Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Custom foam pillow OEM in Vietnam

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Memory foam pillow OEM factory Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.PU insole OEM production in China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam graphene sports insole ODM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Thailand OEM/ODM hybrid insole services

Photo taken in 2015 of a burning forest in Belterra, in the Brazilian Amazon. In this photo, the flames are about 30cm high. The continuous fire line can be seen at the back of the photo, together with a lot of smoke. Credit: Adam Ronan/Rede Amazônia Sustentável Amazon degradation from logging, fires, and drought drives major carbon emissions and biodiversity loss. Mitigation must go beyond deforestation, incorporating smart forest monitoring systems to curb impacts. A new study recently published in Science reveals that the Amazon rainforest has been damaged to a much greater extent than previously thought, with over a third of the remaining forest impacted by human activity. A study led by a team of 35 international scientists from institutions such as Brazil’s University of Campinas, the Amazon Environmental Research Institute, the National Institute for Space Research, and the UK’s Lancaster University reveals that up to 38% of the remaining Amazon forest – equivalent to ten times the size of the UK – has been impacted by human disturbance. This results in carbon emissions comparable to or greater than those from deforestation. Photo taken in 2015 of a burning forest in Belterra, in the Brazilian Amazon. While the flames cannot be seen, the smoke coming out of the forest is clear. Credit: Adam Ronan/Rede Amazônia Sustentável The work is the result of the AIMES (Analysis, Integration, and Modelling of the Earth System) project, linked to the Future Earth international initiative, which brings together scientists and researchers who study sustainability. The findings are the result of an analytical review of previously published scientific data, based on satellite imagery and a synthesis of published data outlining changes in the Amazon region between 2001 and 2018. The authors define the concept of degradation as transient or long-term changes in forest conditions caused by humans. Photo taken in 2019, four years after a fire affected this forest fragment, which has been previously also affected by multiple anthropogenic disturbances, including selective logging, edge effects, and fires. Photo taken in Belterra, in the Brazilian Amazon. Credit: Marizilda Cruppe/Rede Amazônia Sustentável Degradation is different from deforestation, where the forest is removed altogether and a new land use, such as agriculture, is established in its place. Although highly degraded forests can lose almost all of the trees, the land use itself does not change. The authors evaluate four key disturbances driving forest degradation: forest fire, edge effects (changes that occur in forests adjacent to deforested areas), selective logging (such as illegal logging), and extreme drought. Different forest areas can be affected by one or more of these disturbances. Photo taken in 2019, four years after a fire affected this forest fragment, which has been previously also affected by multiple anthropogenic disturbances, including selective logging, edge effects, and fires. Photo taken in Belterra, in the Brazilian Amazon. Credit: Marizilda Cruppe/Rede Amazônia Sustentável “Despite uncertainty about the total effect of these disturbances, it is clear that their cumulative effect can be as important as deforestation for carbon emissions and biodiversity loss,” said Jos Barlow, a Professor of conservation science at Lancaster University in the UK and co-author of the paper. The scientists assess that the degradation of the Amazon also has significant socioeconomic impacts, which should be further investigated in the future. Extended summary figure of the article. Credit: Alex Argozino/Studio Argozino/Science magazine “Degradation benefits the few, but places important burdens on many,” says Dr. Rachel Carmenta, a co-author based at the University of East Anglia, in the UK. “Few people profit from the degradation processes, yet many lose out across all dimensions of human well-being – including health, nutrition, and the place attachments held for the forest landscapes where they live. Furthermore, many of these burdens are hidden at present; recognizing them will help enable better governance with social justice at the center.” Photo taken in 2015 of a burning forest in Belterra, in the Brazilian Amazon. In this photo, the fire line is clear, as well as the smoke of the burning forest. Credit: Adam Ronan/Rede Amazônia Sustentável In a projection made by the team for 2050, the four degradation factors will continue to be major sources of carbon emissions into the atmosphere, regardless of the growth or suppression of deforestation of the forest. “Even in an optimistic scenario, when there is no more deforestation, the effects of climate change will see degradation of the forest continue, leading to further carbon emissions,” says Dr. David Lapola, leader of the study and researcher at the Centre for Meteorological and Climatic Research Applied to Agriculture at Unicamp. However, “preventing the advance of deforestation remains vital, and could also allow more attention to be directed to other drivers of forest degradation.” Photo taken in 2018, three years after a fire affected this logged forest that was also affected by edge effects. Photo taken in Belterra, in the Brazilian Amazon. Credit: Erika Berenguer The authors propose creating a monitoring system for forest degradation, as well as prevention and curbing of illegal logging and controlling the use of fire. One suggestion is the concept of “smart forests” which, like the idea of “smart cities”, would use different types of technologies and sensors to collect useful data in order to improve the quality of the environment. “Public and private actions and policies to curb deforestation will not necessarily address degradation as well,” says Dr. Lapola. “It is necessary to invest in innovative strategies.” Reference: “The drivers and impacts of Amazon forest degradation” by David M. Lapola, Patricia Pinho, Jos Barlow, Luiz E. O. C. Aragão, Erika Berenguer, Rachel Carmenta, Hannah M. Liddy, Hugo Seixas, Camila V. J. Silva, Celso H. L. Silva-Junior, Ane A. C. Alencar, Liana O. Anderson, Dolors Armenteras, Victor Brovkin, Kim Calders, Jeffrey Chambers, Louise Chini, Marcos H. Costa, Bruno L. Faria, Philip M. Fearnside, Joice Ferreira, Luciana Gatti, Victor Hugo Gutierrez-Velez, Zhangang Han, Kathleen Hibbard, Charles Koven, Peter Lawrence, Julia Pongratz, Bruno T. T. Portela, Mark Rounsevell, Alex C. Ruane, Rüdiger Schaldach, Sonaira S. da Silva, Celso von Randow and Wayne S. Walker, 27 January 2023, Science. DOI: 10.1126/science.abp8622

Researchers have discovered that 5-formylcytosine (5fC) activates genes in early embryonic development, revealing a new type of epigenetic DNA modification in vertebrates. This breakthrough uncovers 5fC’s role during crucial developmental stages and opens the door for further research on its function in diseases like cancer. Credit: SciTechDaily.com In the embryonic development of vertebrates, 5-formylcytosine activates genes. Professor Christof Niehrs and his team at the Institute of Molecular Biology (IMB) in Mainz, Germany, have identified a DNA modification known as 5-formylcytosine (5fC) as an epigenetic switch that activates genes during the early stages of embryonic development. This finding proves for the first time that vertebrates have more than one type of epigenetic DNA mark and sheds new light on how genes are regulated in the earliest stages of development. Their findings were published in the journal Cell. 5fC is only the second proven epigenetic DNA modification besides methylcytosine Our bodies are composed of trillions of cells, all working together to form a functional organism. Yet each of us started off as just a single fertilized egg cell. To become a whole human being, this single cell must multiply rapidly, forming all the correct organs in the right places. This process of development depends on thousands of genes being activated at exactly the right time and place. The activation/deactivation of genes is controlled by so-called epigenetic modifications, i.e., chemical groups attached to DNA and its associated proteins that act like traffic lights to switch genes on or off. 5fC activates genes in the early embryo. Credit: IMB For decades, scientists thought that vertebrates had only one type of epigenetic modification on DNA called cytosine methylation, which is associated with gene silencing. Ten years ago, three more chemical modifications were discovered in vertebrate DNA, but as they were only present in very small amounts scientists were uncertain if they were functional epigenetic marks. Now, Professor Christof Niehrs and his team have shown for the first time that one of these modifications, 5-formylcytosine, is involved in activating genes in early development. The discovery is significant because it proves that vertebrates have more than one type of epigenetic DNA mark and uncovers a new, previously unknown mechanism of epigenetic gene regulation. “These findings are a real breakthrough in epigenetics because 5fC is only the second proven epigenetic DNA modification besides methylcytosine,” said Niehrs, Founding and Scientific Director of the IMB, which was opened on the campus of Johannes Gutenberg University Mainz (JGU) in 2011. Investigating 5fC in Frog and Mouse Embryos In their study, the scientists looked at 5fC in frog embryos. Using microscopy and chromatography, they discovered that 5fC increases dramatically at the very start of development during a key step called zygotic activation when many genes become switched on. As Eleftheria Parasyraki, the first author of the study, explained: “The observation of 5fC in microscopically visible tiny dots, or chromocenters, was exciting. Based on them, we suspected that 5fC must do something important in early embryonic development.” To prove that 5fC is an activating epigenetic mark, the scientists genetically manipulated enzymes in the embryo to increase or decrease the amount of 5fC on the DNA. Increasing 5fC resulted in increased gene expression while decreasing 5fC reduced gene expression, indicating that it was indeed the presence of 5fC on the DNA that activates genes. Finally, the scientists also observed 5fC chromocenters in mouse embryos during zygotic gene activation. This suggested that 5fC likely acts as an activating epigenetic mark in both mammals and frogs. The revelation that 5fC is an activating epigenetic regulator on DNA raises many questions as to how exactly it acts and what its role is beyond early zygotic genome activation. In particular, cancer cells can have very high amounts of 5fC. Additional studies on 5fC will be needed to answer these questions, which may ultimately help us to better understand how we develop and how gene regulation is disrupted in disease. Reference: “5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming” by Eleftheria Parasyraki, Medhavi Mallick, Victoria Hatch, Viviana Vastolo, Michael U. Musheev, Emil Karaulanov, Alexandr Gopanenko, Simon Moxon, Maria Méndez-Lago, Dandan Han, Lars Schomacher, Debasish Mukherjee and Christof Niehrs, 29 August 2024, Cell. DOI: 10.1016/j.cell.2024.08.011

A study by MBARI and collaborating scientists used gene linkages to establish that comb jellies, not sponges, are the most distantly related animal to all other animals, helping to clarify a fundamental question about animal evolution that dates back over 700 million years. Mapping gene linkages provides clear-cut evidence for comb jellies as sibling group to all other animals. A groundbreaking study published in Nature by MBARI researchers and their collaborators offers fresh insights into the earliest points of animal evolution, tracing back over 700 million years. The study revolves around the mystery of which animal, sponges or comb jellies (ctenophores), represents the most distant relation to all other animals. By mapping sets of genes found together on a single chromosome across a wide array of animals, the researchers presented strong evidence that comb jellies form the sibling group to all other animals. A study published by MBARI researchers and their collaborators today (May 17) in Nature provides new insights about one of the earliest points in animal evolution that happened more than 700 million years ago. For more than a century, scientists have been working to understand the pivotal moment when an ancient organism gave rise to the diverse array of animals in the world today. As technology and science have advanced, scientists have investigated two alternative hypotheses for which animals—sponges or comb jellies, also known as ctenophores—were most distantly related to all other animals. Identifying this outlier—known as the sibling group—has long eluded scientists. In the new study, a team of researchers from MBARI, the University of California, Berkeley, the University of California, Santa Cruz, and the University of Vienna mapped sets of genes that are always found together on a single chromosome, in everything from humans and hamsters to crabs and corals, to provide clear evidence that comb jellies are the sibling group to all other animals. Understanding the relationships among animals will help shape our thinking about how key features of animal anatomy, such as the nervous system or digestive tract, have evolved over time. “We developed a new way to take one of the deepest glimpses possible into the origins of animal life. We’ve used genetics to travel back in time about one billion years to get the strongest evidence yet to answer a fundamental question about the earliest events in animal evolution,” said Darrin Schultz, previously a graduate student researcher at MBARI and UC Santa Cruz and now a postdoctoral researcher at the University of Vienna. “This finding will lay the foundation for the scientific community to begin to develop a better understanding of how animals—and humans—have evolved.” For years, scientists have investigated whether sponges or comb jellies were most distantly related to all other animals. Detailed genetic maps have provided clear-cut evidence that comb jellies—like this California sea gooseberry (Hormiphora californensis)— are a sibling group to all other animals. Credit: Darrin Schultz © 2021 MBARI Chromosome Linkages: A Window into Ancient Evolution All of the genes in an animal are organized in sequences on chromosomes. The location of an individual gene sequence can change over time, but changes to the linkages between genes on a particular chromosome are rare and largely irreversible. Until now, scientists have only looked at the similarities in the sequencing of individual genes to answer long-standing questions about the most ancient animal relationships. Schultz and team examined the linkages between genes on specific chromosomes, which are deeply conserved throughout time. They identified patterns that exist in a variety of animals and mapped those linkages back to the earliest point in animal evolution. The team found strong evidence that comb jellies represent a unique lineage whose ancestors diverged before the common ancestor of all other animals. The team compares this event to a genetic fork in the road of evolution that happened hundreds of millions of years ago. One lone single-celled organism, the ancestor of all animals, was traveling along that road with its two offspring. One child, which would evolve into comb jellies as we know them today, took one path. As it evolved, the genes on its chromosomes stayed in a specific order and did not change much. The other child, which would evolve into sponges and all other animals as we know them today, took the other path. Many of the genes on its chromosomes rearranged themselves and fused together. Because these rearrangements are irreversible and passed down generation to generation, they are detectable even today. By tracking these rearrangements, the team found clear-cut evidence that comb jellies, not sponges, are the sibling group to all other animals. “The fingerprints of this ancient evolutionary event are still present in the genomes of animals hundreds of millions of years later,” said Schultz. “This research helps strengthen the foundation of our understanding of the genetics of animal life. It gives us context for understanding what makes animals animals. This work will help us understand the basic functions we all share, like how they sense their surroundings, how they eat, and how they move.” Background More than 700 million years ago, different groups of small organisms split off the tree of life to evolve along their own independent paths, becoming the animals we know today. Researchers began working to understand the relationships between animals more than a century ago, and for most of this time period, they assumed that sponges split off the tree of life hundreds of millions of years ago making them the sibling group to all other animals. However, 15 years ago, researchers were able to use new DNA-sequencing technologies to find the first evidence that ctenophores, not sponges, were the sibling group of all other animals. This research sparked a great effort by the scientific community to develop new ways to confirm the identity of the oldest branch of the animal family tree, but a definitive answer remained unclear. While groups of animals have evolved hundreds of millions of years apart, a remarkably large number of genes remain linked to the same chromosomes across these vastly different groups. Over time, the sequence of genes on each chromosome may change, but the actual link to the chromosome remains the same, except for in rare circumstances. Researchers have historically compared the gene sequences that coded for key proteins to infer how groups of organisms are related to one another. However, they found that this technique did not give reliable answers about whether sponges or ctenophores were the sibling group of all other animals. MBARI researchers used a novel technique to find new clues in the genomes of comb jellies and sponges. First, Schultz and the team sequenced the genomes for the entire length of each chromosome for two comb jellies and two marine sponges as well as three single-celled close relatives of animals—a choanoflagellate, a filasterean amoeba, and an ichthyosporean—in order to create a more complete and organized picture of each one’s genes. With the complete chromosome sequences in hand, MBARI researchers looked for patterns of linked genes to help answer the question of whether sponges or ctenophores are the most distant relative of all other animals. Because links between genes and chromosome location change relatively slowly, these changes reveal how ancient genomes may have been arranged. Distinct, rare changes and conserved patterns can be used to unambiguously unite all descendant lineages. This can help resolve long-standing questions about animal relationships. When they examined the chromosome-scale genome of comb jellies, they saw a grouping of genes that was very different from the patterns in other animals. Most importantly, they found patterns of genes that were shared between the ctenophores and three single-celled non-animals, whereas those patterns have been shuffled and mixed in all other animals, from sponges to sparrows. Comparing specific patterns of linked genes allowed researchers to build a deeply-rooted tree of animal life and better establish the order in which branches split off from the main trunk. The team uses two decks of cards—one blue and one yellow—as an analogy for how these gene linkages work. The blue and yellow cards in each deck are separate and represent genes on distinct chromosomes. First, the two decks merge, representing chromosome fusion events. Then, shuffling the decks further is like swapping genes between chromosomes. Each shuffle yields an increasingly small chance that you could cut the deck and have all blue cards in one half and all yellow cards in the other. Likewise, following patterns of genes across the tree of animal life, there would be an increasingly small chance that gene linkages from ancestral organisms would be reproduced by chance in the furthest branches of the tree. Reference: “Ancient gene linkages support ctenophores as sister to other animals” by Darrin T. Schultz, Steven H. D. Haddock, Jessen V. Bredeson, Richard E. Green, Oleg Simakov and Daniel S. Rokhsar, 17 May 2023, Nature. DOI: 10.1038/s41586-023-05936-6 Funding for this research was provided by the David and Lucile Packard Foundation, MBARI, the National Science Foundation (GRFP DGE 1339067 and DEB-1542679), the European Research Council’s Horizon 2020: European Union Research and Innovation Programme (grant No. 945026), internal funds of the Okinawa Institute of Science and Technology Molecular Genetics Unit, the Chan Zuckerberg Biohub Network, and the Marthella Foskett Brown Chair in Biological Sciences.

DVDV1551RTWW78V