Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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Breathable insole ODM development Indonesia

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Latex pillow OEM production in Indonesia

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Orthopedic pillow OEM development factory Taiwan

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.ODM pillow factory in Vietnam

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam insole ODM for global brands

A breakthrough in genetic research has uncovered a “spatial grammar” in DNA, showing that the positioning of transcription factors critically influences gene activity, potentially reshaping how we understand gene regulation and disease. Researchers have discovered a “spatial grammar” in DNA that redefines the role of transcription factors in gene regulation, influencing our understanding of genetic variations and disease. A recently uncovered code within DNA, referred to as “spatial grammar,” may unlock the secret to how gene activity is encoded in the human genome. This breakthrough finding, identified by researchers at Washington State University and the University of California, San Diego and published in Nature, revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists’ understanding of gene regulation and how genetic variations may influence gene expression in development or disease. Discovery of Positional Dependence Transcription factors, the proteins that control which genes in one’s genome are turned on or off, play a crucial role in this code. Long thought of as either activators or repressors of gene activity, this research shows the function of transcription factors is far more complex. “Contrary to what you will find in textbooks, transcription factors that act as true activators or repressors are surprisingly rare,” said WSU assistant professor Sascha Duttke, who led much of the research at WSU’s School of Molecular Biosciences in the College of Veterinary Medicine. Rather, the scientists found that most activators can also function as repressors. “If you remove an activator, your hypothesis is you lose activation,” said Bayley McDonald, a WSU graduate student who was part of the research team. “But that was true in only 50% to 60% of the cases, so we knew something was off.” Looking closer, researchers found the function of many transcription factors was highly position-dependent. They discovered that the spacing between transcription factors and their position relative to where a gene’s transcription began determined the level of gene activity. For example, transcription factors might activate gene expression when positioned upstream or ahead of where a gene’s transcription begins but inhibit its activity when located downstream, or after a gene’s transcription start site. “It is the spacing, or ‘ambience,’ that determines if a given transcription factor acts as an activator or repressor,” Duttke said. “It just goes to show that similar to learning a new language, to learn how gene expression patterns are encoded in our genome, we need to understand both its words and the grammar.” Implications for Genetic Research By integrating this newly discovered ‘spatial grammar,’ Christopher Benner, associate professor at UC San Diego, anticipates scientists can gain a deeper understanding of how mutations or genetic variations can affect gene expression and contribute to disease. ”The potential applications are vast,” Benner said. “At the very least, it will change the way scientists study gene expression.” Reference: “Position-dependent function of human sequence-specific transcription factors” by Sascha H. Duttke, Carlos Guzman, Max Chang, Nathaniel P. Delos Santos, Bayley R. McDonald, Jialei Xie, Aaron F. Carlin, Sven Heinz and Christopher Benner, 17 July 2024, Nature. DOI: 10.1038/s41586-024-07662-z

Artistic reconstruction of mating position in Olenoides serratus. Credit: Holly Sullivan Fossil evidence from the Cambrian trilobite Olenoides serratus suggests that ancient arthropods used clasper-like limbs during mating, similar to modern horseshoe crabs. Fossils can tell scientists a lot about an animal such as their morphology, their environment, and where to place them in the tree of life. One thing though that’s very difficult to observe in the fossil record is an animal’s reproductive behavior. It takes a very uniquely preserved fossil to reveal the secrets behind reproductive strategies in some of the earliest complex animals. In a new study published today (May 6, 2022) in the journal Geology, PhD candidate Sarah R. Losso and Professor Javier Ortega-Hernández, both in the Department of Organismic and Evolutionary Biology at Harvard, reveal the mating behavior of trilobites from the mid-Cambrian fossil, Olenoides serratus. Trilobites are a group of 520-250 million years old arthropods likely near the branching point of two major groups of arthropods, the chelicerates (horseshoe crabs, spiders, and scorpions) and the mandibulates (centipedes, crabs, and insects). They dominant the Paleozoic Era fossil record, are found on every continent, and have over 20,000 described species. They are named for the three-lobed appearance of their durable exoskeleton enriched in calcite, which is easily preserved and has produced an excellent fossil record. Trilobite morphology has been extensively studied, but little is known about trilobite reproduction. Rare examples include those of unfertilized eggs that have been found underneath the head of a presumably female specimen, as well as clusters of fertilized eggs which were deposited in sediment during the Cambrian. Researcher have hypothesized that large clusters of trilobites fossilized together might represent mass molting and mating events similar to those observed in living marine species such as the Atlantic horseshoe crab Limulus polyphemus. Yet, the reproductive behavior of trilobites, including their mating and fertilization, remains practically unknown. Reconstruction of mating in Olenoides serratus: a) Diagram showing appendages of the male align with the exoskeleton of the female. b) Artistic reconstruction of mating position. Credit: Holly Sullivan (https://www.sulscientific.com/) Unique Fossil Reveals Clasps on Olenoides Serratus Losso, who is working on a comprehensive redescription of the morphology of Olenoides, studied and imaged every Olenoides serratus specimen available from the Royal Ontario Museum, the Geological Survey of Canada, and the Invertebrate Paleontology collections at the Smithsonian Institution. O. serratus is known from several sites in North America, but all specimens with preserved appendages were collected from the Burgess Shale in British Columbia, Canada. Unlike the exoskeleton, appendages (antennae, legs and gills) do not get preserved very frequently because they are not reinforced with calcite. The preservation of appendages requires unique conditions at the time of burial, which are present in the Burgess Shale and other rare sites with exceptional fossil preservation. While examining one well-preserved fossil from the Burgess Shale housed in the Royal Ontario Museum, Losso discovered peculiarly modified clasper-like legs in the mid-body similar to those found on adult male horseshoe crabs, suggesting a similar mating strategy. Losso examined 65 specimens with preserved appendages known to date. Twenty-three specimens had legs preserved in the correct part of the body where the clasper-like appendages were found; however, with their intact exoskeleton claspers would not be visible even if present because of the reduced size. Four specimens provided a clear view of the tenth and eleventh appendage pairs, but only one specimen of O. serratus revealed that are modified into claspers. The three other specimens with visible appendage pairs had a more conventional leg-like appearance. Adult male specimen of the trilobite Olenoides serratus with claspers: a) Part. b) Counter part. Credit: Sarah R. Losso Evidence of Sexual Dimorphism in Trilobites Although the specimen of O. serratus with claspers is missing half its exoskeleton it worked in the researcher’s favor. “This specimen is truly unique in that it is well preserved enough to show the exceptional details of the limbs modified into claspers, but broken so we can actually see these reduced limbs that would otherwise be covered by the dorsal exoskeleton,” said Losso. “Ironically, if the specimen were better preserved with a complete dorsal exoskeleton we would not have as much information about its limbs as we do now.” Losso made several measurements of the individual pieces of the reduced appendages and compared them to appendages in the body of the same specimen and to appendages known from different Olenoides in that same position. This demonstrated that the smaller appendages have a unique morphology only known from this specimen. Losso then examined specialized appendages in other living arthropods for comparison and to understand what the appendages could be used for. There are thousands of species of trilobites that have a 200-million-year-old history. But without a close living relative it is difficult to know reproductive behavior. Horseshoe crabs, though not closely related to trilobites, are often used as modern analogs because they superficially look like trilobites making for a useful comparison. Horseshoe crabs, like Limulus, are marine arthropods known for mass spawning events off the coast of Delaware and Cape Cod. During these events, males use their claspers to grab onto the female so they are correctly positioned to fertilize eggs released by the female. Claspers are special hook-like appendages often found in male arthropods. The male uses the claspers to hold onto the female during mating. Different groups have convergently evolved this appendage in different parts of the body depending on the exact mode of mating in that clade. Branchiopods and horseshoe crabs have both evolved claspers, but they function in different ways according to the female’s exoskeleton. For instance, branchiopods clasp on to the carapace, while Limulus clasps on to the spines. In O. serratus, the males claspers would line up with the spines on the female’s pygidium. First Direct Evidence of Trilobite Reproductive Behavior “We knew it could not be for mastication because the appendages are not near the head or mouth, they’re in the middle of the body,” Losso said. “This shows sexual dimorphism in trilobites, but in this case it is only expressed in the appendages. This tells us more about the reproduction in trilobites and how they would have mated, which previously has been hard to understand and has been very speculative based on modern analogies.” “There are very few cases of fossils that have directly informed reproductive ecology and behavior, particularly in fossils this old. In this case, because there is a structure that is very specifically adapted for this function, it is possible to make this particular argument, and more particular of trilobites,” said Ortega-Hernández. “This really is the first time that it is possible to show these limbs so heavily modified for this function. And it provides strong evidence to suggest that a Limulus, or horseshoe crab-like behavior, already existed in the Cambrian completely by convergence. So, it really helps us to get a sense of how these animals were actually living millions of years ago.” “Trilobites can help us understand the evolution of the most abundant and diverse group of animals and produce insights into the reproductive ecology of early animals,” said Losso. Reference: “Claspers in the mid-Cambrian Olenoides serratus indicate horseshoe crab-like mating in trilobites” by Sarah R. Losso and  Javier Ortega-Hernández, 6 May 2022, Geology. DOI: 10.1130/G49872.1

A scanning electron micrograph shows small purple Patescibacteria cells growing on the surface of much larger cells. New research led by Joseph Mougous’ lab at UW Medicine in Seattle reveals their lifecycle, their genes, and some of the molecular mechanisms that may be behind their unusual lifestyle. These epibiotic bacteria are Southlakia epibionticum. Credit: Yaxi Wang, Wai Pang Chan and Scott Braswell/University of Washington Scientists uncover the genes essential for the unusual lifestyle of minuscule bacteria that live on the surface of larger bacteria. Patescibacteria are a mysterious group of minute microbes with elusive survival methods. While scientists can only cultivate a handful of these types, they are part of a diverse family found in many environments. The few types of Patescibacteria that researchers can grow in the lab reside on the cell surfaces of another, larger host-microbe. Patescibacteria in general lack the genes required to make many molecules necessary for life, such as the amino acids that make up proteins, the fatty acids that form membranes, and the nucleotides in DNA. This has led researchers to speculate that many of them rely on other bacteria to grow. In a study recently published in Cell, researchers present the first glimpse into the molecular mechanisms behind the unusual Patescibacteria lifestyle. This breakthrough was made possible by the discovery of a way to genetically manipulate these bacteria, an advance that has opened a world of possible new research directions. “While metagenomics can tell us which microbes live on and within our bodies, the DNA sequences alone do not give us insight into their beneficial or detrimental activities, especially for organisms that have never before been characterized,” said Nitin S. Baliga of the Institute for System Biology in Seattle, which contributed many computational and systems analyses to the study. Epibiotic bacteria researcher Larry A. Gallagher at a microscope in a microbiology lab at the University of Washington School of Medicine. Credit: S. Brook Peterson/University of Washington “The ability to genetically perturb Patescibacteria opens up the possibility of applying a powerful systems analysis lens to rapidly characterize the unique biology of obligate epibionts,” he added, in reference to organisms that must live on another organism to survive. Exploring Microbial Dark Matter The teams behind the study, headed by Joseph Mougous’ lab in the Department of Microbiology at the University of Washington School of Medicine and the Howard Hughes Medical Institute, were interested in Patescibacteria for several reasons. They are among the many poorly understood bacteria whose DNA sequences pop up in large-scale genetic analyses of genomes found in species-rich microbial communities from environmental sources. This genetic material is referred to as “microbial dark matter” because little is known about the functions it encodes. Microbial dark matter is likely to contain information about biochemical pathways with potential biotechnology applications, according to the Cell paper. It also holds clues to the molecular activities that support a microbial ecosystem, as well as to the cell biology of the assorted microbial species gathered in that system. The group of Patescibacteria analyzed in this latest research belongs to the Saccharibacteria. These live in a variety of land and water environments but are best known for inhabiting the human mouth. They have been part of the human oral microbiome at least since the Middle Stone Age and have been linked to human oral health. In the human mouth, Saccharibacteria requires the company of Actinobacteria, which serve as their hosts. To better understand the mechanisms employed by Saccharibacteria to relate with their hosts, the researchers used genetic manipulation to identify all the genes essential for a Saccharibacterium to grow. Yaxi Wang, an epibiotic bacteria researcher, at an anaerobic workstation in a microbiology lab at the University of Washington School of Medicine in Seattle. Credit: S. Brook Peterson/University of Washington “We are tremendously excited to have this initial glimpse into the functions of the unusual genes these bacteria harbor,” said Mougous, professor of microbiology. “By focusing our future studies on these genes, we hope to unravel the mystery of how Saccharibacteria exploit host bacteria for their growth.” Saccharibacteria’s Unique Strategies for Survival Possible host-interaction factors uncovered in the study include cell surface structures that may help Saccharibacteria attach to host cells and a specialized secretion system that might be used for transporting nutrients. Another application of the authors’ work was the generation of Saccharibacteria cells that express fluorescent proteins. With these cells, the researchers performed time-lapse microscopic fluorescent imaging of Saccharibacteria growing with their host bacteria. “Time-lapse imaging of Saccharibacteria-host cell cultures revealed surprising complexity in the lifecycle of these unusual bacteria,” noted S. Brook Peterson, a senior scientist in the Mougous lab. The researchers reported that some Saccharibacteria serve as mother cells by adhering to the host cell and repeatedly budding to generate small swarmer offspring. These little ones move on to search for new host cells. Some of the progeny, in turn, became mother cells, while others appeared to interact unproductively with a host. The researchers think that additional genetic manipulation studies will open the door to a wider understanding of the roles of what they described as “the rich reserves of microbial dark matter these organisms contain” and potentially uncover yet unimagined biological mechanisms. Reference: “Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle” by Yaxi Wang, Larry A. Gallagher, Pia A. Andrade, Andi Liu, Ian R. Humphreys, Serdar Turkarslan, Kevin J. Cutler, Mario L. Arrieta-Ortiz, Yaqiao Li, Matthew C. Radey, Jeffrey S. McLean, Qian Cong, David Baker, Nitin S. Baliga, S. Brook Peterson and Joseph D. Mougous, 7 September 2023, Cell. DOI: 10.1016/j.cell.2023.08.017 This interdisciplinary and collaborative study was fostered by the newly created Microbial Interactions & Microbiome Center (called by its acronym mim_c), which Mougous directs. The mission of mim_c is to lower barriers to microbiome research studies and advance collaborations through connections of like-minded researchers from across disciplines. Here, mim_c was the catalyst joining the Mougous lab with oral microbiome expert Jeffrey McClean in the Department of Periodontics, UW School of Dentistry. The lead authors on this study were Yaxi Wang and Larry A. Gallagher of the UW Department of Microbiology. The senior authors were Baliga, Peterson and Mougous. Biochemists Qian Cong from University of Texas Southwestern, and David Baker and other researchers from the UW Medicine Institute for Protein Design also contributed to the work, along with McClean. Mougous and Baker are Howard Hughes Medical Institute investigators. Mougous holds the Lynn M. and Michael D. Garvey Endowed Chair at the University of Washington. The study was supported by grants from the National Institutes of Health, the National Science Foundation, the Department of Defense’s Defense Threat Reduction Agency, the Bill & Melinda Gates Foundation, and the Welch Foundation.

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