Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Eco-friendly pillow OEM manufacturer Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.High-performance insole OEM China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand foot care insole ODM expert

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam OEM factory for footwear and bedding

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam graphene product OEM service

MIT researchers have discovered that chromatin spends most of its time in a partially looped state (middle). Fully formed loops (right) occur only three to six percent of the time, they found. Credit: Courtesy of the researchers, edited by MIT News MIT research finds genome loops don’t last long in cells; theories of how loops control gene expression may need to be revised. In human chromosomes, DNA is coated by proteins to form an extremely long beaded string. This “string” is folded into multiple loops, which are thought to aid cells in controlling gene expression and facilitating DNA repair, among other functions. According to a new MIT study, these loops are more dynamic and shorter-lived than previously thought. The researchers were able to track the movement of one stretch of the genome in a living cell for roughly two hours in the latest study. They discovered that this segment was only fully looped 3 to 6% of the time, with the loop lasting only about 10 to 30 minutes. According to the researchers, the findings suggest that scientists’ present understanding of how loops regulate gene expression may need to be changed. “Many models in the field have been these pictures of static loops regulating these processes. What our new paper shows is that this picture is not really correct,” says Anders Sejr Hansen, the Underwood-Prescott Career Development Assistant Professor of Biological Engineering at MIT. “We suggest that the functional state of these domains is much more dynamic.” Hansen is one of the senior authors of the new study, along with Leonid Mirny, a professor in MIT’s Institute for Medical Engineering and Science and the Department of Physics, and Christoph Zechner, a group leader at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, and the Center for Systems Biology Dresden. MIT postdoc Michele Gabriele, recent Harvard University PhD recipient Hugo Brandão, and MIT graduate student Simon Grosse-Holz are the lead authors of the paper, which was published on April 14, 2022, in the journal Science. Out of the Loop Using computer simulations and experimental data, scientists including Mirny’s group at MIT have shown that loops in the genome are formed by a process called extrusion, in which a molecular motor promotes the growth of progressively larger loops. The motor stops each time it encounters a “stop sign” on DNA. The motor that extrudes such loops is a protein complex called cohesin, while the DNA-bound protein CTCF serves as the stop sign. These cohesin-mediated loops between CTCF sites were seen in previous experiments. However, those experiments only offered a snapshot of a moment in time, with no information on how the loops change over time. In their new study, the researchers developed techniques that allowed them to fluorescently label CTCF DNA sites so they could image the DNA loops over several hours. They also created a new computational method that can infer the looping events from the imaging data. “This method was crucial for us to distinguish signal from noise in our experimental data and quantify looping,” Zechner says. “We believe that such approaches will become increasingly important for biology as we continue to push the limits of detection with experiments.” The researchers used their method to image a stretch of the genome in mouse embryonic stem cells. “If we put our data in the context of one cell division cycle, which lasts about 12 hours, the fully formed loop only actually exists for about 20 to 45 minutes, or about 3 to 6 percent of the time,” Grosse-Holz says. “If the loop is only present for such a tiny period of the cell cycle and very short-lived, we shouldn’t think of this fully looped state as being the primary regulator of gene expression,” Hansen says. “We think we need new models for how the 3D structure of the genome regulates gene expression, DNA repair, and other functional downstream processes.” While fully formed loops were rare, the researchers found that partially extruded loops were present about 92 percent of the time. These smaller loops have been difficult to observe with the previous methods of detecting loops in the genome. “In this study, by integrating our experimental data with polymer simulations, we have now been able to quantify the relative extents of the unlooped, partially extruded, and fully looped states,” Brandão says. “Since these interactions are very short, but very frequent, the previous methodologies were not able to fully capture their dynamics,” Gabriele adds. “With our new technique, we can start to resolve transitions between fully looped and unlooped states.” The researchers hypothesize that these partial loops may play more important roles in gene regulation than fully formed loops. Strands of DNA run along each other as loops begin to form and then fall apart, and these interactions may help regulatory elements such as enhancers and gene promoters find each other. “More than 90 percent of the time, there are some transient loops, and presumably what’s important is having those loops that are being perpetually extruded,” Mirny says. “The process of extrusion itself may be more important than the fully looped state that only occurs for a short period of time.” More Loops to Study Since most of the other loops in the genome are weaker than the one the researchers studied in this paper, they suspect that many other loops will also prove to be highly transient. They now plan to use their new technique study some of those other loops, in a variety of cell types. “There are about 10,000 of these loops, and we’ve looked at one,” Hansen says. “We have a lot of indirect evidence to suggest that the results would be generalizable, but we haven’t demonstrated that. Using the technology platform we’ve set up, which combines new experimental and computational methods, we can begin to approach other loops in the genome.” The researchers also plan to investigate the role of specific loops in disease. Many diseases, including a neurodevelopmental disorder called FOXG1 syndrome, could be linked to faulty loop dynamics. The researchers are now studying how both the normal and mutated form of the FOXG1 gene, as well as the cancer-causing gene MYC, are affected by genome loop formation. Reference: “Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging” by Michele Gabriele, Hugo B. Brandão, Simon Grosse-Holz, Asmita Jha, Gina M. Dailey, Claudia Cattoglio, Tsung-Han S. Hsieh, Leonid Mirny, Christoph Zechner and Anders S. Hansen, 14 April 2022, Science. DOI: 10.1126/science.abn6583 The research was funded by the National Institutes of Health, the National Science Foundation, the Mathers Foundation, a Pew-Stewart Cancer Research Scholar grant, the Chaires d’excellence Internationale Blaise Pascal, an American-Italian Cancer Foundation research scholarship, and the Max Planck Institute for Molecular Cell Biology and Genetics.

Figure 1. Photograph of 41 fungal isolates representative of the A. thaliana root mycobiome. Credit: Stéphane Hacquard/MPIPZ Complex microbial communities inhabit plants and modulate their development. Roots especially, host a wide diversity of micro-organisms – including bacteria and fungi – that directly influence plant health. Researchers from the MPIPZ previously discovered that these fungi are important members of the root microbiome that can promote plant growth, but only when they are kept in check by the combined action of the host innate immune system and root-inhabiting bacteria. In a new study published in Nature Communications, Fantin Mesny, and co-authors provide novel insights into how these fungi colonize roots, why many of them are potentially harmful, and what differentiates beneficial from pathogenic fungi in the root mycobiome (i.e., the fungal component of the root microbiota). To address these questions, the researchers focused on the model plant Arabidopsis thaliana (Thale Cress), which cannot rely on beneficial mycorrhizal fungi to acquire nutrients since it does not harbor the genetic network needed to establish a functional symbiosis with these fungi. A. thaliana likely relies on other fungi to compensate for the loss of mycorrhizal partners and to survive in nature. To better characterize these root-colonizing fungi in their broad diversity, researchers have isolated a variety of fungal strains from the roots of healthy plants across Europe and selected 41 that are representative of the root mycobiome of A.thaliana (Figure 1). In collaboration with INRAE Nancy (France) and the JGI (USA), the genomes of these fungi were sequenced and compared to other fungi that were previously described as saprotrophic, pathogenic, endophytic, or mycorrhizal. Surprisingly, the scientists found that most root mycobiota members – isolated from the roots of healthy plants – derived from ancestors that were likely pathogenic, and have retained a battery of genes that were previously shown to be lost in genomes of beneficial mycorrhizal fungi. These genes encode effector-like small secreted proteins that could modulate the host immune system, and enzymes that can degrade a large number of plant cell-wall constituents including pectin, cellulose, and hemicellulose. These findings raised the possibility that many of these fungi may have retained at least part of their ancestral pathogenic capabilities. To test this hypothesis, A. thaliana plants were grown in a closed system in the absence of any microorganism, or re-colonized with each of the selected 41 fungal isolates. This experiment identified a wide diversity of fungal effects on plant growth, ranging from highly detrimental to beneficial. Notably, the authors observed that the strains most harmful to the plant were colonizing roots much more aggressively than those having beneficial effects. Furthermore, the fungi most often detected in the roots of A. thaliana in nature were also the ones showing harmful effects on their host in mono-association experiments. Previous work from the group of Stéphane Hacquard had suggested that the mycobiome of A. thaliana can become detrimental when the host immune system and the root-inhabiting bacteria do not tightly control the proliferation of these fungi. These new results show that in nature, fungi with a high root-colonizing potential have a high pathogenic potential, explaining the need to control their growth. Using a combination of association methods, including machine-learning models, the authors then associated the fungal effects on A. thaliana growth to genome compositions, and successfully identified a candidate gene family that could explain the detrimental effects and root colonization abilities. This family (pectate lyase PL1_7) encodes enzymes that degrade pectin, an essential constituent of plant cell walls, which is especially abundant in the roots of dicotyledonous plants such as A. thaliana. To validate its involvement in fungal detrimental activity, a gene from this family was introduced into the genome of a fungal species that naturally does not harbor it. The resulting mutant strain was able to colonize roots more aggressively than the original isolate and this increase in fungal load in roots was associated with a penalty on plant performance. According to the last author of the study Stéphane Hacquard, “These results indicate that repertoires of plant cell-wall degrading enzymes in fungal genomes are key genetic determinants driving access to the root endosphere and explaining why robust root colonizers can potentially become harmful if they degrade roots too aggressively.” This study highlighted that the mycobiome of healthy plants in nature is composed of both friends and foes. This finding offers a new perspective on the effects of fungi on plant health, and possibly opens the door to new exciting considerations and developments for agriculture. Taking advantage of these results could potentially provide a rationale on how to design and optimize synthetic fungal communities to obtain beneficial outcomes on plant performance. Reference: “Genetic determinants of endophytism in the Arabidopsis root mycobiome” by Fantin Mesny, Shingo Miyauchi, Thorsten Thiergart, Brigitte Pickel, Lea Atanasova, Magnus Karlsson, Bruno Hüttel, Kerrie W. Barry, Sajeet Haridas, Cindy Chen, Diane Bauer, William Andreopoulos, Jasmyn Pangilinan, Kurt LaButti, Robert Riley, Anna Lipzen, Alicia Clum, Elodie Drula, Bernard Henrissat, Annegret Kohler, Igor V. Grigoriev, Francis M. Martin and Stéphane Hacquard, 10 December 2021, Nature Communications. DOI: 10.1038/s41467-021-27479-y

Humans have inhabited Hispaniola for roughly six thousand years, during which time the island’s rodent diversity dwindled from 11 species to just 1. By determining exactly when these species last appear in the fossil record, authors of a new study pinpoint the historical events that led to their extinction. Credit: Florida Museum photo by Kristen Grace European Colonization and Invasive Species Contributed to Hispaniola’s Rodent Extinctions. The Caribbean island of Hispaniola used to host 11 different rodent species, but now only one remains in the island’s two countries of Haiti and the Dominican Republic. The reasons for the extinction of the other species are unclear, as the timing of each disappearance is unknown, making it hard to identify the cause. Furthermore, the remaining species’ prospects for survival are uncertain. A recent study provides new insights into the history of rodent species on Hispaniola. Scientists from the Florida Museum of Natural History and the Museo Nacional de Historia Natural in the Dominican Republic conducted carbon-dating on the fossils of six hutia species, which are related to capybaras and resemble a combination of a squirrel and a beaver. They also studied thousands of bones previously collected over 40 years and stored at the Florida Museum of Natural History, searching for similarities that may shed light on the recent wave of rodent extinctions. “These hidden gems are what made this study possible,” said Lazaro Viñola Lopez, a doctoral student at the University of Florida and lead author on the study. Despite the preponderance of material available for study, radiocarbon dating on fossils collected in the tropics can be tricky business. The region’s high humidity, moisture, and heat accelerate the degradation of collagen in the fossils needed to date them, leaving scientists with open questions about their antiquity. “They mineralize and lose all organic material really quickly, so there are limitations to what you can date,” Lopez said. The fossils used for this study, however, were excavated from caves and sinkholes, where they were sheltered from harsh conditions and safe from marauding scavengers. Sinkholes often act as traps for animals, which fall in and are unable to escape, while many of the bones found in caves were directly transported there by predators like the Hispaniolan giant barn owl (Tyto ostologa). These large predators declined alongside the hutias and may have succumbed to extinction when their food source disappeared. Hutias and the biological communities they supported flourished on Hispaniola for nearly 20 million years, and it was previously unclear when they began to disappear. Early theories speculated that the species went extinct due to rapid climate change at the end of the ice ages in the late Pleistocene more than 10,000 years ago. More recent theories posit that the arrival of Indigenous people in the Caribbean and the later arrival of Europeans may have played a stronger role. However, researchers have been unable to make an accurate estimate as to when they went extinct without knowing a “last appearance date,” or the age of the youngest specimen to have been discovered. Evidence Points to European Colonization Prior to this study, researchers had only a handful of radiocarbon dates for hutia fossils on which to base their assumptions. Here, the authors add carbon dates for an additional six species, all of which survived the period of climate change originally theorized to have done them in. This directly implicates humans in their disappearance. It is estimated that the first humans arrived on Hispaniola somewhere between 4,000 – 6,000 years ago. This lines up with a handful of older extinctions from the six dated species, including Rhizoplagiodontia lemkei, which was determined to have died out less than 6,000 years ago. Beginning roughly 3,000 years ago, another group of Indigenous people moved into the Caribbean from present-day Venezuela. These early islanders hunted hutias and even set up an inter-island exchange of the animals, but these practices seem to have been carried out sustainably. Instead, European colonization appears to have been the main cause of hutia decline. Radiocarbon dates indicate that seven species went extinct within the last 2,000 years. Of these, at least three coincided with the arrival of Europeans. Lopez suspects that gradual habitat destruction, rising human population numbers, and the introduction of invasive species eventually led to the demise of hutias along with several other mammal and bird species. “When Europeans came to the island they brought several animals with them, like rats, dogs, and cats,” he said. “Is it possible that these species went extinct because of competition with these new animals? That’s just one of the questions we can ask now because of this study.” According to Lopez, the results serve as a jumping-off point for many future studies into Caribbean rodents. “We are just scratching the surface,” he explained. “Right now, we only have nine new biometric dates. Imagine what we could do with 20, or even 50 dates. With a more detailed chronology, we can start to theorize about the past relationships between these species and the humans on the island.” Reference: “Endemic rodents of Hispaniola: biogeography and extinction timing during the Holocene” by Lazaro Willian Viñola-López, Jonathan I. Bloch, Juan N. Almonte Milán and Michelle J. LeFebvre, 29 October 2022, Quaternary Science Reviews. DOI: 10.1016/j.quascirev.2022.107828 The study was funded by the American Society of Mammalogists.

DVDV1551RTWW78V