Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Graphene sheet OEM supplier China

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.ODM pillow for sleep brands China

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Innovative pillow ODM production solution in Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China high-end foam product OEM/ODM

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam custom product OEM/ODM services

New research shows that uncontrolled growth in cancer cells leads to a state of senescence, affecting their ability to divide. This finding challenges current cancer treatment methods using growth and division inhibitors and suggests the need for alternative treatment strategies. Credit: SciTechDaily.com ETH Zurich researchers are illuminating what can happen when cells exceed their normal size and become senescent. Their new findings could help to optimize cancer treatments. If cells in cell cultures grow while being treated with division-suppressing agents, their growth becomes excessive and they permanently lose their ability to divide. However, if the cells are treated with a combination of division inhibitors and growth inhibitors, they remain capable of dividing after these substances have been discontinued. The findings could be transferred to certain cancer therapies, but first need to be clinically tested and confirmed. Understanding Cell Growth and Cancer Growth is a fundamental biological process and a prerequisite for living organisms to develop and reproduce. The processes of cell growth (i.e. the production of new biomass) and of cell division must be coordinated with each other. In multicellular organisms such as humans, the growth of cells must also be coordinated with their environment so that cells are present in the right number and size to form functional tissue or organs. Cell growth is therefore strictly regulated and takes place only when certain growth signals are present. But cancer cells are different. They grow unchecked, they divide over and over again, and they don’t react to stop signals from their environment. Cells in which only division is suppressed (left) continue to grow and lose their ability to divide, whereas cells in which growth and division are suppressed do not. Credit: Sandhya Manohar / ETH Zürich A Dual Nature of Cancer Cells Now several studies published in the journal Molecular Cell show that uncontrolled growth is not only an advantage for cancer cells but also a weakness. One of these studies was led by Professor Gabriel Neurohr from the Institute of Biochemistry at ETH Zurich. For several years, he and his group have been researching how cell growth influences cell function. They are also investigating what happens when cells exceed their normal size and enter a state that the researchers refer to as senescence. In this state, the cells are preternaturally large and lose their ability to divide. Nevertheless, they are still active and can influence their environment, such as by releasing messenger substances. Senescent cells are found in normal tissue and play an important role in the aging process. However, senescence can also be induced with chemical substances, and because it leads to a loss of the capacity to divide, it is the goal of certain cancer treatments. A Breakdown in DNA Repair Neurohr’s colleague Sandhya Manohar has now investigated whether excessive size affects cellular functions in senescent cells. In her research, she treated a non-cancerous cell line and a breast cancer cell line with substances that inhibit growth and division. When she used only division-suppressing substances in her cell cultures, the cells were indeed no longer able to divide, but they continued to grow and went into senescence. As a result, they permanently lost their ability to divide. This effect persisted even after Manohar had discontinued the division inhibitors. An important reason for the loss of the ability to divide is that the enlarged cells can no longer repair damage to their genetic material, such as double-stranded DNA breaks. Such breaks always occur spontaneously when a cell duplicates its genetic material prior to cell division. In addition, these cells cannot correctly activate a key signaling pathway (p53-​p21), which is critical for a coordinated response to DNA breaks. As a result, the damage is not repaired efficiently enough. What this means for enlarged cells is that numerous irreparable DNA breaks accumulate during division – to the point where division is no longer possible. Questioning Combination Therapy in Cancer Treatment Yet when the researchers treated the cells with division-inhibiting and growth-inhibiting substances simultaneously, the cells were able to divide and multiply normally again after both substances were discontinued. “In cancer therapy, this is precisely what you don’t want,” Neurohr says. Growth-​ and division-inhibiting agents are already being used in cancer treatment. “Based on our observations in cell cultures, we would expect an increased relapse rate when treating a tumor with division inhibitors and growth inhibitors at the same time. It would make more sense to first use a division inhibitor, then a drug that further damages the DNA of the cells and makes division completely impossible,” Neurohr explains. Further Research and Clinical Implications Thus far, the ETH researchers have tested their new findings only on cell cultures. With both growth and division strongly dependent on the cell environment, the team cannot transfer these results directly to a clinical setting. Trials with organoids or on tissue samples are thus needed first to better test the potential treatment. Clinical studies investigating various combinations of division inhibitors and other medications are also underway. The idea put forth by the ETH researchers under Neurohr has support from studies by three other international research teams, also published in the same issue of Molecular Cell. These studies show that cancer cells with hyperactive growth are sensitive to treatment with division inhibitors. As these substances are already being used to treat certain types of breast cancer, the new findings could have a long-term impact on cancer treatment. Reference: “Genome homeostasis defects drive enlarged cells into senescence” by Sandhya Manohar, Marianna E. Estrada, Federico Uliana, Karla Vuina, Patricia Moyano Alvarez, Robertus A.M. de Bruin and Gabriel E. Neurohr, 16 November 2023, Molecular Cell. DOI: 10.1016/j.molcel.2023.10.018 This research was funded by an SNSF Professorial Fellowship for Gabriel Neurohr and an ETH Fellowship for Sandhya Manohar.

Manipulator arm on the HyBIS hybrid remotely operated vehicle collecting crust samples from the Rio Grande Rise. Credit: Bramley Murton Researchers conducted the first large-scale survey of the microbiota present in the seamount’s ferromanganese crusts, describing bacteria and archaea involved in the nutrient cycle and formation of metals. The abundant biological and mineral diversity of the Rio Grande Rise, a seamount in the depths of the Atlantic Ocean about 1,500 km from the coast of Brazil, is probably due to a great extent to little-known microscopic creatures.  Researchers affiliated with the University of São Paulo’s Oceanographic Institute (IO-USP), collaborating with colleagues at the UK’s National Oceanography Center, investigated the microorganisms inhabiting the seamount’s ferromanganese crusts and concluded that bacteria and archaea are probably responsible for maintaining the abundant local life, besides being involved in the process of biomineralization that forms the metals present in the crusts.  An article published in the journal Microbial Ecology describes the study, which was funded by FAPESP and the UK’s Natural Environment Research Council (NERC).  In 2014, the International Seabed Authority (ISA) awarded Brazil a 15-year grant of mineral exploitation rights to the Rio Grande Rise. Comprising 167 member states plus the European Union, the ISA is mandated under the United Nations Convention on the Law of the Sea to organize, regulate and control all mineral-related activities in the international seabed area, which corresponds to some 50% of the total area of the world’s oceans. “Very little is known about the area’s biodiversity or about the impact of mining on its ecosystems,” said Vivian Pellizari, a professor at IO-USP and principal investigator for the study.  The study was part of a Thematic Project supported by FAPESP. The article is one of the results of the PhD research of Natascha Menezes Bergo, currently a postdoctoral research intern at IO-USP. “Although the process known as microbial biomineralization is well-known, oxidation and precipitation of manganese hadn’t been proved, and we had no idea how it occurred in ocean areas. In July 2020, however, an article by US researchers was published in Nature showing for the first time that bacteria use manganese to convert carbon dioxide into biomass via a process called chemosynthesis,” said Bergo, who participated in sample collection in 2018 on the UK research vessel RRS Discovery.  “One of these bacteria, which belongs to the group Nitrospirae, was present in the DNA sequences we extracted from crust samples collected at the Rio Grande Rise. This is strong evidence that the metals there are formed not just by a geological process but also by a biological process in which microorganisms play an important part,” she noted.  Besides iron and manganese, the crusts are rich in cobalt, nickel, molybdenum, niobium, platinum, titanium and tellurium, among other elements. Cobalt is essential to the production of rechargeable batteries, for example, and tellurium is a key input for the production of high-efficiency solar cells. In late 2018, Brazil applied to the ISA for an extension of its continental shelf to include the Rio Grande Rise. In other parts of the world, similar areas that have been studied for longer with the same objectives include the Clarion-Clipperton Zone and the Takuyo-Daigo Seamount, both in the North Pacific, as well as the Tropic Seamount in the North Atlantic. Formation The Rio Grande Rise has an area of some 150,000 km2 (58,000 mi²), three times the size of Rio de Janeiro state, and depths ranging from 800 m to 3,000 m (2,600 ft to 9,800 ft). Formed when present-day Africa and South America separated from the supercontinent Gondwana between 146 million years ago (mya) and 100 mya, the Rise was an island that sank some 40 mya, probably owing to the weight of a volcano and its lava and the movement of tectonic plates.  On one of their 2018 expeditions, the researchers collected from a part of the Rise samples of the ferromanganese crusts and of the coral skeletons that live on them, as well as calcarenite rock and biofilms on the crusts’ surfaces. These biofilms are structured microbial communities enveloped in substances they secrete to protect themselves from threats such as lack of nutrients or potential toxins. “Finding biofilm was an interesting surprise, as it’s an indicator of an incipient biomineralization process,” Bergo said. “We found the same microorganisms in our biofilm, coral, calcarenite and crust samples. The only difference was the age of the surfaces. The coral is more recent than the crusts, and the biofilm is even younger.” A total of 666,782 DNA sequences were recovered from the samples. The bacteria and archaea found by the scientists belong to groups known to be involved in the nitrogen cycle whereby ammonia is converted into nitrite and nitrate, and hence to serve as a source of energy for other microorganisms. Besides Nitrospirae, they found other prokaryotes such as the archaeon class Nitrososphaeria. Sequencing of the samples also revealed groups involved in the methane cycle such as Methylomirabilales and Deltaproteobacteria. The results amplify scientists’ understanding of the microbial diversity and potential ecological processes found on the ferromanganese crusts of the South Atlantic seabed. They will also contribute to future regulation of possible mining activities in the area of the Rio Grande Rise. “As the crusts are removed, local circulation will probably change and this, in turn, will change the available supply of organic matter and nutrients, and hence the local microbiome and all the life associated with it,” Bergo said. “Besides, the crusts grow 1 mm every 1 million years on average, so there won’t be time for recolonization. It’s no accident that so many studies have been published recently on how to assess and mitigate the impact of deep-sea mining.” Reference: “Microbial Diversity of Deep-Sea Ferromanganese Crust Field in the Rio Grande Rise, Southwestern Atlantic Ocean” by Natascha Menezes Bergo, Amanda Gonçalves Bendia, Juliana Correa Neiva Ferreira, Bramley J. Murton, Frederico Pereira Brandini and Vivian Helena Pellizari, 16 January 2021, Microbial Ecology. DOI: 10.1007/s00248-020-01670-y

Scientists discover how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans. Neuronal Plasticity in Chronic Pain-Induced Anxiety Revealed Hokkaido University researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans. Chronic pain is persistent and inescapable, and can lead to maladaptive emotional states. It is often comorbid with psychiatric disorders, such as depression and anxiety disorders. It is thought that chronic pain causes changes in neural circuits, and gives rise to depression and anxiety. Researchers at Hokkaido University have identified the neuronal circuit involved in chronic pain-induced anxiety in mice. Their research, which was published on April 27, 2022, in the journal Science Advances, could lead to the development of new treatments for chronic pain and psychiatric disorders such as anxiety disorders and major depressive disorder.   “Clinicians have known for a long time that chronic pain often leads to anxiety and depression, however the brain mechanism for this was unclear,” said Professor Masabumi Minami of the Faculty of Pharmaceutical Sciences at Hokkaido University, the corresponding author of the paper. The researchers looked at how neuronal circuits were affected by chronic pain in mice. They used an electrophysiological technique to measure the activities of neurons after four weeks of chronic pain. They found that chronic pain caused the neuroplastic change which suppressed the neuronal pathway projecting from the brain region called bed nucleus of the stria terminalis (BNST) to the region called lateral hypothalamus (LH).  Neuronal circuit involved in chronic pain-induced maladaptive anxiety. Increased excitability (white arrow) of BNSTCART neurons causes a sustained suppression (black arrow) of LH-projecting BNST neurons during chronic pain, thereby enhancing anxiety-like behavior. Credit: Naoki Yamauchi, et al. Science Advances. April 27, 2022 Using chemogenetics, an advanced technique to manipulate neuronal activity, they showed that restoration of the suppressed activity of this neuronal pathway attenuated the chronic pain-induced anxiety. These findings indicate that chronic pain-induced functional changes in the neuronal circuits within the BNST leads to maladaptive anxiety. “These findings could not only lead to improved treatment of chronic pain, but also to new therapeutics for anxiety disorders,” says Minami. Reference: “Chronic pain–induced neuronal plasticity in the bed nucleus of the stria terminalis causes maladaptive anxiety” by Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano and Masabumi Minami, 27 April 2022, Science Advances. DOI: 10.1126/sciadv.abj5586 This study was supported by Grant-in-Aid for Scientific Research (B) (JP20H03389) and for Challenging Research (Exploratory) (JP19K22477, JP21K19318) and Grant-in-Aid for JSPS Fellows (JP20J14256) from the Japan Society for the Promotion of Science (JSPS), and by the Japan Agency for Medical Research and Development (AMED) under Grant Number JP21gm0910012s0105 and JP21zf0127004.

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