Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Cushion insole OEM solution Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Private label insole and pillow OEM China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.ODM pillow factory for sleep product brands

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Vietnam flexible graphene product manufacturing

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.ESG-compliant OEM manufacturer in Vietnam

Tengchong Yunnan hot springs in China, where some of the newly described Brockarchaeota were collected. Credit: Jian-Yu Jiao/Sun Yat-Sen University The tree of life just got a little bigger: A team of scientists from the U.S. and China has identified an entirely new group of microbes quietly living in hot springs, geothermal systems, and hydrothermal sediments around the world. The microbes appear to be playing an important role in the global carbon cycle by helping break down decaying plants without producing the greenhouse gas methane. “Climate scientists should take these new microbes into account in their models to more accurately understand how they will impact climate change,” said Brett Baker, assistant professor at The University of Texas at Austin’s Marine Science Institute who led the research published today (April 23, 2021) in Nature Communications. The new group, which biologists call a phylum, is named Brockarchaeota after Thomas Brock, a pioneer in the study of microbes that live in extreme environments such as the hot springs of Yellowstone National Park. Sadly, Brock died on April 4. His research led to a powerful biotech tool called PCR, which is used, among other things, in gene sequencing and COVID-19 tests. “The description of these new microbes from hot springs is a fitting tribute to Tom’s legacy in microbiology,” Baker added. Tibetan hot spring, where some of the newly described Brockarchaeota were collected. Credit: En-Min Zhou/Yunnan University So far, Brockarchaeota have not been successfully grown in a laboratory or imaged under a microscope. Instead, they were identified by painstakingly reconstructing their genomes from bits of genetic material collected in samples from hot springs in China and hydrothermal sediments in the Gulf of California. Baker and the team used high-throughput DNA sequencing and innovative computational approaches to piece together the genomes of the newly described organisms. The scientists also identified genes that suggest how they consume nutrients, produce energy and generate waste. “When we looked in public genetic databases, we saw that they had been collected all around the world but described as ‘uncultured microorganisms,'” said Valerie De Anda, first author of the new paper, referring to specimens collected by other researchers from hot springs in South Africa and Wyoming’s Yellowstone, and from lake sediments in Indonesia and Rwanda. “There were genetic sequences going back decades, but none of them were complete. So, we reconstructed the first genomes in this phylum and then we realized, wow, they are around the world and have been completely overlooked.” Location of samples from which Brockarchaeota genomes (orange) and 16S rRNA gene sequences (blue) have been recovered. The size of the circle corresponds to the total number of Brockarchaeota-related sequences in each location. Credit: University of Texas at Austin The Brockarchaeota are part of a larger, poorly studied group of microbes called archaea. Until now, scientists thought that the only archaea involved in breaking down methylated compounds — that is, decaying plants, phytoplankton, and other organic matter — were those that also produced the greenhouse gas methane. “They are using a novel metabolism that we didn’t know existed in archaea,” said De Anda. “And this is very important because marine sediments are the biggest reservoir of organic carbon on Earth. These archaea are recycling carbon without producing methane. This gives them a unique ecological position in nature.” A phylum is a broad group of related organisms. To get a sense of just how large and diverse phyla are, consider that the phylum Chordata alone includes fish, amphibians, reptiles, birds, mammals, and sea squirts. The phylum Arthropoda, which accounts for about 80% of all animals, includes insects, arachnids (such as spiders, scorpions, and ticks) and crustaceans (crabs, lobsters, shrimp, and other tasty sea denizens). In July 2020, Baker, De Anda, and others suggested the possible existence of several new phyla among the archaea, including Brockarchaeota, in a review article in Nature Microbiology. This latest study adds more than a dozen new species to Brockarchaeota, describes their metabolism, and demonstrates that they are indeed a distinctly new phylum. In addition to breaking down organic matter, these newly described microbes have other metabolic pathways that De Anda speculates might someday be useful in applications ranging from biotechnology to agriculture to biofuels. Reference: “Brockarchaeota, a novel archaeal phylum with unique and versatile carbon cycling pathways” by Valerie De Anda, Lin-Xing Chen, Nina Dombrowski, Zheng-Shuang Hua, Hong-Chen Jiang, Jillian F. Banfield, Wen-Jun Li and Brett J. Baker, 23 April 2021, Nature Communications. DOI: 10.1038/s41467-021-22736-6 The study’s co-corresponding authors are Baker and Wen-Jun Li from Sun Yat-Sen University and Southern Marine Science and Engineering Guangdong Laboratory (China). The other authors are Lin-xing Chen and Jillian F. Banfield from the University of California, Berkeley; Nina Dombrowski formerly in Baker’s lab at UT Austin and now at Royal Netherlands Institute for Sea Research and Utrecht University; Zheng-Shuang Hua from Sun Yat-Sen University (China) and Dartmouth College; and Hong-Chen Jiang from China University of Geosciences. This work was funded in part by the U.S. National Science Foundation, China’s Ministry of Science and Technology and the National Natural Science Foundation of China. The sequencing was partially conducted by the U.S. Department of Energy Joint Genome Institute.

Imperial College London researchers discover hair follicles have a unique mechanism to sense touch, releasing neurotransmitters in response. This may shed light on inflammatory skin conditions like eczema. Hair follicles help sense touch by releasing serotonin and histamine, activating sensory nerves. This discovery may provide new insights into inflammatory skin diseases like eczema. Researchers from Imperial College London have uncovered a hidden mechanism within hair follicles that allow us to feel touch. Before this discovery, it was widely believed that touch was sensed solely through nerve endings in the skin and around hair follicles. However, this recent study reveals that cells inside the hair follicles – the entities enveloping the hair strand – can also sense touch in cell cultures. The researchers also found that these hair follicle cells release the neurotransmitters histamine and serotonin in response to touch – findings that might help us in the future to understand histamine’s role in inflammatory skin diseases like eczema. The Unexpected Role of Hair Follicles Lead author of the paper Dr Claire Higgins, from Imperial’s Department of Bioengineering, said: “This is a surprising finding as we don’t yet know why hair follicle cells have this role in processing light touch. Since the follicle contains many sensory nerve endings, we now want to determine if the hair follicle is activating specific types of sensory nerves for an unknown but unique mechanism.” A Touchy Subject We feel touch using several mechanisms: sensory nerve endings in the skin detect touch and send signals to the brain; richly innervated hair follicles detect the movement of hair fibers; and sensory nerves known as C-LTMRs, that are only found in hairy skin, process emotional, or ‘feel-good’ touch. Now, researchers may have uncovered a new process in hair follicles. To carry out the study, the researchers analyzed single-cell RNA sequencing data of human skin and hair follicles and found that hair follicle cells contained a higher percentage of touch-sensitive receptors than equivalent cells in the skin.  They established co-cultures of human hair follicle cells and sensory nerves, then mechanically stimulated the hair follicle cells, finding that this led to activation of the adjacent sensory nerves. Neurotransmitters in Touch Perception They then decided to investigate how the hair follicle cells signaled to the sensory nerves. They adapted a technique known as fast scan cyclic voltammetry to analyze cells in culture and found that the hair follicle cells were releasing the neurotransmitters serotonin and histamine in response to touch. When they blocked the receptor for these neurotransmitters on the sensory neurons, the neurons no longer responded to the hair follicle cell stimulation. Similarly, when they blocked synaptic vesicle production by hair follicle cells, they were no longer able to signal to the sensory nerves. They therefore concluded that in response to touch, hair follicle cells release that activate nearby sensory neurons. The researchers also conducted the same experiments with cells from the skin instead of the hair follicle. The cells responded to light touch by releasing histamine, but they didn’t release serotonin. Dr Higgins said: “This is interesting as histamine in the skin contributes to inflammatory skin conditions such as eczema, and it has always been presumed that immune cells release all the histamine. Our work uncovers a new role for skin cells in the release of histamine, with potential applications for eczema research.” Looking Forward The researchers note that the research was performed in cell cultures, and will need to be replicated in living organisms to confirm the findings. The researchers also want to determine if the hair follicle is activating specific types of sensory nerves. Since C-LTMRs are only present within hairy skin, they are interested to see if the hair follicle has a unique mechanism to signal to these nerves that we have yet to uncover. Reference: “Mechanical stimulation of human hair follicle outer root sheath cultures activates adjacent sensory neurons” by Julià Agramunt, Brenna Parke, Sergio Mena, Victor Ubels, Francisco Jimenez, Greg Williams, Anna DY Rhodes, Summik Limbu, Melissa Hexter, Leigh Knight, Parastoo Hashemi, Andriy S. Kozlov and Claire A. Higgins, 27 October 2023, Science Advances. DOI: 10.1126/sciadv.adh3273 This work was funded by Engineering and Physical Research Council (EPSRC, part of UKRI), Proctor & Gamble, Wellcome Trust, and Biotechnology and Biological Sciences Research Council (BBSRC, part of UKRI).

Scientists discovered a molecular mechanism of long-term memory that is also involved in memory loss in old age. The MPS-2 protein, regulated by NHR-66, is vital for long-term memory and declines with age, but restoring it reverses memory loss. Researchers at the University of Basel have discovered a molecular mechanism that plays a central role in intact long-term memory. This mechanism is also involved in physiological memory loss in old age. Many life forms, from worms to humans, have differentiated memory functions, such as short-term and long-term memory. Interestingly, at the cell and molecule level, many of these functions are nearly identical from life form to life form. Detecting the molecules involved in memory processes is of great importance to both basic and clinical research, since it can point the way to the development of drugs for memory disorders. Key Gene mps-2 Linked to Memory Formation By studying roundworms (Caenorhabditis elegans), scientists at the Transfaculty Research Platform for Molecular and Cognitive Neurosciences (MCN) at the University of Basel have now discovered a molecular mechanism of long-term memory that is also involved in memory loss in old age. They report on their findings in the journal Current Biology. The team led by Dr Attila Stetak, Professor Andreas Papassotiropoulos, and Professor Dominique de Quervain used sensory stimuli to first examine the learning and memory ability of genetically modified roundworms lacking a certain gene, mps-2. This gene contains the blueprint for part of a voltage-dependent ion channel in the nerve cell membrane and is suspected of playing a role in memory functions. It was found that modified worms had equally good short-term memory as unmodified specimens. However, as the length of the experiment increased, the researchers found that the genetically modified worms were less able to retain what they learned. Without mps-2, they had a reduced long-term memory. Age-Related Memory Loss In roundworms, as in humans, a loss of memory can be observed with increasing age. However, the molecular basis for this process is largely unclear. In further experiments, the researchers were able to prove that unmodified worms with the mps-2 gene exhibit a strong reduction of the MPS-2 protein, the product of the gene, in old age. This was related to reduced memory performance. This lack of MPS-2 protein proved not to be a passive but an actively regulated process. The research team was able to identify another protein, NHR-66, as responsible for regulating this deficiency. NHR-66 actively curbs the reading of the mps-2 gene and thus production of the MPS-2 protein in old age. If in older worms MPS-2 protein level was artificially induced or their NHR-66 was turned off, they had a similarly good memory as younger worms. Both molecules, MPS-2 and NHR-66, therefore make for interesting targets for drugs that could mitigate age-related memory loss. In further studies, the researchers want to examine therapeutic options based on their discovery. Reference: “Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline” by Bank G. Fenyves, Andreas Arnold, Vaibhav G. Gharat, Carmen Haab, Kiril Tishinov, Fabian Peter, Dominique de Quervain, Andreas Papassotiropoulos and Attila Stetak, 30 November 2020, Current Biology. DOI: 10.1016/j.cub.2020.10.069 The current study is part of the Basel Genetics Memory Project of the Transfaculty Research Platform for Molecular and Cognitive Neurosciences, led by Andreas Papassotiropoulos and Dominique de Quervain. The aim is for the findings to be transferred from basic research into pharmaceutical studies and clinical projects as quickly as possible.

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