Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

🔗 Learn more or get in touch:
🌐 Website: https://www.deryou-tw.com/
📧 Email: shela.a9119@msa.hinet.net
📘 Facebook: facebook.com/deryou.tw
📷 Instagram: instagram.com/deryou.tw

High-performance insole OEM factory Taiwan

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Vietnam flexible graphene product manufacturing

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Pillow ODM design company in Indonesia

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.High-performance insole OEM Thailand

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Indonesia anti-odor insole OEM service

An illustration and microscopic images show the relationship between motion-sensing vestibular hair cells (blue) of the innermost ear and the cup-shaped “calyx” (green) structures of adjoining nerves that connect directly to the brain. The rapid flow of information through the synapses helps stabilize balance and vision in humans and many other animals. Researchers from Rice University, the University of Chicago and the University of Illinois Chicago created the first quantitative model that shows how potassium ions (K+) and electrical signals are transmitted across the synapses to rapidly deliver information to the brain. Credit: Aravind Chenrayan Govindaraju/Rice University The Inner Ear Has a Need for Speed The sensory organs responsible for enabling us to walk, dance, and move our heads without feeling dizzy or losing balance are equipped with specialized synapses that process signals faster than any other in the human body. After more than a decade and a half of research, a team of neuroscientists, physicists, and engineers from various institutions have finally uncovered the workings of the specialized synapses. This breakthrough will pave the way for further research that has the potential to enhance treatments for vertigo and balance disorders, which affect up to one-third of Americans over the age of 40. The new study in the Proceedings of the National Academy of Sciences describes the workings of “vestibular hair cell-calyx synapses,” which are found in organs of the innermost ear that sense head position and movements in different directions. Aravind Chenrayan Govindaraju, an applied physics graduate student at Rice University, at the COMSOL Multiphysics finite-element modeling station he used to find hidden details of an inner-ear mechanism that helps mammals balance via the fastest-known signal in the brain. Credit: Rice University “Nobody fully understood how this synapse can be so fast, but we have shed light on the mystery,” said Rob Raphael, a Rice University bioengineer who co-authored the study with the University of Chicago’s Ruth Anne Eatock, the University of Illinois Chicago’s Anna Lysakowski, current Rice graduate student Aravind Chenrayan Govindaraju, and former Rice graduate student Imran Quraishi, now an assistant professor at Yale University. Rob Raphael is an associate professor of bioengineering in Rice University’s George R. Brown School of Engineering. Credit: Rice University Synapses are biological junctions where neurons can relay information to one another and other parts of the body. The human body contains hundreds of trillions of synapses, and almost all of them share information via quantal transmission, a form of chemical signaling via neurotransmitters that requires at least 0.5 milliseconds to send information across a synapse. Prior experiments had shown a faster, “nonquantal” form of transmission occurs in vestibular hair cell-calyx synapses, the points where motion-sensing vestibular hair cells meet afferent neurons that connect directly to the brain. The new research explains how these synapses operate so quickly. In each, a signal-receiving neuron surrounds the end of its partner hair cell with a large cuplike structure called a calyx. The calyx and hair cell remain separated by a tiny gap, or cleft, measuring just a few billionths of a meter. Unique Structure and Function of the Vestibular Calyx “The vestibular calyx is a wonder of nature,” Lysakowski said. “Its large cup-shaped structure is the only one of its kind in the entire nervous system. Structure and function are intimately related, and nature obviously devoted a great deal of energy to produce this structure. We’ve been trying to figure out its special purpose for a long time.” From the ion channels expressed in hair cells and their associated calyces, the authors created the first computational model capable of quantitatively describing the nonquantal transmission of signals across this nanoscale gap. Simulating nonquantal transmission allowed the team to investigate what happens throughout the synaptic cleft, which is more extensive in vestibular synapses than other synapses. “The mechanism turns out to be quite subtle, with dynamic interactions giving rise to fast and slow forms of nonquantal transmission,” Raphael said. “To understand all this, we made a biophysical model of the synapse based on its detailed anatomy and physiology.” The model simulates the voltage response of the calyx to mechanical and electrical stimuli, tracking the flow of potassium ions through low-voltage-activated ion channels from pre-synaptic hair cells to the post-synaptic calyx. Insights from Simulations of Nonquantal Transmission Raphael said the model accurately predicted changes in potassium in the synaptic cleft, providing key new insights about changes in electrical potential that are responsible for the fast component of nonquantal transmission; explained how nonquantal transmission alone could trigger action potentials in the post-synaptic neuron; and showed how both fast and slow transmission depends on the close and extensive cup formed by the calyx on the hair cell. Eatock said, “The key capability was the ability to predict the potassium level and electrical potential at every location within the cleft. This allowed the team to illustrate that the size and speed of nonquantal transmission depend on the novel structure of the calyx. The study demonstrates the power of engineering approaches to elucidate fundamental biological mechanisms, one of the important but sometimes overlooked goals of bioengineering research.” Quraishi began constructing the model and collaborating with Eatock in the mid-2000s when he was a graduate student in Raphael’s research group and she was on the faculty of Baylor College of Medicine, just a few blocks from Rice in Houston’s Texas Medical Center. His first version of the model captured important features of the synapse, but he said gaps in “our knowledge of the specific potassium channels and other components that make up the model was too limited to claim it was entirely accurate.” Since then, Eatock, Lysakowski, and others discovered ion channels in the calyx that transformed scientists’ understanding of how ionic currents flow across hair cell and calyx membranes. Qurashi said, “The unfinished work had weighed on me,” and he was both relieved and excited when Govindaraju, a Ph.D. student in applied physics, joined Raphael’s lab and resumed work on the model in 2018. “By the time I started on the project, more data supported nonquantal transmission,” Govindaraju said. “But the mechanism, especially that of fast transmission, was unclear. Building the model has given us a better understanding of the interplay and purpose of different ion channels, the calyx structure, and dynamic changes in potassium and electric potential in the synaptic cleft.” Raphael said, “One of my very first grants was to develop a model of ion transport in the inner ear. It is always satisfying to achieve a unified mathematical model of a complex physiological process. For the past 30 years — since the original observation of nonquantal transmission — scientists have wondered, ‘Why is this synapse so fast?’ and, ‘Is the transmission speed related to the unique calyx structure?’ We have provided answers to both questions.” Evolutionary Significance of the Vestibular Calyx He said the link between the structure and function of the calyx “is an example of how evolution drives morphological specialization. A compelling argument can be made that once animals emerged from the sea and began to move on land, swing in trees and fly, there were increased demands on the vestibular system to rapidly inform the brain about the position of the head in space. And at this point, the calyx appeared.” Raphael said the model opens the door for a deeper exploration of information processing in vestibular synapses, including research into the unique interactions between quantal and nonquantal transmission. He said the model could also be a powerful tool for researchers who study electrical transmission in other parts of the nervous system, and he hopes it will aid those who design vestibular implants, neuroprosthetic devices that can restore function to those who have lost their balance. Reference: “Nonquantal transmission at the vestibular hair cell–calyx synapse: KLV currents modulate fast electrical and slow K+ potentials” by Aravind Chenrayan Govindaraju, Imran H. Quraishi, Anna Lysakowski and Robert M. Raphael, 3 January 2023, Proceedings of the National Academy of Sciences. DOI: 10.1073/pnas.2207466120 The study was funded by the National Institutes of Health, the Hearing Health Foundation, and Rice University.

An immune signal promotes the production of energy-burning beige fat, potentially leading to new ways to treat obesity and metabolic disorders. Cytokine increases production of “beige fat” to burn more cellular energy. An immune signal promotes the production of energy-burning “beige fat,” according to a new study published in the open-access journal PLOS Biology by Zhonghan Yang of Sun Yat-Sen University, Guangzhou, China, and colleagues. The finding may lead to new ways to reduce obesity and treat metabolic disorders. The beige color in beige fat comes from its high concentration of mitochondria, the cell’s powerhouses. Mitochondria burn high-energy molecules like fats and sugars with oxygen, releasing energy. Normally, that energy is stored as ATP, the energy currency that the cell uses for almost all its activities. But in beige fat, mitochondria accumulate a protein called “uncoupling protein-1” that limits ATP production, generating heat instead. Babies are born with “brown fat,” a similar tissue concentrated in the shoulder region, which helps them stay warm, but brown fat is gradually lost with age. Not-so-beige fat is more widely distributed and can be generated throughout life in response to both cold and neuronal or hormonal stimulation. Recent work, including by the authors of the new study, has revealed that cytokines—immune system signaling molecules—play a role in regulation of beige fat. To explore that regulation further, the authors manipulated levels of the cytokine interleukin-25, and showed that an increase in the cytokine could mimic the effects of both cold and stimulation of a hormone receptor in increasing the production of beige fat in mice. They traced the signaling chain further, showing that IL-25 exerted its effects through two other cytokines, which in turn regulated immune cells called macrophages. Those cells acted on neurons that terminate in the beige fat tissue, promoting an increase in production of the neurotransmitter norepinephrine, which was already known to promote beige fat production. Thus, the authors’ work revealed the sequence of regulatory signals that begins with IL-25 and ends with release of norepinephrine and an increase in beige fat. Finally, the authors showed that administering IL-25 to mice that were eating a high-fat diet prevented them from becoming obese and improved their ability to maintain their responsiveness to insulin, which is impaired in chronic obesity. “Our results show that interleukin-25 plays a key role in production of beige fat,” Yang said, “and point toward increasing interleukin-25 signaling as a potential treatment for obesity.” Reference: “IL-25–induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice” by Lingyi Li, Lei Ma, Zewei Zhao, Shiya Luo, Baoyong Gong, Jin Li, Juan Feng, Hui Zhang, Weiwei Qi, Ti Zhou, Xia Yang, Guoquan Gao and Zhonghan Yang, 5 August 2021, PLOS Biology. DOI: 10.1371/journal.pbio.3001348 Funding: This work was funded by the National Nature Science Foundation of China(grant number No: 81570764, 81770808, 81701414, 81872165 and 81871211), National Key R&D Program of China (grant number No. 2018YFA0800403), Guangdong Provincial Key R&D Program (grant number No: 2018B030337001 and 2019B020227003), Key Project of Nature Science Foundation of Guangdong Province, China (grant number No. 2019B1515120077), Guangdong Natural Science Fund (grant number No: 2019A1515011810 and 2020A1515010365), Guangdong Science and Technology Project (grant number No. 2017A020215075), Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translation Research of Hakka Population (grant number No. 2018B030322003KF01), Guangzhou Science and Technology Project (grant number No: 201807010069, 201803010017 and 202002020022) and Shenzhen Science and Technology Project (grant number No. JCYJ20190807154205627) received by Weiwei Qi, Ti Zhou, Xia Yang, Guoquan Gao and Zhonghan Yang. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

COVID-19 suppresses the body’s innate inflammatory response by diverting mitochondrial genes from their typical function. Mitochondrial and metabolic dysfunction in individuals may result in a compromised first line of defense against COVID-19. Discovery of unique virus traits offer possible explanations as to why older adults and people with diabetes or heart disease can have more severe responses to COVID-19 than others, say USC researchers. Seeking to understand why COVID-19 is able to suppress the body’s immune response, new research from the University of Southern California (USC) Leonard Davis School of Gerontology suggests that mitochondria are one of the first lines of defense against COVID-19 and identifies key differences in how SARS-CoV-2, the virus that causes COVID-19, affects mitochondrial genes when compared to other viruses. These differences offer possible explanations as to why older adults and people with metabolic dysfunction have more severe responses to COVID-19 than other individuals and they also provide a starting point for more targeted approaches that may help identify therapeutics, says senior author Pinchas Cohen, professor of gerontology, medicine, and biological sciences and dean of the USC Leonard Davis School. “If you already have mitochondrial and metabolic dysfunction, then you may, as a result, have a poor first line of defense against COVID-19. Future work should consider mitochondrial biology as a primary intervention target for SARS-CoV-2 and other coronaviruses,” he said. The study, published in the Nature journal Scientific Reports, expands on recent findings that COVID-19 mutes the body’s innate inflammatory response and reports that it does so by diverting mitochondrial genes from their normal function. Portrait of Pinchas Cohen, MD, Dean of the USC Leonard Davis School of Gerontology. Credit: USC/Stephanie Kleinman “We already knew that our immune response was not mounting a successful defense to COVID-19, but we didn’t know why,” said lead author Brendan Miller, a senior doctoral student at the USC Leonard Davis School. “What we did differently was look at how the virus specifically targets mitochondria, a cellular organelle that is a crucial part of the body’s innate immune system and energy production.” Making use of the vast amounts of public data being uploaded in the early days of the virus outbreak, the research team performed RNA sequencing analyses that compared mitochondrial-COVID interactions to those of other viruses: respiratory syncytial virus, seasonal influenza A virus, and human parainfluenza virus 3. These reanalyses identified three ways in which COVID-19, but not the other viruses, mutes the body’s cellular protective response. Chief among their findings is that SARS-CoV-2 uniquely reduces the levels of a group of mitochondrial proteins, known as Complex One, that are encoded by nuclear DNA. It is possible that this effect “quiets” the cell’s metabolic output and reactive oxygen species generation, that when functioning correctly, produces an inflammatory response that can kill a virus, they say. Portrait of senior doctoral student Brendan Miller. Credit: USC/Fiona Pestana “COVID-19 is reprogramming the cell to not make these Complex One-related proteins. That could be one way the virus continues to propagate,” says Miller, who notes that this, along with the study’s other observations, still needs to be validated in future experiments. The study also revealed that SARS-CoV-2 does not change the levels of the messenger protein, MAVS mRNA, that usually tells the cell a viral attack has happened. Normally, when this protein gets activated it functions as an alarm system, warning the cell to self-destruct so that the virus cannot replicate, says Miller. In addition, the researchers found that genes encoded by the mitochondria were not being turned on or off by SARS-CoV-2 — a process that is believed to produce energy that can help the cell evade a virus — at rates to be expected when confronted with a virus. “This study adds to a growing body of research on mitochondrial-COVID interactions and presents tissue and cell-specific effects that should be carefully considered in future experiments,” said Cohen. Reference: “Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples” by Brendan Miller, Ana Silverstein, Melanie Flores, Kevin Cao, Hiroshi Kumagai, Hemal H. Mehta, Kelvin Yen, Su-Jeong Kim and Pinchas Cohen, 8 January 2021, Scientific Reports. DOI: 10.1038/s41598-020-79552-z Funding sources for the study include the National Institutes of Health, including grants R01AG061834 (Cohen) and P01AG034906 (Cohen), and the National Institute on Aging (AG000037, Miller). Dr. Cohen is a co-founder, stockholder, and board member of Cohbar Inc.

DVDV1551RTWW78V