Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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🌐 Website: https://www.deryou-tw.com/
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Graphene sheet OEM supplier Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan graphene material ODM factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Graphene cushion OEM factory in Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam eco-friendly graphene material processing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Innovative insole ODM solutions in Taiwan

Researchers have made progress against citrus greening disease by developing hybrid citrus trees that produce desirable orange-like fruit and resist the disease. Through genetic analysis, they’ve created tools for early flavor profile screening, marking a significant step in ensuring future hybrids combine disease tolerance with the essential sweet orange flavor. Antibiotic-resistant infection is projected to catch up to cancer as the leading cause of death by 2050, making understanding and limiting the spread of antibiotic-resistant bacteria a priority worldwide. In a paper recently published in the Proceedings of the National Academy of Sciences (PNAS), a research team co-led by Michael S. Gilmore, Ph.D., Chief Scientific Officer at Mass Eye and Ear, describes the discovery of 18 never-before-seen species of bacteria of the Enterococcus type that contain hundreds of new genes – findings that may offer new clues into antibiotic resistance as scientists hunt for ways to curb these infections. Enterococci are leading causes of multidrug-resistant infections, particularly following surgery and in hospitalized patients. The infections can be lethal and contribute to more than $30 billion annually in added healthcare costs. The Importance of Antibiotics “Over the past 75 years, antibiotics have saved hundreds of millions of lives and have contributed greatly to the success of all types of surgery,” said Gilmore, who also is director of the Infectious Disease Institute at Harvard Medical School. “Over the past 30 years, however, many of the most problematic bacteria have become increasingly resistant to antibiotics and this is now reaching crisis proportions. Our findings may improve understanding of how resistance genes spread to hospital bacteria and threaten human health.” Discovered in the 1920s, antibiotics like penicillin are compounds naturally produced by microbes in the soil. Gilmore notes that antibiotic-producing microbes thrive in rotting leaves and plant matter on the forest floor and give forest soil its smell. The Role of Insects in Antibiotic Resistance Gilmore and Ashlee Earl, Ph.D., director of the Bacterial Genomics Group at Broad, assembled an international team of scientists, including elite adventurers, to scour remote corners of the globe for scat, soil and other samples that would likely contain bacteria of the Enterococcus type. The diversity of specimens they collected spanned samples from penguins migrating through sub-Antarctic waters, duiker and elephants from Uganda; insects, bivalves, sea turtles, and wild turkeys from Brazil to the United States; kestrel and vultures from Mongolia; wallaby, swans, and wombats from Australia; and zoo animals and wild birds from Europe. The team’s collection efforts had previously led to the discovery of new classes of bacterial toxins and showed that Enterococcus bacteria arose about 425 million years ago when the first animals, ancestors of millipedes and worms, came onto land. They likely dominated the planet for about 50 million years before four-legged animals came ashore. Adventure Scientist Stevie Anna Plummer with scat and water samples collected during a 2016 Nepal expedition to collect samples for the Global Microbe Study. Credit: Adventure Scientists (photo by Paul Amos) Their most recent collections expanded the genus diversity of enterococcal strains by more than 25 percent and in doing so, uncovered more clues, revealing that insects and other invertebrates are likely by far the greatest natural source for enterococci bacteria, including species that are naturally antibiotic-resistant. “Until recently, most of what we’ve understood about the genetics of enterococcus come from those that make us sick, and that’s a problem — like trying to understand darkness without ever seeing the light,” said Earl. “Expanding our view to include those from outside of hospitals, with the help of citizen scientists, gave us the contrast we needed to identify how they make people sick in the hospital, and also gives the public the chance to co-own solutions.” Gilmore posits that insects have been eating the rotting plant material, and naturally giving themselves a dose of the antibiotics in the process. He hypothesizes that for hundreds of millions of years, bacteria in the guts of these insects like Enterococcus have been exposed to those antibiotics and have become resistant. In the 1940s and ’50s, when humans first began taking antibiotics, the resistances were already in the environment and worked their way into the bacteria that cause human infection. “The COVID-19 pandemic revealed that nature contains many infectious risks for humans,” said Gilmore. “This study shows that insects and their relatives in nature are a large and uncharacterized reservoir of undiscovered genes in microbes closely related to those that cause some of the most antibiotic-resistant infections.” Reference: “Global diversity of enterococci and description of 18 previously unknown species” by Julia A. Schwartzman, Francois Lebreton, Rauf Salamzade, Terrance Shea, Melissa J. Martin, Katharina Schaufler, Aysun Urhan, Thomas Abeel, Ilana L. B. C. Camargo, Bruna F. Sgardioli, Janira Prichula, Ana Paula Guedes Frazzon, Gonzalo Giribet, Daria Van Tyne, Gregg Treinish, Charles J. Innis, Jaap A. Wagenaar, Ryan M. Whipple, Abigail L. Manson, Ashlee M. Earl and Michael S. Gilmore, 28 February 2024, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2310852121 This project was supported by the Harvard-wide Program on Antibiotic Resistance, NIH/NIAID grant AI083214 and U19AI110818 to the Broad Institute. Portions of the work were supported by a Research Sabbatical grant to Gilmore from Research to Prevent Blindness to explore the origins of antibiotic resistance. Schwartzman was supported by the NIH Ruth Kirschstein fellowship F32GM121005.

New research indicates that pain experienced by newborns can lead to long-lasting genetic changes in their immune cells, intensifying pain responses as they grow, especially in females, highlighting the need for more specific treatments. Credit: SciTechDaily.com Research in mice indicates that focusing on genetic alterations in macrophage cells could be beneficial. Recent research increasingly suggests that the human body can retain memories of pain from injuries sustained in infancy, including life-saving surgeries, well into adolescence. These early experiences appear to change how a child’s pain response system develops at a genetic level, resulting in more intense reactions to pain later in life. Such changes also appear to occur more often among females. Now research led by experts at Cincinnati Children’s pinpoints how and where the genetic changes that create such long-lasting pain memory occur. According to their study, published in the journal Cell Reports, the key changes are occurring in developing macrophage cells—one of the major elements of the immune system. “Our experiments help to further confirm how pain memories affect female newborns for longer periods of time. Specifically, our data indicates that an epigenetic change (changes that occur post-birth vs inherited gene variations) occurs in macrophages after an early-life injury, which in turn promotes more-intense pain responses to other injuries that occur later in life,” says corresponding author Michael Jankowski, PhD, associate director of the Pediatric Pain Research Center at Cincinnati Children’s. Early-life injury can change how the body’s pain response system develops at a genetic level, leading to a pain “memory” that can affect response to injuries occurring years later, according to a study in Cell Reports published by experts at Cincinnati Children’s. Credit: Cell Reports and Cincinnati Children’s Adam Dourson, PhD, now working at Washington University in St. Louis, was the study’s lead author. The experiments show that male mice experiencing similar early-life injury show the same epigenetic changes but did not sustain the same long-term pain memory as females. Further testing also showed that changes, occurring in a gene called p75NTR, can be found in human macrophage cells. In female mice, the pain memory effects were detected for more than 100 days after the initial injury. Incisions caused stem cells in the bone marrow to generate macrophages that were “primed” to respond more intensely to injuries, which in turn increases pain. In humans, a similar timeframe would be roughly 10-15 years. “It was surprising to us to see how a single, local insult so dramatically altered the systemic macrophage epigenetic/transcriptomic landscape,” Jankowski says. This new understanding of neonatal pain memory underscores fundamental differences that exist between the genetic activity of a still-developing newborn immune system versus the mature system adults have. That means it will be complicated to determine how surgeons and care teams might go about adjusting how they manage recovery care for newborn and infant girls. “Simply changing pain medication doses may not be the answer. There’s always a balancing act between controlling pain and minimizing the possible harmful side effects of existing medications. Instead, our findings suggest there’s a need to develop more-specific, better-targeted treatments that could prevent the re-programming of macrophage cells in response to injury,” Jankowski says. Next steps More research is needed to use this new information to develop therapies to control immune “pain memories.” In this study, blocking the p75NTR receptor in young mice did blunt the ability of macrophages to communicate to sensory neurons and partially prevented prolonged pain-like behaviors. However, it remains unclear if similar methods can be safely used to target human macrophages. “Emerging technologies appear capable of specifically blocking the p75NTR receptor in macrophages, but it will require considerably more research before this approach would be ready for human clinical trials,” Jankowski says. Reference: “Macrophage memories of early-life injury drive neonatal nociceptive priming” by Adam J. Dourson, Adewale O. Fadaka, Anna M. Warshak, Aditi Paranjpe, Benjamin Weinhaus, Luis F. Queme, Megan C. Hofmann, Heather M. Evans, Omer A. Donmez, Carmy Forney, Matthew T. Weirauch, Leah C. Kottyan, Daniel Lucas, George S. Deepe and Michael P. Jankowski, 18 April 2024, Cell Reports. DOI: 10.1016/j.celrep.2024.114129 Funding for this study included multiple grants from the National Institutes of Health (R01NS105715, R01NS113965, F31NS122494, R01HL160614, P30 AR070549; an ARC award from Cincinnati Children’s and support from the Leukemia and Lymphoma Society.

Gut section with fluorescently labeled bacteria. Credit: Huimin Ye An international team of scientists led by microbiologists Professor Alexander Loy from the University of Vienna and Professor David Schleheck from the University of Konstanz has uncovered new metabolic capabilities of gut bacteria. For the first time, the researchers have analyzed how microbes in the gut process the plant-based, sulfur-containing sugar sulfoquinovose. Sulfoquinovose is a sulfonic acid derivative of glucose and is found in all green vegetables such as spinach and lettuce. Their study discovered that specialized bacteria cooperate in the utilization of the sulfosugar, producing hydrogen sulfide. This gas — known for its rotten egg smell — has disparate effects on human health: at low concentrations, it has an anti-inflammatory effect, while increased amounts of hydrogen sulfide in the intestine, in turn, are associated with diseases such as cancer. The study has been published in the current issue of The ISME Journal. Diet and the gut microbiome With the consumption of a single type of vegetable such as spinach, hundreds of chemical components enter our digestive tract. There, they are further metabolized by the gut microbiome, a unique collection of hundreds of microbial species. The gut microbiome thus plays a major role in determining how nutrition affects our health. “So far, however, the metabolic capabilities of many of these microorganisms in the microbiome are still unknown. That means we don’t know what substances they feed on and how they process them,” explains Buck Hanson, lead author of the study and a microbiologist at the Center for Microbiology and Environmental Systems Science (CMESS) at the University of Vienna. “By exploring the microbial metabolism of the sulfosugar sulfoquinovose in the gut for the first time, we have shed some light into this black box,” he adds. The study thus generates knowledge that is necessary to therapeutically target the interactions between nutrition and the microbiome in the future. Sulfosugars from green plants and algae Sulfoquinovose is a sulfonic acid derivative of glucose and is found as a chemical building block primarily in green vegetables such as spinach, lettuce, and algae. From previous studies by the research group led by microbiologist David Schleheck at the University of Konstanz, it was known that other microorganisms can in principle use the sulfosugar as a nutrient. In their current study, the researchers from the Universities of Konstanz and Vienna used analyses of stool samples to determine how these processes specifically take place in the human intestine. “We have now been able to show that, unlike glucose, for example, which feeds a large number of microorganisms in the gut, sulfoquinovose stimulates the growth of very specific key organisms in the gut microbiome,” says David Schleheck. These key organisms include the bacterium of the species Eubacterium rectale, which is one of the ten most common gut microbes in healthy people. “The E. rectale bacteria ferment sulfoquinovose via a metabolic pathway that we have only recently deciphered, producing, among other things, a sulfur compound, dihydroxypropane sulfonate or DHPS for short, which in turn serves as an energy source for other intestinal bacteria such as Bilophila wadsworthia. Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,” explains the microbiologist. A question of dose: hydrogen sulfide in the intestine Hydrogen sulfide is produced in the intestine by our own body cells as well as by specialized microorganisms and has a variety of effects on our body. “This gas is a Janus-faced metabolic product,” explains Alexander Loy, head of the research group at the University of Vienna. “According to current knowledge, it can have a positive but also a negative effect on intestinal health.” A decisive factor, he says, is the dose: In low amounts, hydrogen sulfide can have an anti-inflammatory effect on the intestinal mucosa, among other things. Increased hydrogen sulfide production by gut microbes, on the other hand, is associated with chronic inflammatory diseases and cancer. Until now, mainly sulfate and taurine, which are found in increased amounts in the intestine as a result of a diet rich in meat or fat, were known to be sources of hydrogen sulfide for microorganisms. The discovery that sulfoquinovose from green foods such as spinach and algae also contribute to the production of the gas in the gut therefore comes as a surprise. “We have shown that we can use sulfoquinovose to promote the growth of very specific gut bacteria that are an important component of our gut microbiome. We now also know that these bacteria in turn produce the contradictory hydrogen sulfide from it,” Loy sums up. Further studies by the scientists from Konstanz and Vienna will now clarify whether and how the intake of the plant-based sulfosugar can have a health-promoting effect. “It is also possible that sulfoquinovose could be used as a so-called prebiotic,” adds Schleheck. Prebiotics are food ingredients or additives that are metabolized by specific microorganisms and used to explicitly support the intestinal microbiome. Key facts: Study shows that the sulfosugar sulfoquinovose from green vegetables promotes the growth of important gut bacteria Specialized bacteria cooperate in the utilization of the sulfosugar sulfoquinovose, producing hydrogen sulfide, which has an anti-inflammatory effect in low concentrations, while increased amounts are associated with diseases such as cancer Joint study by the Universities of Konstanz and Vienna involving the research groups led by the microbiologists Professor David Schleheck from the University of Konstanz and Professor Alexander Loy from the University of Vienna References: “Sulfoquinovose is a select nutrient of prominent bacteria and a source of hydrogen sulfide in the human gut” by Buck T. Hanson, K. Dimitri Kits, Jessica Löffler, Anna G. Burrichter, Alexander Fiedler, Karin Denger, Benjamin Frommeyer, Craig W. Herbold, Thomas Rattei, Nicolai Karcher, Nicola Segata, David Schleheck and Alexander Loy, 31 March 2021, The ISME Journal. DOI: 10.1038/s41396-021-00968-0 “Environmental and Intestinal Phylum Firmicutes Bacteria Metabolize the Plant Sugar Sulfoquinovose via a 6-Deoxy-6-sulfofructose Transaldolase Pathway” by Benjamin Frommeyer, Alexander W. Fiedler, Sebastian R. Oehler, Buck T. Hanson, Alexander Loy, Paolo Franchini, Dieter Spiteller and David Schleheck, 28 August 2020, iScience. DOI: 10.1016/j.isci.2020.101510 Funding: The work of Professor Schleheck’s group at the University of Konstanz is funded by the German Research Foundation (DFG)

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