Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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High-performance insole OEM Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Insole ODM factory in Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom graphene foam processing Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Indonesia custom insole OEM supplier

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Eco-friendly pillow OEM manufacturer China

Scientists have mapped the brain’s structure and activity at an unprecedented level, revealing new principles of neural communication. The MICrONS Project’s success could transform how we understand intelligence and brain diseases. It is considered the most complicated neuroscience experiment ever attempted. Credit: SciTechDaily.com A team of over 150 scientists has achieved what once seemed impossible: a complete wiring and activity map of a tiny section of a mammalian brain. This feat, part of the MICrONS Project, rivals the Human Genome Project in ambition and scope, using cutting-edge AI, microscopy, and teamwork to map over 200,000 brain cells and millions of synapses. Among many revelations, researchers uncovered surprising new rules for how inhibitory neurons selectively influence others, providing insight into how thought, memory, and disorders like Alzheimer’s might emerge from cellular interactions. This achievement opens the door to a new era in brain science and medical breakthroughs. Cracking the Brain’s Wiring Code From a tiny piece of brain tissue no larger than a grain of sand, scientists have achieved what once seemed impossible: creating a detailed, functional wiring diagram of part of the brain. In 1979, molecular biologist Francis Crick famously predicted it would be “[impossible] to create an exact wiring diagram for a cubic millimeter of brain tissue and the way all its neurons are firing.” But now, after seven years of work, more than 150 scientists and researchers from around the world have brought that vision much closer to reality. This image shows a subset of more than 1,000 of the 120,000 brain cells (neuron + glia) reconstructed in the MICRONS project. Each reconstructed neuron is a different random color. In this image, the glowing neurons are colored. Credit: Forrest Collman/Allen Institute MICrONS Project: A Historic Brain Mapping Breakthrough The Machine Intelligence from Cortical Networks (MICrONS) Project has produced the most detailed wiring diagram of a mammalian brain ever made. The results, shared on April 9 across ten scientific papers published in the Nature family of journals, offer unprecedented insight into how the brain is structured and how it functions, especially within the visual system. The dataset, available through the MICrONS Explorer, totals 1.6 petabytes – about the same as 22 years of continuous HD video. “The MICrONS advances published in this special issue of Nature are a watershed moment for neuroscience, comparable to the Human Genome Project in their transformative potential,” said David A. Markowitz, Ph.D., former IARPA program manager who coordinated this work. “IARPA’s moonshot investment in the MICrONS program has shattered previous technological limitations, creating the first platform to study the relationship between neural structure and function at scales necessary to understand intelligence. This achievement validates our focused research approach and sets the stage for future scaling to the whole brain level.” Building the Brain’s 3D Blueprint Scientists at Baylor College of Medicine began by using specialized microscopes to record the brain activity from a one cubic millimeter portion of a mouse’s visual cortex as the animal watched various movies and YouTube clips. Afterward, Allen Institute researchers took that same cubic millimeter of the brain and sliced it into more than 25,000 layers, each 1/400th the width of a human hair, and used an array of electron microscopes to take high-resolution pictures of each slice. Finally, another team at Princeton University used artificial intelligence and machine learning to reconstruct the cells and connections into a 3D volume. Combined with the recordings of brain activity, the result is the largest wiring diagram and functional map of the brain to date, containing more than 200,000 cells, four kilometers of axons (the branches that reach out to other cells), and 523 million synapses (the connection points between cells). A Forest of Neural Connections “Inside that tiny speck is an entire architecture like an exquisite forest,” said Clay Reid, M.D., Ph.D., senior investigator and one of the early founders of electron microscopy connectomics who brought this area of science to the Allen Institute 13 years ago. “It has all sorts of rules of connections that we knew from various parts of neuroscience, and within the reconstruction itself, we can test the old theories and hope to find new things that no one has ever seen before.” The findings from the studies reveal new cell types, characteristics, organizational and functional principles, and a new way to classify cells. Among the most surprising findings was the discovery of a new principle of inhibition within the brain. Scientists previously thought of inhibitory cells – those that suppress neural activity – as a simple force that dampens the action of other cells. However, researchers discovered a far more sophisticated level of communication: Inhibitory cells are not random in their actions; instead, they are highly selective about which excitatory cells they target, creating a network-wide system of coordination and cooperation. Some inhibitory cells work together, suppressing multiple excitatory cells, while others are more precise, targeting only specific types. Surprising Discoveries in Brain Inhibition “This is the future in many ways,” explained Andreas Tolias, Ph.D., one of the lead scientists who worked on this project at both Baylor College of Medicine and Stanford University. “MICrONS will stand as a landmark where we build brain foundation models that span many levels of analysis, beginning from the behavioral level to the representational level of neural activity and even to the molecular level.” What this Means for Science and Medicine Understanding the brain’s form and function and the ability to analyze the detailed connections between neurons at an unprecedented scale opens new possibilities for studying the brain and intelligence. It also has implications for disorders like Alzheimer’s, Parkinson’s, autism, and schizophrenia involving disruptions in neural communication. “If you have a broken radio and you have the circuit diagram, you’ll be in a better position to fix it,” said Nuno da Costa, Ph.D., associate investigator at the Allen Institute. “We are describing a kind of Google map or blueprint of this grain of sand. In the future, we can use this to compare the brain wiring in a healthy mouse to the brain wiring in a model of disease.” Big Science, Big Collaboration The MICrONS Project is a collaborative effort of more than 150 scientists and researchers from the Allen Institute, Princeton, Harvard, Baylor College of Medicine, Stanford, and many others. “Doing this kind of large, team-scale science requires a lot of cooperation,” said Forrest Collman, Ph.D., associate director of data and technology at the Allen Institute. “It requires people to dream big and to agree to tackle problems that aren’t obviously solvable, and that’s how advances happen.” The collaborative, global effort was made possible by support from the Intelligence Advanced Research Projects Activity (IARPA) and National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® Initiative, or The BRAIN Initiative®. Foundations for Future Treatments “The BRAIN Initiative plays a critical role in bringing together scientists from various disciplines to perform complex and challenging research that cannot be achieved in isolation,” said John Ngai, Ph.D., director of The BRAIN Initiative®. “Basic science building blocks, like how the brain is wired, are the foundation we need to better understand brain injury and disease, to bring treatments and cures closer to clinical use.” A map of neuronal connectivity, form, and function from a grain of sand-sized portion of the brain is not just a scientific marvel, but a step toward understanding the elusive origins of thought, emotion, and consciousness. The “impossible” task first envisioned by Francis Crick in 1979 is now one step closer to reality. Reference: “Functional connectomics spanning multiple areas of mouse visual cortex” by The MICrONS Consortium, 9 April 2025, Nature. DOI: 10.1038/s41586-025-08790-w

Newly found fossils of different stages in the life cycle of the ancient lamprey may upend our ideas about vertebrate evolution. Above, an artist’s rendering of a hatchling P. riniensis. Credit: Illustration by Kristen Tietjen Long-Accepted Theory of Vertebrate Origin Upended by Lamprey Fossils A new study out of the University of Chicago, the Canadian Museum of Nature and the Albany Museum challenges a long-held hypothesis that the larvae of modern lampreys are a holdover from the distant past, resembling the ancestors of all living vertebrates, including ourselves. The new fossil discoveries indicate that ancient lamprey hatchlings more closely resembled modern adult lampreys, and were completely unlike their modern larvae counterparts. The results were published on March 10, 2021, in Nature. “We’ve basically removed lampreys from the position of the ancestral condition of vertebrates,” said first author Tetsuto Miyashita, formerly a Chicago Fellow at the University of Chicago and now a paleontologist at the Canadian Museum of Nature. “So now we need an alternative.” Artist’s reconstruction showing the life stages of the fossil lamprey Priscomyzon riniensis. It lived around 360 million years ago in a coastal lagoon in what is now South Africa. Clockwise from right: A tiny, yolk-sac carrying hatchling with its large eyes; a juvenile; and an adult showing its toothed sucker. Credit: Kristen Tietjen Lampreys—unusual jawless, eel-like creatures—have long provided insights into vertebrate evolution, said Miyashita. “Lampreys have a preposterous life cycle,” he said. “Once hatched, the larvae bury themselves in the riverbed and filter feed before eventually metamorphosing into blood-sucking adults. They’re so different from adults that scientists originally thought they were a totally different group of fish. “Modern lamprey larvae have been used as a model of the ancestral condition that gave rise to the vertebrate lineages,” Miyashita continued. “They seemed primitive enough, comparable to wormy invertebrates, and their qualities matched the preferred narrative of vertebrate ancestry. But we didn’t have evidence that such a rudimentary form goes all the way back to the beginning of vertebrate evolution.” Newly discovered fossils in Illinois, South Africa and Montana are changing the story. Connecting the dots between dozens of specimens, the research team realized that different stages of the ancient lamprey lifecycle had been preserved, allowing paleontologists to track their growth from hatchling to adult. On some of the smallest specimens, about the size of a fingernail, soft tissue preservation even shows the remains of a yolk sac, indicating that fossil record had captured these lampreys shortly after hatching. Crucially, these fossilized juveniles are quite unlike their modern counterparts (known as “ammocoetes”), and instead look more like modern adult lampreys, with large eyes and toothed sucker mouths. Most excitingly, this phenotype can be seen during the larval phase in multiple different species of ancient lamprey. Multiple Lineages, Same Developmental Pattern “Remarkably, we’ve got enough specimens to reconstruct a trajectory from hatchling to adult in several independent lineages of early lampreys,” said Michael Coates, a professor in the Department of Organismal Biology and Anatomy at UChicago, “and they each show the same pattern: the larval form was like a miniature adult.” From left: Study co-authors Michael Coates (left) and Rob Gess excavate fossils from the 360-million-year-old Waterloo Farm black shales in South Africa. Credit: University of Chicago The researchers say that these results challenge the 150-year-old evolutionary narrative that modern lamprey larvae offer a glimpse of deep ancestral vertebrate conditions. By demonstrating that ancient lampreys never went through the same blind, filter-feeding stage seen in modern species, the researchers have falsified this cherished ancestral model. Reconsidering the Root of Vertebrate Evolution After looking back at the fossil record, the team now believes that extinct armored fishes known as ostracoderms might instead represent better candidates for the root of the vertebrate family tree, whereas modern lamprey larvae are a more recent innovation. The team thinks the evolution of filter-feeding larvae may have allowed lampreys to populate rivers and lakes. Fossil lampreys reported in the new study all came from marine sediments, but modern lampreys mostly live in freshwater. The researchers say that this is the sort of discovery that can rewrite textbooks. “Lampreys are not quite the swimming time capsules that we once thought they were,” said Coates. “They remain important and essential for understanding the deep history of vertebrate diversity, but we also need to recognize that they, too, have evolved and specialized in their own right.” The team credits the hard work of their collaborators and co-authors, including Rob Gess of the Albany Museum in South Africa, with identifying multiple larval fossil samples, and Kristen Tietjen of the University of Kansas with CT scan and life reconstruction of fossil lampreys. For more on this research, read Fossilized Fish Larvae Discovery Challenges Long-Accepted Theory of Vertebrate Origin. Reference: “Non-ammocoete larvae of Palaeozoic stem lampreys” by Tetsuto Miyashita, Robert W. Gess, Kristen Tietjen and Michael I. Coates, 10 March 2021, Nature. DOI: 10.1038/s41586-021-03305-9 Funding: National Science Foundation

Artistic representation of numerical discrimination in Drosophila. Credit: Mercedes Bengochea, Maria Ines Oviedo In a study at the Paris Brain Institute, fruit flies demonstrated numerical sensitivity, preferring larger quantities and distinguishing between quantities based on clear ratios. The crucial role of LC11 neurons in this skill was identified, highlighting the cognitive capabilities of insects and their importance in understanding human brain function. In the animal world, you don’t need to learn a numeral system – such as the ten-digit Indo-Arabic system we commonly use – to be able to count. Animals constantly use numerical information from their environment to make decisions. Estimating the number of conspecifics in a competing group before engaging in conflict, the amount of food available in a difficult-to-reach location, or the number of potential sexual partners in a new territory is essential for survival and reproduction. This skill can reach an astonishing level of refinement; for example, certain species of ants orient themselves in the desert by estimating the number of steps required to reach a target. Animals’ Numerical Sensitivity and Neural Correlates “Numerical sensitivity, i.e., the ability to perceive information related to quantities, exists in many vertebrates and invertebrates. It has been documented in primates, birds, amphibians, fish, and bees, explains Mercedes Bengochea, a post-doctoral researcher in Bassem Hassan’s team at Paris Brain Institute. You don’t need to enumerate numbers to distinguish between one, two, several and many! However, we didn’t know which neuronal circuits were involved in this skill.” To investigate this question, researchers must record the brain activity of an animal during a numerical task, then activate or deactivate specific neural cells to determine which areas of the brain are involved. These operations are difficult to carry out on vertebrates, but the right tools already exist with fruit flies. “Drosophila melanogaster is a model of choice for studying cognition. These insects adjust their behavior in the face of a threat according to the number of fellow flies who could help, adds the researcher. In the event of imminent danger, the smaller the size of its group, the more likely they are to freeze to stay safe.” Fruit Flies’ Numeric Perception: An Exploration To determine whether fruit flies can accurately evaluate numbers and assign values to perceived quantities, Mercedes Bengochea and her colleagues used an experimental setting that has already proven its relevance. They placed the flies in arenas called “Buridan arenas,” where they were exposed to visual stimuli: in that case, two sets of objects. The researchers then determined which stimulus the insects preferred by measuring the time they spent inspecting either set. Their results indicate that fruit flies stayed longer near the set containing three objects than the set that had only one – regardless of the size of the objects or the total volume occupied by the set. This taste for larger quantities was preserved when the insects had to choose between groups of 2 or 4 objects and 2 or 3 objects. “The flies, however, were unable to distinguish between sets of respectively 3 and 4 objects, explains Mercedes Bengochea. It seems that the ratio between these two numbers is not sufficient for them to perceive a difference. On the other hand, they can very easily compare a group of 4 and a group of 8 objects – a ratio of simple to double”. Fruit flies are, therefore, not limited to counting to 3: the ratio between the quantities evaluated must be clear enough to be perceived. Assessing Ratios: A Common Animal Skill Comparing two quantities is a simple visual task common in many animals, including humans. It helps us estimate the size of a large group at a glance, such as a crowd at a concert that contains too many people to be counted one by one. Identifying the Neural Circuits Involved Which neural circuits are involved in this system of numerical discrimination in Drosophila remains to be determined. To do this, the researchers successively “switched off” different areas of the insects’ brains, preventing the transmission of nerve signals at synapses. After several tests, they observed that the activity of a column of neurons located in the optic lobe, LC11 neurons (for lobular columnar neurons 11), was necessary for flies to distinguish different sets of objects. “In a second experiment, we taught the insects to go against their natural inclination for large numbers, using a simple conditioning method: an appetizing dose of sugar was placed next to the smallest sets of objects, adds the researcher. Momentarily, thanks to the lure of the food, we made them prefer the small numbers. But once the LC11s had been inactivated, the insects no longer showed any preference… for either large or small quantities. This confirms that these neurons are essential for comparing quantities, regardless of the value fruit flies assign to them.” LC11s are also involved in the social behavior of fruit flies: they are activated when insects must adapt their defense strategy according to the number of congeners flying nearby. “We believe that the ability to assess quantities has been decisive in the evolution of invertebrates, explains Bassem Hassan, head of the ‘Brain Development’ team. The cognitive solutions insects use to ‘count’ are very simple. Several studies have shown that, in a computational model, a few artificial neurons are enough to perform a numerical task.” Flies will never help us do our accounting. However, like other insects, we are often tempted to underestimate their cognitive abilities and the subtlety of their social behavior. It’s a mistake made even more regrettable because, without them, our understanding of the human brain would remain terribly limited. Reference: “Numerical discrimination in Drosophila melanogaster” by Mercedes Bengochea, Jacobo D. Sitt, Veronique Izard, Thomas Preat, Laurent Cohen and Bassem A. Hassan, 14 July 2023, Cell Reports. DOI: 10.1016/j.celrep.2023.112772

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