Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.High-performance insole OEM Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Flexible manufacturing OEM & ODM Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance graphene insole OEM factory Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan ergonomic pillow OEM supplier

African turquoise killifish embryos survive dry seasons by entering diapause, using ancient genes to halt and resume embryonic development. Similar genetic expressions are found in other species, including mice. (Artist’s concept of a fish, rather than an embryo, in suspended animation.) Credit: SciTechDaily.com How Killifish Embryos Use Suspended Animation To Survive Over 8 Months of Drought The African turquoise killifish utilizes a unique survival strategy through diapause, leveraging ancient genes to endure dry seasons. This mechanism involves pausing embryonic development, which is later resumed. Research also indicates similar genetic patterns in other species, suggesting a shared evolutionary trait for suspended animation. Suspended Animation in African Turquoise Killifish Transient ponds in Zimbabwe and Mozambique are home to African turquoise killifish. To survive the annual dry season, the fish’s embryos enter a state of extreme suspended animation or “diapause” for approximately 8 months. A new study has revealed the evolutionary adaptations that allow the killifish to sustain this remarkable survival technique. Published on May 30 in the journal Cell, the findings indicate that killifish developed the ability to diapause less than 18 million years ago by co-opting ancient genes that originated more than 473 million years ago. Comparative analyses further demonstrate that similar gene expression patterns during diapause are found in other animals, including the house mouse. “The whole program is like day and night—there is life in the normal state and life in the diapause state, and the way this happened was by reshuffling or re-wiring the regulatory region of a whole set of genes,” says senior author and molecular biologist Anne Brunet of Stanford University. Pair of killifish. Credit: Rogelio Barajas and Xiaoai Zhao Rapid Maturation and Reproduction of Killifish African turquoise killifish mature faster than any other vertebrate species, and adults live for only around 6 months, even in captivity. The fish reproduce rapidly before their watery homes disappear, but their embryos remain behind in the dry mud, ready to hatch when the next year’s rains come. Embryonic diapause also occurs in other vertebrate species, including fish, reptiles, and some mammals, but killifish diapause is remarkably extreme because it lasts for such an extended period (8 months on average and up to 2 years in the lab) and because killifish embryos enter suspended animation much later in development than other animals. “It’s roughly in the middle of development, and many organs are already formed by that stage— they have a developing brain and a heart which stops beating in diapause and then starts again,” says first author Param Priya Singh of the University of California, San Francisco. “Killifish are the only vertebrate species that we know of that can undergo diapause so late in development.” Male killifish. Credit: Rogelio Barajas and Xiaoai Zhao Detailed Gene Analysis During Diapause To understand diapause evolution, the research team first characterized the gene expression of the African turquoise killifish (Nothobranchius furzeri) during different developmental stages. They focused on duplicated copies of genes called “paralogs,” because gene duplication is one of the primary mechanisms by which new genes originate and specialize. Overall, the researchers identified 6,247 paralog pairs that exhibited specialized gene expression patterns during diapause. Surprisingly, they estimated that most of the diapause-specialized genes were “very ancient” paralogs, having originated more than 473 million years ago. “Even though diapause evolved relatively recently, the genes that are specialized in diapause are really ancient,” said Brunet. “We found that most of the genes that specialize for diapause in killifish are very ancient paralogs, which means that they were duplicated in the common ancestor of all vertebrates.” Comparative Analysis Across Species Since diapause also occurs in some other species of killifish, the researchers compared gene expression between embryos of the African turquoise killifish, the South American killifish (Austrofundulus limnaeus), which also undergoes diapause, and two killifish species that do not undergo diapause, the red-striped killifish (Aphyosemion striatum) and lyretail killifish (Aphyosemion austral). They found significant overlap in gene expression patterns between the African turquoise and South American killifish, which evolved diapause independently of each other, but not in the two non-diapausing species. Likewise, the researchers found significant correlation in the gene expression patterns of house mouse (Mus musculus) embryos during diapause and showed that diapause-specialized genes in mice also have very ancient origins. “This suggests that the same mechanisms that enable diapause have been repeatedly co-opted for the evolution of diapause across distantly related species,” says Singh. Next, the investigators explored how these diapause-specialized genes are regulated in the killifish. They identified several key transcription factors that control the altered gene expression patterns seen during diapause, including REST and FOXO3, which are known to be expressed during hibernation (a different form of suspended animation) in mammals. Notably, several of these regulatory genes are involved in lipid metabolism, which has a distinctive profile during diapause. “One of the key elements of diapause is this special lipid metabolism,” said Brunet. “During diapause, they seem to have much higher levels of triglycerides and very long chain fatty acids, which are forms of storage and also perhaps aid with long-term protection of the organism’s membranes.” Future Directions in Diapause Research The team plans to continue investigating how different species regulate diapause and dig deeper into the role of lipid metabolism during diapause and other types of suspended animation. “It’s such a complex state that I think we are just scratching the surface,” said Singh. “We want to go deeper into specific aspects of how lipid metabolism is regulated during diapause, and we are also interested in examining the role of specific cell types during diapause.” Reference: “Evolution of diapause in the African turquoise killifish by remodeling the ancient gene regulatory landscape” by Param Priya Singh, G. Adam Reeves, Kévin Contrepois, Katharina Papsdorf, Jason W. Miklas, Mathew Ellenberger, Chi-Kuo Hu, Michael P. Snyder and Anne Brunet, 28 May 2024, Cell. DOI: 10.1016/j.cell.2024.04.048 This research was supported by the Glenn Foundation for Medical Research, the NOMIS Distinguished Scientist and Scholar award, the Stanford Center for Computational, Evolutionary, and Human Genomics, the National Institutes of Health, and the National Science Foundation

The neuroactivity of one million neurons in the mouse brain, at unprecedented resolution. Credit: Alipasha Vaziri New microscopy technique reveals activity of one million neurons across the mouse brain. Capturing the intricacies of the brain’s activity demands resolution, scale, and speed—the ability to visualize millions of neurons with crystal clear resolution as they actively call out from distant corners of the cortex, within a fraction of a second of one another. Now, researchers have developed a microscopy technique that will allow scientists to accomplish this feat, capturing detailed images of activity of a vast number of cells across different depths in the brain at high speed and with unprecedented clarity. Published in Nature Methods, the research demonstrates the power of this innovation, dubbed light beads microscopy, by presenting the first vivid functional movies of the near-simultaneous activity of one million neurons across the mouse brain. “Understanding the nature of the brain’s densely interconnected network requires developing novel imaging techniques that can capture the activity of neurons across vastly separated brain regions at high speed and single-cell resolution,” says Rockefeller’s Alipasha Vaziri. “Light beads microscopy will allow us to investigate biological questions in a way that had not been possible before.” A focus on microscopy Whether it’s whiskers that seek hazards by flicking to and fro, or hand-eye-coordination that helps a human hit a baseball, animals rely upon the call and response of the sensory, motor, and visual regions of the brain. Cells from far reaches of the cortex coordinate this feat through a web of neuroactivity that weaves distant regions of the brain into interconnected symphonies. Scientists are only now beginning to untangle this web, with the help of cutting-edge microscope technology. The combination of two-photon scanning microscopy and fluorescent tags is the gold standard when it comes to imaging the activity of neurons within less transparent brain tissues, which are prone to scattering light. It involves firing a focused laser pulse at a tagged target. A few nanoseconds after the pulse hits its mark, the tag emits fluorescent light that can be interpreted to give scientists an idea of the level of neuroactivity detected. But two-photon microscopy suffers from a fundamental limitation. Neurobiologists need to record simultaneous interactions between the sensory, motor, and visual regions of the brain, but it is difficult to capture the activity in such a broad swath of the brain without sacrificing resolution or speed. Designing an ideal microscope for visualizing interactions between far apart brain regions can feel like plugging holes in a sinking ship. In the interests of high resolution, scientists often must sacrifice scale—or zoom out to take in the larger structure, at the cost of resolution. This can be overcome by snapping a series of high-resolution images from distant corners of the brain separately, later stitching them together. But then speed becomes an issue. “We need to capture many neurons at distant parts of the brain at the same time at high resolution,” Vaziri says. “These parameters are almost mutually exclusive.” An innovative resolution Light beads microscopy offers a creative solution and pushes the limits of imaging speed to what’s maximally obtainable – only limited by physical nature of fluorescence itself. This is done by eliminating the “deadtime” between sequential laser pulses when no neuroactivity is recorded and at the same time the need for scanning. The technique involves breaking one strong pulse into 30 smaller sub pulses – each at a different strength – that dive into 30 different depths of scattering mouse brain but induce the same amount of fluorescence at each depth. This is accomplished with a cavity of mirrors that staggers the firing of each pulse in time and ensures that they can all reach their target depths via a single microscope focusing lens. With this approach, the only limit to the rate at which samples can be recorded is the time that it takes the fluorescent tags to flare. That means broad swaths of the brain can be recorded within the same time it would take a conventional two-photon microscope to capture a mere smattering of brain cells. Vaziri and colleagues then put light beads microscopy to the test by integrating it into a microscopy platform that allows for optical access to a large brain volume enabling the recording of the activity of more than one million neurons across the entire cortex of the mouse brain for the first time. Because Vaziri’s method is an innovation that builds on two photon microscopy, many labs already have or can commercially obtain the technologies necessary to perform light beads microscopy, as described in the paper. Labs that are less familiar with these techniques could benefit from a simplified, self-contained module that Vaziri is currently developing for more widespread use. “There’s no good reason why we didn’t do this five years ago,” he says. “It would have been possible—the microscope and laser technology existed. No one thought of it.” Ultimately, the goal is to complement rather than replace current techniques. “There are neurobiological questions for which the standard two-photon microscope is sufficient,” Vaziri says. ” But light beads microscopy allows us to address questions that existing methods cannot.” Reference: “High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy” by Jeffrey Demas, Jason Manley, Frank Tejera, Kevin Barber, Hyewon Kim, Francisca Martínez Traub, Brandon Chen and Alipasha Vaziri, 30 August 2021, Nature Methods. DOI: 10.1038/s41592-021-01239-8

New research finds that continuous artificial light harms honey bees by disrupting their sleep patterns and circadian rhythms, thereby threatening their role in pollination and ecosystem health. Researchers at UC San Diego discovered that artificial light significantly disrupts the circadian rhythms of honey bees, which affects their health and essential pollination activities. Honey bees, key to ecosystem stability and global food security, experience reduced sleep and impaired behaviors under constant light. This study highlights the broader implications of light pollution on pollinator health and the urgency to develop protective strategies. Digital Devices and Sleep Disruption Sleep experts warn that using screens in bed can interfere with our sleep, as light from phones and other devices disrupts our natural sleep patterns. This finding is part of a broader understanding of how light affects our circadian biology and the crucial balance of our sleep-wake cycles. Researchers at the University of California San Diego have discovered that light disruption affects more than just human health. In a new study led by PhD candidate Ashley Kim and Professor James Nieh, artificial light was found to disrupt the circadian rhythms of honey bees, posing a significant threat to their role as vital pollinators. The prevalence of light pollution on sleeping honey bees varies from region to region. Credit: Ashley Kim, Nieh Lab, UC San Diego Impact of Light on Honey Bee Health “Our research shows just how sensitive honey bees are to changes in their environment, particularly to something as seemingly benign as artificial light,” said Kim of the study, published today (November 12) in Scientific Reports. “By disrupting their circadian rhythms, we see clear evidence of reduced sleep periods. This raises significant concerns, not only for bee health but also for the health of ecosystems that depend on them for pollination.” Honey bees play a crucial role as pollinators of wild plants and important crops, providing services that support ecosystem stability and global food security. Without pollination, crops worth tens of millions of dollars would be at risk. Honey bees generally prefer to nest in dark environments, although a small amount of light can enter from the hive entrance. Sleeping bees typically remain immobile but exhibit subtle movements if disturbed by nestmates. However, bees sleep outside when they swarm or when they form “bee beards” outside the nest on hot evenings, which are increasing under climate change. While the prevalence of artificial light at night (ALAN), or light pollution, on sleeping honey bees varies from region to region, modern urban environments are increasingly exposed to artificial light conditions, especially as temperatures rise. Because there has been a resurgence of urban beekeeping in many areas to support bees and their critical pollination services, bees that experience hotter weather are now potentially more exposed to ALAN. Researchers compared groups of bees that underwent normal sleep in the dark with others that were subjected to continuous artificial light. Credit: Ashley Kim, Nieh Lab, UC San Diego Bee Behavior Under Artificial Light Like us, when bees experience a poor night’s sleep and disrupted circadian patterns, problems in behavior and function emerge. Sleep is crucial for the health and fitness of honey bee colonies since they depend on an intricate system of communication known as the “waggle dance” that informs hive mates about the location of food sources in the environment. Bees dance more poorly and therefore do not communicate as well if they do not get enough sleep. Through a series of experiments spanning several years, the UC San Diego researchers compared groups of bees that underwent normal sleep in the dark with others that were subjected to continuous artificial light. The results clearly showed that prolonged exposure to light significantly disrupted the circadian rhythms of honey bees, leading to impaired behaviors. Since the bees were video recorded 24 hours a day during the experiments, Kim could immediately see the effects of disrupted sleep. Professor James Nieh and graduate student Ashley Kim. Credit: School of Biological Sciences, UC San Diego Addressing Light Pollution and Pollinator Health “Even without analyzing the data you can tell that there was something going on… the bees that were under constant light slept less,” said Kim. “The effects of light pollution on biological systems is fairly unknown and something people normally don’t think about, which is why it’s a rapidly evolving field.” Among the details described in the paper: Bees exposed to continuous light slept less and were more frequently disturbed by their peers compared to those kept in normal darkness. Also, bees under continuous light exhibited a preference for darker areas within their experimental cages. “Understanding the factors that affect bee health, such as light pollution, is essential for developing strategies to protect pollinator populations,” said Nieh. “Light pollution is a growing issue, with artificial light now covering a quarter of the Earth’s surface, and this research sheds new light on how such disturbances may be harming pollinators.” Two coauthors of the study, Aura Velazquez (Universidad La Salle México) and Belen Saavedra (Berea College), are undergraduate students who participated in the research as part of UC San Diego’s ENLACE initiative, a binational summer program in which students conduct research during a seven-week project. “I am pleased that the ENLACE summer research program was pivotal in providing research experiences for the student authors of this study,” said Olivia Graeve, the director of the ENLACE Program at UC San Diego and a professor in the Department of Mechanical and Aerospace Engineering, Jacobs School of Engineering. “By fostering collaboration between students from Latin America and the United States, we help young researchers gain valuable hands-on experience, building skills and friendships that extend across borders. This project exemplifies the impact of ENLACE, as it brings together diverse perspectives to address global challenges like pollinator health and environmental sustainability.” Nieh and study coauthor Benjamin Smarr, a faculty member in the Shu Chien-Gene Lay Department of Bioengineering, Jacobs School of Engineering, and Halıcıoğlu Data Science Institute, were recently awarded a related grant — which extends to human impacts — from the new Chancellor’s Interdisciplinary Team Catalyst Fund. “Harmonizing the Pulse of Life: Pioneering Circadian Insights for Human and Ecosystem Health at UC San Diego” furthers research on circadian biology and ecosystem health. The Nieh and Smarr labs will collaborate to examine circadian rhythms across scales, from individual bees to entire ecosystems. “The Catalyst Grant allows us to connect research on honey bee circadian rhythms to larger questions about biological synchronization across ecosystems and human health,” said Nieh. “This program fosters interdisciplinary collaboration, bringing together experts in biology, data science and medicine to address pressing issues like light pollution and its impact on pollinator health. Our work with the Catalyst Grant strengthens UC San Diego’s role in advancing solutions for both environmental sustainability and human well-being.” Reference: “Exposure to constant artificial light alters honey bee sleep rhythms and disrupts sleep” by Ashley Y. Kim, Aura Velazquez, Belen Saavedra, Benjamin Smarr and James C. Nieh, 12 November 2024, Scientific Reports. DOI: 10.1038/s41598-024-73378-9

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