Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Flexible manufacturing OEM & ODM Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Insole ODM factory in Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand ODM expert for comfort products

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam ergonomic pillow OEM supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan foot care insole ODM expert

A recent study identified Interleukin-18 as a trigger for Eosinophilic esophagitis, a chronic immune disease affecting children. The research suggests that inhibiting the protein’s release could prevent the disease and proposes an existing drug, VX-765, as a potential treatment. Eosiniphilic esophagitis was not identified as a disease until the 1990s. Decades later, a treatment may have been discovered. A new study from Tulane University has identified a new treatment for a chronic immune system disease that can prevent children from eating. Eosinophilic esophagitis (EoE) is triggered by food allergies or airborne allergens which causes a type of white blood cell, eosinophils, to build up in the lining of the esophagus. This causes the esophagus to shorten and the esophageal wall to thicken, making swallowing difficult and causing food to get stuck in the throat. Disease Prevalence and Newly Identified Cause The disease occurs in an estimated 1 in 2,000 adults but more frequently affects children (1 in 1,500) where symptoms can be harder to diagnose and pose greater risks as difficulty feeding can lead to malnutrition, weight loss, and poor growth. The new study, published today (July 31)  in Nature’s Communications Biology journal, found that the disease is caused by Interleukin-18 (IL-18), a protein involved in the innate immune response that can cause inflammation if produced in excess. When a food allergen enters the body, it activates a pathway responsible for regulating the innate immune system, resulting in the release of proinflammatory proteins like IL-18. This produces the eosinophils which damage the esophagus. Discovering Potential Treatment The study found that successfully inhibiting this pathway, called the NLRP3 pathway, and the release of IL-18 prevented the development of EoE from both food and airborne allergens. “Parents and doctors may not be aware of this, but this is a very prominent and serious disease in the pediatric population, and it is increasing in number because it is directly related to food allergens, which are also on the rise,” said lead author Dr. Anil Mishra, director of the Eosinophilic Disorder Center at the Tulane University School of Medicine. “In this study, we show that after treating the disease in animals, the disease is gone and completely in remission.” The Study’s Impact The findings are crucial for a disease that was not identified until the 1990s. For many years, EoE was misdiagnosed as gastrointestinal reflux disease (GERD), despite GERD medication being ineffective for treating EoE. Additionally, this study’s findings replace decades of thinking that Th2 cells play a major role in triggering EoE. “Given the paucity of mechanistic information and treatment strategies for EoE, we feel the proposed studies are highly relevant and are poised to have a major impact on establishing the significance of NLRP3-IL-18 pathway in the initiation of EoE pathogenesis,” Mishra said. The Next Steps The study identified one existing drug, VX-765, as an inhibitor that may work as a treatment for humans. Importantly, this inhibitor would only deplete pathogenic eosinophils generated and transformed by IL-18 and not affect white blood cells created by IL-5, a protein important for maintaining innate immunity. Mishra said a clinical trial would be the next step to determining the treatment’s effectiveness. Reference: “Allergen-induced NLRP3/caspase1/IL-18 signaling initiate eosinophilic esophagitis and respective inhibitors protect disease pathogenesis” by Chandra Sekhar Yadavalli, Sathisha Upparahalli Venkateshaiah, Sandeep Kumar, Hemanth Kumar Kandikattu, Lokanatha Oruganti, Chandra Sekhar Kathera and Anil Mishra, 31 July 2023, Communications Biology. DOI: 10.1038/s42003-023-05130-4

Regions of the protein’s flexibility: not very flexible (blue), moderately flexible (green/yellow) and highly flexible (red). However, both the central alpha helix and the N-terminus (start of the protein) display stable folding in comparison with the rest of the protein. Credit: Adam Damry International team of researchers investigates how evolution forms the structure and function of a newly emerged protein in flies. Proteins are the key component in all modern forms of life. Haemoglobin, for example, transports the oxygen in our blood; photosynthesis proteins in the leaves of plants convert sunlight into energy; and fungal enzymes help us brew beer and bake bread. Researchers have long been examining the question of how proteins mutate or come into existence in the course of millennia. That completely new proteins – and, with them, new properties – can emerge practically out of nothing, was inconceivable for decades, in line with what the Greek philosopher Parmenides said: “Nothing can emerge from nothing” (ex nihilo nihil fit). Working with colleagues from the USA and Australia, researchers from the University of Münster have now reconstructed how evolution forms the structure and function of a newly emerged protein in flies. This protein is essential for male fertility. The results have been published in the journal Nature Communications. Background It had been assumed up to now that new proteins emerge from already existing proteins – by a duplication of the underlying genes and by a series of small mutations in one or both gene copies. In the past ten years, however, a new understanding of protein evolution has come about: proteins can also develop from so-called non-coding DNA (deoxyribonucleic acid) – in other words, from that part of the genetic material which does not normally produce proteins – and can subsequently develop into functional cell components. This is surprising for several reasons: for many years, it had been assumed that, in order to be functional, proteins had to take on a highly developed geometrical form (a “3D structure”). It had further been assumed that such a form could not develop from a gene emerging at random, but would require a complex combination of amino-acids enabling this protein to exist in its functional form. Fruit flies (shown here mating) served as the study model. Credit: Mareike Kopping Despite decades of trying, researchers worldwide have not yet succeeded in constructing proteins with the desired 3D structures and functions, which means that the “code” for the formation of a functioning protein is essentially unknown. While this task remains a puzzle for scientists, nature has proven to be more adept at the formation of new proteins. A team of researchers headed by Prof. Erich Bornberg-Bauer, from the Institute of Evolution and Biodiversity at the University of Münster, discovered, by comparing the newly analyzed genomes in numerous organisms, that species not only differ through duplicated protein-coding genes adapted in the course of evolution. In addition, proteins are constantly being formed de novo (“anew”) – i.e. without any related precursor protein going through a selection process. The vast majority of these de novo proteins are useless, or even slightly deleterious, as they can interfere with existing proteins in the cell. Such new proteins are quickly lost again after several generations, as organisms carrying the new gene encoding the protein have impaired survival or reproduction. However, a select few de novo proteins prove to have beneficial functions. These proteins integrate into the molecular components of cells and eventually, after millions of years of minor modifications, become indispensable. There are some important questions which many researchers wonder about in this context: How do such novel proteins look like upon birth?  How do they change, and which functions do they assume as the “new kids on the block?” Spearheaded by Prof. Bornberg-Bauer’s group in Münster, an international team of researchers has answered this question in much detail for “Goddard,” a fruit fly protein that is essential for male fertility. Methodology The research proceeded on three related fronts across three continents. At the College of the Holy Cross in Massachusetts, USA, Dr. Prajal Patel and Prof. Geoff Findlay used CRISPR/Cas9 genome editing to show that male flies that do not produce Goddard are sterile, but otherwise healthy. Meanwhile, Dr. Andreas Lange and PhD student Brennen Heames of Prof. Bornberg-Bauer’s group used biochemical techniques to predict the shape of the novel protein in present-day flies. They then used evolutionary methods to reconstruct the likely structure of Goddard ~50 million years ago when the protein first arose. What they found was quite a surprise: “The ancestral Goddard protein looked already very much like the ones which exist in fly species today,” Erich Bornberg-Bauer explains. “Right from the beginning, Goddard contained some structural elements, so-called alpha-helices, which are believed to be essential for most proteins.” To confirm these findings, the scene shifted to the Australian National University in Canberra, where Dr. Adam Damry and Prof. Colin Jackson used intensive, computational simulations to verify the predicted shape of the Goddard protein. They validated the structural analysis of Dr. Lange and showed that Goddard, in spite of its young age, is already quite stable – though not quite as stable as most fly proteins that are believed to have existed for longer, perhaps hundreds of millions of years. The results match up with several other current studies, which have shown that the genomic elements from which protein-coding genes emerge are activated frequently – tens of thousands of times in each individual. These fragments are then “sorted” through the process of evolutionary selection. The ones which are useless or harmful – the vast majority – are quickly discarded. But those which are neutral, or are slightly beneficial, can be optimized over millions of years and changed into something useful. Reference: “Structural and functional characterization of a putative de novo gene in Drosophila” by Andreas Lange, Prajal H. Patel, Brennen Heames, Adam M. Damry, Thorsten Saenger, Colin J. Jackson, Geoffrey D. Findlay and Erich Bornberg-Bauer, 12 March 2021, Nature Communications. DOI: 10.1038/s41467-021-21667-6 Funding: The research undertaken received funding from the European Grant EsCat within the Horizon 2020 Research and Innovation Framework Programme No. 722610 (Münster), from the ARC Centres of Excellence in Peptide and Protein Science and Synthetic Biology (Australia), and from an NSF CAREER Grant #1652013 (USA).

Researchers of the Department of Ethology, Eötvös Loránd University have been investigating dogs’ reactions to wolf howls. Credit: Gáti Oszkár Dániel Researchers of the Department of Ethology, Eötvös Loránd University (ELTE) have been investigating dogs’ reactions to wolf howls. Are there dogs that are more prone to reply with howling? Are these dogs genetically closer to wolves? To answer these questions, the effects of the dogs’ breed, age, and sex on their behavior were tested in this study. Results of this extraordinary research will be published today in the journal Communications Biology. When one hears a howl in the forest, the first thing that he associates that sound with is the wolf. And it’s true, howling is a characteristic communication form of wolves, but it is also widespread among canine species. They use it for long-distance communication with others, to mark territory boundaries, and also, to define the position of the other wolves, which in most cases, also reply with howling. Among their domesticated relatives, our best friend the domestic dog, the situation seems a bit more complicated: some breeds, like wolf-like sled dogs, are widely believed to be “hard-howlers,” meaning that they howl frequently, even in ‘reply’ to irrelevant sounds like bells, sirens or music, while others never howl even once during their life, even though they are capable of producing them. Dog breeds genetically closer to wolves reply to wolf howl playbacks more with howling and also show more stress than breeds genetically farther from the wild relatives – but interestingly, this genetic difference appeared only among older dogs. Researchers of the Department of Ethology, Eötvös Loránd University aimed to solve the mystery of dog howling, and examine whether is it true that specific breeds are more prone to howl and whether this has anything to do with their genetic closeness to wolves. To answer these questions, the researchers tested 68 purebred family dogs by playing back recordings of wolf howls and observing their reactions in a behavioral laboratory. To test the effect of the breed, the different breeds’ genetic similarity to wolves (so-called “root distance”) was used as a measure. Researchers of the Department of Ethology, Eötvös Loránd University have been investigating dogs’ reactions to wolf howls. Are there dogs that are more prone to reply with howling? Are these dogs genetically closer to wolves? To answer these questions, the effects of the dogs’ breed, age and sex on their behaviour were tested in this study. Results of this extraordinary research were published in Communications Biology. Credit: Lehoczki Fanni and Gáti Oszkár Dániel “According to our results, breeds which are genetically more similar to wolves (“ancient breeds”), are more prone to reply with their own howls to wolf howl playbacks. On the other hand, breeds more distantly related to wolves (“modern breeds”) typically reacted with barking instead of howls. It seems that although howling is present in most breeds’ repertoire, it lost its functionality due to the changed social environment, thus, modern breeds do not use it in adequate situations,” explains Fanni Lehoczki, the first author of the study. “Additionally, we found that breeds which howl more also show more stress-related behaviours in this situation.” We assume that more ancient breeds, which are genetically closer to wolves, can process the information encoded in wolf howls better than modern breeds. Thus, ancient breeds of our study might become stressed by intruding on a pack’s territory and use howling for the sake of avoidance, just as wolves do,” says Tamás Faragó, postdoctoral researcher at the Department of Ethology, ELTE and the senior author of the study. “Interestingly, this genetic effect on howling occurs only among older dogs (>5 years), for which an experience- or some age-related personality effect can be a plausible explanation. It is possible that- in line with our hypothesis, that howling appearing with a higher level of stress is a fear reaction – older dogs are more fearful, which was already suggested by previous studies, but these speculations require further investigation.” Besides the breed and age of the dog, the effect of other features like sex and reproductive status were also tested. Researchers of the Department of Ethology, Eötvös Loránd University have been investigating dogs’ reactions to wolf howls. Are there dogs that are more prone to reply with howling? Are these dogs genetically closer to wolves? To answer these questions, the effects of the dogs’ breed, age, and sex on their behavior were tested in this study. Results of this extraordinary research were published in Communications Biology. Credit: Gáti Oszkár Dániel “What we found is that something is going on with the male sex hormones, as there is no difference between intact and spayed females, but intact and neutered males do behave differently. Neutered males, which are in lack of testosterone, howl more in response to the playbacks. As neutered males are suggested to be more fearful, this result can be in line with our findings about responsiveness and more stressed behavior. Thus, the dog howl may mean “I am scared, don’t come closer,” explains Fanni Lehoczki This is the first study specifically investigating howling in domestic dogs. The findings support the hypothesis that domestication and selective breeding by humans fundamentally changed dogs’ vocal repertoire and both the perception and production of howling in dogs. This insight brings us closer to understanding the history and impact of the profoundly important relationship between humans and their “best friends” the domestic dog. Reference: “Genetic distance from wolves affects family dogs’ reactions towards howls” by Fanni Lehoczki, Attila Andics, Arik Kershenbaum, Eniko Kubinyi, Daniela Passilongo, Holly Root-Gutteridge, Friederike Range, Vicente Palacios Sánchez, Lori Schmidt, Simon W. Townsend, Stuart K. Watson and Tamás Faragó, 6 February 2023, Communications Biology. DOI: 10.1038/s42003-023-04450-9 This research was funded by the Eötvös Loránd University; Eötvös Loránd Research Network; European Research Council (Horizon 2020); Hungarian Academy of Sciences (János Bolyai Research Scholarship, Premium Postdoctoral Scholarship, ’Lendület’ grant,); National Brain Programme; National Excellence Program; Austrian Science Fund (FWF); UK’s Biological and Biotechnology Research Council; Swiss National Science Foundation; NCCR Evolving Language, Swiss National Science Foundation Agreement.

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