Indigenous whalers would reward the beowas the tongue of the dead whale. This was soon known as the Law of the Tongue.” Reference: “Ancestry testing of “Old Tom,” a killer whale central to mutualistic interactions with human whalers” by Isabella M Reeves, John A Totterdell, Emma L Betty, David M Donnelly, Angela George, Steven Holmes, Luciana Moller, Karen A Stockin, Rebecca Wellard, Charlie White and Andrew D Foote, 12 October 2023, Journal of Heredity. DOI: 10.1093/jhered/esad058 The study was funded by the Royal Society of South Australia, the Playford Trust Foundation, the Australian Government, and the European Research Council.

These distant primate cousins of humans are among the few mammal species in which male-female partners stick together year after year. Credit: David Haring, Duke Lemur Center Lemurs Show There’s No Single Formula for Lasting Love Humans aren’t the only mammals that form long-term bonds with a single, special mate — some bats, wolves, beavers, foxes, and other animals do, too. But new research suggests the brain circuitry that makes love last in some species may not be the same in others. The study, appearing February 12 in the journal Scientific Reports, compares monogamous and promiscuous species within a closely related group of lemurs, distant primate cousins of humans from the island Madagascar. Red-bellied lemurs and mongoose lemurs are among the few species in the lemur family tree in which male-female partners stick together year after year, working together to raise their young and defend their territory. Once bonded, pairs spend much of their waking hours grooming each other or huddled side by side, often with their tails wrapped around each other’s bodies. Males and females of these species spend a third of their lifetime with the same mate. The same cannot be said of their closest relatives, who change partners often. The Rarity of Mammalian Monogamy To biologists, monogamy is somewhat a mystery. That’s in part because in many animal groups it’s rare. While around 90% of bird species practice some form of fidelity to one partner, only 3% to 5% of mammals do. The vast majority of the roughly 6,500 known species of mammals have open relationships, so to speak. “It’s an uncommon arrangement,” said lead author Nicholas Grebe, a postdoctoral associate in professor Christine Drea’s lab at Duke University. Which raises a question: what makes some species biologically inclined to pair up for the long haul while others play the field? Hormones Behind Lasting Bonds Studies over the last 30 years in rodents point to two hormones released during mating, oxytocin, and vasopressin, suggesting that the key to lasting love may lie in differences in how they act on the brain. Some of the first clues came from influential research on prairie voles, small mouse-like mammals that, unlike most rodents, mate for life. When researchers compared the brains of monogamous prairie voles with their promiscuous counterparts, montane voles, and meadow voles, they found that prairie voles had more “docking sites” for these hormones, particularly in parts of the brain’s reward system. Since these “cuddle chemicals” were found to enhance male-female bonds in voles, researchers have long wondered if they might work the same way in humans. That’s why the Duke-led team turned to lemurs. Despite being our most distant primate relatives, lemurs are a closer genetic match to humans than voles are. The researchers used an imaging technique called autoradiography to map binding sites for oxytocin and vasopressin in the brains of 12 lemurs that had died of natural causes at the Duke Lemur Center. The animals represented seven species: monogamous red-bellied and mongoose lemurs along with five promiscuous species in the same genus. “They’re really the only comparable natural experiment to look for biological signatures of monogamy in primates,” Grebe said. Comparing the brain imaging results in lemurs with previous results in voles and monkeys revealed some noticeable differences in the density and distribution of hormone receptors. In other words, oxytocin and vasopressin appear to act on different parts of the brain in lemurs — which means they may also have different effects, depending on their target cell’s location. But within lemurs, the researchers were surprised to find few consistent differences between monogamous species and promiscuous ones. “We don’t see evidence of a pair-bond circuit” akin to that found in rodent brains, Grebe said. Testing the Limits of Oxytocin As a next step, the team is looking at how lemur couples behave toward each other if the actions of oxytocin are blocked, by feeding them an antagonist that temporarily prevents oxytocin from binding to its receptors in the brain. So what can lemurs teach us about love? The authors say their findings caution against drawing simple conclusions based on rodent experiments about how human social behaviors came to be. Oxytocin may be the “potion of devotion” for voles, but it may be the combined actions and interactions of multiple brain chemicals, along with ecological factors, that create long-lasting bonds in lemurs and other primates, including humans, Grebe said. “There are probably a number of different ways through which monogamy is instantiated within the brain, and it depends on what animals we’re looking at,” Grebe said. “There’s more going on than we originally thought.” Reference: “Neural Correlates of Mating System Diversity: Oxytocin and Vasopressin Receptor Distributions in Monogamous and Non-Monogamous Eulemur” by Nicholas M. Grebe, Annika Sharma, Sara M. Freeman, Michelle C. Palumbo, Heather B. Patisaul, Karen L. Bales and Christine M. Drea, 12 February 2021, Scientific Reports. DOI: 10.1038/s41598-021-83342-6 Other authors were: Annika Sharma at Duke, Sara Freeman at Utah State University, Michelle Palumbo at the California National Primate Research Center, Heather Patisaul at North Carolina State University, and Karen Bales at the University of California, Davis. This work was supported by grants from the National Science Foundation (SBE-1808803), the National Institute of Mental Health (NIMH R21MH115680), the Josiah Charles Trent Memorial Foundation Endowment Fund, the Charles Lafitte Foundation for Research, and Duke University.

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