Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Flexible manufacturing OEM & ODM Thailand

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ODM pillow for sleep brands Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.High-performance insole OEM Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand OEM factory for footwear and bedding

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia high-end foam product OEM/ODM

By studying genetic incompatibilities in mosquitoes, Virginia Tech scientists aim to control mosquito populations through genetic manipulation, offering an alternative to traditional insecticides and reducing disease spread. Credit: SciTechDaily.com Understanding mosquito genetics for mosquito-borne diseases such as Zika and dengue can lead to better control methods, reducing their spread around the world. Virginia Tech researchers identified genetic anomalies in mosquitoes that can help create all-male populations to reduce mosquito-borne diseases like Zika and dengue. Their findings highlight the potential of genetic strategies over traditional insecticides, which are declining in effectiveness. Groundbreaking Genetic Research on Mosquitoes Scientists at Virginia Tech have discovered a new way to identify genetic targets useful for the control of mosquito populations, potentially offering an alternative to insecticides. Their study, published today (July 22) in the scientific journal Communications Biology, focused on the genetic basis of species incompatibility. They crossed Ae. aegypti, a major global arboviral disease vector, and its sibling species, Ae. mascarensis, from the Indian Ocean. When offspring is crossed back with one parent, about 10 percent of the progeny becomes intersex and is unable to reproduce. Jiangtao Liang (at left) uses a microscope to conduct mosquito research in Igor Sharakhov’s lab. Credit: Max Esterhuizen for Virginia Tech Unveiling Genetic Incompatibilities and Sex Determination The researchers identified abnormalities in the sex determination pathways of these intersex mosquitoes. They found that these mosquitoes are genetic males but express both male and female genes, leading to mixed physical traits. By understanding these genetic factors, they hope to develop strategies to create all-male mosquito populations, which could help control mosquito numbers by eliminating females. This research also could help identify genes affecting female mosquito behavior, aiding in future vector control methods. Jiangtao Liang analyzes a mosquito under a microscope. Credit: Max Esterhuizen for Virginia Tech Potential for Enhanced Disease Control Through Genetics These findings are significant for controlling diseases such as Zika and dengue, as better mosquito control can reduce the spread of these diseases. Though insecticides have been relatively effective at controlling mosquito populations in the past, they are now being reevaluated as they are significantly decreasing in effectiveness and are not ecologically friendly. Detailed Analysis of Genetic Expressions and Implications “We studied the hybridization of two mosquito species, found that intersex individuals have disrupted sex determination pathways, and identified sex-specific gene expressions,” said Igor Sharakhov, one of the researchers on the project and professor of entomology and an affiliated faculty with the Fralin Life Sciences Institute. “This study can help identify new sex determination pathway genes that can be used in mosquito control strategies.” The researchers looked at three areas in their study: The morphological and anatomical level with these intersexes, including external and internal organs, especially reproductive organs Genes involved in the sex determination pathway, specifically three genes: one master regulator to see whether it’s expressed or not and two other genes that create male-specific and female-specific splicing variants Overall gene expression in those mosquitoes to define what is normal and abnormal in terms of global expression of genes associated with sexual differentiation Insights Into Morphological Abnormalities and Genetic Variants “What we found is that the morphological abnormalities start in the pupal stage during development, and in adults, the most severe cases have both testes and ovaries in one individual, which is very unusual for these species,” Sharakhov said. “Now we want to understand what causes these abnormalities.” The researchers found that intersex mosquitoes express both male and female variants of sex determination genes, leading to mixed morphologies. While female-biased genes are expressed normally in intersexes, male-biased genes show decreased expression in certain male reproductive parts, though testes-related genes remain at normal levels. Implications for Future Mosquito Control Strategies The study can aid mosquito control by identifying new sex determination pathway genes to create all-male populations, thereby eliminating females and reducing vector numbers. Additionally, the identification of sex-specific genes can help develop genetic constructs to manipulate traits in wild populations. “Since the intersex is genetically male but expresses female transcripts, it provides a system to identify genes affecting female behavior, which can be useful for future vector control strategies,” said Jiangtao Liang, a postdoctoral associate in entomology. “Intersexes can serve as a valuable model for the discovery of genetic factors involved in sex determination, sexual differentiation, mating, host-seeking, and blood-biting behaviors in mosquitoes. Finding new sex determination pathway genes and their disruptions in mosquitoes will contribute to the effective control of disease vectors through genetic manipulations based on sex separation.” For diseases such as Zika and dengue, understanding mosquito genetics can lead to better control methods, reducing the spread of disease around the world. Reference: “Hybridization between Aedes aegypti and Aedes mascarensis mosquitoes leads to disruption of male sex determination” by Jiangtao Liang, Lin Kang, Pawel Michalak and Igor V. Sharakhov, 22 July 2024, Communications Biology. DOI: 10.1038/s42003-024-06560-4

A study shows that warming waters cause fish to alter their prey selection towards smaller, more abundant species, potentially increasing extinction risks due to unmet metabolic needs, highlighting marine ecosystems’ vulnerability to climate change. According to a recent study in Nature Climate Change, fish are adapting their hunting and feeding patterns in response to warmer ocean temperatures, a shift that models indicate could increase the likelihood of extinctions. Led by researchers at the German Centre for Integrative Biodiversity Research (iDiv) and the Friedrich Schiller University Jena, the researchers found that fish in the Baltic Sea respond to temperature increases by consuming the first prey they encounter. This change in foraging behavior led to the fish selecting prey that tends to be more abundant and smaller. Small prey present in their environment at all temperatures included brittle stars, small crustaceans, worms, and mollusks. Fish, like many other consumer species, need more food when temperatures increase because their metabolism also increases. Although more abundant prey provides an immediate energy source, this so-called flexible foraging behavior means fish are missing out on opportunities to satisfy their long-term energy needs by consuming larger prey that provides more calories. The European Flounder (Platichthys flesus) is a sit-and-wait predator and one of the six species included in the study database. Credit: J Fredriksson, Wikimedia Commons Model food web calculations show that this mismatch between a fish’s energetic requirements and their actual food intake could lead to more extinctions under warmer conditions, with fish ultimately starving because they are not eating enough to meet their energetic needs. The model, which can also be applied to other consumer species, suggests this is especially true for species higher up in food chains. The authors suggest that overall, this flexible foraging behavior may make communities more vulnerable to climate change. “It is usually assumed that species will adapt their foraging to maximize the amount of energy they consume”, explains first author Benoit Gauzens of iDiv and the University of Jena. “But these findings suggest fish – and other animals, too – may respond to the stress of climate change in unexpected and inefficient ways.” Data from fish stomachs The researchers analyzed ten years of data about the stomach contents of six commercially important fish species with different feeding strategies in the Bay of Kiel. For example, flatfish, like the European flounder (Platichthys flesus), tend to be sit-and-wait predators, whereas Atlantic Cod (Gadus morhua) are more actively foraging feeders. The researchers used a database of the stomach contents of six different fish species in the Bay of Kiel in the western Baltic Sea. Credit: N Einstein, Wikimedia Commons Collected year-round from 1968 to 1978, this data provided insight into the fish’s diets – what was in their stomachs – and which prey was present in their environment at different temperatures. The stomach contents indicated that fish gradually shifted their focus from less abundant prey to more abundant prey as waters became warmer. “Fish species in the Baltic Sea and elsewhere are facing a multitude of man-made pressures, like overfishing or pollution,” adds co-author Gregor Kalinkat of the Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB). “The effect of more inefficient prey searching behavior under warming might be another, so far overlooked factor leading to fish stocks that cannot recover even when fisheries pressure is significantly reduced.” Using these insights, the researchers then calculated how this change in foraging behavior at different temperatures impacts other species and the ecosystem overall using mathematical food web models based on theoretical communities. The results suggest that this change in foraging behavior when temperature increases leads to more extinctions for consumer species, like fish. These extinctions, in turn, come with knock-on effects for other species in the community. “Adaptation of foraging behavior to local environmental conditions is usually a key to maintaining high levels of biodiversity in ecosystems,” Gauzens adds. “It is therefore puzzling to see that this might not be entirely true in the context of temperature increase.” Though striking, the implications of the findings are estimated as they are currently based on theoretical models. In future, the researchers hope to test the mechanism in a natural environment and study different organisms to see whether they exhibit similar or different changes in their foraging behavior. Reference: “Flexible foraging behaviour increases predator vulnerability to climate change” by Benoit Gauzens, Benjamin Rosenbaum, Gregor Kalinkat, Thomas Boy, Malte Jochum, Susanne Kortsch, Eoin J. O’Gorman and Ulrich Brose, 27 February 2024, Nature Climate Change. DOI: 10.1038/s41558-024-01946-y

Scientists have found that verteporfin, a drug already approved by the FDA for eye disease, stopped the replication of SARS-CoV-2, the virus that causes COVID-19. An interdisciplinary research team led by the University of California, Los Angeles (UCLA) discovered that a drug already approved by the Food and Drug Administration (FDA) for eye disease, verteporfin, stopped the replication of SARS-CoV-2, the virus that causes COVID-19. Their laboratory study identified the Hippo signaling pathway as a potential target for therapies against the coronavirus. Background Many important human biological processes are controlled by complicated chain reactions called signaling pathways, in which certain proteins act as messenger molecules that promote or block the signals of other proteins. The lead researchers were investigating the Hippo pathway, which controls the size of organs in the body, in earlier National Institutes of Health–funded studies of the Zika virus, which can cause undersized brains in infants. Noticing that this pathway also seemed to have virus-fighting effects, they launched the current study investigating SARS-CoV-2. This chart shows levels of SARS-CoV-2 and deactivated YAP (pYAP127) in healthy cultured cells (mock) and cultured cells infected with the original strain of COVID-19 (SARS-CoV-2 Parental) and the Delta strain (SARS-CoV-2 Delta). Asterisks in the insets indicate uninfected cells. Credit: UCLA/Broad Stem Cell Research Center Method The scientists performed experiments using tissue samples from people with COVID-19, as well as cultured human heart and lung cells selected to closely reflect how healthy cells respond to SARS-CoV-2 infection. They observed changes in many genes involved with the Hippo signaling pathway after infection. In addition, they examined a protein called YAP, or Yes-associated protein, whose activity is blocked when the Hippo pathway is activated. The scientists found that in the cultured human cells, both the original strain and Delta variant of SARS-CoV-2 activated the Hippo pathway in the first few days after infection. When they silenced this pathway and increased YAP, the virus replicated itself more. They team also pretreated cells with verteporfin, which blocks YAP in the eye disease known as choroidal neovascularization, and then infected them with SARS-CoV-2. In the verteporfin-treated cells, concentrations of the coronavirus were below detectable levels, compared to more than 60,000 units of the virus per milliliter in an untreated control group. Impact The results indicate verteporfin may be a candidate to treat COVID-19, and its status as FDA-approved could make it easier to launch clinical trials to verify its safety and effectiveness against the coronavirus. The study showed that the Hippo pathway is activated within days of SARS-CoV-2 infection, suggesting that treatments using the mechanism could be deployed before symptoms arise to reduce the severity of disease. Reference: “Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response” by Gustavo Garcia Jr., Arjit Vijey Jeyachandran, Yijie Wang, Joseph Ignatius Irudayam, Sebastian Castillo Cario, Chandani Sen, Shen Li, Yunfeng Li, Ashok Kumar, Karin Nielsen-Saines, Samuel W. French, Priya S. Shah, Kouki Morizono, Brigitte N. Gomperts, Arjun Deb, Arunachalam Ramaiah, Vaithilingaraja Arumugaswami, 8 November 2022, PLOS Biology. DOI: 10.1371/journal.pbio.3001851 The study’s first author is Gustavo Garcia Jr., a former UCLA staff research associate, and the corresponding authors are Vaithilingaraja Arumugaswami, a UCLA associate professor of molecular and medical pharmacology and a member of the California NanoSystems Institute at UCLA and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, and Arunachalam Ramaiah of the Tata Institute for Genetics and Society in India. Other co-authors are Arjit Jeyachandran, Yijie Wang, Joseph Irudayam, Sebastian Castillo Cario, Chandani Sen, Shen Li, Yunfeng Li, Karin Nielsen-Saines, Samuel French, Kouki Morizono, Brigitte Gomperts, and Arjun Deb, all of UCLA; Ashok Kumar of Wayne State University; and Priya Shah of UC Davis. The study was funded by the UCLA David Geffen School of Medicine, the Broad Stem Cell Research Center, the UCLA W.M. Keck Foundation COVID-19 Research Award Program, the National Institutes of Health (NIH), and the Tata Institute.

DVDV1551RTWW78V