Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Vietnam OEM/ODM hybrid insole services

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Pillow ODM design and manufacturing company in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Thailand anti-bacterial pillow ODM design

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.PU insole OEM production factory in Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan high-end foam product OEM/ODM factory

Yale scientists have reprogrammed the genetic code of an organism, creating a novel genomically recoded organism (GRO) with only one stop codon, enabling the production of synthetic proteins with new functions. This breakthrough paves the way for advanced biotherapeutics and biomaterials with vast medical and industrial applications. Yale researchers have created “Ochre,” a genomically recoded organism that enables the production of synthetic proteins with novel properties, paving the way for groundbreaking applications in medicine, biotechnology, and industry. Synthetic biologists from Yale successfully rewrote the genetic code of an organism—a novel genomically recoded organism (GRO) with a single stop codon—using a cellular platform they developed that enables the production of new classes of synthetic proteins. Researchers say these synthetic proteins offer the promise of innumerable medical and industrial applications that can benefit society and human health. A new study published in the journal Nature describes the creation of the landmark GRO, known as “Ochre,” which fully compresses redundant (or “degenerate”) codons into a single codon. A codon is a sequence of three nucleotides in DNA or RNA that codes for a specific amino acid, which serves as the biochemical building block for proteins. “This research allows us to ask fundamental questions about the malleability of genetic codes,” said Farren Isaacs, professor of molecular, cellular, and developmental biology at Yale School of Medicine and of biomedical engineering at Yale’s Faculty of Arts and Sciences, who is co-senior author of the paper. “It also demonstrates the ability to engineer the genetic code to endow multi-functionality into proteins and usher in a new era of programmable biotherapeutics and biomaterials.” Building on Past Breakthroughs in Genomic Recoding The landmark advance builds on a 2013 study by the team, published in Science, which described the construction of the first GRO. In that study, the researchers demonstrated new solutions for safeguarding genetically engineered organisms and for producing new classes of synthetic proteins and biomaterials with “unnatural,” or human-created, chemistries. Ochre is a major step toward creating a non-redundant genetic code in E. coli, specifically, which is ideally suited to produce synthetic proteins containing multiple, different synthetic amino acids. A codon, a sequence of three nucleotides in DNA and RNA that codes for a specific amino acid, acts like an “instruction manual” for protein synthesis, telling the cell which of the 20 natural amino acids to add to a growing protein chain — or, in the case of the three “stop” codons (known as TAG, TGA, and TAA), signaling the termination of protein synthesis. Yale scientists recoded a cell to have a single, non-degenerative TAA codon. The newly “free” TGA and TAG codons have been reassigned to encode nonstandard amino acids into synthetic proteins that possess new chemistries with innumerable applications. Credit: Yale University / Michael S. Helfenbein Jesse Rinehart, an associate professor of cellular and molecular physiology at the Yale School of Medicine and co-senior author on the study, called the breakthrough a “profound piece of whole genome engineering based on over 1,000 precise edits at a scale an order of magnitude greater than any engineering feat we have previously done.” “This is an exciting new platform technology that opens up an array of applications for biotechnology both in the academic realm and in the commercial sector,” Rinehart said. “We want to advance our general knowledge of science but we also want to enable industrial applications that are beneficial to society.” The codon, a sequence of three nucleotides in DNA or RNA, acts like an “instruction manual” for protein synthesis, telling the cell which of the 20 natural amino acids to add to a growing protein chain (or, in the case of “stop” codons, signaling the termination of protein synthesis). In this process, known as translation, the genetic information carried in a messenger RNA (mRNA), via the genetic code, dictates not only the order of amino acids but also when the process should start and stop. Reprogramming the Genetic Code for Novel Functions Michael Grome, a postdoctoral associate in molecular, cellular, and developmental biology at Yale and first author of the study, likened codons to three-letter words within a sentence in the genetic recipe for life. Inside the cell, he said, there are ribosomes that act like 3-D printers that read the recipe. Each word calls for one “ingredient” amino acid from among the list of 20 natural amino acids that make up proteins. “A lot of these words are equivalent, or synonymous,” Grome said. “We set out to add more ingredients for building proteins, so we took three of these words for ‘stop’ and made them one. Two words were removed, then we re-engineered the cell so they were ‘freed’ for new function. We then engineered a cell that recognized the word to say something new, to represent a new ingredient.” Specifically, the researchers eliminated two of the three stop codons that terminate protein production. The recoded genome reassigned four codons to non-degenerate functions, including the two recoded stop codons dedicated to encoding nonstandard, or unnatural, amino acids into protein. In addition to introducing thousands of precise edits across the genome, the work required AI-guided design and re-engineering of essential protein and RNA translation factors to create a strain capable of adding two nonstandard amino acids into its recipe book. These nonstandard amino acids imbue proteins with multiple new properties, such as programmable biologics with reduced immunogenicity (a substance’s ability to induce an immune response in the body) or biomaterials with enhanced conductivity. The results reflect years of recoding work by the two labs at the Yale Systems Biology Institute on West Campus. The collaboration between Rinehart and Isaacs dates to 2010 when they began working in neighboring labs. Isaacs has long been interested in engineering genomes — much like, he said, an architect might plan and make changes to a building. Rinehart’s work focuses on proteins — how they are made and how the stage might be set for them to carry out other actions. “We recognized we have complementary expertise and that both labs bring a broad set of expertise and capability,” Rinehart said. Isaacs is excited about what he describes as the potentially “killer” applications for programmable protein biologics that the new platform will make possible. One such application involves engineering protein drugs with synthetic chemistries to decrease the frequency of dosing or undesirable immune responses. The team reported such an application using their first-generation GRO in a 2022 study. In that study they encoded non-standard amino acids into protein, demonstrating a safer, controllable approach to precisely tune the half-life of protein biologics. The new Ochre cell expands these capabilities for use in the construction of multi-functional biologics. Isaacs and Rinehart are currently acting as advisors to Pear Bio, a Yale biotechnology spin-off that has licensed the technology for commercializing programmable biologics. Reference: “Engineering a genomically recoded organism with one stop codon” by Michael W. Grome, Michael T. A. Nguyen, Daniel W. Moonan, Kyle Mohler, Kebron Gurara, Shenqi Wang, Colin Hemez, Benjamin J. Stenton, Yunteng Cao, Felix Radford, Maya Kornaj, Jaymin Patel, Maisha Prome, Svetlana Rogulina, David Sozanski, Jesse Tordoff, Jesse Rinehart and Farren J. Isaacs, 5 February 2025, Nature. DOI: 10.1038/s41586-024-08501-x

Every year, millions of birds undertake incredible journeys, often covering thousands of miles, to reach their seasonal habitats. This annual migration is driven by changes in food availability, weather patterns, and the need to breed. The UCLA study has the potential to enhance scientists’ understanding of the dangers faced by birds and their capacity for adaptation. It is widely understood that adverse weather conditions can disorient birds during their fall migrations, leading them to end up in unfamiliar territory. But why, even when the weather is not a major factor, do birds travel far away from their usual routes? According to a recent paper by ecologists at the University of California, Los Angeles (UCLA), disturbances in the Earth’s magnetic field may cause birds to stray from their migration paths, a phenomenon known as “vagrancy.” This can occur even in ideal weather conditions and is particularly prevalent during fall migration. The findings were recently published in the journal Scientific Reports. With North America’s bird populations steadily declining, assessing the causes of vagrancy could help scientists better understand the threats birds face and the ways they adapt to those threats. For example, birds that wind up in unfamiliar territory are likely to face challenges finding food and habitats that suit them, and may die as a result. But it also could be beneficial for birds whose traditional homes are becoming uninhabitable due to climate change, by “accidentally” introducing the animals into geographic regions that are now better suited for them. The Role of Geomagnetic Fields in Migration Earth’s magnetic field, which runs between the North and South Poles, is generated by several factors, both above and below the planet’s surface. Decades’ worth of lab research suggests that birds can sense magnetic fields using magnetoreceptors in their eyes. The new UCLA study lends support to those findings from an ecological perspective. “There’s increasing evidence that birds can actually see geomagnetic fields,” said Morgan Tingley, the paper’s corresponding author and a UCLA associate professor of ecology and evolutionary biology. “In familiar areas, birds may navigate by geography, but in some situations, it’s easier to use geomagnetism.” But birds’ ability to navigate using geomagnetic fields can be impaired when those magnetic fields are disturbed. Such disturbances can come from the sun’s magnetic field, for example, particularly during periods of heightened solar activity, such as sunspots and solar flares, but also from other sources. “If the geomagnetic field experiences disturbance, it’s like using a distorted map that sends the birds off course,” Tingley said. Evidence Linking Geomagnetic Disturbances to Vagrancy Lead researcher Benjamin Tonelli, a UCLA doctoral student, worked with Tingley and postdoctoral researcher Casey Youngflesh to compare data from 2.2 million birds, representing 152 species, that had been captured and released between 1960 and 2019 — part of a United States Geological Survey tracking program — against historic records of geomagnetic disturbances and solar activity. While other factors such as weather likely play bigger roles in causing vagrancy, the researchers found a strong correlation between birds that were captured far outside of their expected range and the geomagnetic disturbances that occurred during both fall and spring migrations. But the relationship was particularly pronounced during the fall migration, the authors noted. Geomagnetic disturbances affected the navigation of both young birds and their elders, suggesting that birds rely similarly on geomagnetism regardless of their level of migration experience. Surprising Effects of Solar Activity The researchers had expected that geomagnetic disturbances associated with heightened solar activity would be associated with the most vagrancy. To their surprise, solar activity actually reduced the incidence of vagrancy. One possible reason is that radiofrequency activity generated by the solar disturbances could make birds’ magnetoreceptors unusable, leaving birds to navigate by other cues instead. “We think the combination of high solar activity and geomagnetic disturbance leads to either a pause in migration or a switch to other cues during fall migration,” Tonelli said. “Interestingly, birds that migrate during the day were generally exceptions to this rule — they were more affected by solar activity.” Although the researchers only studied birds, their methods and findings could help scientists understand why other migratory species, including whales, become disoriented or stranded far from their usual territory. “This research was actually inspired by whale strandings, and we hope our work will help other scientists who study animal navigation,” Tingley said. To make the research more accessible to the birdwatching public, Tonelli developed a web-based tool that tracks geomagnetic conditions and predicts vagrancy in real-time. The tracker is offline during the winter, but it will go live again in the spring, when migration begins again. Reference: “Geomagnetic disturbance associated with increased vagrancy in migratory landbirds” by Benjamin A. Tonelli, Casey Youngflesh, and Morgan W. Tingley, 9 January 2023, Scientific Reports. DOI: 10.1038/s41598-022-26586-0

Plastics are widely used but difficult to degrade, posing an ecological challenge. A team from SIAT developed degradable “living plastics” using synthetic biology and polymer engineering. They engineered Bacillus subtilis spores to produce Burkholderia cepacia lipase (BC-lipase), an enzyme that breaks down plastic. These spores were mixed with poly(caprolactone) (PCL) to create the plastics, maintaining the material’s physical properties. When the plastic surface is eroded, the spores release the enzyme, leading to a nearly complete breakdown of the plastic. Credit: Dai Zhuojun Scientists developed engineered spores embedded in plastics that remain stable during use but degrade rapidly when exposed to specific environmental triggers. This innovative approach could significantly mitigate plastic pollution. The findings, led by Dr. Dai Zhuojun’s research group at the Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), were recently published in Nature Chemical Biology. The study leverages the natural resilience of spores, which can endure extreme environmental conditions, by programming them to secrete plastic-degrading enzymes under specific circumstances. These spores are embedded into plastic matrices through standard plastic processing methods, such as high temperature, high pressure, or the use of organic solvents. In normal conditions, the spores remain dormant, ensuring the plastic’s stable performance. However, when exposed to specific triggers like surface erosion or composting, the spores activate and initiate the degradation process, leading to the plastic’s complete breakdown. Research Background The invention of plastics has improved our daily lives, but the massive production and improper disposal of plastic waste have made plastic pollution a major environmental issue. In 2016, Yoshida et al. discovered a bacterium, Ideonella sakaiensis, in poly (ethylene terephthalate) (PET)-contaminated soil near a recycling facility in Japan. This bacterium can grow using PET as its main carbon source by producing two key enzymes: PETase and MHETase. Since then, numerous synthetic biology research has been focused on discovering, designing, and evolving the relevant plastic-degrading enzymes, but there has been little exploration of innovative methods for creating degradable plastics. Dormant Spores and Living Plastics Microorganisms have developed intrinsic mechanisms to defend against harsh conditions over billions of years. One classical example is the formation of spores that are resilient to dryness, high temperatures, and high pressure (similar conditions in plastics processing). Using synthetic biology, the research team engineered Bacillus subtilis with a genetic circuit to control the secretion of a plastic-degrading enzyme (lipase BC from Burkholderia cepacia). Under stress from heavy metal ions, Bacillus subtilis forms spores. The team mixed these engineered spores with poly (caprolactone) (PCL) plastic granules and produced spore-containing plastics through high-temperature extrusion or solvent dissolution. Tests showed that these “living plastics” had similar physical properties to regular PCL plastics. During daily use, the spores remain dormant, ensuring the plastic’s stable performance. Spore Release and Degradation Initiation The first key step in plastic degradation is to release the spores embedded in the living plastic for cell revival. Researchers have first demonstrated two methods of spore release. One method uses an enzyme (lipase CA) to erode the plastic surface. These released spores then germinated and expressed the lipase BC, which bound to the ends of PCL polymer chains and near-completely degraded the PCL molecules (final molecular weight <500 g/mol). The results showed that living plastic could degrade efficiently within 6-7 days, while ordinary PCL plastic subjected only to surface damage (lipase CA) still had a large amount of plastic debris after 21 days. Another method for spores release is composting. In the absence of any additional exogenous agents, living plastics in soil could completely degrade within 25-30 days, while traditional PCL plastic took about 55 days to degrade to a level that was invisible to the naked eye. Beyond PCL Plastics As mentioned earlier, PCL’s processing conditions are relatively ‘mild’ among plastics. To verify the system’s general applicability, the team continued to test other commercial plastic systems. They mixed spores carrying GFP expression plasmids with PBS (polybutylene succinate), PBAT (polybutylene adipate-co-terephthalate), PLA (polylactic acid), PHA (polyhydroxyalkanoates), and even PET (poly (ethylene terephthalate)) and processed the mixture at temperatures as high as 300oC. By releasing the spores through physical grinding, they surprisingly found that the spores could still revive and expressed the GFP. These results have laid a solid foundation for extending the method with other types of plastics. To validate the potential for scaling up the system, the research team also conducted a small-scale industrial test on PCL system using a single-screw extruder. The generated living PCL still exhibited rapid and efficient degradation property (degrade within 7 days). In the absence of external factors, the living PCL maintained a stable shape, demonstrating its robustness during the service (stable in Sprite for two months). This study provides a novel method for fabricating green plastics that can function steadily when the spores are latent and decay when the spores are aroused and shed light on the development of materials for sustainability. Reference: “Degradable living plastics programmed by engineered spores” by Chenwang Tang, Lin Wang, Jing Sun, Guangda Chen, Junfeng Shen, Liang Wang, Ying Han, Jiren Luo, Zhiying Li, Pei Zhang, Simin Zeng, Dianpeng Qi, Jin Geng, Ji Liu and Zhuojun Dai, 21 August 2024, Nature Chemical Biology. DOI: 10.1038/s41589-024-01713-2

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