Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Taiwan pillow OEM manufacturer

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Taiwan high-end foam product OEM/ODM factory

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.China anti-odor insole OEM service

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Private label insole and pillow OEM Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China sustainable material ODM solutions

Researchers used computer models to investigate the evolutionary role of aging. They challenge the notion that aging has no positive function, suggesting it might expedite evolution in changing environments, thereby benefiting subsequent generations. Their findings indicate that aging could be an advantageous trait selected by natural evolution. Credit: SciTechDaily.com The mystery of aging has fascinated people for millennia, with many willing to do anything to halt or reverse this process, because aging is typically associated with gradual deterioration of most body functions. While senescence is a natural part of life, biologists understand surprisingly little about the emergence of this process during evolution. It is not clear whether aging is inevitable, because there are organisms that seemingly do not age at all, moreover, the phenomenon known as negative aging, or rejuvenation, does exist: some turtles’ vital functions improve with age. Researching Aging’s Evolutionary Role Researchers of the Institute of Evolution led by Academician Eörs Szathmáry have endeavored to prove the validity of a previously proposed but still unproven theory of aging. The theory suggests that under the right circumstances, evolution can favor the proliferation of genes controlling senescence. To test the hypothesis, the researchers used a computer model they had developed. This model is an algorithm capable of simulating long-term processes in populations of organisms and genes under circumstances controlled by the scientists. Essentially, with such models, evolutionary scenarios can be run, yielding results in a few hours rather than over millions of years. Modern evolutionary research would be inconceivable without computer modeling. Exploring Aging’s Purpose The fundamental question of the research was simple: Is there any meaning of aging? Does it serve any evolutionary function, or is it indeed a bitter and fatal by-product of life? “Aging can have an evolutionary function if there is a selection for senescence. In our research, we aimed to uncover this selection,” says Eörs Szathmáry. “According to classical explanations, aging emerges in the populations even without selection. That is because individuals would die sooner or later without aging as well (as a consequence of illness or accidents), therefore the force of natural selection in the population would get weaker and weaker. This creates an opportunity for the genes which have an adverse effect for chronologically old individuals (thus causing senescence) to accumulate. Which would mean aging is only a collateral consequence of evolution and has no adaptive function.” Challenging Conventional Wisdom During the last century, using different biological mechanisms, several evolutionary theories were formulated for the explanation of inevitable aging, which has no positive function. Several scientists accepted this assumption as fact, but when non-aging organisms were discovered, more and more researchers questioned the inevitability of senescence, and suggested perhaps aging could have some advantages as well. “It has become accepted in the evolutionary biology community that the classical non-adaptive theories of aging cannot explain all the aging patterns of nature, which means the explanation of aging has become an open question once again,” says Szathmáry. “Alternative adaptive theories offer solutions for this problem by suggesting positive consequences of senescence. For example, it is possible that in a changing environment, aging and death are more advantageous for individuals, because this way the competition, which hampers the survival and reproduction of the more adaptable progeny with better gene compositions, can be decreased.” However, this scenario holds true only if individuals are predominantly surrounded by their relatives. Otherwise, during sexual reproduction, the non-aging individuals “steal” the better (that is better suited for changed environment) genes from the members of the aging population, and therefore the significant senescence disappears. Aging as an Evolutionary Catalyst After running the model, the Hungarian biologists found that aging can indeed accelerate evolution. This is advantageous in a changing world because the faster adaptation can find the adequate traits more quickly, thereby supporting the survival and spread of descendent genes. This means that senescence can become a really advantageous characteristic and be favored by natural selection. Reference: “Directional selection coupled with kin selection favors the establishment of senescence” by András Szilágyi, Tamás Czárán, Mauro Santos and Eörs Szathmáry, 23 October 2023, BMC Biology. DOI: 10.1186/s12915-023-01716-w Funding: National Research, Development and Innovation Office (Hungary), Bolyai János Research Fellowship of the Hungarian Academy of Sciences, New National Excellence Program of the Ministry for Culture and Innovation, Ministerio de Ciencia e Innovación, Generalitat de Catalunya 2021, Distinguished Guest Scientists Fellowship Programme of the Hungarian Academy of Sciences, Volkswagen Foundation (initiative “Leben? –Ein neuer Blick der Naturwissenschaften auf die grundlegenden Prinzipien des Lebens,” project “A unified model of recombination in life”)

Researchers at MIT, the Broad Institute, and the National Institutes of Health have developed a new search algorithm that has identified 188 kinds of new rare CRISPR systems in bacterial genomes. Credit: Broad Institute By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more. Microbial sequence databases contain a wealth of information about enzymes and other molecules that could be adapted for biotechnology. But these databases have grown so large in recent years that they’ve become difficult to search efficiently for enzymes of interest. New Search Algorithm for CRISPR Systems Now, scientists at the McGovern Institute for Brain Research at MIT, the Broad Institute of MIT and Harvard, and the National Center for Biotechnology Information (NCBI) at the National Institutes of Health have developed a new search algorithm that has identified 188 kinds of new rare CRISPR systems in bacterial genomes, encompassing thousands of individual systems. The work was published on November 23 in the journal Science. The algorithm, which comes from the lab of pioneering CRISPR researcher Professor Feng Zhang, uses big-data clustering approaches to rapidly search massive amounts of genomic data. The team used their algorithm, called Fast Locality-Sensitive Hashing-based clustering (FLSHclust) to mine three major public databases that contain data from a wide range of unusual bacteria, including ones found in coal mines, breweries, Antarctic lakes, and dog saliva. The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. The new systems could potentially be harnessed to edit mammalian cells with fewer off-target effects than current Cas9 systems. They could also one day be used as diagnostics or serve as molecular records of activity inside cells. Exploring CRISPR’s Diversity The researchers say their search highlights an unprecedented level of diversity and flexibility of CRISPR and that there are likely many more rare systems yet to be discovered as databases continue to grow. “Biodiversity is such a treasure trove, and as we continue to sequence more genomes and metagenomic samples, there is a growing need for better tools, like FLSHclust, to search that sequence space to find the molecular gems,” says Zhang, a co-senior author on the study and the James and Patricia Poitras Professor of Neuroscience at MIT with joint appointments in the departments of Brain and Cognitive Sciences and Biological Engineering. Zhang is also an investigator at the McGovern Institute for Brain Research at MIT, a core institute member at the Broad, and an investigator at the Howard Hughes Medical Institute. Eugene Koonin, a distinguished investigator at the NCBI, is co-senior author on the study as well. Searching for CRISPR CRISPR, which stands for clustered regularly interspaced short palindromic repeats, is a bacterial defense system that has been engineered into many tools for genome editing and diagnostics. To mine databases of protein and nucleic acid sequences for novel CRISPR systems, the researchers developed an algorithm based on an approach borrowed from the big data community. This technique, called locality-sensitive hashing, clusters together objects that are similar but not exactly identical. Using this approach allowed the team to probe billions of protein and DNA sequences — from the NCBI, its Whole Genome Shotgun database, and the Joint Genome Institute — in weeks, whereas previous methods that look for identical objects would have taken months. They designed their algorithm to look for genes associated with CRISPR. “This new algorithm allows us to parse through data in a time frame that’s short enough that we can actually recover results and make biological hypotheses,” says Soumya Kannan PhD ’23, who is a co-first author on the study. Kannan was a graduate student in Zhang’s lab when the study began and is currently a postdoc and Junior Fellow at Harvard University. Han Altae-Tran PhD ’23, a graduate student in Zhang’s lab during the study and currently a postdoc at the University of Washington, was the study’s other co-first author. “This is a testament to what you can do when you improve on the methods for exploration and use as much data as possible,” says Altae-Tran. “It’s really exciting to be able to improve the scale at which we search.” Discovering New CRISPR Variants In their analysis, Altae-Tran, Kannan, and their colleagues noticed that the thousands of CRISPR systems they found fell into a few existing and many new categories. They studied several of the new systems in greater detail in the lab. They found several new variants of known Type I CRISPR systems, which use a guide RNA that is 32 base pairs long rather than the 20-nucleotide guide of Cas9. Because of their longer guide RNAs, these Type I systems could potentially be used to develop more precise gene-editing technology that is less prone to off-target editing. Zhang’s team showed that two of these systems could make short edits in the DNA of human cells. And because these Type I systems are similar in size to CRISPR-Cas9, they could likely be delivered to cells in animals or humans using the same gene-delivery technologies being used today for CRISPR. One of the Type I systems also showed “collateral activity” — broad degradation of nucleic acids after the CRISPR protein binds its target. Scientists have used similar systems to make infectious disease diagnostics such as SHERLOCK, a tool capable of rapidly sensing a single molecule of DNA or RNA. Zhang’s team thinks the new systems could be adapted for diagnostic technologies as well. The researchers also uncovered new mechanisms of action for some Type IV CRISPR systems, and a Type VII system that precisely targets RNA, which could potentially be used in RNA editing. Other systems could potentially be used as recording tools — a molecular document of when a gene was expressed — or as sensors of specific activity in a living cell. Mining Biochemical Data The scientists say their algorithm could aid in the search for other biochemical systems. “This search algorithm could be used by anyone who wants to work with these large databases for studying how proteins evolve or discovering new genes,” Altae-Tran says. The researchers add that their findings illustrate not only how diverse CRISPR systems are, but also that most are rare and only found in unusual bacteria. “Some of these microbial systems were exclusively found in water from coal mines,” Kannan says. “If someone hadn’t been interested in that, we may never have seen those systems. Broadening our sampling diversity is really important to continue expanding the diversity of what we can discover.” Reference: “Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering” by Han Altae-Tran, Soumya Kannan, Anthony J. Suberski, Kepler S. Mears, F. Esra Demircioglu, Lukas Moeller, Selin Kocalar, Rachel Oshiro, Kira S. Makarova, Rhiannon K. Macrae, Eugene V. Koonin and Feng Zhang, 23 November 2023, Science. DOI: 10.1126/science.adi1910 This work was supported by the Howard Hughes Medical Institute; the K. Lisa Yang and Hock E. Tan Molecular Therapeutics Center at MIT; Broad Institute Programmable Therapeutics Gift Donors; The Pershing Square Foundation, William Ackman and Neri Oxman; James and Patricia Poitras; BT Charitable Foundation; Asness Family Foundation; Kenneth C. Griffin; the Phillips family; David Cheng; and Robert Metcalfe.

Remotely operated vehicle (ROV Jason) takes samples of hydrothermal microbial mat 2000m below sea level in the Guaymas Basin, Mexico. Credit: Image courtesy of Peter Girguis and E/V Nautilus Viruses in deep-sea vents interact with diverse hosts, sharing immunity between symbiotic bacteria and archaea, revealing broader viral roles in ecosystems. On Earth, viruses are the most plentiful and varied forms of life, inhabiting every environment. For example, in the ocean, viruses are even more abundant than microbes, outnumbering them by a factor of ten. Viruses replicate by infecting living organisms, ranging from humans and animals to insects and even microbes. Although the existence of environmental viruses that infect microbes is not a novel discovery, the extent of their prevalence was previously unknown. Researchers are just starting to comprehend the rich diversity of viruses and the effects they have on and their functions within ecosystems. A new study published in Nature Microbiology examines viruses that infect microbes in the deep sea and finds evidence that viruses interact with a far more diverse set of hosts than was previously thought. The study’s findings could aid in a better understanding of viruses and in engineering virus therapies. Lead author Ph.D. candidate Yunha Hwang and senior author Professor Peter Girguis, both in the Department of Organismic and Evolutionary Biology, collected samples from deep-sea hydrothermal vent microbial mats during a 2021 expedition in the Guaymas Basin, Mexico. These microbial mats are composed of massive numbers of bacteria and archaea, microbes that dominate in these ecosystems. Both are microbial, but bacteria and archaea are very distinct taxa; as different from each other as bacteria are from people. Symbiosis and Shared Immunity Between Bacteria and Archaea Though worlds apart, many archaea and bacteria survive through symbiotic relationships. At hydrothermal vents, bacteria and archaea form masses that can harness energy from the methane found in these environments. While this relationship is necessary for survival, it does not change the fact that these two lineages are biologically very different. Which made it even more surprising to Hwang and Girguis to discover that both bacteria and archaea carried immunity against the same viruses. One of the proposed models where horizontal transfer of immunity results in increased community-wide resilience against viruses. Credit: Image created using BioRender by Yunha Hwang “We were baffled when we saw the results,” said Hwang, “because whether they’re symbiotic or not, infection machinery is thought to be very complicated and host-specific. If archaea and bacteria are so different how can one virus infect both?” That question led the researchers to think about all the diverse ways in which viruses can interact with microbes that go beyond infection. Most work on viruses has been done in laboratories with one culture and one virus. Studies have only recently begun to extend to natural environments, which requires the use of different tools as microbes are not easy to culture in labs. “Around ninety-nine percent or more of the microbes that we know exist in nature we can’t culture in the lab,” Hwang said, “now we are able to sequence microbial DNA without culturing what’s in the ocean or in the soil. And with that, we can ask, ‘What are the viruses that are there and what are their interactions?’” Before joining Girguis’s lab, Hwang studied viruses in desert environments and observed that host-virus interactions in nature are much more nuanced than in laboratory settings. The deep-sea vents – in contrast to desert soils – harbor large microbial mats with billions of microbes engaging in symbiotic relations. In observing these unique environments the researchers asked, if microbes live in such high densities, are there viruses that have broader “host ranges?” In other words, were they capable of infecting diverse microbes? They sequenced DNA from the samples and recovered metagenome-assembled genomes of the microbes and viruses. They used CRISPR spacers (which encode the microbe’s immunological memory) to infer to which viruses in the sample the microbe is immune. To confirm their findings, they employed a newer technique called Hi-C (high throughput chromosome conformation capture) sequencing. If viral DNA is found inside a cell, the Hi-C technique can sequence crosslinked viral and host DNA. Finding statistically significant contact between viral DNA and microbial DNA, the researchers could confirm their findings that viral DNA are in not just one type of cell, but phylogenetically distant cells as well. Symbiotic Immunity and Interconnected Ecosystems “The CRISPR spacer analysis and Hi-C data showed a striking pattern that viruses genomically interact with very distantly related sets of microbes, particularly those that are in symbiosis with each other,“ said Hwang, “this interaction results in a very intriguing phenomenon where symbiotic microbes carry immunological memory against the same viruses, which means there is an advantage in symbiotic partners collaborating that exists also in their immunity. We have seen this within populations of bacteria, but we haven’t seen it across distantly related species. This is quite a poignant finding in that it reveals how interconnected the natural environment is.” “Yunha is very clever to have designed an experiment that takes advantage of vent microbial mats to better understand the role of viruses in habitats where microbial densities are crazy high,” said Girguis, “she’s also very thoughtful in looking for patterns in the genomes of both archaea and bacteria. The CRISPR spacer and Hi-C data showed us that the bacteria interacted, in some way or another, with the same virus as the archaea, which is totally wild.” The study challenges the conventional wisdom that viruses interact with a narrow set of hosts. And while the researchers are still gathering the direct evidence of a single kind of virus infecting these two very different hosts, the data clearly shows evidence of both bacteria and archaea having immunity against the same virus. These results led Hwang and Girguis to propose different models of host-virus interactions with ecological and evolutionary implications that go beyond infection. They suggest that viral interactions with microbes that are not the virus’s primary hosts may actually be prevalent in nature, particularly where microbes exist in a symbiotic relationship. It’s very unlikely the same virus can infect both bacteria and archaea,” Hwang said. “Instead, we propose that either one partner gained and retained immunity after a non-infectious encounter with a virus, and/or immunity was horizontally transferred between symbiotic partners.” The polyvalent nature of host-virus interactions in natural environments, and the diverse modes of interaction beyond infection, present important considerations as researchers move towards using viruses for biotechnological and medical applications, such as virus therapy in natural environments like the gut. “These host-virus interactions in natural environments show immunity can cross large phylogenetic distances resulting in inter-populations building greater viral resilience together,” said Hwang. Reference: “Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats” by Yunha Hwang, Simon Roux, Clément Coclet, Sebastian J. E. Krause and Peter R. Girguis, 6 April 2023, Nature Microbiology. DOI: 10.1038/s41564-023-01347-5

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