Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Private label insole and pillow OEM production factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Arch support insole OEM from Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Indonesia custom product OEM/ODM services

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Smart pillow ODM manufacturer Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Breathable insole ODM innovation factory Taiwan

A new discovery shows that cells can tailor their stress response, offering clues to treating cancers and brain diseases more effectively. Credit: SciTechDaily.com Cells don’t just follow a rigid script when responding to stress – they’re far more adaptable than we thought. A new study reveals that this stress response can be fine-tuned depending on the type and intensity of the threat. This discovery, called the “split-integrated stress response,” could reshape our approach to diseases like cancer and neurodegeneration, where cells either self-destruct or dangerously adapt. How Cells React Under Stress When the body’s cells encounter stress, such as toxins, mutations, starvation, or other threats, they pause their normal activities. Instead, they shift focus to conserve energy, repair damage, and strengthen their defenses. If the stress is mild or temporary, the cells recover and return to normal. But if the damage is too severe, they trigger self-destruction. For decades, scientists believed this stress response followed a simple, linear process: sensors inside the cell detect the problem, activate a key protein, which then modifies another protein to slow or shut down normal cellular functions. But new research from Case Western Reserve University, published today (March 26) in Nature, reveals the process is far more flexible and compartmentalized than previously thought. The team discovered that cells can fine-tune their response depending on the type, strength, and duration of the stress. They call this more sophisticated system the “split-integrated stress response,” or s-ISR – a finding that could open the door to new ways of killing cancer cells and treating neurodegenerative diseases. Maria Hatzoglou. Credit: Case Western Reserve University A Flexible and Adaptive System Maria Hatzoglou, professor of the Department of Genetics and Genome Sciences at the Case Western Reserve School of Medicine and the study’s principal investigator, found for the first time a cell’s response to stress can be fine-tuned depending its nature, intensity, and duration. This flexibility provides novel insights into how cells in organisms – from yeast to humans – adapt to their environment. “This study represents a new way of thinking about cellular stress,” Hatzoglou said. “ISR is not a one-size-fits-all system like we used to think. Instead, it can change and adjust depending on the type, strength, and length of the stress the cell is experiencing.” Vanishing White Matter Disease: A Case Study The study used mouse models of Vanishing White Matter Disease, which causes progressive degeneration of the brain’s white matter in children, leading to neurological problems like motor difficulties, seizures, and cognitive decline. Hatzoglou’s research revealed that cells carrying the gene causing the disease had mutations in the key protein normally responsible for shutting down operations in the cell under stress. Somehow, the brain cells adapt and mostly function normally but are exceptionally vulnerable, self-destructing even under mild stress. The research team, which included colleagues at Case Western Reserve, McGill University, and Karolinska Institute, determined how the cells reacted explained why patients showa significant decline in cognitive and motor abilities after relatively minor stressors like fever or mild head trauma. Implications for Other Neurodegenerative Diseases Other late-onset neurodegenerative diseases like multiple sclerosis and amyotrophic lateral sclerosis (better known as ALS) may share a similar mechanism, the researchers said. Diseased brain cells adapt to preserve functions under normal conditions, but modest stressors accelerate the decline. Targeting Cancer’s Stress Adaptation Understanding this adaptation to stress could lead to new targets for cancer chemotherapy, Hatzoglou said, because cancer cells respond to stressors like chemotherapy in one of two ways: either self-destruct or mutate to preserve their function, becoming resistant to the treatment. With that knowledge, she said she plans to study chemotherapy-resistant breast cancer cells to better understand how those cells adapt to stress and find new targets for treating disease. Reference: “Plasticity of the mammalian integrated stress response” by Chien-Wen Chen, David Papadopoli, Krzysztof J. Szkop, Bo-Jhih Guan, Mohammed Alzahrani, Jing Wu, Raul Jobava, Mais M. Asraf, Dawid Krokowski, Anastasios Vourekas, William C. Merrick, Anton A. Komar, Antonis E. Koromilas, Myriam Gorospe, Matthew J. Payea, Fangfang Wang, Benjamin L. L. Clayton, Paul J. Tesar, Ashleigh Schaffer, Alexander Miron, Ilya Bederman, Eckhard Jankowsky, Christine Vogel, Leoš Shivaya Valášek, Jonathan D. Dinman, Youwei Zhang, Boaz Tirosh, Ola Larsson, Ivan Topisirovic and Maria Hatzoglou, 26 March 2025, Nature. DOI: 10.1038/s41586-025-08794-6 The study was funded by the National Institutes of Health, Case Comprehensive Cancer Center, Terry Fox Foundation Oncometabolism Team, Canadian Institutes for Health Research, Swedish Research Council, Swedish Cancer Society and National Multiple Sclerosis Society.

Different from other types of plasmids, IncP1-type plasmid have very broad transfer range even to archaea and eukarya, and its analysis is applicable to both prevention of the spread of antibiotic resistance genes and gene introduction to various organisms. Credit: Kazuki Moriguchi, Hiroshima University Mutant genes can promote genetic transfer across taxonomic kingdoms. Bacteria do not sexually reproduce, but that does not stop them from exchanging genetic information as it evolves and adapts. During conjugal transfer, a bacterium can connect to another bacterium to pass along DNA and proteins. Escherichia coli bacteria, commonly called E. coli, can transfer at least one of these gene-containing plasmids to organisms across taxonomic kingdoms, including to fungi and protists. Now, researchers from Hiroshima University have a better understanding of this genetic hat trick, which has potential applications as a tool to promote desired characteristics or suppress harmful ones across genetic hosts. They recently published their results in Frontiers in Microbiology. Plasmids transfer from one bacterium — the donor — to another — the recipient. A particular kind of plasmid, called IncP1, can be hosted by a variety of bacteria and, seemingly as a result of its broad hosts, can transfer DNA to recipients beyond bacteria. The hypothesis is that the plasmid contains genes cultivated from different hosts and donors, resulting in this unique ability. “Although conjugation factors encoded on plasmids have been extensively analyzed, those on the donor chromosome have not,” said paper author Kazuki Moriguchi, associate professor, Program of Basic Biology, Graduate School of Integrated Sciences for Life, Hiroshima University. There have been some studies on the various genes, according to Moriguchi, but the function of the genes was not examined, so it is not clear how they were related to the conjugation mechanism. In this study, the researchers conducted a genome-wide survey on an extensive collection of bacteria mutants as donors to yeast. The mutants were engineered to have specific genes “knocked out” in order to study how the overall system performs without the presence of that specific gene, allowing researchers to infer information about the gene’s function. “We focused on ‘up’ mutants that have the ability to accelerate conjugative transfer to both prokaryotes and eukaryotes as they could be potent donor strains applicable to gene introduction tools,” Moriguchi said, noting how IncP1’s ability to transmit genetic material across kingdoms could be used to develop precise tools to introduce genes capable of changing how the bacteria perform certain functions or react to changes in their environments. Out of 3,884 mutants surveyed, three were identified that could conjugate across E. coli or from E. coli to yeast without accumulating genetic material, indicating that the genes worked together. The researchers analyzed the genes but were unable to elucidate the exact target or targets of conjugation mechanism that allows for cross-kingdom transfer. However, their analysis did reveal how the genes appear to work. Two of the genes work to repress the unknown target in the E. coli donor. Simultaneously, the third gene is inactivated, allowing another unknown target to resume activity. “The results suggest that the unknown target factors of these three genes form a complex in order to activate or repress the conjugation, either directly or indirectly at an identical step or steps of the IncP1 conjugation machinery, although the exact mechanism beyond this phenomenon remains unknown,” Moriguchi said.   According to Moriguchi, the data collected in this study can help facilitate the breeding of donor strains from various bacteria, each of which carries a high affinity with target organisms in addition to having a high conjugation ability. Reference: “Isolation and Analysis of Donor Chromosomal Genes Whose Deficiency Is Responsible for Accelerating Bacterial and Trans-Kingdom Conjugations by IncP1 T4SS Machinery” by Fatin Iffah Rasyiqah Mohamad Zoolkefli, Kazuki Moriguchi, Yunjae Cho, Kazuya Kiyokawa, Shinji Yamamoto and Katsunori Suzuki, 20 May 2021, Frontiers in Microbiology. DOI: 10.3389/fmicb.2021.620535 Co-authors include Fatin Iffah Rasyiqah Mohamad Zoolkefli, Shinji Yamamoto and Katsunori Suzuki, Department of Biological Science, Graduate School of Science; Suzuki and Kazuya Kiyokawa, Program of Basic Biology, Graduate School of Integrated Sciences for Life; and Yunjae Cho, Department of Biological Science, Faculty of Science.   The Japan Society for the Promotion of Science funded this work in part.

Oregon State University research has identified the oldest known specimen of a fungus parasitizing an ant, and the fossil also represents a new fungal genus and species. Credit: George Poinar Jr., OSU Oregon State University research has identified the oldest known specimen of a fungus parasitizing an ant, and the fossil also represents a new fungal genus and species. “It’s a mushroom growing out of a carpenter ant,” said OSU’s George Poinar Jr., an international expert in using plant and animal life forms preserved in amber to learn about the biology and ecology of the distant past. A mushroom is the reproductive structure of many fungi, including the ones you find growing in your yard, and Poinar and a collaborator in France named their discovery Allocordyceps baltica. They found the new type of Ascomycota fungi in an ant preserved in 50-million-year-old amber from Europe’s Baltic region. “Ants are hosts to a number of intriguing parasites, some of which modify the insects’ behavior to benefit the parasites’ development and dispersion,” said Poinar, who has a courtesy appointment in the OSU College of Science. “Ants of the tribe Camponotini, commonly known as carpenter ants, seem especially susceptible to fungal pathogens of the genus Ophiocordyceps, including one species that compels infected ants to bite into various erect plant parts just before they die.” A mushroom is the reproductive structure of many fungi, including the ones you find growing in your yard, and OSU’s George Poinar Jr. and a collaborator in France named their discovery Allocordyceps baltica. They found the new type of Ascomycota fungi in an ant preserved in 50-million-year-old amber from Europe’s Baltic region. Credit: George Poinar Jr., OSU Doing so, he explains, puts the ants in a favorable position for allowing fungal spores to be released from cup-shaped ascomata – the fungi’s fruiting body –protruding from the ants’ head and neck. Carpenter ants usually make their nests in trees, rotting logs and stumps. The new fungal genus and species shares certain features with Ophiocordyceps but also displays several developmental stages not previously reported, Poinar said. To name the genus, placed in the order Hypocreales, Poinar and fellow researcher Yves-Marie Maltier combined the Greek word for new – alloios – with the name of known genus Cordyceps. “We can see a large, orange, cup-shaped ascoma with developing perithecia – flask-shaped structures that let the spores out – emerging from the rectum of the ant,” Poinar said. “The vegetative part of the fungus is coming out of the abdomen and the base of the neck. We see freestanding fungal bodies also bearing what look like perithecia, and in addition we see what look like the sacs where spores develop. All of the stages, those attached to the ant and the freestanding ones, are of the same species.” The mushroom is coming out of the ant’s rectum, and vegetative part of the fungus is emerging from its abdomen and neck. Credit: George Poinar Jr., OSU The fungus could not be placed in the known ant-infecting genus Ophiocordyceps because ascomata in those species usually come out the neck or head of an ant, Poinar said, and not the rectum. “There is no doubt that Allocordyceps represents a fungal infection of a Camponotus ant,” he said. “This is the first fossil record of a member of the Hypocreales order emerging from the body of an ant. And as the earliest fossil record of fungal parasitism of ants, it can be used in future studies as a reference point regarding the origin of the fungus-ant association.” Reference: “Allocordyceps baltica gen. et sp. nov. (Hypocreales: Clavicipitaceae), an ancient fungal parasite of an ant in Baltic amber” by George Poinar and Yves-Marie Maltier, 5 June 2021, Fungal Biology. DOI: 10.1016/j.funbio.2021.06.002

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