Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan insole OEM manufacturer

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam custom insole OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand orthopedic insole OEM manufacturer

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam neck support pillow OEM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.One-stop OEM/ODM solution provider Indonesia

New research challenges traditional views on ATP production and mitochondrial membrane potential, revealing that oxidative phosphorylation occurs in mitochondrial cristae and that sodium plays a significant role in charge gradients, with implications for mitochondrial diseases like LHON. A study conducted by researchers from the University of São Paulo sheds light on new discoveries about the mechanisms of oxidative phosphorylation in ATP production. Recent findings highlight the involvement of sodium in mitochondrial respiration. In an article published in Trends in Biochemical Sciences, Alicia Kowaltowski, a full professor at the University of São Paulo’s Institute of Chemistry (IQ-USP) in Brazil, calls for a “rewriting” of textbooks regarding the location of the electron transport chain in mitochondria and the role of sodium in mitochondrial respiration. Kowaltowski is also a member of the Research Center for Redox Processes in Biomedicine (Redoxoma), a Research, Innovation, and Dissemination Center (RIDC) funded by FAPESP and based at IQ-USP. The article, co-authored with Fernando Abdulkader, a professor at the University of São Paulo’s Biomedical Sciences Institute (ICB-USP), highlights a number of new discoveries about oxidative phosphorylation mechanisms, including an innovative study published in the journal Cell by José Antonio Enríquez and colleagues at the Spanish National Center for Cardiovascular Research, revealing the unexpected role of sodium in maintaining mitochondrial membrane potential. Textbook Misconceptions About ATP Production “Knowledge evolves, and what we present to students should also evolve,” Kowaltowski said. “Until a few years ago, we were sure that mitochondria produced ATP via oxidative phosphorylation in the intermembrane space, where the inner and outer membranes interact. This has changed. We’ve discovered that the process occurs in the mitochondrial cristae. The textbooks are wrong and it’s time to make the correction. The research done by Enríquez and his group has shown that mitochondrial membrane potential is also a property that may be somewhat different, and this too is a topic that isn’t addressed in the textbooks.” Often called the “energy currency” of cells, adenosine triphosphate (ATP) is produced in mitochondria by oxidative phosphorylation, a process of energy transfer driven by electron and proton gradients across the inner mitochondrial membrane. This mechanism links the gradual oxidation of electron donors in the electron transport chain to the pumping of protons through the membrane, generating the electrochemical gradient required for ATP synthesis. Sodium and membrane potential Scientists have known for some time that the proton gradient in mitochondria is narrow, owing to cellular buffering mechanisms that assure pH stabilization. The charge gradient is therefore considered the key factor in proton pumping. Until recently, this gradient was attributed to potassium, the most abundant cation in cells, but the study by Enríquez et al. showed that between 30% and 50% of the charge gradient can be attributed to sodium transported in exchange for protons in complex I of the electron transport chain. Complex I transfers electrons (initially derived from food) from the coenzyme NADH (nicotinamide adenine dinucleotide) to the other complexes in the chain. Part of the complex also functions as an exchanger of sodium ions for protons. “This study made two important contributions. It identified a second fundamental function of complex I, and it demonstrated the role of sodium in maintaining mitochondrial membrane potential,” Enríquez said. According to Kowaltowski and Abdulkader, the discovery was unexpected because cells do not contain a large amount of sodium, but the article by Enríquez et al. presents convincing evidence. The researchers deployed a large number of experimental models, including mutants of respiratory chain components, as well as several methodological approaches using different ionophores and sodium-depleted media. The experiments involved painstaking bioenergetic measurements, including calibrated quantifications of membrane potential, which are rarely found in the scientific literature. The study also showed that a point mutation in complex I associated with Leber hereditary optic neuropathy (LHON) specifically impairs proton-sodium exchange without affecting electron transport or proton pumping via the complex. LHON is a rare neurodegenerative mitochondrial disorder affecting the optic nerve and potentially causing vision loss in young adults. “The researchers not only describe a novel mechanism that’s central to the energy metabolism, but also relate it directly to a disease,” Kowaltowski said. Reference: “Textbook oxidative phosphorylation needs to be rewritten” by Alicia J. Kowaltowski and Fernando Abdulkader, 21 November 2024, Trends in Biochemical Sciences. DOI: 10.1016/j.tibs.2024.11.002 The study was funded by the ão Paulo Research Foundation.

This image shows trails left by sponges as they crawl across the seafloor. Credit: AWI OFOBS team, PS101 Sponges: They are considered to be one of the most primitive forms of animal life, because they have neither locomotion organs nor a nervous system. A team around deep-sea scientist Antje Boetius has now discovered that sponges leave trails on the sea floor in the Arctic deep sea. They conclude that the animals might move actively — even if only a few centimeters per year. They are now publishing these unique findings in the journal Current Biology. The surprise was great when researchers looked at high-resolution images of the sea floor of the Arctic deep sea in detail: Path-like tracks across the sediments ended where sponges were located. These trails were observed to run in all directions, including uphill. “We conclude from this that the sponges might actively move across the sea floor and leave these traces as a result of their movement,” reports Dr Teresa Morganti, sponge expert from the Max Planck Institute for Marine Microbiology in Bremen. This is particularly exciting because science had previously assumed that most sponges are attached to the seafloor or are passively moved by ocean currents and, usually down slopes. “There are no strong currents in the Arctic deep sea that could explain the structures found on the sea floor,” explains expedition leader Prof. Antje Boetius, who works together with deep-sea biologist Dr Autun Purser from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) in the HGF-MPG Joint Research Group for Deep-Sea Ecology and Technology. The recently published recordings were made during an expedition at 87 °North at the Karasik Seamount about 350 kilometers (220 miles) away from the North Pole with the research icebreaker Polarstern in 2016 with a towed camera system OFOBS (Ocean Floor Observation and Bathymetry System). “With OFOBS we can create 3D models from the deep sea. The seamount’s summit was densely populated with sponges. 69 percent of our images showed trails of sponge spicules, many of which led to live animals,” reports Autun Purser. This figure shows typical sponge spicule trails. Credit: AWI OFOBS team, PS101; Morganti et al./Current Biology Many questions arise from these observations: Why do the sponges move? How do they orient themselves? Possible reasons for locomotion could be foraging, avoiding unfavorable environmental conditions, or to distribute offspring. Searching for food in particular plays a major role in nutrient-poor ecosystems such as the Arctic deep sea. Sponges have an important function there anyway. As filter feeders they can utilize particle and dissolved organic matter and are intensively involved in nutrient and matter recycling by means of their bacterial symbionts. Sponges also provide arctic fish and shrimp useful structures to use as a habitat. However, the scientists still have to investigate the mechanisms of locomotion. For more on this research, read Mysterious Ocean-Floor Trails Show Arctic Sponges on the Move. Reference: “In situ observation of sponge trails suggests common sponge locomotion in the deep central Arctic” by Teresa M. Morganti, Autun Purser, Hans Tore Rapp, Christopher R. German, Michael V. Jakuba, Laura Hehemann, Jonas Blendl, Beate M. Slaby and Antje Boetius, 26 April 2021, Current Biology. DOI: 10.1016/j.cub.2021.03.014

The human lipidome, encompassing all the body’s lipids, is gaining attention for its role in human physiology, particularly its direct influence by diet and gut microbes, and its potential in disease intervention, especially in conditions like Type 2 diabetes. A recent study dives deep into the lipidome, revealing its association with health indicators like insulin resistance, aging, and response to infections, and its potential for predicting biological aging and guiding health interventions. Stanford researchers mapped 800 lipids, revealing their role in insulin resistance, infection response, and aging. Lipid profiles could serve as biomarkers for disease and biological aging, offering potential for future health interventions. The sequencing of the human genome promised a revolution in medicine, but scientists soon realized that a genetic blueprint alone does not show the body in action. That required understanding the proteome – all the proteins, expressed by our genes, forming the cellular machinery that performs the bulk of the body’s functions. Now, another set of molecules known as the lipidome – all the lipids in our bodies – is filling in more details of human physiology. Lipids are a broad category of small, fatty, or oily molecules, including triglycerides, cholesterol, hormones, and some vitamins. In our bodies, they make up cell membranes, act as cellular messengers, and store energy; they play key roles in responding to infection and regulating our metabolism. Our genome is essentially stable. Our proteome, though influenced by our health and environment, is largely dependent on what’s encoded by our genes. In contrast, our lipidome can be directly altered, in part, by what we eat and which microbes live inside our gut, making it more malleable and perhaps more responsive to interventions. But the number and variety of lipid molecules – there are at least thousands – has made them hard to study. “Lipids are very understudied,” said Michael Snyder, PhD, the Stanford W. Ascherman, MD, FACS Professor in Genetics. “They are involved in pretty much everything, but because they’re so heterogeneous, and there are so many of them, we probably don’t know what most lipids really do.” A new study from Snyder’s lab, published Sept. 11 in Nature Metabolism, is among the first to deeply dive into the human lipidome and track how it changes under healthy and diseased conditions, particularly in the development of Type 2 diabetes. Indicators of Health More than 100 participants, including many at risk for diabetes, were tracked for up to 9 years, providing blood samples every three months when healthy and every few days during illness. Using mass spectrometry techniques, which separate compounds by their molecular mass and electric charge, researchers cataloged some 800 lipids and their associations with insulin resistance, viral infection, aging, and more.  The researchers found that although everyone’s lipidome has a distinctive signature that remains stable over time, certain types of lipids changed predictably with a person’s health. For example, more than half of the cataloged lipids were associated with insulin resistance – when the body’s cells cannot use insulin to take up glucose from the blood — which can lead to Type 2 diabetes. Though insulin resistance can be diagnosed by measuring blood glucose, understanding changes to the lipidome helps uncover the biological processes at work. “Every molecule that is associated with a disease has a chance of telling us more about the mechanism and may be serving as a target for affecting the disease progression,” said Daniel Hornburg, Ph.D., a former post-doctoral scholar in Snyder’s lab and co-lead author of the study. The researchers also identified more than 200 lipids that fluctuate over the course of a respiratory viral infection. Rising and falling levels of these lipids matched the body’s higher energy metabolism and inflammation in early infection, and may indicate the trajectory of the disease. Those with insulin resistance showed some anomalies in these responses to infection as well as a weaker response to vaccinations. Aging Fast and Slow The wide age range of the participants – 20 to 79 years old – and the length of the study allowed the researchers to see how the lipidome changes with aging. They found that most lipids, such as cholesterol, increase with aging, but a few, including omega-3 fatty acids, known for their health benefits, decrease. Moreover, these signs of aging in the lipidome do not occur at the same rate in everyone. Insulin resistance, for example, seems to accelerate them.  “It raises the interesting question of whether lipid profiles could predict whether an individual is biologically aging more quickly or more slowly,” said Si Wu, PhD, co-lead author of the study and another former postdoc in Snyder’s lab. Another surprising insight, Wu said, was how consistently certain groups of lipids, such as ether-linked phosphatidylethanolamines, which are thought to be antioxidants and involved in cell signaling, were associated with better health. They may be candidates for new ways to monitor health or even taken as dietary supplements. Next, Snyder’s lab hopes to follow leads from this broad survey to look at correlations between specific lipids and lifestyle changes. Reference: “Dynamic lipidome alterations associated with human health, disease and ageing” by Daniel Hornburg, Si Wu, Mahdi Moqri, Xin Zhou, Kevin Contrepois, Nasim Bararpour, Gavin M. Traber, Baolong Su, Ahmed A. Metwally, Monica Avina, Wenyu Zhou, Jessalyn M. Ubellacker, Tejaswini Mishra, Sophia Miryam Schüssler-Fiorenza Rose, Paula B. Kavathas, Kevin J. Williams and Michael P. Snyder, 11 September 2023, Nature Metabolism. DOI: 10.1038/s42255-023-00880-1

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