Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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ESG-compliant OEM manufacturer in Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China OEM/ODM hybrid insole services

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam OEM insole and pillow supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Graphene insole OEM factory Vietnam

An illustration of antibodies (red) seeking out the Lassa virus glycoprotein complex (GPC, white) in the human bloodstream. New research on the structure of the GPC, which is coated in sugar molecules (yellow), helped researchers define its interactions with effective antibodies. Credit: Hailee Perrett, Scripps Research By comparing the structures of protein complexes from different lineages of the dangerous Lassa virus, a Scripps Research team identified new antibodies and vaccine targets. Every year, hundreds of thousands of people in West Africa become infected with Lassa virus, which can cause Lassa fever and lead to severe illness, long-term side effects or death. There are currently no widely approved treatments or vaccines for the disease. Now, scientists at Scripps Research have determined the structure of the critical protein complex that lets Lassa virus infect human cells. The research, published online in the journal Cell Reports, also identified new antibodies that bind to these proteins and neutralize the virus, paving the way toward more effective vaccines and treatments for Lassa virus. “This work is a big step forward in our ability to isolate new antibodies to relevant sites of vulnerability on the virus, and it provides a basis to conduct rational vaccine design to broadly protect people against many lineages of the Lassa virus,” says senior author Andrew Ward, PhD, professor of Integrative Structural and Computational Biology at Scripps Research. “These new reagents described in the paper are already being put to good use and yielding exciting new results.” Like many viruses, Lassa virus exists in a variety of lineages, each with slight variations in its genes. This diversity has made it challenging to pinpoint antibodies that recognize all versions of Lassa virus. Scientists have also struggled to isolate Lassa glycoproteins—the spike-like proteins that surround the virus and are the target of most antibodies. In the infectious virus, these glycoproteins exist in complexes of three, called trimers. For decades, however, scientists were only able to isolate glycoproteins in the lab as single proteins and not in their trimer complexes. In 2022, Ward and colleagues discovered how to use nanoparticles to hold the glycoproteins together into trimers. In the new work, they used that technique to isolate and structurally characterize trimers of the glycoproteins from four different Lassa virus lineages. Surprisingly, the glycoprotein structures from the distinct lineages were extremely similar. “We were hoping to see more obvious differences that would explain why antibodies didn’t recognize all the lineages,” says Hailee Perrett, a Scripps Research graduate student and first author of the work. “Instead, we found a very high level of conservation across the peptide and sugar components of the protein.” Identifying Potent Antibodies Against Lassa Virus Using the same stable glycoproteins, Ward, Perrett and their colleagues next used blood samples from patients who had recovered from Lassa virus to isolate antibodies against the glycoprotein trimers. They found new antibodies and characterized previously discovered antibodies that recognize different lineages of the Lassa virus glycoprotein, which may be useful in developing a treatment or preventive vaccine against the virus. The team is already planning future experiments to pinpoint more antibodies against the Lassa virus glycoproteins, as well as further analyzing the protein structures to identify places on the glycoproteins that are ideal for targeting with drugs. “Our goals were to not only try and define some of the structural details of these different Lassa viruses, but to provide foundational protocols and resources for the field,” says Perrett. “We hope our approaches and initial findings help push the science in this field forward.” Reference: “Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies” by Hailee R. Perrett, Philip J.M. Brouwer, Jonathan Hurtado, Maddy L. Newby, Lin Liu, Helena Müller-Kräuter, Sarah Müller Aguirre, Judith A. Burger, Joey H. Bouhuijs, Grace Gibson, Terrence Messmer, John S. Schieffelin, Aleksandar Antanasijevic, Geert-Jan Boons, Thomas Strecker, Max Crispin, Rogier W. Sanders, Bryan Briney and Andrew B. Ward, 18 May 2023, Cell Reports. DOI: 10.1016/j.celrep.2023.112524 In addition to Ward and Perrett, authors of the study, “Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies,” include Philip J.M. Brouwer, Jonathan Hurtado, Grace Gibson, Terrence Messmer, Aleksandar Antanasijević and Bryan Briney of Scripps Research; Maddy L. Newby and Max Crispin of University of Southampton; Lin Liu and Geert-Jan Boons of University of Georgia; Helena Müller-Kräuter, Sarah Müller Aguirre and Thomas Strecker of Philipps-University Marburg; Judith A. Burger, Joey H. Bouhuijs and Rogier W. Sanders of Amsterdam University; and John S. Schieffelin of Tulane University. This work was supported by a David C. Fairchild Endowed Fellowship, the Achievement Rewards for College Scientists Foundation, the National Institutes of Health (1F31Al172358, R01 AI165692, R01 AI171438), the Netherlands Organisation for Scientific Research, the amfAR Mathilde Krim Fellowship in Biomedical Research (#110182-69-RKVA), a Vici fellowship from the Netherlands Organisation for Scientific Research, the Fondation Dormeur in Vaduz, the Deutsche Forschungsgemeinschaft (197785619/SFB1021), the International AIDS Vaccine Initiative (INV008352/OPP1153692) and the Bill and Melinda Gates Foundation (OPP1170236).

New research sheds light on the mechanism of action of aspirin, a widely used medication for pain, fever, inflammation, and reducing cardiovascular disease risk. Although aspirin’s inhibition of the cyclooxygenase enzyme (COX) is known, its detailed cellular targets have remained unclear. Findings from a study led by Subhrangsu Mandal, a professor at the University of Texas at Arlington, could help develop safer aspirin alternatives and potentially improve cancer immunotherapies. Understanding how aspirin reduces inflammation could lead to alternatives with fewer side effects. New research has revealed important information about how aspirin works. Even though this drug has been available commercially since the late 1800s, scientists have not yet fully elucidated its detailed mechanism of action and cellular targets. The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies. Aspirin, which is a nonsteroidal anti-inflammatory drug, is one of the most widely used medications in the world. It is used to treat pain, fever, and inflammation, and an estimated 29 million people in the U.S. take it daily to reduce the risk of cardiovascular diseases. Scientists know that aspirin inhibits the cyclooxygenase enzyme, or COX, which creates messenger molecules that are crucial in the inflammatory response. Researchers led by Subhrangsu Mandal, a professor of chemistry and biochemistry at the University of Texas at Arlington, have discovered more about this process. Researchers have made new discoveries about aspirin’s mechanism of action and cellular targets. Their findings suggest potential interplay between cyclooxygenase enzyme, or COX, and indoleamine dioxygenases, or IDOs, during inflammation. Credit: Subhrangsu Mandal, University of Texas at Arlington Prarthana Guha, a graduate student in Mandal’s lab, presented the team’s findings at Discover BMB, the annual meeting of the American Society for Biochemistry and Molecular Biology, March 25–28 in Seattle. Avisankar Chini also made significant contributions to the study. “Aspirin is a magic drug, but long-term use of it can cause detrimental side effects such as internal bleeding and organ damage,” Mandal said. “It’s important that we understand how it works so we can develop safer drugs with fewer side effects.” Aspirin’s Effects on Tryptophan Metabolism The team found that aspirin controls transcription factors required for cytokine expression during inflammation while also influencing many other inflammatory proteins and noncoding RNAs that are critically linked to inflammation and immune response. Mandal said this work has required a unique interdisciplinary team with expertise in inflammation signaling biology and organic chemistry. They also showed that aspirin slows the breakdown of the amino acid tryptophan into its metabolite kynurenine by inhibiting associated enzymes called indoleamine dioxygenases, or IDOs. Tryptophan metabolism plays a central role in the inflammation and immune response. “We found that aspirin downregulates IDO1 expression and associated kynurenine production during inflammation,” Mandal said. “Since aspirin is a COX inhibitor, this suggests potential interplay between COX and IDO1 during inflammation.” Implications for Cancer Immunotherapy IDO1 is an important target for immunotherapy, a type of cancer treatment that helps the body’s immune system seek out and destroy cancer cells. Because COX inhibitors modulate the COX–IDO1 axis during inflammation, the researchers predict that COX inhibitors might also be useful as drugs for immunotherapy. Mandal and his team are now creating a series of small molecules that modulate COX–IDO1 and will explore their potential use as anti-inflammatory drugs and immunotherapeutic agents. Meeting: Discover BMB Research in Mandal’s lab is funded by National Institute of Health grant R15 HL142032-01.

The enteric nervous system (ENS), often called the second brain, plays a crucial role in digestion, immunity, and communication with the brain. Researchers have discovered that ENS development continues after birth and includes neurons derived from mesoderm, challenging long-held scientific beliefs and opening avenues for potential new treatments for aging and gastrointestinal diseases. Discoveries May Pave the Way for Improved Therapies for Gastrointestinal Issues Following your gut. Losing your appetite. A gutsy move. Though we often consider the gut as merely a digestive tool, these common expressions reflect the central role the gut plays in a much wider range of essential functions. The entire digestive tract is lined by the enteric nervous system (ENS), a vast network of millions of neurons and glial cells—the two primary cell types also found in the central nervous system. While often called the second brain, the ENS not only generates the same neurotransmitters but actually predates the evolution of the central nervous system in the brain. The functions of the ENS are crucial to life and extend far beyond digestion, as it regulates immunity, gut secretions, and enables complex, bi-directional communication between the gut and the brain. This is why a happy gut co-exists with a happy brain, and why digestive issues can lead to changes in mood and behavior. Since the mid-20th century, scientists have believed that the ENS is derived from the neural crest before birth and remains unchanged after. Now, in a paper published in the journal eLife, researchers at Beth Israel Deaconess Medical Center (BIDMC) present a completely new paradigm describing a developmental pathway by which ENS development continues after birth in mice and human tissue samples. This discovery overturns decades of scientific dogma on the fundamental biology of neuroscience and of ENS, by showing evidence for the first time of a non-ectodermal and a mesodermal origin for large numbers of enteric neurons born after birth. The findings show the relevance of these neurons to the maturation and aging of the ENS in health and disease. The Aging Process and ENS Neuron Evolution “These results indicate for the first time that the mesoderm is an important source of neurons in the second largest nervous system of the body,” said Subhash Kulkarni, Ph.D., a staff scientist at BIDMC and an assistant professor in the Division of Medical Sciences at Harvard Medical School. “How we mature and how we age is central to our understanding of health and disease in our rapidly aging population. The increasing proportion of neurons of mesodermal lineage is a natural consequence of maturation and aging; further, this lineage can be expected to have distinct vulnerabilities to disease.” Using transgenic mice models, high-resolution microscopy, and genetic analyses, Kulkarni and colleagues analyzed the ENS neuronal populations in adult mice and human tissues. Using mice models, the team found that while the early post-natal ENS cells were from the expected neural crest lineage, that pattern changed rapidly as the animal matured. Kulkarni and colleagues documented the arrival and continual expansion of a novel population of enteric neurons that were derived from the mesoderm—the same lineage that gives rise to the muscle and heart cells. This newly discovered population of mesoderm-derived neurons expanded with age, such that they comprised a third of all enteric neurons in adolescent mice, half of all enteric neurons in adult mice, and then eventually outnumbered the original neural crest-derived population of enteric neurons in aging mice. By assessing the molecular signature of these neurons, the team identified new cellular markers that were used to identify this population of mesoderm-derived neurons in human gut tissue. These markers also provided pharmacological targets, which the researchers used to not only manipulate the proportions of the mesodermal neurons in adolescent mice but also reduce their dominant proportions in the aging mouse gut to cure age-associated slowing of gut movement. A Paradigm Shift in Neuroscience and Clinical Medicine “We can now work to understand how these findings can be translated into human systems to provide a disease-modifying cure to aging patients whose chief complaint often includes diseases of the GI tract,” added Kulkarni. “By reversing one of the biggest dogmas of neuroscience, we are now in uncharted territory and, at the same time, have a huge opportunity to understand this hidden basic, translational, and clinical biology of neurons. The newly discovered lineage of neurons presents us with potential new drug targets that could help large populations of patients.” Reference: “Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease” by Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Matthew Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal A. Goff and Pankaj Jay Pasricha, 7 August 2023, eLife. DOI: 10.7554/eLife.88051.1 Co-authors included Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna Leser, Mithra Kumar, Shriya Bakhshi, Elizabeth Vincent, and Loyal A. Goff of Johns Hopkins University School of Medicine; Laren Becker and of Stanford University School of Medicine; Matthew Anderson and Mark Lewandoski of Center for Cancer Research, National Cancer Institute; and Pankaj Jay Pasricha of the Mayo Clinic. The microscopy was performed on the Ross Imaging Core at the Hopkins Conte Digestive Disease Center at the Johns Hopkins University (P30DK089502) using the Olympus FV 3000rs (procured with the NIH-NIDDK S10 OD025244 grant). The 10X Genomics Chromium processing for scRNAseq was performed at the GRCF Core and the sequencing was performed at the CIDR core at the Johns Hopkins University. This work was supported through a grant from the Ludwig Foundation, a grant from the NIA (R01AG066768), a pilot award from the Hopkins Digestive Diseases Basic & Translational Research Core Center grant (P30DK089502), a pilot award from the Diacomp initiative through Augusta University; a Johns Hopkins Catalyst Award; the Maryland Genetics, Epidemiology, and Medicine training program sponsored by the Burroughs Welcome Fund; the Hopkins Conte Digestive Disease Center at the Johns Hopkins University (P30DK089502); NIDDK (R01DK080920); the Maryland Stem Cell Research Foundation (MSCRF130005), and a grant from the AMOS family.

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