Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Arch support insole OEM from Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Innovative pillow ODM solution in Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene insole manufacturer in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Latex pillow OEM production in Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.High-performance graphene insole OEM Taiwan

A new study has found that a class of toxins found in snake and mammalian venom evolved from the same ancestral gene. A new study has found that a class of toxins found in snake and mammalian venom evolved from the same ancestral gene. A new study has found that venoms found in snakes and mammals share a common origin Researchers traced the origin of a class of toxins, called kallikrein serine proteases, to a salivary protein found in a common ancestor Results from the evolutionary tree also showed that non-toxic salivary kallikreins in mammals, including those found in mice and human saliva, also evolved from the same ancestral gene The study provides strong evidence for the hypothesis that venom evolved from a common group of genes with toxic potential that existed in the ancestor of snakes and mammals Snakes, some lizards, and even a few mammals can have a venomous bite. Although these lineages split more than 300 million years ago, their venoms have evolved from the same ancestral salivary protein, reported scientists today (December 22, 2021) in BMC Biology. Researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) in Japan and the Australian National University focused on a class of toxins found in most snake venoms and all other reptile and mammalian venoms called kallikrein serine proteases and traced their origins to a gene found in a common ancestor. “Venoms are cocktails of toxic proteins that have evolved across the whole animal kingdom, typically as a method of killing or immobilizing prey,” explained Agneesh Barua, co-first author and PhD student at OIST. “The oral venom systems found in snakes are particularly complex, and the origin of their venoms is still unclear.” Salivary kallikreins, like those found in mice, humans, and venomous mammals like shrews and solenodons, are closely related to toxic serine protease kallikreins found in venomous snakes. Credit: OIST In a previous paper, Barua and his colleagues found that the mammal salivary gland and snake venom gland share a similar pattern of activity in a group of regulatory genes, suggesting that the foundation needed for venom to evolve exists in both snakes and mammals. “In that paper, we hypothesized that in the ancestor of snakes and mammals, there was a common group of genes that had a toxic potential,” said Barua. “Snakes and mammals then took different evolutionary paths, with snake lineages evolving diverse and increasingly toxic concoctions, while in mammals, venom did evolve, but to a much lesser degree. But what we wanted to know is whether the toxins within mammal and snake venom evolved from a common ancestral gene.” Kallikrein serine proteases are a kind of protein-degrading enzyme, which play a key role in regulating blood pressure. Mammal saliva contains small quantities of these proteins, although their function remains unclear to this day. But in venomous snakes and mammals, like shrews and solenodons, these proteins have evolved toxicity. When injected in high amounts, they drastically reduce blood pressure, potentially causing unconsciousness and even death. Early on, researchers noticed biochemical similarities between kallikrein serine proteases in snake venoms and those in mammal saliva, but scientists did not know until now whether they were, in fact, related. “There are so many different serine proteases that have a high degree of similarity, that until now, it was too difficult to isolate the right genes needed to determine the evolutionary history,” said Barua. With recent advances in genomic methods, the research group were able to identify and compare all the kallikrein genes in reptiles, amphibians, fishes and mammals to create an evolutionary tree. Excitingly, they found that snake venom kallikrein serine proteases and mammal salivary kallikreins did evolve from the same ancestral gene. “This is really strong evidence for our hypothesis that venom evolved from a common group of genes in an ancestor that had a toxic potential,” said Barua. “But the most surprising thing was that non-toxic salivary kallikreins, like those found in humans and mice, also evolved from the same ancestral gene.” In fact, the researchers found that the non-toxic kallikreins in mammal saliva were more closely related to the venomous toxins found in snakes than to other kallikreins found within mammals. Overall, this evidence suggests that salivary kallikrein proteins in mammals, including humans, also have the evolutionary potential to become toxic. But, Barua quickly added, there is a caveat. “Just because we have the building blocks to evolve venom doesn’t mean this will occur. Venom is really energetically expensive to make, so there had to be a strong ecological pressure for it, which humans, and most mammals don’t have.” But what this does tell us, he said, is that the line between venomous and non-venomous mammals is blurrier than previously thought. Reference: “Co-option of the same ancestral gene family gave rise to mammalian and reptilian toxins” by Agneesh Barua, Ivan Koludarov and Alexander S. Mikheyev, 23 December 2021, BMC Biology. DOI: 10.1186/s12915-021-01191-1

New research explores the link between genetic mutations and infertility, specifically focusing on mitochondrial disruptions in egg cells. It opens potential new treatment strategies for infertility by targeting mitochondrial abnormalities. Approximately 48 million couples globally face infertility challenges, which can arise from multiple factors. In mammals, such as humans, the ovaries are responsible for egg production. Dysfunctions in this process can result in female infertility. Premature ovarian insufficiency is one such condition, marked by impaired egg production before reaching the age of 40. Up to 3.7% of females experience infertility as a result of this condition, and around 30% of cases are due to genetic variations. Professor Kehkooi Kee, from Tsinghua University, China, who helped lead the study, has been investigating this condition for several years. “In 2019, our collaborators, Professor Li’s team, encountered a family with premature ovarian insufficiency in which changes to a gene called Eif4enif1 appeared to be responsible for the disease,” said Professor Kee. The researchers decided to reproduce this genetic change in mice to try to understand how it affects human infertility. They show that the eggs of these mice are affected by changes to their mitochondria – the powerhouses of the cell – and published their new discovery in the journal Development. The researchers used CRISPR to introduce the genetic change in the mice. They allowed these mice to grow up and then compared their fertility with the fertility of mice whose DNA had not been edited. Yuxi Ding, the first author and a MD/PhD student who led the study, found that the average number of total follicles (the tiny sacs that contain developing eggs) was reduced by approximately 40% in older and genetically edited mice (the average pup number in every litter was reduced by 33%. Importantly, when grown in a dish, about half of the eggs that were fertilized did not survive beyond the early stages of development. This demonstrated that, just like the human patients, these mice were experiencing problems with fertility. Mitochondrial Disruption and Fertility When the researchers studied the eggs from these mice under the microscope, they noticed something unusual about their mitochondria. Mitochondria produce the energy that cells, including egg cells, need. Mitochondria are usually evenly distributed throughout the egg, but the mitochondria in eggs from mice with the genetic variation were clustered together. “We were actually surprised by the differences in the mitochondria,” said Professor Kee. “At the time we were doing this research, a link between Eif4enif1 and mitochondria had not been seen before.” It seems likely that these misbehaving mitochondria are contributing to the fertility problems in these mice, leading the researchers to propose that restoring proper mitochondrial behavior might improve fertility. This study provides direction for future research in human infertility, such as establishing whether mitochondrial defects are also found in the eggs of human patients with premature ovarian insufficiency and whether these same mitochondrial defects are observed in embryos after the eggs are fertilized. In addition, testing whether restoring the normal distribution of mitochondria improves fertility could become a new treatment strategy. “Our research suggests that rescuing oocyte mitochondria abnormality could be a potential therapeutic target for clinical infertility patients with genetic variants,” says Professor Kee. The study was funded by the National Natural Science Foundation of China, the Outstanding Young Talents Program of the Capital Medical University, the Ministry of Science and Technology of the People’s Republic of China, and the Beijing Hospital Authority Youth Program.

DNA valve controlling molecular processes along DNA. Credit: Thomas Gorochowski Scientists created DNA valves for controlling cellular processes, using nanopore sequencing for rapid development. This technology opens new avenues for gene regulation and genome editing. Scientists at the University of Bristol have developed new biological parts that are able to shape the flow of cellular processes along DNA. The work, now published in the journal Nature Communications, offers a fresh perspective on how information is encoded in DNA and new tools for building sustainable biotechnologies. Despite being invisible to the naked eye, microorganisms are integral for our survival. They operate using DNA, often referred to as the code of life. DNA encodes numerous tools that could be useful to us, but we currently lack a complete understanding of how to interpret DNA sequences. Challenges in Understanding Microbial DNA Matthew Tarnowski, first author and a PhD student in Bristol’s School of Biological Sciences, said: “Understanding the microbial world is tricky. While reading a microbe’s DNA with a sequencer gives us a window into the underlying code, you still need to read a lot of different DNA sequences to understand how it actually works. It’s a bit like trying to learn a new language, but from only a few small fragments of text.” To tackle this problem, the Bristol team focused on how the information encoded in DNA is read, and specifically, how the flow of cellular processes along DNA are controlled. These biological information flows orchestrate many of the core functions of a cell and an ability to shape them would offer a way to guide cellular behaviors. Inspiration from Nature for DNA Valves Taking inspiration from nature, where it is known that flows on DNA are often complex and interwoven, the team focused on how these flows could be regulated by creating “valves” to tune the flow from one region of DNA to another. Dr. Thomas Gorochowski, senior author and Royal Society University Research Fellow at the University of Bristol, said: “Similar to a valve that controls the rate that a liquid flows through a pipe, these valves shape the flow of molecular processes along DNA. These flows allow cells to make sense of the information stored in their genomes and the ability to control them enables us to reprogram their behaviors in useful ways.” Designing new biological parts can typically take a huge amount of time. To get around this problem, the team employed methods to enable the rapid assembly of many DNA parts in parallel and a sequencing technology based on ‘nanopores’ that allowed them to simultaneously measure how each part worked. Dr. Gorochowski added: “Harnessing the unique features of nanopore sequencing was the step needed to unlock our ability to effectively design the biological valves. Rather than separately building and testing a couple at a time, we could instead assemble and test thousands in a mixed pool, helping us pull apart their design rules and better understand how they work.” Applications and Future Directions The authors go on to further show how valves can be used for regulating other biological components in the cell, opening avenues to the future simultaneous control of many genes and complex editing of genomes. Looking forward, the team are currently considering how this technology could be used responsibly. Dr. Mario Pansera, distinguished researcher of the Post-Growth Innovation Lab at the University of Vigo, Spain, said: “Now that they have crafted these tools, a big question is how they can be used responsibly and equitably in the real world. Post-growth entrepreneurship offers useful approaches for imagining more deliberative and inclusive ways to put such technology at the service of people.” Reference: “Massively parallel characterization of engineered transcript isoforms using direct RNA sequencing” by Matthew J. Tarnowski and Thomas E. Gorochowski, 21 January 2022, Nature Communications. DOI: 10.1038/s41467-022-28074-5 This work was funded by the Royal Society, BBSRC/EPSRC Bristol Centre for Synthetic Biology (BrisSynBio) and EPSRC/BBSRC Synthetic Biology Centre for Doctoral Training (SynBioCDT) with support from the Bristol BioDesign Institute (BBI).

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