Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Arch support insole OEM from Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene sheet OEM supplier Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Soft-touch pillow OEM service in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Graphene insole OEM factory China

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam graphene material ODM solution

Human number processing may stem from the putamen, offering insights into evolution and safer brain surgeries. Thinking about numbers engages a brain region linked to fundamental functions, offering key insights for education and neurological procedures, researchers report. New research suggests that the unique human ability to conceptualize numbers may be deeply embedded within the brain. Further, the results of the study by Oregon Health & Science University involving neurosurgery patients suggest new possibilities for tapping into those areas to improve learning among people bedeviled by math. “This work lays the foundation to deeper understanding of number, math, and symbol cognition — something that is uniquely human,” said senior author Ahmed Raslan, M.D., professor and chair of neurological surgery in the OHSU School of Medicine. “The implications are far-reaching.” The study was published in the journal PLOS ONE. Raslan and co-authors recruited 13 people with epilepsy who were undergoing a commonly used surgical intervention to map the exact location within their brains where seizures originate, a procedure known as stereotactic electroencephalography. During the procedure, researchers asked the patients a series of questions that prompted them to think about numbers as symbols (for example, 3), as words (“three”), and as concepts (a series of three dots). New research from Ahmed Raslan, M.D., and OHSU finds people’s ability to process numbers resides in a portion of the brain that developed in the earliest stages of human evolution. Credit: OHSU/Christine Torres Hicks As the patients responded, researchers found activity in a surprising place: the putamen. Located deep within the basal ganglia above the brain stem, the putamen is an area of the brain primarily associated with elemental functions, such as movement, and some cognitive function, but rarely with higher-order aspects of human intelligence like solving calculus. Neuroscientists typically ascribe consciousness and abstract thought to the cerebral cortex, which evolved later in human evolution and wraps around the brain’s outer layer in folded gray matter. “That likely means the human ability to process numbers is something that we acquired early during evolution,” Raslan said. “There is something deeper in the brain that gives us this capacity to leap to where we are today.” Broader Implications for Neurosurgery and Learning Researchers also found activity as expected in regions of the brain that encode visual and auditory inputs, as well as the parietal lobe, which is known to be involved in numerical and calculation-related functions. From a practical standpoint, the findings could prove useful in avoiding important areas during surgeries to remove tumors or epilepsy focal points, or in placing neurostimulators designed to stop seizures. “Brain areas involved in processing numbers can be delineated and extra care taken to avoid damaging these areas during neurosurgical interventions,” said lead author Alexander Rockhill, Ph.D., a postdoctoral researcher in Raslan’s lab. Researchers credited the patients involved in the study. “We are extremely grateful to our epilepsy patients for their willingness to participate in this research,” said co-author Christian Lopez Ramos, M.D., a neurosurgical resident at OHSU. “Their involvement in answering our questions during surgery turned out to be the key to advancing scientific understanding about how our brain evolved in the deep past and how it works today.” Indeed, the study follows previous lines of research involving the mapping of the human brain during surgery. “I have access to the most valuable human data in nature,” Raslan said. “It would be a shame to miss an opportunity to understand how the brain and mind function. All we have to do is ask the right questions.” In the next stage of this line of research, Raslan anticipates discerning areas of the brain capable of performing other higher-level functions. Reference: “Investigating the Triple Code Model in numerical cognition using stereotactic electroencephalography” by Alexander P. Rockhill, Hao Tan, Christian G. Lopez Ramos, Caleb Nerison, Beck Shafie, Maryam N. Shahin, Adeline Fecker, Mostafa Ismail, Daniel R. Cleary, Kelly L. Collins and Ahmed M. Raslan, 3 December 2024, PLOS ONE. DOI: 10.1371/journal.pone.0313155 In addition to Raslan, Rockhill and Lopez Ramos, co-authors include Hao Tan, M.D., Beck Shafie, Maryam Shahin, M.D., Adeline Fecker, Mostafa Ismail, Daniel Cleary, M.D., and Kelly Collins, M.D., of OHSU; and Caleb Nerison, D.O., now of Lexington Medical Center in South Carolina. The research was supported by a grant from the National Institutes of Health’s BRAIN Initiative in support of Rockhill, award 1UG3NS123723-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

During a significant warming event 93 million years ago, some sharks developed elongated pectoral fins to adapt to hotter ocean temperatures, a change documented in a recent study. These adaptations helped them transition from bottom dwellers to efficient open-water predators, a response that modern sharks may struggle to emulate given today’s rapid climate change. Climate Change Was No Problem for the Big Fish Research shows that sharks evolved from bottom dwellers to open ocean predators during a past global warming event, adapting with physical changes like elongated fins to become more efficient swimmers. The sharks we know today as the open ocean’s top predators evolved from stubby bottom dwellers during a dramatic episode of global warming millions of years ago. A massive outpouring of volcanic lava about 93 million years ago sent carbon dioxide levels soaring, creating a greenhouse climate that pushed ocean temperatures to their hottest. University of California, Riverside (UCR) researchers discovered that some sharks responded to the heat with elongated pectoral fins. Scientific Discovery and Analysis This discovery is documented in a paper published today (June 3) in the journal Current Biology. It was made by taking body length and fin measurements from over 500 living and fossilized shark species. “The pectoral fins are a critical structure, comparable to our arms,” said UCR biology doctoral student and paper first author Phillip Sternes. “What we saw upon review of a massive data set, was that these fins changed shape as sharks expanded their habitat from the bottom to the open ocean.” Sharks that live in different parts of the ocean, and their respective pectoral fins. Credit: Phillip Sternes/UCR Adaptations and Efficiency Longer pectoral fins help make shark movements much more efficient. “Their fins are comparable to the wings of commercial airplanes, long and narrow, to minimize the amount of energy needed for movement,” Sternes said. The researchers also saw that the open-water sharks got faster compared to bottom dwelling sharks. “Shark muscle is very sensitive to temperature,” said Tim Higham, professor in UCR’s Department of Evolution, Ecology, and Organismal Biology and paper co-author. “The data helped us make a correlation between higher temperatures, tail movement, and swimming speeds,” Higham said. Habitats and Evolutionary Pressures Most living shark species are still bottom dwellers, occupying what scientists refer to as the benthic zone. These benthic sharks do not loom as large in popular culture as their fierce open-water relatives. Many of the bottom dwellers are slender, flatter, more medium-sized predators. Only about 13% of modern sharks are fast-swimming open-water predators. The researchers believe that breathing may have become difficult for their ancient relatives. Oxygen levels near the bottom during the Cretaceous period likely dropped as the heat increased. Temperature Trends and Historical Context Modern sea surface temperatures average about 68 degrees Fahrenheit. In the Cretaceous they were much warmer, reaching an average of about 83 degrees. The high heat of the Cretaceous did not happen overnight, and neither did the sharks’ evolution. “We had pretty warm open-sea surface temperatures throughout the era, and then a distinct spike that took place over a one- or two-million-year period,” said associate professor at Claremont McKenna College and paper co-author Lars Schmitz. Evolutionary Impact of Climate Change As global warming drove an evolution in some groups of animals, including sharks, it caused the extinction of others. Because those evolutionary changes happened on a longer time scale in the past, it is difficult to predict exactly how sharks or other marine life will respond to current warming trends. Biologists are seeing some sharks, including tropical species like tiger and bull sharks, starting to swim farther north. But it is unclear whether threatened sharks will again be able to adapt where they live and survive the rapidly increasing heat. “The temperature is going up so fast now, there is nothing in the geologic record I am aware of that we can use for a true comparison,” Sternes said. Reference: “The rise of pelagic sharks and adaptive evolution of pectoral fin morphology during the Cretaceous” by Phillip C. Sternes, Lars Schmitz and Timothy E. Higham, 3 June 2024, Current Biology. DOI: 10.1016/j.cub.2024.05.016

Octopuses have complex “camera” eyes, as seen here in a juvenile animal. Credit: Nir Friedman Cephalopods like octopuses, squids, and cuttlefish are highly intelligent animals with complex nervous systems. A team of researchers has now shown that their evolution is linked to a dramatic expansion of their microRNA repertoire. If we go far enough back in evolutionary history, we encounter the last known common ancestor of humans and cephalopods: a primitive wormlike animal with minimal intelligence and simple eyespots. Later, the animal kingdom can be divided into two groups of organisms – those with backbones and those without. While vertebrates, particularly primates and other mammals, went on to develop large and complex brains with diverse cognitive abilities, invertebrates did not. With one exception: the cephalopods. Scientists have long wondered why such a complex nervous system was only able to develop in these mollusks. Now, an international team led by researchers from the Max Delbrück Center and Dartmouth College in the United States has put forth a possible reason. In a paper published in the journal Science Advances, they explain that octopuses possess a massively expanded repertoire of microRNAs (miRNAs) in their neural tissue – reflecting similar developments that occurred in vertebrates. “So, this is what connects us to the octopus!” says Professor Nikolaus Rajewsky, Scientific Director of the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), head of the Systems Biology of Gene Regulatory Elements Lab, and the paper’s last author. He explains that this finding probably means miRNAs play a fundamental role in the development of complex brains. Octopuses have both a central brain and a peripheral nervous system – one that is capable of acting independently. Credit: Nir Friedman In 2019, Rajewsky read a publication about genetic analyses conducted on octopuses. Scientists had discovered that a lot of RNA editing occurs in these cephalopods – meaning they make extensive use of certain enzymes that can recode their RNA. “This got me thinking that octopuses may not only be good at editing, but could have other RNA tricks up their sleeve too,” recalls Rajewsky. And so he began a collaboration with the Stazione Zoologica Anton Dohrn marine research station in Naples, which sent him samples of 18 different tissue types from dead octopuses. The results of this analyses were surprising: “There was indeed a lot of RNA editing going on, but not in areas that we believe to be of interest,” says Rajewsky. The most interesting discovery was in fact the dramatic expansion of a well-known group of RNA genes, microRNAs. A total of 42 novel miRNA families were found – specifically in neural tissue and mostly in the brain. Given that these genes were conserved during cephalopod evolution, the team concludes they were clearly beneficial to the animals and are therefore functionally important. Rajewsky has been researching miRNAs for more than 20 years. Instead of being translated into messenger RNAs, which deliver the instructions for protein production in the cell, these genes encode small pieces of RNA that bind to messenger RNA and thus influence protein production. These binding sites were also conserved throughout cephalopod evolution – another indication that these novel miRNAs are of functional importance. Cephalopods playing with microRNAs (yellow): microRNAs may be linked to the emergence of complex brains in cephalopods. Credit: Grygoriy Zolotarov New microRNA Families “This is the third-largest expansion of microRNA families in the animal world, and the largest outside of vertebrates,” says lead author Grygoriy Zolotarov, MD, a Ukrainian scientist who interned in Rajewsky’s lab at MDC-BIMSB while finishing medical school in Prague, and later. “To give you an idea of the scale, oysters, which are also mollusks, have acquired just five new microRNA families since the last ancestors they shared with octopuses – while the octopuses have acquired 90!” Oysters, adds Zolotarov, aren’t exactly known for their intelligence. Rajewsky’s fascination with octopuses began years ago, during an evening visit to the Monterey Bay Aquarium in California. “I saw this creature sitting on the bottom of the tank and we spent several minutes – so I thought – looking at each other.” He says that looking at an octopus is very different to looking at a fish: “It’s not very scientific, but their eyes do exude a sense of intelligence.” Octopuses have similarly complex “camera” eyes to humans. From an evolutionary perspective, octopuses are unique among invertebrates. They have both a central brain and a peripheral nervous system – one that is capable of acting independently. If an octopus loses a tentacle, the tentacle remains sensitive to touch and can still move. The reason why octopuses are alone in having developed such complex brain functions could lie in the fact that they use their arms very purposefully – as tools to open shells, for instance. Octopuses also show other signs of intelligence: They are very curious and can remember things. They can also recognize people and actually like some more than others. Researchers now believe that they even dream, since they change their color and skin structures while sleeping. Alien-Like Creatures “They say if you want to meet an alien, go diving and make friends with an octopus,” says Rajewsky. He’s now planning to join forces with other octopus researchers to form a European network that will allow greater exchange between the scientists. Although the community is currently small, Rajewsky says that interest in octopuses is growing worldwide, including among behavioral researchers. He says it’s fascinating to analyze a form of intelligence that developed entirely independently of our own. But it’s not easy: “If you do tests with them using small snacks as rewards, they soon lose interest. At least, that’s what my colleagues tell me,” says Rajewsky. “Since octopuses aren’t typical model organisms, our molecular-biological tools were very limited,” says Zolotarov. “So we don’t yet know exactly which types of cell express the new microRNAs.” Rajewsky’s team is now planning to apply a technique, developed in Rajewsky’s lab, which will make the cells in octopus tissue visible at a molecular level. Reference: “MicroRNAs are deeply linked to the emergence of the complex octopus brain”25 November 2022, Science Advances. DOI: 10.1126/sciadv.add9938

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