Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Flexible manufacturing OEM & ODM Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam ODM expert for comfort products

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Taiwan custom neck pillow ODM

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Private label insole and pillow OEM Taiwan

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan graphene product OEM factory

A new robotic platform can speed up directed evolution more than 100-fold, and allows hundreds of evolving populations to be monitored at the same time. The work was led by Kevin Esvelt and colleagues at the MIT Media Lab. MIT’s PRANCE system revolutionizes directed evolution by leveraging robotics to perform numerous experiments simultaneously, enhancing the development of novel molecules and offering insights into the natural evolutionary process. Natural evolution is a slow process that relies on the gradual accumulation of genetic mutations. In recent years, scientists have found ways to speed up the process on a small scale, allowing them to rapidly create new proteins and other molecules in their lab. This widely-used technique, known as directed evolution, has yielded new antibodies to treat cancer and other diseases, enzymes used in biofuel production, and imaging agents for magnetic resonance imaging (MRI). Researchers at MIT have now developed a robotic platform that can perform 100 times as many directed-evolution experiments in parallel, giving many more populations the chance to come up with a solution, while monitoring their progress in real-time. In addition to helping researchers develop new molecules more rapidly, the technique could also be used to simulate natural evolution and answer fundamental questions about how it works. “Traditionally, directed evolution has been much more of an art than a science, let alone an engineering discipline. And that remains true until you can systematically explore different permutations and observe the results,” says Kevin Esvelt, an assistant professor in MIT’s Media Lab and the senior author of the new study. MIT graduate student Erika DeBenedictis and postdoc Emma Chory are the lead authors of the paper, which appears today in Nature Methods. Rapid Evolution Directed evolution works by speeding up the accumulation and selection of novel mutations. For example, if scientists wanted to create an antibody that binds to a cancerous protein, they would start with a test tube of hundreds of millions of yeast cells or other microbes that have been engineered to express mammalian antibodies on their surfaces. These cells would be exposed to the cancer protein that the researchers want the antibody to bind to, and researchers would pick out those that bind the best. Scientists would then introduce random mutations into the antibody sequence and screen these new proteins again. The process can be repeated many times until the best candidate emerges. About 10 years ago, as a graduate student at Harvard University, Esvelt developed a way to speed up directed evolution. This approach harnesses bacteriophages (viruses that infect bacteria) to help proteins evolve faster toward a desired function. The gene that the researchers hope to optimize is linked to a gene needed for bacteriophage survival, and the viruses compete against each other to optimize the protein. The selection process is run continuously, shortening each mutation round to the lifespan of the bacteriophage, which is about 20 minutes, and can be repeated many times, with no human intervention needed. Using this method, known as phage-assisted continuous evolution (PACE), directed evolution can be performed 1 billion times faster than traditional directed evolution experiments. However, evolution often fails to come up with a solution, requiring the researchers to guess which new set of conditions will do better. The technique described in the new Nature Methods paper, which the researchers have named phage and robotics-assisted near-continuous evolution (PRANCE), can evolve 100 times as many populations in parallel, using different conditions. In the new PRANCE system, bacteriophage populations (which can only infect a specific strain of bacteria) are grown in wells of a 96-well plate, instead of a single bioreactor. This allows for many more evolutionary trajectories to occur simultaneously. Each viral population is monitored by a robot as it goes through the evolution process. When the virus succeeds in generating the desired protein, it produces a fluorescent protein that the robot can detect. “The robot can babysit this population of viruses by measuring this readout, which allows it to see whether the viruses are performing well, or whether they’re really struggling and something needs to be done to help them,” DeBenedictis says. If the viruses are struggling to survive, meaning that the target protein is not evolving in the desired way, the robot can help save them from extinction by replacing the bacteria they’re infecting with a different strain that makes it easier for the viruses to replicate. This prevents the population from dying out, which is a cause of failure for many directed evolution experiments. “We can tune these evolutions in real-time, in direct response to how well these evolutions are occurring,” Chory says. “We can tell when an experiment is succeeding and we can change the environment, which gives us many more shots on goal, which is great from both a bioengineering perspective and a basic science perspective.” Novel Molecules In this study, the researchers used their new platform to engineer a molecule that allows viruses to encode their genes in a new way. The genetic code of all living organisms stipulates that three DNA base pairs specify one amino acid. However, the MIT team was able to evolve several viral transfer RNA (tRNA) molecules that read four DNA base pairs instead of three. In another experiment, they evolved a molecule that allows viruses to incorporate a synthetic amino acid into the proteins they make. All viruses and living cells use the same 20 naturally occurring amino acids to build their proteins, but the MIT team was able to generate an enzyme that can incorporate an additional amino acid called Boc-lysine. The researchers are now using PRANCE to try to make novel small-molecule drugs. Other possible applications for this kind of large-scale directed evolution include trying to evolve enzymes that degrade plastic more efficiently, or molecules that can edit the epigenome, similarly to how CRISPR can edit the genome, the researchers say. With this system, scientists can also gain a better understanding of the step-by-step process that leads to a particular evolutionary outcome. Because they can study so many populations in parallel, they can tweak factors such as the mutation rate, size of original population, and environmental conditions, and then analyze how those variations affect the outcome. This type of large-scale, controlled experiment could allow them to potentially answer fundamental questions about how evolution naturally occurs. “Our system allows us to actually perform these evolutions with substantially more understanding of what’s happening in the system,” Chory says. “We can learn about the history of the evolution, not just the end point.” Reference: “Systematic molecular evolution enables robust biomolecule discovery” by Erika A. DeBenedictis, Emma J. Chory, Dana W. Gretton, Brian Wang, Stefan Golas and Kevin M. Esvelt, 30 December 2021, Nature Methods. DOI: 10.1038/s41592-021-01348-4 The research was funded by the MIT Media Lab, an Alfred P. Sloan Research Fellowship, the Open Philanthropy Project, the Reid Hoffman Foundation, the National Institute of Digestive and Kidney Diseases, the National Institute for Allergy and Infectious Diseases, and a Ruth L. Kirschstein NRSA Fellowship from the National Cancer Institute.

Particle simulations capture the cycles in which bacterial cells grow and then divide. Credit: Weady et. al (2024); Lucy Reading-Ikkanda/Simons Foundation Crowded cells form concentric circles by slowing growth, a study finds. Scott Weady’s team’s models could help manage harmful microbial growth. Like many other organisms, cells may become stressed when subjected to mosh-pit-level crowding. However, unlike other life forms, cells under physical stress from crowding by neighbors can find some relief by dramatically slowing their growth, forming a beautiful pattern of concentric circles in the process. This finding, discovered through simulations and modeling of dividing bacterial colonies, is described in a new study published in Physical Review Letters. These insights could inform new strategies for slowing the growth of harmful microorganisms in infections or manufacturing, says study lead author Scott Weady, a research fellow at the Flatiron Institute’s Center for Computational Biology in New York City. “I was definitely surprised to see that cells under this kind of mechanical stress can mitigate growth in that way,” Weady says. “It’s interesting that they form these concentric circles where each ring shows how much they’ve been stifled by their neighbors, ultimately impacting how large they can grow. It’s a robust pattern that comes from a very simple rule, and it’s just something that no one had really thought to measure before.” Weady co-authored the study with fellow Flatiron Institute researchers Bryce Palmer, Adam Lamson, Reza Farhadifar, and Michael Shelley, as well as Taeyoon Kim of Purdue University. An infographic explaining the new findings about cell proliferation. Credit: Lucy Reading-Ikkanda/Simons Foundation A Deep Dive Into Dividing Cells Weady’s group is interested in biophysical modeling — or, as he puts it, how small-scale rules govern large-scale behaviors. In this case, his team wanted to investigate cell proliferation, the process by which cells divide to make more copies of themselves. The group began with an exploratory approach, examining simulations of growing bacterial colonies. In the beginning, they were looking at more general measures like cell size regulation but then started noticing a pattern. Typically, the cell proliferation process is exponential: A cell splits in two, and those offspring split in two, and so forth, to keep growing at an increasing rate. In their simulations, however, the team noticed that cells weren’t dividing as you’d expect — in fact, their proliferation rate significantly slowed as their environment became more crowded. “You start with a single cell, which feels little or no stress. Then it divides, and those cells divide, and the cells closer to the center get more and more stressed because there’s more pushing on them, and that causes them to slow their growth,” Weady says. “And so as you move toward the edge of the circle, you get these bands of nonuniform stress sensitivity that manifest as concentric circles.” A video illustration of the continuum model shows how the process plays out in motion. Credit: Weady et. al (2024) New Insights From Cellular Modeling This initial work is based on particle simulations, which illustrate how the proliferation process plays out in a relatively small number of cells. Based on this data, the team then developed what’s called a continuum model, which estimates how the process could work in extremely large numbers of cells. “With particle simulations, you’re looking at something discrete — in this case bacteria that you’re tracking over time,” says Weady. “But the continuum model operates differently, by assuming that the number of particles is very large, so that you can represent it as a continuous material. This helps us better investigate the process on a larger scale and understand how robust it is.” Excitingly, the team found that their continuum model matched up very well with what they saw in the particle simulations, suggesting that their hunch was true: Cells backed into a corner will slow their own growth, creating an arresting pattern in the process. Potential Applications and Future Research Cell proliferation is valuable to study because it’s such a fundamental process, but also because when the proliferating cells are harmful (think: a bacterial infection), they can cause detrimental effects. “It’s important to figure out how the process is naturally regulated, as well as how to control it,” says Weady. “Our model identifies environmental factors that can enhance a cell’s response to mechanical stress, and promoting these factors could slow down exponential growth.” The model developed in this study could also serve as a basis to investigate other cellular behaviors. “I think the model is a useful tool for people who want to look at perturbations to the way cells respond, whether through stress, nutrient access, or something else,” Weady says. “It’s very clear how to ask those questions with a model like this, so I find that exciting as far as what it will enable more broadly.” Reference: “Mechanics and Morphology of Proliferating Cell Collectives with Self-Inhibiting Growth” by Scott Weady, Bryce Palmer, Adam Lamson, Taeyoon Kim, Reza Farhadifar and Michael J. Shelley, 10 October 2024, Physical Review Letters. DOI: 10.1103/PhysRevLett.133.158402

A groundbreaking study by Prof. Benoit Vanhollebeke and his team reveals that brain blood vessels have a unique development process, paving the way for targeted therapies in neurological diseases. Cardiovascular diseases, such as heart attacks and strokes, stand as the top killers globally, taking approximately 18 million lives annually. This observation justifies the adage that you are only as old as your arteries, and explains why researchers are working relentlessly to understand how the cardiovascular system develops and functions. Led by Prof. Benoit Vanhollebeke – Professor at the Department of Molecular Biology, Faculty of Science, Université libre de Bruxelles and recent awardee of the 2024 Lambertine Lacroix Prize for Cardiovascular Diseases – a ULB team has just made an important discovery. Contrary to the generally accepted idea that blood vessels form in a similar way throughout the body, Giel Schevenels and colleagues have discovered that those irrigating the brain obey different, totally unprecedented rules. The researchers discovered that cerebral vessels are equipped with a specific enzyme that is essential for them to invade the brain. The findings were recently published in the journal Nature. The Blood-Brain Barrier and Future Therapeutic Approaches “What I find noteworthy in this study is that the mechanism of brain angiogenesis that we are disclosing simultaneously enables the vessels to acquire specific properties adapted to the neuronal environment, known as the blood-brain barrier. So there seems to be a functional alignment between the very birth of the vessels and their specific functions,” explains Benoit Vanhollebeke. The blood-brain barrier is a set of characteristics of the brain’s blood vessels that strongly limit exchanges between blood and brain tissue. This protects the brain from toxic components circulating in the blood. “The identification of this mechanism gives us hope that it will one day be possible to develop therapeutic approaches specifically targeting cerebral vessels, which is an important clinical issue in many neurological pathologies,” concludes the researcher. Reference: “A brain-specific angiogenic mechanism enabled by tip cell specialization” by Giel Schevenels, Pauline Cabochette, Michelle America, Arnaud Vandenborne, Line De Grande, Stefan Guenther, Liqun He, Marc Dieu, Basile Christou, Marjorie Vermeersch, Raoul F. V. Germano, David Perez-Morga, Patricia Renard, Maud Martin, Michael Vanlandewijck, Christer Betsholtz and Benoit Vanhollebeke, 3 April 2024, Nature. DOI: 10.1038/s41586-024-07283-6 Research in Professor Vanhollebeke’s laboratory has been supported in recent years by the ERC, the FNRS, the Queen Elisabeth Medical Foundation, the ULB Foundation and the Welbio.

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