Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

Thailand custom insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Customized sports insole ODM Vietnam

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow OEM for wellness brands China

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Pillow OEM for wellness brands Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia athletic insole OEM supplier

Structure of a cilium of the green alga Clamydomonas reinhardtii (tomographic segmentation): the cilium is covered by a protein layer (FMG 1). Underneath lies the inner glycocalyx and the ciliary membrane. The innermost part is the ‘skeleton’ of microtubule-based complexes, the so-called axoneme. Credit: A. Nievergelt/adapted from Hoepfner et al. (2025) Proteins in the sheath of cellular protrusions control how effectively cells can adhere to surfaces. Biological cells often feature thin, hair-like structures on their surface called cilia, which play key roles in movement and sensing environmental signals. A team of researchers from Germany and Italy has recently uncovered new details about the protective layer that surrounds these cilia. This layer, known as the glycocalyx, is composed of sugar-rich proteins called glycoproteins. As the cell’s first point of contact with its environment, the glycocalyx influences how cells adhere to surfaces, move, and detect external signals. Until now, its precise structure remained unclear. The research team has now successfully mapped the detailed architecture of the glycocalyx in the unicellular green alga Chlamydomonas reinhardtii, identifying the glycoproteins FMG1B and FMG1A as its primary components. FMG1A is a previously unknown variant of FMG1B, and the two glycoproteins show a biochemical similarity to mucin proteins found in mammals. Mucins are also glycoproteins and a central component of protective mucus found in many organisms, for example, on mucous membranes or in internal organs. Functional Role of the Glycoproteins For their study, the team removed the two glycoproteins from the alga, which resulted in the cilia showing significantly increased stickiness. Nonetheless, the algal cells were still able to move on surfaces by means of the adhering cilia. This led the researchers to conclude that these proteins do not, as previously assumed, directly enable adhesion to surfaces and transmit the force needed for gliding motility from inside the cilium, but instead form a protective layer that regulates the adhesiveness of the cilia. “This discovery expands our knowledge of how cells regulate direct interaction with their environment,” explains plant biotechnologist Prof Michael Hippler from the University of Münster (Germany). “We are also gaining insights into how similar protective mechanisms might work in other organisms,” adds Dr Adrian Nievergelt from the Max Planck Institute of Molecular Plant Physiology in Potsdam (Germany), who collaborated on the project with Dr Gaia Pigino’s research group at the Human Technopole in Milan (Italy). The team used a wide range of cutting-edge imaging and protein analysis techniques, including cryogenic electron tomography and electron microscopy, fluorescence microscopy, mass spectrometry, as well as genetic manipulation to remove the glycoproteins from the algal genome. Reference: “Unwrapping the Ciliary Coat: High-Resolution Structure and Function of the Ciliary Glycocalyx” by Lara M. Hoepfner, Adrian P. Nievergelt, Fabrizio Matrino, Martin Scholz, Helen E. Foster, Jonathan Rodenfels, Alexander von Appen, Michael Hippler and Gaia Pigino, 5 March 2025, Advanced Science. DOI: 10.1002/advs.202413355 Funding: European Research Council, Deutsche Forschungsgemeinschaft, Human Frontier Science Program, European Molecular Biology Organization

Scientists at the Max Planck Institute for Marine Microbiology have found that Methanothermococcus thermolithotrophicus, a methanogen previously believed incapable of converting sulfate into sulfide due to the process’s high energy costs and harmful byproducts, can in fact grow on sulfate. The researchers discovered five genes encoding sulfate-reduction-associated enzymes in the methanogen’s genome, and by characterizing these enzymes, they assembled the first sulfate assimilation pathway from a methanogen. How a methanogenic microbe reassembles a metabolic pathway piece by piece to transform Sulfate into a cellular building block. Researchers have discovered that the methanogen Methanothermococcus thermolithotrophicus can convert sulfate into sulfide, defying previous assumptions. By identifying a unique sulfate assimilation pathway in this methanogen, the findings open up the possibility of safer and more cost-effective biogas production through genetic engineering. Sulfur, an Essential Building Block of Life Sulfur is a fundamental element of life and all organisms need it to synthesize cellular materials. Autotrophs, such as plants and algae, acquire sulfur by converting sulfate into sulfide, which can be incorporated into biomass. However, this process requires a lot of energy and produces harmful intermediates and byproducts that need to be immediately transformed. As a result, it was previously believed that microbes known as methanogens, which are usually short on energy, would be unable to convert sulfate into sulfide. Therefore, it was assumed that these microbes, which produce half of the world’s methane, rely on other forms of sulfur, such as sulfide. A Methanogen Assimilating Sulfate? This dogma was broken in 1986 with the discovery of the methanogen Methanothermococcus thermolithotrophicus, growing on sulfate as the only sulfur source. How is this possible, considering the energetic costs and toxic intermediates? Why is it the only methanogen that seems to be capable of growing on this sulfur species? Does this organism use chemical tricks or a yet unknown strategy to allow sulfate assimilation? Marion Jespersen and Tristan Wagner at the Max Planck Institute for Marine Microbiology have now found answers to these questions and published them in the journal Nature Microbiology.  PhD student Marion Jespersen works on a fermenter in which M. thermolithotrophicus grows exclusively on sulfate as sulfur source. Credit: Tristan Wagner / Max Planck Institute for Marine Microbiology The first challenge the researchers met was to get the microbe to grow on the new sulfur source. “When I started my PhD, I really had to convince M. thermolithotrophicus to eat sulfate instead of sulfide,” says Marion Jespersen. “But after optimizing the medium, Methanothermococcus became a pro at growing on sulfate, with cell densities comparable to those when growing on sulfide.” “Things got really exciting when we measured the disappearance of sulfate as the organism grew. This was when we could really prove that the methanogen converts this substrate.” This allowed the researchers to safely cultivate M. thermolithotrophicus in bioreactors in large scales, as they were no longer dependent on the toxic and explosive hydrogen sulfide gas for growth. “It provided us with enough biomass to study this fascinating organism,” explains Jespersen. Now the researchers were ready to dig into the details of the underlying processes. The First Molecular Dissection of the Sulfate Assimilation Pathway To understand the molecular mechanisms of sulfate assimilation, the scientists analyzed the genome of M. thermolithotrophicus. They found five genes that had the potential to encode sulfate-reduction-associated enzymes. “We managed to characterize every one of those enzymes and therefore explored the complete pathway. A true tour de force when you think about its complexity,” says Tristan Wagner, head of the Max Planck Research Group Microbial Metabolism. The cascade of chemical reaction starting from sulfate (SO42-) to sulfide (H2S). Credit: Marion Jespersen / Max Planck Institute for Marine Microbiology By characterizing the enzymes one-by-one, the scientists assembled the first sulfate assimilation pathway from a methanogen. While the first two enzymes of the pathway are well known and occur in many microbes and plants, the next enzymes were of a new kind. “We were stunned to see that it appears as if M. thermolithotrophicus has hijacked one enzyme from a dissimilatory sulfate-reducing organism and slightly modified it to serve its own needs,” says Jespersen. While some microbes assimilate sulfate as a cellular building block, others use it to obtain energy in a dissimilatory process – as humans do when respiring oxygen. The microbes that perform dissimilatory sulfate-reduction employ a different set of enzymes to do so. The methanogen studied here converted one of these dissimilatory enzymes into an assimilatory one. “A simple, yet highly effective strategy and most likely the reason why this methanogen is able to grow on sulfate. So far, this particular enzyme has only been found in M. thermolithotrophicus and no other methanogens,” Jespersen explains. However, M. thermolithotrophicus also needs to cope with two poisons that are generated during the assimilation of sulfate. That´s what the last two enzymes of the pathway are made for: The first one, again similar to a dissimilatory enzyme, generates sulfide from sulfite. The second one is a new type of phosphatase with robust efficiency to hydrolyze the other poison, shortly known as PAP.  “It seems that M. thermolithotrophicus collected genetic information from its microbial environment that enabled it to grow on sulfate. By mixing and matching assimilatory and dissimilatory enzymes, it created its own functional sulfate reduction machinery,” says Wagner.  New Avenues for Biotechnological Application Hydrogenotrophic methanogens, such as M. thermolithotrophicus, have the amazing ability to convert dihydrogen (H2, for example artificially produced from renewable energy) and carbon dioxide (CO2) into methane (CH4). In other words, they can convert the greenhouse gas CO2 into the biofuel CH4, which can be used, for example, to heat our homes. To do this, methanogens are grown in large bioreactors. A current bottleneck in the cultivation of methanogens is their need for the highly hazardous and explosive hydrogen sulfide gas as a sulfur source. With the discovery of the sulfate-assimilation pathway in M. thermolithotrophicus, it is possible to genetically engineer methanogens that are already used in biotechnology to use this pathway instead – leading to safer and more cost-effective biogas production.  “An unresolved burning question is why M. thermolithotrophicus would assimilate sulfate in nature. For this, we will have to go out into the field and see if the enzymes required for this pathway are also expressed in the natural environment of the microbe,” concludes Wagner. Reference: “Assimilatory sulfate-reduction in the marine methanogen Methanothermococcus thermolithotrophicus” by Marion Jespersen and Tristan Wagner, 5 June 2023, Nature Microbiology. DOI: 10.1038/s41564-023-01398-8

An elephant investigating elephant dung with his trunk at the Boteti River. Credit: Connie Allen Traveling elephants pay close attention to scent trails of dung and urine left by other elephants, new research shows. Scientists monitored well-used pathways and found that wild African savannah elephants — especially those traveling alone — were “highly attentive,” sniffing and tracking the trail with their trunks. This suggests these scents act as a “public information resource,” according to researchers from the University of Exeter and Elephants for Africa. More research is now needed to find out whether humans can create artificial elephant trails to divert elephants away from farms and villages, where conflict with humans can cause devastation to communities. Alternatively, scent trails could be placed to improve the efficiency of routes connecting elephant populations between protected areas. An elephant pathway. Credit: Connie Allen “Our findings suggest an important role of an elephant’s sense of smell in long-distance navigation,” said lead author Connie Allen, of Exeter’s Centre for Research in Animal Behaviour. “As elephants follow these trails, they deposit their own urine and dung, which reinforces the pathway’s presence for future elephants. “We see great potential for these findings to be applied to elephant management and conservation — primarily as a method for manipulating elephant movements. “We carried out this study in Botswana, where the main threat to elephants is conflict with humans. By removing the existing scent paths that lead elephants to close contact with humans in problem areas, and redirecting them, perhaps we could reduce such conflicts happening.” Male elephants in the Makgadikgadi. Credit: Connie Allen The proposed technique could also aid efforts in Botswana to reconnect elephants with populations across southern Africa. The study, which examined a predominantly male population, also found that urine deposits from adult elephants were more likely to attract attention than that of younger (subadult) males. “African elephants may therefore be able to discern the age and maturity of individuals they can expect to encounter from remote urine cues on pathways,” Allen explained. Reference: “Field evidence supporting monitoring of chemical information on pathways by male African elephants” by Connie R.B. Allen, Lauren J.N. Brent, Thatayaone Motsentwa and Darren P. Croft, 26 May 2021, Animal Behaviour. DOI: 10.1016/j.anbehav.2021.04.004 The study received funding from the Leverhulme Trust.

DVDV1551RTWW78V