Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Innovative insole ODM solutions factory in Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Latex pillow OEM production facility in Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ESG-compliant OEM/ODM production factory in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia OEM/ODM hybrid insole services

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China sustainable material ODM solutions

Scientists at the National Institutes of Health have identified new genetic risk factors for two types of non-Alzheimer’s dementia, with a previously unknown variant discovered in the TCPN1 gene associated with Lewy body dementia. Discovery Provides Potential Clues for Lewy Body and Frontotemporal Dementias In a collaborative effort between the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS) and National Institute on Aging (NIA), scientists have discovered new genetic risk factors for non-Alzheimer’s dementia types, Lewy body dementia (LBD) and frontotemporal dementia (FTD). Published in Cell Genomics, the research team identified large-scale DNA changes, known as structural variants, by analyzing thousands of DNA samples using cutting-edge computer algorithms and machine learning. The study revealed a previously unknown variant in the TCPN1 gene associated with a higher risk for developing LBD, while also confirming well-established risk factors for FTD in the C9orf72 and MAPT genes. The researchers have made the analysis code and raw data available to the scientific community, along with an interactive app for further study. Scientists at the National Institutes of Health have identified new genetic risk factors for two types of non-Alzheimer’s dementia. These findings were published in Cell Genomics and detail how researchers identified large-scale DNA changes, known as structural variants, by analyzing thousands of DNA samples. The team discovered several structural variants that could be risk factors Lewy body dementia (LBD) and frontotemporal dementia (FTD). The project was a collaborative effort between scientists at the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) at NIH. Structural variants have been implicated in a variety of neurological disorders. Unlike more commonly studied mutations, which often affect one or a few DNA building blocks called nucleotides, structural variants represent at least 50 but often hundreds, or even thousands, of nucleotides at once, making them more challenging to study. “If you imagine that our entire genetic code is a book, a structural variant would be a paragraph, page, or even an entire chapter that has been removed, duplicated, or inserted in the wrong place,” said Sonja W. Scholz, M.D., Ph.D., investigator in the neurogenetics branch of NINDS and senior author of this study. By combining cutting-edge computer algorithms capable of mapping structural variations across the whole genome with machine learning, the research team analyzed whole-genome data from thousands of patient samples and several thousand unaffected controls. TCPN1 Variant in Lewy Body Dementia A previously unknown variant in the gene TCPN1 was found in samples from patients with LBD, a disease, that like Parkinson’s disease, is associated with abnormal deposits of the protein alpha-synuclein in the brain. This variant, in which more than 300 nucleotides are deleted from the gene, is associated with a higher risk for developing LBD. While this finding is new for LBD, TCPN1 is a known risk factor for Alzheimer’s disease, which could mean that this structural variant plays a role in the broader dementia population. “From a genetics standpoint, this is a very exciting finding,” said Dr. Scholz. “It provides a point of reference for cell biology and animal model studies and possibly down the road, a target for intervention.” By looking at a group of 50 genes implicated in inherited neurodegenerative diseases, the investigators were able to identify additional rare structural variants, including several that are known to cause disease. The analyses also identified two well-established risk factors for FTD changes in the C9orf72 and MAPT genes. These proof-of-concept findings bolstered the strength of the study’s new findings by demonstrating that the algorithms were properly working.   Because reference maps for currently-available structural variants are limited, the researchers generated a catalog based on the data obtained in these analyses. The analysis code and all the raw data are now available to the scientific community for use in their studies. An interactive app also allows investigators to study their genes of interest and ask which variants are present in controls vs. LBD or FTD cases. The authors assert these resources may make complex genetic data more accessible to non-bioinformatics experts, which will accelerate the pace of discovery. “Research to unravel the intricate genetic architecture of neurodegenerative diseases is resulting in significant advances in scientific understanding,” said Bryan J. Traynor, M.D., Ph.D., senior investigator at NIA. “With each discovery, we shed light on the mechanisms behind neuronal cell death or dysfunction, paving the way for precision medicine to combat these debilitating and fatal disorders.” Researchers expect that the dataset will continue to grow as additional data are analyzed. Reference: “Genome-wide structural variant analysis identifies risk loci for non-Alzheimer’s dementias” by Karri Kaivola, Ruth Chia, Jinhui Ding, Memoona Rasheed, Masashi Fujita, Vilas Menon, Ronald L. Walton, Ryan L. Collins, Kimberley Billingsley, Harrison Brand, Michael Talkowski, Xuefang Zhao, Ramita Dewan, Ali Stark, Anindita Ray, Sultana Solaiman, Pilar Alvarez Jerez, Laksh Malik, Ted M. Dawson, Liana S. Rosenthal, Marilyn S. Albert, Olga Pletnikova, Juan C. Troncoso, Mario Masellis, Julia Keith, Sandra E. Black, Luigi Ferrucci, Susan M. Resnick, Toshiko Tanaka, The American Genome Center, International LBD Genomics Consortium, International ALS/FTD Consortium, PROSPECT Consortium, Eric Topol, Ali Torkamani, Pentti Tienari, Tatiana M. Foroud, Bernardino Ghetti, John E. Landers, Mina Ryten, Huw R. Morris, John A. Hardy, Letizia Mazzini, Sandra D’Alfonso, Cristina Moglia, Andrea Calvo, Geidy E. Serrano, Thomas G. Beach, Tanis Ferman, Neill R. Graff-Radford, Bradley F. Boeve, Zbigniew K. Wszolek, Dennis W. Dickson, Adriano Chiò, David A. Bennett, Philip L. De Jager, Owen A. Ross, Clifton L. Dalgard, J. Raphael Gibbs, Bryan J. Traynor and Sonja W. Scholz, 4 May 2023, Cell Genomics. DOI: 10.1016/j.xgen.2023.100316 This work was supported in part by the Intramural Research Program at NINDS and NIA.

The Leaf litter frog (Haddadus binotatus) emits a distress call at frequencies that humans cannot hear but predators can. Credit: Henrique Nogueira For the first time in South America, researchers recorded the use of ultrasound by a frog endemic to the Atlantic Rainforest in Brazil, which has more species of amphibians than any other country. Other frogs may use very high-frequency calls. A study reported in the journal Acta Ethologica recorded the use of ultrasound by amphibians for the first time in South America. It also describes the first documented case of the use of ultrasound for defense against predators, in a distress call of ear-piercing intensity to many animals, but inaudible to humans. “Some potential predators of amphibians, such as bats, rodents and small primates, are able to emit and hear sounds at this frequency, which humans can’t. One of our hypotheses is that the distress call is addressed to some of these, but it could also be the case that the broad frequency band is generalist in the sense that it’s supposed to scare as many predators as possible,” said Ubiratã Ferreira Souza, first author of the article. The study was part of his master’s research at the State University of Campinas’s Institute of Biology (IB-UNICAMP) in São Paulo state, Brazil, with a scholarship from FAPESP. Unveiling the Ultrasonic World of Amphibians Another hypothesis is that the scream is meant to attract another animal to attack the predator which is threatening the amphibian, in this case, the Leaf litter frog (Haddadus binotatus), a species endemic to the Brazilian Atlantic Rainforest. The researchers recorded the distress call on two occasions. When they analyzed the sound using special software, they found that it had a frequency range of 7 kilohertz (kHz) to 44 kHz. Humans cannot hear frequencies higher than 20 kHz, which are classed as ultrasound. Observations of Defensive Behaviors in Frogs While emitting its distress call, this frog makes a series of movements typical of defense against predators. It raises the front of its body, opens its mouth wide and jerks its head backward. It then partially closes its mouth and emits a call that ranges from a frequency band audible to humans (7 kHZ-20 kHz) to an inaudible ultrasound band (20 kHz-44 kHz). “In light of the fact that amphibian diversity in Brazil is the highest in the world, with more than 2,000 species described, it wouldn’t be surprising to find that other frogs also emit sounds at these frequencies,” said Mariana Retuci Pontes, a co-author of the article and a PhD candidate at IB-UNICAMP with a scholarship from FAPESP. Potential Cross-Species Ultrasonic Communication The use of this strategy by another species may have been accidentally discovered by Pontes herself. In January 2023, during a visit to the Upper Ribeira State Tourism Park (PETAR) in Iporanga, São Paulo state, Pontes saw on a rock an animal that was probably a Hensel’s big-headed frog (Ischnocnema henselii), although she did not collect the animal to identify the species precisely. Holding the frog by the legs in an attempt to take a photograph, she was surprised to find that its defensive movement and distress call closely resembled those of H. binotatus. A lancehead pit viper (Bothrops jararaca) was a few feet away, apparently confirming the hypothesis that this behavior is a response to predators. Research Evolution and Future Directions She was able to record a video but could not analyze the sound track to confirm the presence of the ultrasound frequency band. Taking hold of a frog’s legs is a move typically used by researchers to simulate an attack by a predator, according to the documentation for H. binotatus. “Both species live in leaf litter, are similar in size [between 3 cm and 6 cm], and have similar predators, so it’s possible that I. henselii also uses this distress call with ultrasound to defend itself against natural enemies,” said Luís Felipe Toledo, last author of the article and a professor at IB-UNICAMP. He is principal investigator for the project “From the natural history to the conservation of Brazilian amphibians,” supported by FAPESP. The first time Toledo suspected that H. binotatus emitted sounds at frequencies too high for humans to hear was in 2005 when he was a PhD candidate at São Paulo State University’s Institute of Biosciences (IB-UNESP) in Rio Claro. However, he was unable to verify frequencies above 20 kHz owing to limitations of the equipment available at the time. There are also recordings of ultrasound calls by three Asian amphibian species, but the frequencies concerned are used for communication between individuals of the same species. In mammals, ultrasound use is common among whales, bats, rodents and small primates. Its use by amphibians for self-defense against predators was unknown until the study by Souza et al. The researchers now plan to address a number of questions raised by the discovery, such as which predators are sensitive to the distress call, how they react to it, and whether the call is intended to scare them or to attract their natural enemies. “Could it be the case that the call is meant to attract an owl that will attack a snake that’s about to eat the frog?” Souza wondered. Reference: “Ultrasonic distress calls and associated defensive behaviors in Neotropical frogs” by Ubiratã Ferreira Souza, Guilherme Augusto-Alves, Mariana Retuci Pontes, Lucas Machado Botelho, Edélcio Muscat and Luís Felipe Toledo, 8 January 2024, acta ethologica. DOI: 10.1007/s10211-023-00435-3 The study was also supported by FAPESP via a doctoral scholarship awarded to Guilherme Augusto Alves and another project led by Toledo.

Genetic mutations are changes or variations in an organism’s DNA sequence, which can have a range of effects on its traits and characteristics. Some mutations can have a positive impact, such as those that provide resistance to diseases, while others can be harmful, causing genetic disorders or increasing the risk of certain diseases. Mutation Transmission in the Male Germline The male reproductive system is a hotspot for the emergence of new genes, which may explain why more new mutations are passed down from fathers rather than mothers. However, the reason why older fathers tend to pass on more mutations than younger ones has remained unclear. A recent study in Nature Ecology & Evolution by scientists from Rockefeller University sheds light on why older male fruit flies are more likely to transmit mutations to their offspring. This research could provide insight into the risk of inherited diseases in humans. Researchers in Li Zhao‘s lab studied mutations that occur during the production of sperm from germline cells, known as spermatogenesis. They found that mutations are common in the testes of both young and old fruit flies, but more abundant in older flies from the outset. Moreover, many of these mutations seem to be removed in younger fruit flies during spermatogenesis by the body’s genomic repair mechanisms—but they fail to be fixed in the testes of older flies. “We were trying to test whether the older germline is less efficient at mutation repair, or whether the older germline just starts out more mutated,” says first author Evan Witt, a former graduate student in the lab and now a computational biologist at Biomarin Pharmaceuticals. “Our results indicate that it’s actually both. At every stage of spermatogenesis, there are more mutations per RNA molecule in older flies than in younger flies.” RNA sequencing data from fruit fly testes showing the marked difference between older sperm-related cells (teal, at left) and younger ones (pink, at right). Credit: Laboratory of Evolutionary Genetics and Genomics Self–Care at the Genetic Level Genomes keep themselves tidy using a handful of repair mechanisms. When it comes to testes, they have to work overtime; testes have the highest rate of gene expression of any organ. Moreover, genes that are highly expressed in spermatogenesis tend to have fewer mutations than those that are not. This sounds counterintuitive, but it makes sense: One theory to explain why the testes express so many genes holds that it might be a sort of genomic surveillance mechanism—a way to reveal, and then weed out, problematic mutations. But when it comes to older sperm, the researchers found, the weed-whacker apparently sputters out. Previous research suggests that a faulty transcription-coupled repair mechanism, which only fixes transcribed genes, could be to blame. Inherited or New Mutations? To get these results, scientists in the Laboratory of Evolutionary Genetics and Genomics did single-cell sequencing on the RNA from the testes of about 300 fruit flies, roughly half of them young (48 hours old) and half old (25 days old), advancing a line of inquiry they began in 2019. In order to understand whether the mutations they detected were somatic, or inherited from the flies’ parents, or de novo—arising in the individual fly’s germline—they then sequenced the genome of each fly. They were able to document that each mutation was a true original. “We can directly say this mutation was not present in the DNA of that same fly in its somatic cells,” says Witt. “We know that it’s a de novo mutation.” This unconventional approach—inferring genomic mutations from single-cell RNA sequencing and then comparing them to the genomic data—allowed the researchers to match mutations to the cell type in which they occurred. “It’s a good way to compare mutational load between cell types because you can follow them throughout spermatogenesis,” Witt says. The Human Connection The next step is to expand the analysis to more age groups of flies and test whether or not this transcription repair mechanism can occur—and if it does, identify the pathways responsible, Witt says. “What genes,” he wonders, “are really driving the difference between old and young flies in terms of mutation repair?” Because fruit flies have a high reproductive rate, investigating their mutation patterns can offer new insights into the effect of new mutations in human health and evolution, says Zhao. Witt adds, “It’s largely unknown whether a more mutated male germline is more or less fertile than a less mutated one. There’s not been very much research on it except for at a population level. And if people inherit more mutations from aging fathers, that increases the odds of de novo genetic disorders or certain types of cancers.” Reference: “Transcriptional and mutational signatures of the Drosophila ageing germline” by Evan Witt, Christopher B. Langer, Nicolas Svetec, and Li Zhao, 12 January 2023, Nature Ecology & Evolution. DOI: 10.1038/s41559-022-01958-x

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