Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China orthopedic insole OEM manufacturer

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand ergonomic pillow OEM supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan eco-friendly graphene material processing factory

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand OEM insole and pillow supplier

A study on nematodes shows that smell aversion triggers a response that could extend their lifespan and offers insights into potential treatments for human neurodegenerative diseases. Credit: SciTechDaily In a study involving nematode worms, scientists found that when these worms were exposed to a specific compound released by harmful bacteria, it triggered the activation of a neural pathway. This activation led to an increase in the lifespan of the worms and a reduction in protein aggregation, which is known to be a contributing factor in the development of neurodegenerative illnesses. An organism’s reaction to repugnant odors can be an indicator of the organism’s capacity to protect itself from harmful substances and live longer. This at least is what happens in the case of nematodes of the species Caenorhabditis elegans. Although nematodes (roundworms or threadworms) do not look remotely like humans, for about 50 years they have been used as a model for biological studies. The advantages include a simple nervous system, few cells and genes, many of which have the same functions as our own, and a short lifespan averaging 17 days, which is ideal for research on aging. An article published in the journal Nature Aging reports the findings of a study showing that odorant molecules secreted by pathogenic bacteria not only produced an aversive response in C. elegans, which retreated to avoid the threat but also triggered a neural circuit that induced a response in other tissues of the nematode. This response includes more efficient processing of toxic proteins and control of the aggregation of these and other proteins produced by the worms. The relevance of this is that in humans a buildup of these proteins is one of the factors associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The red blotches in this image of the nematode C. elegans are a pair of neurons with the UPRER pathway activated in response to the odorant molecule 1-undecene . Credit: Evandro de Souza & Max Thompson “They can sense danger in the environment by smell, heightening their stress responses even before they locate any pathogenic bacteria. Smell also prevents aggregation of proteins involved in disease, potentially extending their lifespan,” said Evandro Araújo de Souza, first author of the article. The study was part of his postdoctoral research at the Neurobiology Division of the Medical Research Council Laboratory of Molecular Biology (MRC-LMB) in Cambridge in the United Kingdom. Souza is one of 32 scientists selected for FAPESP’s Project Generation, which supports research based on bold ideas conducted by early-career researchers with outstanding potential. In September, he embarked on the next stage of the study at the State University of Campinas’s Institute of Biology (IB-UNICAMP) in Brazil, where he will conduct the project “Mechanisms of regulation of proteostasis in peripheral tissues by the nervous system”.  Scenting danger In the study, nematodes exposed to 1-undecene, an odorant molecule, lived longer than those that had no contact with the odor secreted by bacteria. Responses to the stimulus could be seen in the intestine, evidencing the existence of a circuit connecting olfactory perception to the rest of the body.  “These findings suggest that manipulating perceptions of chemical substances could one day be a route to intervention in neurodegenerative and age-related diseases. However, more research is needed to establish whether similar cell signaling pathways and mechanisms also operate in humans,” said Rebecca Taylor, a researcher at MRC-LMB and last author of the article. According to the researchers, other studies had already shown that mice have a neural circuit linking the brain to the liver when these animals smell certain kinds of food, and it makes sense to hypothesize that the mammalian nervous system could trigger a response by other organs when stimulated, as is the case in nematodes. “If we find a molecule that can mediate this circuit connecting the perception of odor to the organism’s response, we could have a promising route to develop novel treatments,” Souza said. Partially revealed circuit In the study, the nematodes were placed on different plates from those containing the odorants to demonstrate that it was not direct contact between the worms and the substances that caused aversion but only their smell. The odorants used were those secreted by pathogenic bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus, which are harmful to nematodes. Three of these compounds including 1-undecene were associated with aversive responses in C. elegans. The researchers decided to focus on 1-undecene in subsequent experiments as it induced aversion without being toxic.  When they analyzed the worms exposed to the substance, they observed activation of the endoplasmic reticulum unfolded protein response (UPRER) in the intestine. This is a defense the organism uses to trigger repair mechanisms or eliminate defective proteins. In worms with mutations in two genes that regulate the UPRER (ire-1 and xbp-1), the response was not activated by 1-undecene, showing that this cellular signaling pathway was essential to the activation of UPRER by the substance. Other experiments confirmed this result. Another group of mutant nematodes exposed to 1-undecene failed to produce neurotransmitters such as serotonin, dopamine, and glutamate, among others, but the researchers were unable to identify a role for any of these molecules.  Next, they focused on DAF-7, a protein and gene equivalent to transforming growth factor-beta (TGF-β) in mammals, where it plays an important role in the neural circuits that govern behavior such as aversion to pathogens. When production of DAF-7 was inhibited, odorant-induced UPRER was not activated, evidencing its role in this response. “We now know the route we need to follow, especially because the protein has an equivalent in humans,” Souza said. Reference: “Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation” by Evandro A. De-Souza, Maximillian A. Thompson and Rebecca C. Taylor, 27 July 2023, Nature Aging. DOI: 10.1038/s43587-023-00467-1 The study was funded by the São Paulo Research Foundation.

The picture shows an RNA polymerase ribozyme thought to be implicated in the origin of life. The ribozyme is shown frozen in ice to symbolize how it was frozen in time for imaging and how it works best under ice-cold conditions. The active site is highlighted by a yellow/red light and the proposed position of the template-product helix is shown in transparent. Credit: Rune Kidmose RNA is thought to have sparked the origin of life by self-copying. Researchers from Aarhus University, Denmark, and MRC LMB Cambridge, England, have revealed the atomic structure of an “RNA copy machine” through cryo-EM. This breakthrough sheds light on a primordial RNA world and fuels advancements in RNA nanotechnology and medicine. How the intricate molecular machinery of life arose from simple beginnings has been a long-standing question. Several lines of evidence point towards a primordial “RNA world,” where an “RNA copy machine” (a so-called replicase) started making copies of itself and other RNA molecules to kick-start evolution and life itself. However, the ancient replicase appears to have been lost in time and its role in modern biology has been taken over by more efficient protein machines. To support the RNA world hypothesis, researchers have been seeking to re-create an equivalent of the RNA replicase in the laboratory. While such molecular “Doppelgangers” of the ancient replicase have been discovered, both their detailed molecular structure and mode of action has remained elusive due to the difficulty of determining the structure of dynamic RNA molecules. Structure of an ice-loving RNA replicase In a research paper published in PNAS, a team of researchers now report the first atomic structure of an RNA replicase using cryogenic electron microscopy (cryo-EM). The RNA replicase being studied was developed by the Holliger lab (MRC LMB Cambridge, UK) to be efficient at copying long templates using nucleotide triplets in the eutectic ice phase (similar to slush-ice). Returning from postdoctoral studies in the Holliger lab, Emil L. Kristoffersen, currently assistant professor at Aarhus University, facilitated a collaboration with the Andersen lab (Aarhus University, Denmark) to determine the structure of the RNA replicase by cryo-EM. Interestingly, the structure shows striking similarities to protein-based polymerases with domains for template binding, polymerization, and substrate discrimination arranged in a molecular shape resembling an open hand. “It was surprising to find that a ribozyme that we evolved artificially in the test tube would display features of naturally occurring protein polymerases. This indicates that evolution can discover convergent molecular solutions no matter if the material is RNA or protein”, explains Philipp Holliger, program leader at MRC LMB Cambridge, UK. Model for RNA synthesis in an RNA world To better understand how the RNA replicase works, the researchers did a comprehensive mutational study to highlight the crucial elements of the RNA structure. This analysis confirmed features of the catalytic site but also revealed the importance of two so-called kissing-loop interactions, which bind the scaffolding and the catalytic subunits together, as well as the importance of a specific RNA domain for fidelity, that is the accuracy with which the replicase copies RNA strands. While the researchers could not determine the structure of the replicase “in-action” while actively copying RNA, it was possible to build a model for RNA-based RNA copying that is consistent with all experimental data. “Cryo-EM is a powerful method for studying the structure and dynamical features of RNA molecules. By combing cryo-EM data with experiments, we were able to build a model of the inner workings of this complex RNA machine,” tells Ewan McRae, who did the cryo-EM work as a postdoc in the Andersen lab at Aarhus University but has now started his own research group at Houston Methodist Research Institute, Texas, USA. Inspiration for RNA nanotechnology and medicine The study provides an exciting first glimpse of an RNA replicase thought to reside at the very root of the tree of life. The currently developed RNA-based replicases are however very inefficient (as compared to protein-based polymerases) and cannot yet sustain their own replication and evolution. The structural insight provided by the reported study may help in designing more efficient replication mechanisms and thus get us closer to developing RNA world scenarios in the test tube. “The properties of RNA replicases may be further improved by using chemical modifications that could exist in an RNA world. In addition, research into the origin of life leads to the discovery of several novel RNA building blocks that may be used in the emerging field of RNA nanotechnology and medicine”, explains Ebbe Sloth Andersen, associate professor at Aarhus University, Denmark. Reference: “Cryo-EM structure and functional landscape of an RNA polymerase ribozyme” by Ewan K. S. McRae, Christopher J. K. Wan, Emil L. Kristoffersen, Kalinka Hansen, Edoardo Gianni, Isaac Gallego, Joseph F. Curran, James Attwater, Philipp Holliger and Ebbe S. Andersen, 11 January 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2313332121 The research was funded by Independent Research Fund Denmark (9040-00425B), Novo Nordisk Foundation (NNF21OC0070452), Canadian Natural Sciences and Engineering Research Council (532417), Carlsberg Foundation (CF20-0635, CF17-0809), Lundbeck Foundation (R250-2017-1502), Medical Research Council, as part of United Kingdom Research and Innovation (also known as UK Research and Innovation (UKRI)) (MC_U105178804), Volkswagen Foundation (96 755), Herchel Smith studentship (2017), and Marie Curie fellowship (H2020-MSCA-IF-2018-845303).

A study suggests a worm named after late-night comedian Conan O’Brien may be contributing to the decrease in Caribbean spiny lobster landings. (AI-generated image of “worm that looks like Conan O’Brien.” See an actual image of Carcinonemertes conanobrieni below.) A nemertean worm, Carcinonemertes conanobrieni, discovered by a Clemson University biologist, is suspected to negatively impact the reproduction of Caribbean spiny lobsters, thereby contributing to their decreased numbers. The worm’s effect on the lobster’s reproductive cycle could have significant implications for the marine ecosystem and the lobster industry. A species of nemertean worm discovered by a Clemson University marine biologist five years ago affects the reproductive performance of Caribbean spiny lobsters, a critical species in the Caribbean Sea and the Gulf of Mexico. Antonio Baeza, an associate professor in the Department of Biological Sciences, discovered the new worm while researching parental behaviors of the spiny lobster Panulirus argus in the Florida Keys. Baeza good-naturedly named the worm Carcinonemertes conanobrieni after comedian Conan O’Brien because of its physical characteristics — long-bodied and pale with a slight tint of orange. The worm has been found off the coast of the Colombian and West Indies. The spiny lobster is an ecologically significant and commercially lucrative species in the Caribbean Sea and the Gulf of Mexico. A worm discovered by a Clemson University scientist is affecting its reproductive performance. Credit: Clemson University College of Science Caribbean spiny lobsters, which get their name from the forward-pointing spines that cover their bodies, live in the Atlantic Ocean’s tropical and subtropical waters as far north as North Carolina, as well as the Caribbean Sea and the Gulf of Mexico. They are one of the Caribbean’s most ecologically significant and commercially lucrative species. Caribbean spiny lobster landings have decreased over the past decade. Scientists don’t know why, although they have identified several possibilities – overfishing, declining water quality, global climate change, and environmental degradation. A new study published in the journal BMC Zoology shows the worm discovered by Baeza is likely a contributor, too. Baeza discovered the Carcinonemertes conanobrieni while he was conducting research on parental behaviors of the Caribbean spiny lobster. Credit: Clemson University College of Science Artisan fishers caught 90 egg-bearing spiny lobsters near Pueblo Viejo, Magdalena, Colombia, to determine whether C. conanobrieni affected embryo mortality, fecundity, and reproductive output in brooding females. Of the 90 lobsters, nearly 88% had either nemertean worms or worm cysts and egg masses. Embryo mortality, indicated by empty capsules and dead embryos, ranged between 0% and 43.81% in infected gravid females. Embryo mortality was absent in non-infected gravid female lobsters. Researchers also confirmed that the presence of the worm impacted reproductive output. Antonio Baeza, associate professor in the Department of Biological Sciences at Clemson University. Credit: Clemson University College of Science “The effect of the parasite varies from female to female. Some may be heavily affected; others may not. We don’t know why yet,” Baeza said. “We know the egg predator is affecting the population level, but we cannot say for how much of an effect yet, whether it will be bad or devastating because we don’t have that data yet.” Carcinonemertes worms have been responsible for the collapse of crustacean fisheries on the west coast of North America. Caribbean spiny lobsters are vital for the marine ecosystem because they are prey for many predators, including sharks, large fish such as grouper and snapper, turtles, and octopuses. They are predators, too, and eat snails, crabs, and clams. The clams are part of a different tropic chain, so when lobsters eat them, they link tropic networks and energy flow through the entire ecosystem. “A whole industry and coastal communities along the entire Caribbean basin rely on this species,” Baeza said. Baeza said if researchers can understand the prevalence of the egg predator and its effects, a modeling approach might predict future landings and inform those managing the fishery to minimize adverse effects. In addition to Baeza, Clemson graduate student Natalie Stephens and researchers from Colombia and Chile contributed to the study. Their findings are detailed in the paper “The effect of the egg-predator Carcinonemertes conanobrieni (Nemertea) on the reproductive performance of the Caribbean spiny lobster Panulirus argus.” Reference: “The effect of the egg-predator Carcinonemertes conanobrieni (Nemertea) on the reproductive performance of the Caribbean spiny lobster Panulirus argus” by Amanda Berben, Natalie C. Stephens, Jaime Gonzalez-Cueto, Yulibeth Velasquez, Sigmer Quiroga, María Teresa González and J. Antonio Baeza, 26 June 2023, BMC Zoology. DOI: 10.1186/s40850-023-00165-w

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