Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Flexible manufacturing OEM & ODM factory Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Customized sports insole ODM Thailand

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Insole ODM factory in Thailand

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Innovative pillow ODM solution in Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam graphene sports insole ODM

Malaria continues to affect millions globally, causing substantial mortality and shaping human evolutionary history. Recent studies leveraging ancient DNA have illuminated the historical spread and origins of malaria, showing its adaptation across continents and its profound impact during colonial times. Advances in understanding these patterns offer insights into combating current and future malaria challenges. Credit: SciTechDaily Research into malaria’s history through ancient DNA reveals its profound impact on human evolution and its global spread due to colonialism, military activity, and travel, highlighting challenges in controlling its resurgence. Malaria, one of the world’s deadliest infectious diseases, is caused by several species of single-celled parasites that are transmitted through the bites of infected Anopheles mosquitoes. Despite massive control and eradication efforts, nearly half of the world’s population lives in areas where malaria is transmitted, and the World Health Organization estimates that malaria causes nearly 250 million infections and more than 600,000 deaths each year. In addition to its modern impact, malaria has significantly influenced human evolutionary history. “Although largely a tropical disease today, only a century ago the pathogen’s range covered half the world’s land surface, including parts of the northern USA, southern Canada, Scandinavia, and Siberia,” says lead author Megan Michel, a doctoral researcher at the Max Planck-Harvard Research Center Archaeoscience of the Ancient Mediterranean. “Malaria’s legacy is written in our very genomes: genetic variants responsible for devastating blood disorders such as sickle cell disease are thought to persist in human populations because they confer partial resistance to malaria infection.” Ancient tombs are visible throughout the Upper Mustang region of Nepal. Credit: Christina Warinner Unraveling the Mystery of Malaria’s Origins The origins and spread of the two deadliest species of malaria parasites, Plasmodium falciparum and Plasmodium vivax, remain shrouded in mystery. Malaria infections leave no discernible traces in human skeletal remains, and scant references in historical texts can be difficult to decipher. However, recent advances in the ancient DNA field have revealed that human teeth can preserve traces of pathogens present in a person’s blood at the time of death, providing an opportunity to study illnesses that are normally invisible in the archaeological record. To explore malaria’s enigmatic history, an international team of researchers from 80 institutions reconstructed ancient Plasmodium genome-wide data from 36 malaria-infected individuals spanning 5,500 years of human history on five continents. These ancient malaria cases provide an unprecedented opportunity to reconstruct the worldwide spread of malaria and its historical impact at global, regional, and even individual scales. Present-day traders and travelers in the Upper Mustang region of Nepal. Credit: Christina Warinner Malaria’s Path through the Americas Malaria is endemic in tropical regions of the Americas today, and scientists have long debated whether P. vivax, a malaria species adapted to survive in temperate climates, may have arrived via the Bering Strait with the peopling of the continent or traveled in the wake of European colonization. To track the parasites’ journey into the Americas, the team analyzed ancient DNA from a malaria-infected individual from Laguna de los Cóndores, a high-altitude site situated in the remote cloud forests of the eastern Peruvian Andes. Genomic analysis revealed remarkable similarities between the Laguna de los Cóndores P. vivax strain and ancient European P. vivax, strongly suggesting that European colonizers spread this species to the Americas within the first century or so after contact “Amplified by the effects of warfare, enslavement, and population displacement, infectious diseases, including malaria, devastated Indigenous peoples of the Americas during the colonial period, with mortality rates as high as 90 percent in some places,” says coauthor Evelyn Guevara, a postdoctoral researcher at the University of Helsinki and the MPI-EVA. Remarkably, the team also uncovered genetic links between the Laguna de los Cóndores strain and modern Peruvian P. vivax populations 400 to 500 years later. “In addition to showing that malaria spread rapidly into what is a relatively remote region today, our data suggest that the pathogen thrived there, establishing an endemic focus and giving rise to parasites that are still infecting people in Peru today,” says co-author Eirini Skourtanioti, a postdoctoral researcher at MPI-EVA and MHAAM. Upper Mustang region of Nepal. Credit: Christina Warinner Military Movements and Malaria Spread in Europe While the role of colonialism in the spread of malaria is evident in the Americas, the team uncovered military activities that shaped the regional spread of malaria on the other side of the Atlantic. The cemetery at the Gothic cathedral of St. Rombout’s in Mechelen, Belgium was located adjacent to the first permanent military hospital (1567-1715 CE) in early modern Europe. Ancient human and pathogen DNA identified local cases of P. vivax among the general population buried before the construction of the military hospital, while individuals buried after its construction included cases of the more virulent P. falciparum malaria. “Most interestingly, we observe more cases of malaria in non-local male individuals from the military hospital period,” explains co-author Federica Pierini, a postdoctoral researcher at the MPI-EVA. “We also identified several individuals infected with P. falciparum, a species that thrived in Mediterranean climates before eradication but was not thought to be endemic north of the Alps during this period.” These virulent cases were found in non-local male individuals of diverse Mediterranean origins, who were likely soldiers recruited from northern Italy, Spain, and other Mediterranean regions to fight in the Hapsburg Army of Flanders during the 80 Years’ War. “We find that the large-scale troop movements played an important role in the spread of malaria during this period, similar to cases of so-called airport malaria in temperate Europe today,” explains Alexander Herbig, Group Leader of Computational Pathogenomics at the MPI-EVA. “In our globalized world, infected travelers carry Plasmodium parasites back to regions where malaria is now eradicated, and mosquitoes capable of transmitting these parasites can even lead to cases of ongoing local transmission. Although the landscape of malaria infection in Europe is radically different today than it was 500 years ago, we see parallels in the ways in which human mobility shapes malaria risk.” Artist reconstruction of the life of CHO001, a long-distance trader analyzed in this study who suffered from malaria and was buried at the site of Chokhopani, Nepal, ca 800 BCE. The foreground depicts agricultural fields in the province of Lumbini, a lowland region afflicted with endemic malaria until the 21st century, with the Kali Gandaki River cutting across. The river’s course has long served as an ancient trade route in Nepal. Chokhopani is depicted in the upper right, nestled among the cliffs in which CHO001’s tomb was found. In the middle of the painting, CHO001 is depicted carrying trade goods with his family and traveling up well-worn paths towards the Kora La pass. He is surrounded by fires symbolizing the cyclical malaria fevers he is experiencing after having contracted Plasmodium falciparum at low elevation. Credit: Purna Lama, Boudha Stupa Thanka Centre, Kathmandu, Nepal Unexpected Discoveries in High-Altitude Malaria On the other side of the world, the team unexpectedly identified the earliest known case of P. falciparum malaria at the high Himalayan site of Chokhopani (ca. 800 BCE), located along the Kali Gandaki River Valley in the Mustang District of Nepal. At 2800 meters above sea level, the site lies far outside the habitat range for both the malaria parasite and the Anopheles mosquito. “The region surrounding Chokhopani is cold and quite dry,” said co-author Christina Warinner, Associate Professor of Anthropology at Harvard University and Group Leader at the MPI-EVA. “Neither the parasite nor the mosquitoes capable of transmitting malaria can survive at this altitude. For us, this raised a key question: how did the Chokhopani individual acquire the malaria infection that may have ultimately led to his death?” Human genetic analysis revealed that the infected individual was a local male with genetic adaptations for life at high altitudes. However, archaeological evidence at Chokhopani and other nearby sites suggests that these Himalayan populations were actively engaged in long-distance trade. “We think of these regions today as remote and inaccessible, but in fact the Kali Gandaki River Valley served as a kind of trans-Himalayan highway connecting people on the Tibetan Plateau with the Indian subcontinent,” says co-author Mark Aldenderfer, Distinguished Professor Emeritus at the University of California, Merced, whose excavations in the region have revealed its long-distance trade connections. “Copper artifacts recovered from Chokhopani’s burial chambers prove that the ancient inhabitants of Mustang were part of larger exchange networks that included northern India, and you don’t have to travel very far to reach the low-lying, poorly drained regions of the Nepalese and Indian Terai where malaria is endemic today.” The team believes that the man likely traveled to a lower-altitude malaria-endemic region, possibly for trade or other purposes, before returning or being brought back to Chokhopani, where he was later buried. The intimate details revealed by ancient DNA give clues to the myriad ways that infectious diseases like malaria spread in the past, giving rise to our current disease landscape. The Ongoing Challenge of Malaria Today Today, the human experience of malaria is at a crossroads. Thanks to advances in mosquito control and concerted public health campaigns, malaria deaths reached an all-time low in the 2010s. However, the emergence of antimalarial drug-resistant parasites and insecticide-resistant vectors threatens to reverse decades of progress, while climate change and environmental destruction are making new regions vulnerable to malaria vector species. The team hopes that ancient DNA may provide an additional tool for understanding and even combating this public health threat. “For the first time, we are able to explore the ancient diversity of parasites from regions like Europe, where malaria is now eradicated,” says senior author Johannes Krause, Director of Archaeogenetics at the Max Planck Institute for Evolutionary Anthropology. “We see how mobility and population displacement spread malaria in the past, just as modern globalization makes malaria-free countries and regions vulnerable to reintroduction today. We hope that studying ancient diseases like malaria will provide a new window into understanding these organisms that continue to shape the world we live in today.” Reference: “Ancient Plasmodium genomes shed light on the history of human malaria” by Megan Michel, Eirini Skourtanioti, Federica Pierini, Evelyn K. Guevara, Angela Mötsch, Arthur Kocher, Rodrigo Barquera, Raffaela A. Bianco, Selina Carlhoff, Lorenza Coppola Bove, Suzanne Freilich, Karen Giffin, Taylor Hermes, Alina Hiß, Florian Knolle, Elizabeth A. Nelson, Gunnar U. Neumann, Luka Papac, Sandra Penske, Adam B. Rohrlach, Nada Salem, Lena Semerau, Vanessa Villalba-Mouco, Isabelle Abadie, Mark Aldenderfer, Jessica F. Beckett, Matthew Brown, Franco G. R. Campus, Tsang Chenghwa, María Cruz Berrocal, Ladislav Damašek, Kellie Sara Duffett Carlson, Raphaël Durand, Michal Ernée, Cristinel Fântaneanu, Hannah Frenzel, Gabriel García Atiénzar, Sonia Guillén, Ellen Hsieh, Maciej Karwowski, David Kelvin, Nikki Kelvin, Alexander Khokhlov, Rebecca L. Kinaston, Arkadii Korolev, Kim-Louise Krettek, Mario Küßner, Luca Lai, Cory Look, Kerttu Majander, Kirsten Mandl, Vittorio Mazzarello, Michael McCormick, Patxuka de Miguel Ibáñez, Reg Murphy, Rita E. Németh, Kerkko Nordqvist, Friederike Novotny, Martin Obenaus, Lauro Olmo-Enciso, Päivi Onkamo, Jörg Orschiedt, Valerii Patrushev, Sanni Peltola, Alejandro Romero, Salvatore Rubino, Antti Sajantila, Domingo C. Salazar-García, Elena Serrano, Shapulat Shaydullaev, Emanuela Sias, Mario Šlaus, Ladislav Stanco, Treena Swanston, Maria Teschler-Nicola, Frederique Valentin, Katrien Van de Vijver, Tamara L. Varney, Alfonso Vigil-Escalera Guirado, Christopher K. Waters, Estella Weiss-Krejci, Eduard Winter, Thiseas C. Lamnidis, Kay Prüfer, Kathrin Nägele, Maria Spyrou, Stephan Schiffels, Philipp W. Stockhammer, Wolfgang Haak, Cosimo Posth, Christina Warinner, Kirsten I. Bos, Alexander Herbig and Johannes Krause, 12 June 2024, Nature. DOI: 10.1038/s41586-024-07546-2

Specimen of new bee species, Leioproctus zephyr. Credit: Curtin University Discovery of a New Bee Species with a Unique Snout A new native bee species with a dog-like “snout” has been discovered in the Perth bushland of Western Australia. It was identified through Curtin University-led research that sheds new light on our most important pollinators. Dr. Kit Prendergast, from the Curtin School of Molecular and Life Sciences, named the new species after her pet dog Zephyr after noticing a protruding part of the insect’s face looked similar to a dog’s snout. The name also acknowledges the role her dog played in providing emotional support during her PhD. Dr. Prendergast is the author of a paper on the discovery that was published on October 31 in the Journal of Hymenoptera Research. According to Dr. Prendergast, the rare and remarkable finding would add to existing knowledge about our evolving biodiversity. It would also ensure the bees, named Leioproctus zephyr, were protected by conservation efforts. “When I first examined the specimens that I collected during my PhD surveys discovering the biodiversity of native bees in urbanized regions of the southwest WA biodiversity hotspot, I was instantly intrigued by the bee’s very unusual face,” Dr. Prendergast said. Specimen of new bee species, Leioproctus zephyr. Credit: Curtin University Unusual Appearance Confirms New Species “When I went to identify it, I found it matched no described species, and I was sure that if it was a known species, it would be quite easy to identify given how unusual it was in appearance. “You can only confirm a particular species once you look at them under a microscope and go through the long process of trying to match their characteristics against other identified species, then going through museum collections. “When perusing the WA Museum’s Entomology collection, I discovered that a few specimens of Leioproctus zephyrus had first been collected in 1979, but it had never been scientifically described.” Dr. Prendergast said she was excited to play a role in making this species known and officially naming them. “Insects in general are so diverse and so important, yet we don’t have scientific descriptions or names for so many of them,” Dr. Prendergast said. Restricted Habitat and Foraging Preferences “The Leioproctus zephyr has a highly restricted distribution, only occurring in seven locations across the southwest WA to date, and have not been collected from their original location. They were entirely absent from residential gardens and only present at five urban bushland remnants that I surveyed, where they foraged on two plant species of Jacksonia. “Not only is this species fussy, they also have a clypeus that looks like a snout. Hence, I named them after my dog Zephyr. She has been so important to my mental health and well-being during the challenging period of doing a PhD and beyond.” Dr. Prendergast was able to confirm that the new species was most closely related to other species of unidentified Leioproctus through DNA barcoding. Reference: “Leioproctus zephyr Prendergast (Hymenoptera, Colletidae, Leioproctus), an oligoletic new bee species with a distinctive clypeus” by Kit S. Prendergast, 31 October 2022, Journal of Hymenoptera Research. DOI: 10.3897/jhr.93.85685

Scientists mapped a grain-sized chunk of mouse brain in unprecedented detail, showing how neurons fire in response to what the eyes see. The data reveal over 500 million connections and could be key to understanding how vision works – and what goes wrong in brain disorders. Credit: SciTechDaily.com A massive, multi-year project led by over 150 scientists has produced the most detailed map yet of how visual information travels through the brain – revealing more than 500 million connections in a speck of mouse brain tissue. Using glowing neurons, high-powered electron microscopes, and deep learning, researchers captured both the physical wiring and real-time electrical activity of over 200,000 brain cells. The resulting 1.6-petabyte dataset is not just a technological marvel – it brings us closer to answering age-old questions about how our brains turn light into vision and how brain disorders might arise when this system breaks. Unraveling the Brain’s Visual Code In a major research effort funded by the National Institutes of Health (NIH), scientists have mapped the connections between hundreds of thousands of neurons in the mouse brain and recorded how they respond to visual input. By combining the brain’s wiring with real-time activity, this work lays crucial groundwork for understanding how the brain processes visual information to create the images we see. The human brain processes information through the rapid electrical firing of about 86 billion neurons, each forming part of a vast network with trillions of connections. How we think, feel, and act is rooted in the structure of these connections and the electrical signals flowing through them in milliseconds. Although this new research focuses on just a tiny portion of the brain, it reveals how individual neurons are linked and how those links contribute to function. Insights like these could help explain how the brain works in health, and what goes wrong in conditions like injury or neurological disease. This image shows a subset of more than 1,000 of the 120,000 brain cells reconstructed in the MICRONS project. Each reconstructed neuron is a different random color. It is meant as a symbolic representation of the dataset. There are far more recorded neurons than those that are glowing, and far more reconstructed neurons than were put into the rendering. Credit: The Allen Institute Capturing the Brain in Action To conduct the study, researchers showed video clips to mice that had been genetically modified so that their neurons emit light when active. This allowed the team to record patterns of neuron activity in visual areas of the brain, covering a volume roughly the size of a grain of sand. Despite its small size, the tissue contained astonishing complexity: about four kilometers of axons – slender fibers that carry signals between neurons—interwoven to form over 524 million synapses among more than 200,000 cells. Building the Brain’s 3D Circuit Map To map these connections teams worked 12-hour shifts for 12 straight days to carefully cut and image ultra-thin slices of the brain tissue using electron microscopes (EM). Reconstruction was the most challenging next step, as it required accurately stitching together almost 28,000 EM images to align the connections that cross the volume of brain tissue. This was followed by months of tracing the connections using deep learning algorithms followed by manual, and automated proofreading. Deep learning predictive models that explain visual information processing in the cortex were constructed and validated. In total, the sheer amount of data collected to create this tiny map comes out to 1.6 petabytes, roughly the equivalent of 22 years of continuous HD video. A New Era of Neural Mapping These results come at a time when maps of neurons and their connections are increasingly revealing the mysteries of the brain. In 2023, research funded by the National Institutes of Health Brain Research Through Advancing Innovative Neurotechnologies® Initiative, or The NIH BRAIN Initiative®, produced the first complete cell atlas of the mouse brain, including the types and locations surveyed from more than 32 million cells. Last year, the NIH BRAIN Initiative “Flywire” project led to the complete mapping of the common fruit fly brain, demonstrating the unique value of mapping the whole brain in its entirety. The mouse connectome data detailed in this press release can be visualized online using the MICrONS Explorer resource. Explore Further: A Grain of Brain, 523 Million Synapses, and the Most Complicated Neuroscience Experiment Ever Attempted Reference: “Inhibitory specificity from a connectomic census of mouse visual cortex” by Casey M. Schneider-Mizell, Agnes L. Bodor, Derrick Brittain, JoAnn Buchanan, Daniel J. Bumbarger, Leila Elabbady, Clare Gamlin, Daniel Kapner, Sam Kinn, Gayathri Mahalingam, Sharmishtaa Seshamani, Shelby Suckow, Marc Takeno, Russel Torres, Wenjing Yin, Sven Dorkenwald, J. Alexander Bae, Manuel A. Castro, Akhilesh Halageri, Zhen Jia, Chris Jordan, Nico Kemnitz, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Eric Mitchell, Shanka Subhra Mondal, Shang Mu, Barak Nehoran, Sergiy Popovych, William Silversmith, Nicholas L. Turner, William Wong, Jingpeng Wu, Jacob Reimer, Andreas S. Tolias, H. Sebastian Seung, R. Clay Reid, Forrest Collman and Nuno Maçarico da Costa, 9 April 2025, Nature. DOI: 10.1038/s41586-024-07780-8 Funding for this project was provided through the Machine Intelligence from Cortical Networks (MICrONS) Program of the Intelligence Advanced Research Projects Activity and the NIH BRAIN Initiative. The findings, published in a package of 10 papers published in the Nature family of journals, represent more than seven years of work performed by more than 150 scientists around the world.

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