Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam ergonomic pillow OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan pillow ODM development factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole OEM factory Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Custom foam pillow OEM production factory in Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Innovative pillow ODM solution in Taiwan

Researchers track the intestinal health of fruit flies with a blue dye, hence the name Smurf. Fruit fly intestines damaged by aging leak the blue dye, this image shows an HRJD-modified fly on the left and an unmodified fly of the same age on the right. Credit: ©2024 Hiroki Nagai CC-BY-ND Genes from regenerative organisms rejuvenate intestinal stem cells in fruit flies. In a groundbreaking experiment, Japanese researchers transferred regenerative genes to fruit flies, leading to improved intestinal health and enhanced stem cell activity. This discovery opens new possibilities for anti-aging strategies in higher organisms, including humans, through targeted gene therapy. Researchers including those from the University of Tokyo’s Graduate School of Pharmaceutical Sciences transferred genes from simple organisms capable of regenerating their bodies into common fruit flies, more complex animals that cannot. They found the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest studying genes specific to animals with high regenerative capability may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms. The Pursuit of Longevity Through Regenerative Medicine Do you want to live forever? Some do, some don’t. But we all want to live healthily for however long we have, and a big part of medical research is about this aspect of longevity. One idea, which might sound a little like science fiction, is to upgrade the human body in such a way that it can regenerate itself when injured, diseased, or when aging starts taking its toll, a bit like the superhero character Wolverine from the popular comic book and film series X-Men. Of course, we’re nowhere near that stage yet, but progress is being made in the world of regenerative medicine, albeit the test subjects are just flies for now. The unbelievably tiny intestine of the adult fruit fly, labeled with fluorescent markers. Credit: ©2024 Yuichiro Nakajima CC-BY-ND “In animals capable of whole-body regeneration, such as flatworms and jellyfish, specific genes may help allow regeneration and maintain long-term stem cell functions. Conversely, mammals and insects, which have limited regenerative abilities, may have lost these genes during evolution,” said Associate Professor Yuichiro Nakajima. “It is unclear whether reintroducing these regeneration-associated genes in low regenerative animals could affect their regeneration and aging processes. In our recent study, we focused on the group of genes unique to animals with high regenerative capacity, named highly regenerative species-specific JmjC domain-encoding genes (HRJDs), and transferred them into the fruit fly Drosophila melanogaster, to test their effects.” Unintended Benefits in Aging Fruit Flies Nakajima’s team hoped upgraded fruit flies would regenerate tissue if injured, which didn’t happen. However, Hiroki Nagai, an expert in fruit fly intestines, noticed something else. “Nagai discovered some novel phenotypes, characteristics that manifest from genes in a given set of conditions,” said Nakajima. “HRJDs promoted greater intestinal stem cell division, whilst also suppressing intestinal cells that were mis-differentiating, or going wrong in aged flies. This is in contrast to the use of antibiotics, for example, which might suppress mis-differentiated intestinal cells, but also suppress intestinal stem cell division. For this reason, HRJDs had a measurable effect on the lifespans of fruit flies, which opens the door, or at least provides clues, for the development of new anti-aging strategies. After all, human and insect intestines have surprisingly much in common on a cellular level.” The left two images show intestinal proteins disrupted by aging, and those on the right show the same proteins better preserved against age-related mechanisms due to the HRJD genes. Credit: ©2024 Hiroki Nagai CC-BY-ND Challenges and Future Directions in Regenerative Research Finding this out was not without difficulties, however. Though fruit flies are famous test subjects for biological research, given their relatively short lives and fast rates of reproduction and maturation, their aging process still takes around two months, which affected the experimental schedules for Nakajima’s team, who were also busy with other things. Now that they have reached a striking conclusion, though, there is still much work to be done. “Details of the molecular workings of HRJDs are still unresolved. And it’s unclear whether they work alone or in combination with some other component,” said Nakajima. “Therefore, this is just the start of the journey, but we know now that our modified fruit flies can serve as a valuable resource to uncover unprecedented mechanisms of stem cell rejuvenation in the future. In humans, intestinal stem cells decrease in activity with age, so this research is a promising avenue for stem cell-based therapies.” Reference: “Highly regenerative species-specific genes improve age-associated features in the adult Drosophila midgut” by Hiroki Nagai, Yuya Adachi, Tenki Nakasugi, Ema Takigawa, Junichiro Ui, Takashi Makino, Masayuki Miura and Yu-ichiro Nakajima, 2 August 2024, BMC Biology. DOI: 10.1186/s12915-024-01956-4

A new study by the Salk Institute presents a groundbreaking non-hormonal and reversible male contraceptive method using HDAC inhibitors to block sperm production without affecting libido. This method, targeting the regulation of gene expression in sperm production, promises fewer side effects and fully reversible fertility, indicating a significant advance in the development of male contraceptives. Administering an HDAC inhibitor orally stopped sperm production and fertility in mice without impacting their libido. Surveys show most men in the United States are interested in using male contraceptives. However, their choices are currently restricted to the less reliable condoms or the more intrusive vasectomies. Efforts to create medications that inhibit sperm production, development, or the ability to fertilize have so far achieved modest success, often resulting in partial efficacy or significant adverse effects. The complexity of sperm development poses a significant challenge for scientists attempting to innovate in the field of male contraception, as finding aspects of the process that can be altered safely and effectively remains difficult. Now, scientists at the Salk Institute have found a new method of interrupting sperm production, which is both non-hormonal and reversible. The study, published in Proceedings of the National Academy of Sciences (PNAS) on February 20, 2024, implicates a new protein complex in regulating gene expression during sperm production. The researchers demonstrate that treating male mice with an existing class of drugs, called HDAC (histone deacetylase) inhibitors, can interrupt the function of this protein complex and block fertility without affecting libido. A Novel Approach “Most experimental male birth control drugs use a hammer approach to blocking sperm production, but ours is much more subtle,” says senior author Ronald Evans, professor, director of the Gene Expression Laboratory, and March of Dimes Chair in Molecular and Developmental Biology at Salk. “This makes it a promising therapeutic approach, which we hope to see in development for human clinical trials soon.” Sperm, pictured inside the cross-sectioned tube of the epididymis, were not generated while mice took the HDAC inhibitor drug (top right), but after 60 days off the drug, spermatogenesis was recovered (bottom right). The left column shows sperm at the same time points in a mouse that did not receive the drug. Credit: Salk Institute The human body produces several million new sperm per day. To do this, sperm stem cells in the testes continuously make more of themselves, until a signal tells them it’s time to turn into sperm—a process called spermatogenesis. This signal comes in the form of retinoic acid, a product of vitamin A. Pulses of retinoic acid bind to retinoic acid receptors in the cells, and when the system is aligned just right, this initiates a complex genetic program that turns the stem cells into mature sperm. Salk scientists found that for this to work, retinoic acid receptors must bind with a protein called SMRT (silencing mediator of retinoid and thyroid hormone receptors). SMRT then recruits HDACs, and this complex of proteins goes on to synchronize the expression of genes that produce sperm. Targeted Intervention without Side Effects Previous groups have tried to stop sperm production by directly blocking retinoic acid or its receptor. But retinoic acid is important to multiple organ systems, so interrupting it throughout the body can lead to various side effects—a reason many previous studies and trials have failed to produce a viable drug. Evans and his colleagues instead asked whether they could modulate one of the molecules downstream of retinoic acid to produce a more targeted effect. The researchers first looked at a line of genetically engineered mice that had previously been developed in the lab, in which the SMRT protein was mutated and could no longer bind to retinoic acid receptors. Without this SMRT-retinoic acid receptor interaction, the mice were not able to produce mature sperm. However, they displayed normal testosterone levels and mounting behavior, indicating that their desire to mate was not affected. From left: Ruth Yu, Suk-Hyun Hong, Ronald Evans, Annette Atkins, and Michael Downes. Credit: Salk Institute To see whether they could replicate these genetic results with pharmacological intervention, the researchers treated normal mice with MS-275, an oral HDAC inhibitor with FDA breakthrough status. By blocking the activity of the SMRT-retinoic acid receptor-HDAC complex, the drug successfully stopped sperm production without producing obvious side effects. Another remarkable thing also happened once the treatment was stopped: Within 60 days of going off the pill, the animals’ fertility was completely restored, and all subsequent offspring were developmentally healthy. Reversible Effects and Future Implications The authors say their strategy of inhibiting molecules downstream of retinoic acid is key to achieving this reversibility. Think of retinoic acid and the sperm-producing genes as two dancers in a waltz. Their rhythm and steps need to be coordinated with each other for the dance to work. But if you throw something in that makes the genes miss a step, the two are suddenly out of sync and the dance falls apart. In this case, the HDAC inhibitor causes the genes’ misstep, halting the dance of sperm production. However, if the dancer can find its footing and get back in step with its partner, the waltz can resume. In the same way, the authors say that removing the HDAC inhibitor allows the sperm-producing genes to get back in sync with the pulses of retinoic acid, turning sperm production back on as desired. “It’s all about timing,” says co-author Michael Downes, a senior staff scientist in Evans’ lab. “When we add the drug, the stem cells fall out of sync with the pulses of retinoic acid, and sperm production is halted, but as soon as we take the drug away, the stem cells can reestablish their coordination with retinoic acid and sperm production will start up again.” The authors say the drug doesn’t damage the sperm stem cells or their genomic integrity. While the drug was present, the sperm stem cells simply continued regenerating as stem cells, and when the drug was later removed, the cells could regain their ability to differentiate into mature sperm. “We weren’t necessarily looking to develop male contraceptives when we discovered SMRT and generated this mouse line, but when we saw that their fertility was interrupted, we were able to follow the science and discover a potential therapeutic,” says first author Suk-Hyun Hong, a staff researcher in Evans’ lab. “It’s a great example of how Salk’s foundational biological research can lead to major translational impact.” Reference: “Targeting nuclear receptor corepressors for reversible male contraception” by Suk-Hyun Hong, Glenda Castro, Dan Wang, Russell Nofsinger, Maureen Kane, Alexandra Folias, Annette R. Atkins, Ruth T. Yu, Joseph L. Napoli, Paolo Sassone-Corsi, Dirk G. de Rooij, Christopher Liddle, Michael Downes and Ronald M. Evans, 20 February 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2320129121 Other authors include Glenda Castro, Dan Wang, Russell Nofsinger, Annette R. Atkins, and Ruth T. Yu of Salk, Maureen Kane, Alexandra Folias, and Joseph L. Napoli of UC Berkeley, Paolo Sassone-Corsi of UC Irvine, Dirk G. de Rooij of Utrecht University, and Christopher Liddle of the University of Sydney. The work was supported by the National Institutes of Health (grants CA265762 and CA220468) and the Next Generation Sequencing and Flow Cytometry Cores at Salk, funded by the Salk Cancer Center (NCI grant NIH-NCI CCSG: P30 014195).

The new study uses postmortem brain tissues to understand genomic differences in individuals with attention deficit hyperactivity disorder. Credit: Darry Leja, NHGRI A new study has used postmortem brain tissue to examine genomic differences in individuals with attention deficit hyperactivity disorder. A study led by researchers at the National Human Genome Research Institute, which is part of the National Institutes of Health, has identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The research, published in the journal Molecular Psychiatry, found that individuals with ADHD had differences in genes that encode for chemicals that brain cells use to communicate. These genomic differences may contribute to the symptoms of ADHD. This is the first study to use postmortem human brain tissue to investigate ADHD. Previous research on mental health conditions typically involved non-invasive scans of the brain, which allowed researchers to examine brain structure and activity but did not provide information on the genetic level and how genes may affect cell function and contribute to symptoms. RNA Sequencing Reveals Gene Expression Changes The researchers used a genomic technique called RNA sequencing to probe how specific genes are turned on or off, also known as gene expression. They studied two connected brain regions associated with ADHD: the caudate and the frontal cortex. These regions are known to be critical in controlling a person’s attention. Previous research found differences in the structure and activity of these brain regions in individuals with ADHD. As one of the most common mental health conditions, ADHD affects about 1 in 10 children in the United States. Diagnosis often occurs during childhood, and symptoms may persist into adulthood. Individuals with ADHD may be hyperactive and have difficulty concentrating and controlling impulses, which may affect their ability to complete daily tasks and their ability to focus at school or work. With technological advances, researchers have been able to identify genes associated with ADHD, but they had not been able to determine how genomic differences in these genes act in the brain to contribute to symptoms until now. “Multiple types of genomic studies are pointing towards the expression of the same genes,” said Gustavo Sudre, Ph.D., an associate investigator in the Social and Behavioral Research Branch in NHGRI’s Intramural Research Program, who led this study. “Interestingly, these gene-expression differences were similar to those seen in other conditions, which may reflect differences in how the brain functions, such as in autism.” Connections to Neurotransmitter Function Importantly, the researchers found that these differences affected the expression of genes that code for neurotransmitters, which are chemicals that brain cells use to communicate with one another. In particular, the results revealed differences in gene expression for glutamate neurotransmitters, which are important for brain functions such as attention and learning. “The study advances our understanding of ADHD by showing how the condition is tied to changes in how certain genes are expressed in the brain. This allows us to inch closer to understanding how genomic differences alter gene expression in the brain and contribute to ADHD symptoms,” says Philip Shaw, M.D., Ph.D., senior investigator in the Social and Behavioral Research Branch, who supervised the study. Postmortem studies are rare because of the limited donation of brain tissue but are incredibly valuable because they provide researchers with direct experimental access to the brain. “Such postmortem studies have accelerated our understanding of other mental health challenges, but to date, no such studies have looked at ADHD until now,” said Dr. Shaw. Reference: “Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder” by Gustavo Sudre, Derek E. Gildea, Gauri G. Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K. Auluck, Laura Elnitski, Andreas D. Baxevanis, Stefano Marenco and Philip Shaw, 16 November 2022, Molecular Psychiatry. DOI: 10.1038/s41380-022-01844-9 The study was funded by the National Human Genome Research Institute.

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