Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Insole ODM factory in China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.China custom insole OEM supplier

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Thailand OEM factory for footwear and bedding

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia custom product OEM/ODM services

A bladder assembloid, a reconstituted organoid with three tissue layers of the human bladder. Credit: Kunyoo Shin (POSTECH) POSTECH researchers developed assembloids—advanced organ-like tissues that outperform organoids by replicating mature organ structures and microenvironments. These models enable precise disease modeling and could transform personalized therapy and drug discovery. Organoids are organ-like tissues derived from stem cells that are grown in labs, often referred to as miniature organs. Because they can imitate the structure and function of human organs, it is considered as the next-generation technology for creating artificial organs or developing new drugs. Recently, a research team in Korea introduced a new concept of mini-organs called assembloid that surpasses these organoids to structurally and functionally recapitulate human tissues. These findings were announced in Nature, one of the most prestigious journals in science and technology. A team led by Professor Kunyoo Shin of POSTECH’s Department of Life Sciences has developed multi-layered miniature organs called assembloids that precisely mimic human tissues by three-dimensionally reconstituting stem cells together with various cell types in tissue stroma. The assembloid is a novel, innovative technology that can present a new paradigm for the next-generation drug discovery of intractable diseases as patient-customized human organs that transcend the conventional organoids. Limitations of Current Organoid Technology Organoids are miniature organs that are similar to human organs. However, the current organoid technology has a fundamental limitation in that they cannot mimic the mature structure of organs and lack the microenvironment within the tissues. Furthermore, critical interactions between various cells within the human tissues is lacking. This limitation has been considered a major issue in precisely modeling various intractable diseases including cancer. Patient-derived bladder tumor assembloid, an in vitro tumor tissue that mimics the pathological features of the human bladder cancer. Credit: Kunyoo Shin (POSTECH) Recreating Mature Organs In Vitro To overcome these limitations, Shin’s team developed reconstituted in-vitro human organs called assembloids, which have organized structures of epithelial cells, stromal layers, and outer muscle cells. The researchers found that these assembloids were identical to mature adult organs in terms of cell composition and gene expression at the single-cell level, and that they mimic the in-vivo regenerative response of normal tissues to the injury. In addition, the team developed patient-specific tumor assembloids that perfectly mimic the pathological characteristics of in vivo tumors. Using this tumor assembloid platform with genetic engineering technologies, the team revealed the novel mechanisms in which the signals from the tumor microenvironment determine the plasticity of the tumor cells. These findings show that the signaling feedback between the tumor and stromal cells plays a critical role in controlling the tumor plasticity. This discovery will lead to a novel paradigm in the development of cell differentiation therapy for the treatment of various aggressive types of solid cancers. Modeling Complex Human Diseases “These assembloids are the world’s first in-vitro reconstituted organoids,” explained Eunjee Kim, the first author of the paper. She added, “We can precisely model a variety of complex intractable diseases such as cancer, degenerative diseases, and various neurological diseases including schizophrenia and autism, and understand the pathogenesis of such diseases to ultimately develop better therapeutic options.” “To our knowledge, our efforts to generate assembloids that structurally and functionally recapitulate the pathophysiology of original tissues have not been previously described,” commented Professor Shin who led the study. He added, “Generating such artificial tissues is particularly relevant to modern research because the importance of tissue microenvironments in epithelial tissue homeostasis and the growth of various tumors is increasingly being recognized. We anticipate our study to open a new era of drug discovery that will revolutionize the advancement of patient-customized treatment for various intractable diseases.” Professor Tae-Young Roh, who contributed to the study, remarked, “This study is a great model for interdisciplinary science, and presents a new direction for precise and personalized therapy for various human diseases.” Reference: “Creation of bladder assembloids mimicking tissue regeneration and cancer” by Eunjee Kim, Seoyoung Choi, Byunghee Kang, JungHo Kong, Yubin Kim, Woong Hee Yoon, Hwa-Rim Lee, SungEun Kim, Hyo-Min Kim, HyeSun Lee, Chorong Yang, You Jeong Lee, Minyong Kang, Tae-Young Roh, Sungjune Jung, Sanguk Kim, Ja Hyeon Ku and Kunyoo Shin, 16 December 2020, Nature. DOI: 10.1038/s41586-020-3034-x The research was conducted by Professor Shin and Eunjee Kim in the MS/Ph.D. program of POSTECH’s Department of Life Sciences, and was supported by the Mid-Career Researcher Program, Brain Research Program, Regional Leading Research Center Program, and the Korea Post-Genome Project of the National Research Foundation of Korea. Professor Ja Hyun Koo of Seoul National University Hospital and POSTECH professors Sanguk Kim, Sungjune Jung, and Tae-Young Roh jointly contributed to the research.

This image shows trails left by sponges as they crawl across the seafloor. Credit: AWI OFOBS team, PS101 The aquatic animal known as the sponge is often described as entirely sessile: once they’ve settled in a spot and matured, they aren’t generally thought of as moving around. But, according to a new study in the journal Current Biology on April 26, 2021 — in which researchers describe mysterious trails of light brown sponge spicules (spike-like support elements in sponges) across the Arctic seafloor — that isn’t always so. “We observed trails of densely interwoven spicules connected directly to the underside or lower flanks of sponge individuals, suggesting these trails are traces of motility of the sponges,” the researchers, led by Teresa Morganti of the Max Planck Institute of Marine Microbiology and Autun Purser of the Alfred Wegener Helmholtz Centre for Polar and Marine Research, write. “This is the first time abundant sponge trails have been observed in situ and attributed to sponge mobility.” It looked as though the sponges had “crawled” into their current positions. In fact, sponges do have a motile larval stage. But most species are thought to become sessile as adults. Sponges, after all, have no muscles or specialized organs for moving around. They can react to external stimulation and move a little by contracting or expanding their bodies. There also has been some evidence of movement in sponges raised in the lab. In some cases, that movement involved remodeling their whole bodies. Nevertheless, the new findings took the research team by surprise. The discovery was made by studying video captured in 2016 by the research icebreaker Polarstern as it surveyed the submerged peaks of the permanently ice-covered Langseth Ridge. A towed marine camera sled and a hybrid remotely operated vehicle (HROV) showed that the peaks of the ridge were covered by one of the densest communities of sponges that’s ever been seen. The researchers determined that the impressive sponge populations were primarily comprised of large numbers of Geodia parva, G. hentscheli, and Stelletta rhaphidiophora individuals. They say it’s not clear, given the challenging environment, how the area supports such a vast community of sponges. But, even more intriguing were the numerous trails of sponge spicules. Far from a rarity, the researchers saw trails in nearly 70% of seafloor images that contained living sponges. Those trails were several centimeters in height and up to many meters long. They often connected directly to living sponges. The trails were seen in areas with lots of sponges, as well as in more sparsely populated areas. The researchers report that they also often seemed to be in areas with smaller, juvenile sponges. This figure shows typical sponge spicule trails. Credit: AWI OFOBS team, PS101; Morganti et al./Current Biology The researchers generated 3D models from the images and video to show the way the trails were interwoven with each other. They say that the findings suggest that the moving sponges sometimes change direction. They don’t think the movement is simply a matter of gravity. In fact, the images suggest that the sponges frequently traveled uphill. It may be that the sponges move in order to get food, perhaps driven by the scarce Arctic resources. “These features are all indicative of feeding and population density behavioral trends previously observed in encrusting sponges,” the researchers write. “The extremely low primary productivity, sedimentation, and particle advection rates of the Langseth Ridge region overall result in some of the lowest standing stocks of benthic life; so potentially, this Arctic Geodia community relies on particulate and dissolved fractions from the degradation of old organic debris trapped within the spicule mat as additional food sources. We suggest that the mobility indicated here may be related to sponges searching for and feeding directly on the accumulated detrital matter trapped within the sponge spicule mat underlying the living sponges.” It’s also possible that the movement has something to do with reproduction or the dispersal of young sponges. To learn more about how fast and why the sponges make these unexpected moves, they say that further time-lapse imagery and other studies are needed. Reference: “In situ observation of sponge trails suggests common sponge locomotion in the deep central Arctic” by Teresa M. Morganti, Autun Purser, Hans Tore Rapp, Christopher R. German, Michael V. Jakuba, Laura Hehemann, Jonas Blendl, Beate M. Slaby and Antje Boetius, 26 April 2021, Current Biology. DOI: 10.1016/j.cub.2021.03.014 This work was supported by DFG Cluster of Excellence “The Ocean in the Earth System” at the University of Bremen from the ERC Adv Grant ABYSS, the European Union’s Horizon 2020 research and innovation program, the Helmholtz Association, the Max Planck Society, and NASA.

Researchers at MIT, the Broad Institute, and the National Institutes of Health have developed a new search algorithm that has identified 188 kinds of new rare CRISPR systems in bacterial genomes. Credit: Broad Institute By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more. Microbial sequence databases contain a wealth of information about enzymes and other molecules that could be adapted for biotechnology. But these databases have grown so large in recent years that they’ve become difficult to search efficiently for enzymes of interest. New Search Algorithm for CRISPR Systems Now, scientists at the McGovern Institute for Brain Research at MIT, the Broad Institute of MIT and Harvard, and the National Center for Biotechnology Information (NCBI) at the National Institutes of Health have developed a new search algorithm that has identified 188 kinds of new rare CRISPR systems in bacterial genomes, encompassing thousands of individual systems. The work was published on November 23 in the journal Science. The algorithm, which comes from the lab of pioneering CRISPR researcher Professor Feng Zhang, uses big-data clustering approaches to rapidly search massive amounts of genomic data. The team used their algorithm, called Fast Locality-Sensitive Hashing-based clustering (FLSHclust) to mine three major public databases that contain data from a wide range of unusual bacteria, including ones found in coal mines, breweries, Antarctic lakes, and dog saliva. The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. The new systems could potentially be harnessed to edit mammalian cells with fewer off-target effects than current Cas9 systems. They could also one day be used as diagnostics or serve as molecular records of activity inside cells. Exploring CRISPR’s Diversity The researchers say their search highlights an unprecedented level of diversity and flexibility of CRISPR and that there are likely many more rare systems yet to be discovered as databases continue to grow. “Biodiversity is such a treasure trove, and as we continue to sequence more genomes and metagenomic samples, there is a growing need for better tools, like FLSHclust, to search that sequence space to find the molecular gems,” says Zhang, a co-senior author on the study and the James and Patricia Poitras Professor of Neuroscience at MIT with joint appointments in the departments of Brain and Cognitive Sciences and Biological Engineering. Zhang is also an investigator at the McGovern Institute for Brain Research at MIT, a core institute member at the Broad, and an investigator at the Howard Hughes Medical Institute. Eugene Koonin, a distinguished investigator at the NCBI, is co-senior author on the study as well. Searching for CRISPR CRISPR, which stands for clustered regularly interspaced short palindromic repeats, is a bacterial defense system that has been engineered into many tools for genome editing and diagnostics. To mine databases of protein and nucleic acid sequences for novel CRISPR systems, the researchers developed an algorithm based on an approach borrowed from the big data community. This technique, called locality-sensitive hashing, clusters together objects that are similar but not exactly identical. Using this approach allowed the team to probe billions of protein and DNA sequences — from the NCBI, its Whole Genome Shotgun database, and the Joint Genome Institute — in weeks, whereas previous methods that look for identical objects would have taken months. They designed their algorithm to look for genes associated with CRISPR. “This new algorithm allows us to parse through data in a time frame that’s short enough that we can actually recover results and make biological hypotheses,” says Soumya Kannan PhD ’23, who is a co-first author on the study. Kannan was a graduate student in Zhang’s lab when the study began and is currently a postdoc and Junior Fellow at Harvard University. Han Altae-Tran PhD ’23, a graduate student in Zhang’s lab during the study and currently a postdoc at the University of Washington, was the study’s other co-first author. “This is a testament to what you can do when you improve on the methods for exploration and use as much data as possible,” says Altae-Tran. “It’s really exciting to be able to improve the scale at which we search.” Discovering New CRISPR Variants In their analysis, Altae-Tran, Kannan, and their colleagues noticed that the thousands of CRISPR systems they found fell into a few existing and many new categories. They studied several of the new systems in greater detail in the lab. They found several new variants of known Type I CRISPR systems, which use a guide RNA that is 32 base pairs long rather than the 20-nucleotide guide of Cas9. Because of their longer guide RNAs, these Type I systems could potentially be used to develop more precise gene-editing technology that is less prone to off-target editing. Zhang’s team showed that two of these systems could make short edits in the DNA of human cells. And because these Type I systems are similar in size to CRISPR-Cas9, they could likely be delivered to cells in animals or humans using the same gene-delivery technologies being used today for CRISPR. One of the Type I systems also showed “collateral activity” — broad degradation of nucleic acids after the CRISPR protein binds its target. Scientists have used similar systems to make infectious disease diagnostics such as SHERLOCK, a tool capable of rapidly sensing a single molecule of DNA or RNA. Zhang’s team thinks the new systems could be adapted for diagnostic technologies as well. The researchers also uncovered new mechanisms of action for some Type IV CRISPR systems, and a Type VII system that precisely targets RNA, which could potentially be used in RNA editing. Other systems could potentially be used as recording tools — a molecular document of when a gene was expressed — or as sensors of specific activity in a living cell. Mining Biochemical Data The scientists say their algorithm could aid in the search for other biochemical systems. “This search algorithm could be used by anyone who wants to work with these large databases for studying how proteins evolve or discovering new genes,” Altae-Tran says. The researchers add that their findings illustrate not only how diverse CRISPR systems are, but also that most are rare and only found in unusual bacteria. “Some of these microbial systems were exclusively found in water from coal mines,” Kannan says. “If someone hadn’t been interested in that, we may never have seen those systems. Broadening our sampling diversity is really important to continue expanding the diversity of what we can discover.” Reference: “Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering” by Han Altae-Tran, Soumya Kannan, Anthony J. Suberski, Kepler S. Mears, F. Esra Demircioglu, Lukas Moeller, Selin Kocalar, Rachel Oshiro, Kira S. Makarova, Rhiannon K. Macrae, Eugene V. Koonin and Feng Zhang, 23 November 2023, Science. DOI: 10.1126/science.adi1910 This work was supported by the Howard Hughes Medical Institute; the K. Lisa Yang and Hock E. Tan Molecular Therapeutics Center at MIT; Broad Institute Programmable Therapeutics Gift Donors; The Pershing Square Foundation, William Ackman and Neri Oxman; James and Patricia Poitras; BT Charitable Foundation; Asness Family Foundation; Kenneth C. Griffin; the Phillips family; David Cheng; and Robert Metcalfe.

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