Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan custom insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Indonesia pillow ODM development service

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam anti-odor insole OEM service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Cushion insole OEM solution Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Innovative insole ODM solutions in China

Researchers from Texas A&M AgriLife have traced the origins of the German cockroach, Blattella germanica, to Asia, revealing its evolutionary adaptation to human habitats. The study, published in the Proceedings of the National Academy of Sciences, highlights how these pests, reliant on human activity, have evolved over the last 2,100 years and become resistant to many insecticides. An AgriLife Research study suggests that this pest has evolved thanks to human activities. Research shows that the German cockroach, originating from Asia, adapted to live in human environments over 2,100 years ago and now heavily relies on human activities to spread globally, posing challenges in pest control due to its resistance to insecticides. It turns out a common cockroach found across the globe is a pest of our own making. In a study recently published in Proceedings of the National Academy of Sciences, Texas A&M AgriLife researchers unveiled insights into the origins of the common German cockroach, Blattella germanica. The study included Edward Vargo, Ph.D., professor and endowed chair of urban entomology in the Texas A&M College of Agriculture and Life Sciences Department of Entomology. Texas A&M AgriLife researchers, including Edward Vargo, Ph.D., have traced the German cockroach’s origins to Asia, revealing its evolutionary adaptation to human habitats, as detailed in their study recently published in the Proceedings of the National Academy of Sciences. For centuries, the German cockroach has thrived in close proximity to human populations, infesting homes, apartment buildings, work offices, and other structures. “Unlike many other pest species, which have natural populations in diverse habitats, German cockroaches have no known natural populations,” Vargo said. “They rely solely on human activity and manmade structures.” Evolution That Spans Continents For years, many scientists have wondered where these household pests originated and how they came to scurry across our kitchen floors. This research study addressed these lingering questions by diving deep into the DNA of cockroaches from across six continents. Their analysis uncovered the evolution of this insect species and shed light on the German cockroach’s close association with human habitats. While their name might indicate origins in Germany, that name came from a taxonomist presented with a specimen from Germany, but that is not considered their origin. “Many people speculated over the years that the species’ origins came from Africa or Asia,” Vargo said. “It has been intriguing to find out that those who said Asia were right all along.” The study provides a detailed genetic analysis that shows German cockroaches originated from the Asian cockroach approximately 2,100 years ago. Alongside this development, the cockroaches began to adapt to human-built environments, eventually leading to a dependence on living inside manmade structures. These cockroaches are known for their small size, resilience, and ability to thrive indoors. In addition to their dependence on human-built structures, they have also relied on human transportation for dispersal. As civilizations and travel advanced, it turns out our crisscrossing the world included the German cockroach as a secret passenger. “What is truly interesting here is how fairly recent that evolution occurred and how the German cockroach’s origin is related directly to its association with humans,” Vargo said. Living Among Them Understanding the origins and evolution of the German cockroach’s spread across the world is a crucial discovery for understanding the challenges these pests present. New infestations still occur through the transport of infested items like furniture, appliances, moving boxes, and travel bags. The adaptability and resilience of this species have also led to a resistance to many different insecticides. Vargo said this reality enhances our understanding of what we might expect from this species in the future and prompts us to consider new and innovative ways to mitigate their presence in our daily lives. “Understanding the German cockroach’s history and how quickly it adapted to human habitations and evolved is important because it relates to the pest control resistance of the species now,” Vargo said. “Knowing how they came to exist and thrive can help us better understand how the species might adapt and cause more issues worldwide.” Reference: “Solving the 250-year-old mystery of the origin and global spread of the German cockroach, Blattella germanica” by Qian Tang, Edward L. Vargo, Intan Ahmad, Hong Jiang, Zuzana Kotyková Varadínová, Pilot Dovih, Dongmin Kim, Thomas Bourguignon, Warren Booth, Coby Schal, Dmitry V. Mukha, Frank E. Rheindt and Theodore A. Evans, 20 May 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2401185121

Stanford researchers have engineered a new miniature CRISPR system that should be easier to deliver into human cells. Bioengineers have repurposed a “non-working” CRISPR system to make a smaller version of the genome engineering tool. Its diminutive size should make it easier to deliver into human cells, tissues, and the body for gene therapy. The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it’s time to reimagine CRISPR as a Swiss Army knife. “CRISPR can be as simple as a cutter, or more advanced as a regulator, an editor, a labeler, or imager. Many applications are emerging from this exciting field,” said Qi, who is also an assistant professor of chemical and systems biology in the Stanford School of Medicine and a Stanford ChEM-H institute scholar. The many different CRISPR systems in use or being clinically tested for gene therapy of diseases in the eye, liver, and brain, however, remain limited in their scope because they all suffer from the same flaw: they’re too large and, therefore, too hard to deliver into cells, tissues or living organisms. In a paper published September 3, 2021, in Molecular Cell, Qi and his collaborators announce what they believe is a major step forward for CRISPR: An efficient, multi-purpose, mini CRISPR system. Whereas the commonly used CRISPR systems – with names like Cas9 and Cas12a denoting various versions of CRISPR-associated (Cas) proteins – are made of about 1000 to 1500 amino acids, their “CasMINI” has 529. The researchers confirmed in experiments that CasMINI could delete, activate and edit genetic code just like its beefier counterparts. Its smaller size means it should be easier to deliver into human cells and the human body, making it a potential tool for treating diverse ailments, including eye disease, organ degeneration and genetic diseases generally. Persistent effort To make the system as small as possible, the researchers decided to start with the CRISPR protein Cas12f (also known as Cas14), because it contains only about 400 to 700 amino acids. However, like other CRISPR proteins, Cas12f naturally originates from Archaea – single-celled organisms – which means it is not well-suited to mammalian cells, let alone human cells or bodies. Only a few CRISPR proteins are known to work in mammalian cells without modification. Unfortunately, CAS12f is not one of them. This makes it an enticing challenge for bioengineers like Qi. “We thought, ‘Okay, millions of years of evolution have not been able to turn this CRISPR system into something that functions in the human body. Can we change that in just one or two years?’” said Qi. “To my knowledge, we have, for the first time, turned a nonworking CRISPR into a working one.” Indeed, Xiaoshu Xu, a postdoctoral scholar in the Qi lab and lead author of the paper, saw no activity of the natural Cas12f in human cells. Xu and Qi hypothesized that the issue was that human genome DNA is more complicated and less accessible than microbial DNA, making it hard for Cas12f to find its target in cells. By looking at the computationally predicted structure of the Cas12f system, she carefully chose about 40 mutations in the protein that could potentially bypass this limitation and established a pipeline for testing many protein variants at a time. A working variant would, in theory, turn a human cell green by activating green fluorescent protein (GFP) in its genome. “At first, this system did not work at all for a year,” Xu said. “But after iterations of bioengineering, we saw some engineered proteins start to turn on, like magic. It made us really appreciate the power of synthetic biology and bioengineering.” The first successful results were modest, but they excited Xu and encouraged her to push forward because it meant the system worked. Over many additional iterations, she was able to further improve the protein’s performance. “We started with seeing only two cells showing a green signal, and now after engineering, almost every cell is green under the microscope,” Xu said. “At some moment, I had to stop her,” recalled Qi. “I said ‘That’s good for now. You’ve made a pretty good system. We should think about how this molecule can be used for applications.’” In addition to protein engineering, the researchers also engineered the RNA that guides the Cas protein to its target DNA. Modifications to both components were crucial to making the CasMINI system work in human cells. They tested CasMINI’s ability to delete and edit genes in lab-based human cells, including genes related to HIV infection, anti-tumor immune response, and anemia. It worked on almost every gene they tested, with robust responses in several. Opening the door The researchers have already begun assembling collaborations with other scientists to pursue gene therapies. They are also interested in how they could contribute to advances in RNA technologies – like what has been used to develop the mRNA COVID-19 vaccines – where size can also be a limiting factor. “This ability to engineer these systems has been desired in the field since the early days of CRISPR, and I feel like we did our part to move toward that reality,” said Qi. “And this engineering approach can be so broadly helpful. That’s what excites me – opening the door on new possibilities.” Reference: “Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing” by Xiaoshu Xu, Augustine Chemparathy, Leiping Zeng, Hannah R. Kempton, Stephen Shang, Muneaki Nakamura and Lei S. Qi, 3 September 2021, Molecular Cell. DOI: 10.1016/j.molcel.2021.08.008 Additional Stanford co-authors of the paper are graduate students Augustine Chemparathy and Hannah Kempton, and postdoctoral scholars Leiping Zeng, Stephen Shang and Muneaki Nakamura. Qi is also a member of Stanford Bio-X. the Maternal & Child Health Research Institute (MCHRI), the Stanford Cancer Institute and the Wu Tsai Neurosciences Institute. This research was funded by the Li Ka Shing Foundation.

When the team sequenced the genome of polygamous Red-necked phalaropes for the first time, they found they carried fewer harmful mutations. Credit: Freya Coursey Polygamy in Birds Aids Natural Selection by Reducing Harmful Mutations According to a study led by the Milner Centre for Evolution at the University of Bath, bird species that engage in multiple sexual partnerships have fewer damaging mutations. This study, published in Evolution, provides the first evidence of how polygamy enhances the efficiency of natural selection in wild populations. The majority of birds form a bond with a solitary mate each mating season, while certain species like swans or geese mate for life. In contrast, some bird species are polygamous, having several partners per breeding season, however, it is unclear why they have evolved a different mating system. An international team of scientists led by Bath analyzed the genomes of 150 bird species, spanning all the major bird families and from locations across the world, including six species that were sequenced for the first time. By counting differences between the genes inherited from the individual’s mother and father (termed the heterozygosity), they were able to estimate the level of genetic diversity across each species. They also looked at the frequency of gene mutations in each species and whether they changed the sequence of proteins for which they coded or were “silent”. The former, called non-synonymous polymorphisms, are often detrimental to the individual, whereas silent mutations are generally harmless. Findings on Genetic Diversity and Mutations Contrary to their expectations, they found that polygamous species on the whole were no more diverse than monogamous ones, although the small number of species with polygamous females did have higher than expected genetic diversity. They also found that, relative to the number of silent mutations, the polygamous species had significantly fewer potentially damaging mutations that changed the protein sequence. Implications of Sexual Selection Kees Wanders, a Ph.D. student in the University of Bath’s Department of Life Sciences is funded by the NERC GW4+ Doctoral Training Partnership and is the first author of the paper. He said: “Species evolve through natural selection, where harmful mutations are removed from the population in the long term because individuals with the mutation don’t survive long enough to breed, or individuals with beneficial adaptations survive for longer. “However, species also evolve through sexual selection, where evolution is shaped by individuals competing for access to mates so that only the most desirable characteristics are successfully passed down to offspring. “This research suggests that sexual selection aligns with natural selection in birds so that harmful mutations are removed more efficiently in polygamous populations, where sexual selection is particularly strong. “We still don’t know exactly why some bird species are polygamous when most pair up for a breeding season or even for life. “There are many different theories about why polygamy evolved in these species, but we’ve found the first evidence that it increases the efficiency of natural selection by rooting out harmful mutations and avoiding the effects of inbreeding. “It’s been previously observed by others in the lab in fruit flies, but this is the first time it’s been observed in wild populations of birds.” Dr. Araxi Urrutia, Senior Lecturer at the Milner Centre for Evolution at the University of Bath and last author of the paper, said: “I had a hypothesis that in polygamous species, where individuals can’t easily find a mate and have to travel further to find a breeding partner, that this would mean that there would be more genetic diversity in these species. “However, we were surprised to find there was no evidence for this – instead we found that these species had fewer harmful mutations. “Despite this apparent evolutionary advantage, most birds tend to stick together to raise their chicks because it gives their offspring a better chance of survival.” Reference: “Polygamy and Purifying Selection in Birds” by Kees Wanders, Guangji Chen, Shaohong Feng, Tamas Szekely, Zsolt Végvári, Götz Eichhorn, Araxi Urrutia, Mike Bruford and Guojie Zhang, 29 October 2022, Evolution. DOI: 10.1093/evolut/qpac010 The study was funded by the Natural Environment Research Council. The data for this study was collected as part of the B10K Project, with scientists from China, Wales, Denmark, Hungary, Germany, Netherlands and Mexico contributing to the research.

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