Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan pillow OEM manufacturing factory

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.One-stop OEM/ODM solution provider Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China athletic insole OEM supplier

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.One-stop OEM/ODM solution provider Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan OEM/ODM hybrid insole services

The MYC gene drives muscle growth and adapts to exercise but wanes with age, affecting recovery. Research shows MYC alone can mimic exercise effects, though its oncogenic risks demand cautious therapeutic approaches. A recent study investigates the relationship between exercise and the expression of MYC in skeletal muscles over time, revealing that even minimal doses can promote muscle growth without physical activity. Researchers have long known that there is a relationship between the cancer-associated gene MYC (pronounced “Mick”) and exercise adaptation. When human muscles are exercised, MYC is found to increase transiently in abundance over 24 hours. But as we age, the MYC response to exercise is blunted, perhaps explaining a reduced ability to recover from exercise and maintain or gain muscle. Knowing the precise mechanisms by which MYC drives muscle growth could prove instrumental in creating therapies that reduce muscle loss from aging, potentially improving independence, mobility, and health. New research published in EMBO Reports now adds an important dimension to our understanding of the role of MYC in skeletal muscle. The work is the product of 20 authors representing five institutions: the U of A, the Karolinska Institute in Sweden, Linköping University in Sweden, Oakland University, and the University of Kentucky. Given so many contributors, the paper is rich with data but essentially boils down to two parts. The first is a 24-hour chronicle of the molecular landscape of the human muscles following resistance exercise. The second half examines the use of mouse models to determine if controlled doses, or pulses, of MYC within skeletal muscles would be enough to stimulate muscle growth independent of actual exercise. The short answer: yes. The Molecular Landscape of MYC Co-first author Ronald Jones, a Ph.D. candidate in the U of A’s Department of Health, Human Performance and Recreation, noted that most studies tend to look at the molecular landscape of the human body by taking biopsies prior to exercise and then a few hours later. But by taking multiple biopsies over a period of 24 hours, which the team in Sweden oversaw, the researchers were able to get a more complete profile of how the body adapts to exercise over time and what genes are most important in that process. “We show that the peak of responsiveness and where most things were happening was actually eight hours after exercise,” Jones explained. He added that they found that three hours after exercising, MYC ranked as the third most important molecule. “And then at eight and 24 hours, it was the most influential. So it was really important to get those time points and to map out the body’s response to acute exercise.” Ronald Jones. Credit: University of Arkansas Once the researchers had a clearer understanding of what was happening molecularly in human muscles over time, they wanted to isolate MYC and see if it alone was enough to facilitate muscle growth. This was done by genetically controlling the levels of MYC in their skeletal muscles using a specialized mouse model. The mice weren’t given an exercise wheel, which would naturally promote muscle growth, but were otherwise allowed to move around normally. Samples were then taken from the soleus muscles of their lower legs, which are utilized in basic activities like standing or walking around. Analysis confirmed that MYC alone led to increased muscle mass and fiber size in the soleus in comparison to genetically identical mice that did not have MYC pulses but otherwise lived under identical circumstances. Thus, the team was able to effectively “mimic” the exercise response without exercise. The Meaning of MYC These findings further the argument that MYC is a key player in muscle growth from resistance training. Even so, MYC is not likely to be the basis of a new therapy for sarcopenia or a performance-enhancing drug. MYC regulates roughly 15 percent of the estimated 20,000 genes in the human body, meaning it could have unpredictable downstream effects involving thousands of genes. It is also a potent oncogene, meaning the very growth it promotes in skeletal muscle could stimulate cellular proliferation if overexpressed in organs like the liver, resulting in tumors. Administering MYC alone could have unintended and deadly side effects. Kevin Murach, an assistant professor at the U of A and Jones’ adviser in the department, was a senior and corresponding author on the paper. Murach commented that “it’s interesting that one of the things that is known to cause cancer also regulates the muscle growth response to exercise. This suggests shared regulation and that ‘growth is growth.’” Murach added, “The take-home isn’t necessarily that we need to induce MYC in muscle to mimic exercise, but that we can harness the knowledge of what this oncogene affects in muscle and then try to design therapies and interventions for atrophy and enhancing muscle adaptability that activate those positive downstream effects of MYC without evoking the possibility of oncogenesis.” In addition to being an oncogene, MYC is also one of the four Yamanaka factors, which are four protein transcription factors that can revert highly specified cells (such as a skin cell) back to a stem cell, which is a younger and more adaptable state. In the correct dosages, inducing the Yamanaka factors throughout the body in rodents can ameliorate the hallmarks of aging by mimicking the adaptability that is common to more youthful cells. Of the four factors, only MYC is induced by exercising skeletal muscle. These findings provide further motivation for the researchers to understand what MYC is doing in muscle from an aging context with exercise. Moving forward, Jones will continue to dig deeper into the mysteries of MYC as the focus of his dissertation. “I’m super passionate about it,” he said. “I wake up every day thinking about this project. I love working on this project, and I think MYC is one of the most heavily influential molecules in muscle tissue… but there is still so much we don’t know.” Reference: “The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth” by Sebastian Edman, Jones IIIRonald G, Paulo R Jannig, Rodrigo Fernandez-Gonzalo, Jessica Norrbom, Nicholas T Thomas, Sabin Khadgi, Pieter J Koopmans, Francielly Morena, Toby L Chambers, Calvin S Peterson, Logan N Scott, Nicholas P Greene, Vandre C Figueiredo, Christopher S Fry, Liu Zhengye, Johanna T Lanner, Yuan Wen, Björn Alkner, Kevin A Murach and Ferdinand von Walden, 30 October 2024, EMBO Reports. DOI: 10.1038/s44319-024-00299-z Joining Jones and Murach as co-authors on the paper from the U of A are Sabin Khadgi, a research technician for muscle physiology; PJ Koopmans, a Ph.D. candidate; Toby Chambers, a post-doctoral scholar; Francielly Morena, a recent U of A Ph.D. graduate; and Nicholas Greene, a professor and director of the Exercise Science Research Center.

The extreme steps these microorganisms would take to punish cheater species surprised the researchers. A Study Reveals That Bacteria Can Behave “Spitefully” Annoyed by freeloaders? You are not alone, and taking advantage of others is an issue that affects all species, not just humans. In fact, such selfish behavior is not uncommon in the animal realm, where even cheater species of bacteria display it. An even more intriguing fact was revealed by a York University-led study team that investigated bacteria’s quorum-sensing trait, a complex type of cooperation that allows bacteria to regulate gene expression based on population density. Researchers from Case Western Reserve University and York University collaborated on the research, which was recently published in the journal PLOS Computational Biology. They were astonished to learn that bacterial colonies can go to the point of harming themselves in order to get rid of freeloaders. Enforcing Fairness Through Quorum Sensing “We didn’t expect to see this behavior, which you might even call ‘spiteful’,” says Associate Professor Andrew Eckford of York U’s Lassonde School of Engineering, and the study’s senior author. “But it indicates that quorum sensing is a remarkably flexible tool for enforcing fairness.” In the study, scientists investigated how quorum sensing regulates the supply of shared resources, such as the enzymes that convert food sources into helpful nutrients. When freeloaders steal nutrients without creating enzymes, they discovered that the cheaters can be penalized even if the whole community suffers – similar to canceling a feast when an unwanted visitor sneaks in. Additionally, quorum sensing may starve the whole community if freeloading is widespread and no other food is available. “It’s costly for a bacterium to contribute to the community, so for a selfish individual, it’s best to simply take what’s offered without giving anything back,” explains lead author Alex Moffett, who was a York U postdoctoral fellow at the time of the study. “But obviously this is bad for everyone, so the community needs a way to discourage bad behavior.” Mathematical Modeling of Quorum Sensing Moffett and his colleagues found that instead of relying on the honor system, these microorganisms used quorum sensing to suppress the freeloaders. To further understand how quorum sensing compares to other strategies for controlling the production of public goods, they used mathematical modeling. “Our model captures both how likely ‘cheater’ strains – which do not produce public goods but benefit from them – are to take over a population and how long on average the population will last before going extinct,” says co-author Peter J Thomas, professor of mathematics, applied mathematics and statistics at Case Western Reserve University, Cleveland, Ohio. As quorum sensing plays an important role in bacterial infections such as the lung infections that affect sufferers of cystic fibrosis, the research team hopes to apply the results of this study to understand and disrupt such diseases. “This will help us understand how bacteria can colonize the lungs so effectively, which might point the way to new treatments,” adds Moffett. Reference: “Cheater suppression and stochastic clearance through quorum sensing” by Alexander S. Moffett, Peter J. Thomas, Michael Hinczewski and Andrew W. Eckford, 28 July 2022, PLOS Computational Biology. DOI: 10.1371/journal.pcbi.1010292 The study was funded by the Natural Sciences and Engineering Research Council of Canada, the United States Defense Advanced Research Projects Agency, and the National Science Foundation.

Scientists have detailed the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems, CRISPR-Cas13bt3, used for RNA modification, which operates differently from other proteins in the same family. This discovery allowed them to enhance the tool’s precision, enabling better access and delivery to target editing sites, holding promise for more effective virus combat by targeting RNA. Detailed 3D Modeling Aided Rice Scientists in Enhancing the System’s Precision  Small and precise: These are the ideal characteristics for CRISPR systems, the Nobel-prize winning technology used to edit nucleic acids like RNA and DNA. Scientists from Rice University have described in detail the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems used to shred or modify RNA and employed their findings to further engineer the tool to improve its precision. According to a study published in Nature Communications, the molecule works differently than other proteins in the same family. “There are different types of CRISPR systems, and the one our research was focused on for this study is called CRISPR-Cas13bt3,” said Yang Gao, an assistant professor of biosciences and Cancer Prevention and Research Institute of Texas Scholar who helped lead the study. “The unique thing about it is that it is very small. Usually, these types of molecules contain roughly 1200 amino acids, while this one only has about 700, so that’s already an advantage.” Emmanuel Osikpa (from left) and Xiangyu Deng. Credit: (Photo by Jeff Fitlow/Rice University A diminutive size is a plus as it allows for better access and delivery to target-editing sites, Yang Gao said. CRISPR-Cas13: Targeting RNA Instead of DNA Unlike CRISPR systems associated with the Cas9 protein ⎯ which generally targets DNA ⎯ Cas13-associated systems target RNA, the intermediary “instruction manual” that translates the genetic information encoded in DNA into a blueprint for assembling proteins. Researchers hope these RNA-targeting systems can be used to fight viruses, which generally encode their genetic information using RNA rather than DNA. “My lab is a structural biology lab,” Yang Gao said. “What we are trying to understand is how this system works. So part of our goal here was to be able to see it in three-dimensional space and create a model that would help us explain its mechanism.” Model of a minimal CRISPR-Cas13bt3 molecule generated with a cryo-electron microscope. The RNA to be recognized and cleaved is colored in light blue, while the scissor is formed by the magenta and cyan colored domains. The two loops for controlling the CRISPR-Cas13bt3 are shown in green and red. Credit: Image courtesy of the Yang Gao lab/Rice University The researchers used a cryo-electron microscope to map the structure of the CRISPR system, placing the molecule on a thin layer of ice and shooting a beam of electrons through it to generate data that was then processed into a detailed, three-dimensional model. The results took them by surprise. A Unique Mechanism for RNA Cutting “We found this system deploys a mechanism that’s different from that of other proteins in the Cas13 family,” Yang Gao said. “Other proteins in this family have two domains that are initially separated and, after the system is activated, they come together ⎯ kind of like the arms of a scissor ⎯ and perform a cut. “This system is totally different: The scissor is already there, but it needs to hook onto the RNA strand at the right target site. To do this, it uses a binding element on these two unique loops that connect the different parts of the protein together.” Emmanuel Osikpa (from left), Xue Sherry Gao, Xiangyu Deng, Jamie Smith, Seye J. Oladeji and Yang Gao. Credit: Photo by Jeff Fitlow/Rice University Xiangyu Deng, a postdoctoral research associate in the Yang Gao lab, said it was “really challenging to determine the structure of the protein and RNA complex.” “We had to do a lot of troubleshooting to make the protein and RNA complex more stable, so we could map it,” Deng said. Engineering a More Precise CRISPR System Once the team figured out how the system works, researchers in the lab of chemical and biomolecular engineer Xue Sherry Gao stepped in to tweak the system in order to increase its precision by testing its activity and specificity in living cells. “We found that in cell cultures these systems were able to hone in on a target much easier,” said Sherry Gao, the Ted N. Law Assistant Professor of Chemical and Biomolecular Engineering. “What is really remarkable about this work is that the detailed structural biology insights enabled a rational determination of the engineering efforts needed to improve the tool’s specificity while still maintaining high on-target RNA editing activity.” Xiangyu Deng. Credit: Photo by Jeff Fitlow/Rice University Emmanuel Osikpa, a research assistant in the Xue Gao lab, performed cellular assays that confirmed the engineered Cas13bt3 targeted a designated RNA motif with high fidelity. “I was able to show that this engineered Cas13bt3 performed better than the original system,” Osikpa said. “Xiangyu’s comprehensive study of the structure highlights the advantage that a targeted, structurally guided approach has over large and costly random mutagenesis screening.” Reference: “Structural basis for the activation of a compact CRISPR-Cas13 nuclease” by Xiangyu Deng, Emmanuel Osikpa, Jie Yang, Seye J. Oladeji, Jamie Smith, Xue Gao and Yang Gao, 20 September 2023, Nature Communications. DOI: 10.1038/s41467-023-41501-5 The research was supported by the Welch Foundation (C-2033-20200401, C-1952), the Cancer Prevention and Research Institute of Texas (RR190046), the National Science Foundation (2031242) and the Rice startup fund.

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