Introduction – Company Background

GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.

With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.

With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.

From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.

At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.

By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.

Core Strengths in Insole Manufacturing

At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.

Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.

We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.

With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.

Customization & OEM/ODM Flexibility

GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.

Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.

With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.

Quality Assurance & Certifications

Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.

We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.

Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.

ESG-Oriented Sustainable Production

At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.

To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.

We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.

Let’s Build Your Next Insole Success Together

Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.

From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.

Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.

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China athletic insole OEM supplier

Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.

With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Cushion insole OEM solution Taiwan

Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.

We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Custom foam pillow OEM in Vietnam

At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China ODM expert for comfort products

📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.China high-end foam product OEM/ODM

Overall winner. An invasive orange pore fungus poses unknown ecological consequences for Australian ecosystems. Credit: Cornelia Sattler Cornelia Sattler’s image of the invasive orange pore fungus won the BMC Ecology and Evolution image competition. The competition celebrates nature’s wonders across various categories, blending art and science. A captivating image of the invasive orange pore fungus (Favolaschia calocera), which highlights the potential threats the species may pose to Australian ecosystems, has won the third BMC Ecology and Evolution image competition. The competition showcases the wonder of the natural world — both past and present — and celebrates those working to understand it. The overall winning image depicts bright orange fruiting bodies growing on deadwood in the Australian rainforest and was taken by Cornelia Sattler from Macquarie University, Australia. The orange pore fungus was first observed in Madagascar but is now found throughout the world. Previous research has reported that invasive species, such as the European rabbit, root rot fungus, and feral pigs, threaten 82% of Australian species at risk of extinction. As a result, Australia has particularly strict rules about bringing plants, animals, and organic matter into the country.   Cornelia Sattler said: “Despite its innocent and beautiful appearance, the orange pore fungus is an invasive species that displaces other fungi and is spreading throughout the Australian rainforest. It is important to closely monitor this fungus, whose spores are often transported by humans, in order to safeguard the biodiversity of Australia.” Senior Editorial Board Member Arne Traulsen recommended the entry, saying: “Cornelia Sattler’s image allows us to peek into the world of fungi, organisms that are fascinating and yet underappreciated and understudied.” Additional Award-Winning Entries Beyond the main prize, the competition recognized victors and runners-up in four distinct categories: Research in Action, Protecting our Planet, Plants and Fungi, and Palaeoecology. Research in action: best in category. Exploring the deep. Researchers from the Hoey Reef Ecology Lab deploy an underwater ROV at Diamond Reef within the Coral Sea Marine Park. Credit: Victor Huertas Victor Huertas from James Cook University, Australia took the winning image for the Research in Action category. The photograph depicts the deployment of an underwater remotely operated vehicle at Coral Sea Marine Park, Australia. The device is used to survey oceans at depths that are beyond the reach of divers and has been used to discover new species in reefs and expand the known geographic range of multiple fish species. Research in action: runner-up. Researchers from the University of Glasgow’s Scottish Marine Animal Stranding Scheme conduct a necropsy of a stranded humpback whale. Credit: Submitted by Professor Paul Thompson, photo captured by James Bunyan from Tracks Ecology Senior Editorial Board Member Luke Jacobus said: “This photograph captures the essence of ecological study. It showcases sharp imaging and good storytelling and invites us to be curious about our dynamic world.” Protecting our planet: best in category. Sustainable beekeeping for chimpanzees. Credit: Roberto García-Roa The Protecting our Planet category winner was captured by Roberto García-Roa from the University of Lund, Sweden, and features a sustainable beekeeping project launched by the Chimpanzee Conservation Center in Guinea. The project aims to combat deforestation by encouraging locals to cultivate their own honey. A portion of the profits generated by the project go towards chimpanzee conservation activities. Protecting our planet: runner-up. Protecting future generations of reef sharks. A researcher releases a new-born blacktip reef shark (Carcharhinus melanopterus) in Mo’orea, French Polynesia. Credit: Victor Huertas Senior Editorial Board Member Josef Settele said: “This photo shows how very different aspects of wildlife conservation can be combined into win-win situation that helps simultaneously protect our planet and empower local communities.” Plants and fungi: best in category. A mycoparasitic fungus parasitizing the fruiting body of a zombie-ant fungus. Credit: João Araújo The Plants and Fungi category winner depicts a fungus parasitizing the fruiting body of a zombie-ant fungus — a fungus that can compel infected ants to migrate to locations that are more favorable for its growth — and was taken by João Araújo from the New York Botanical Garden, New York, USA. Plants and fungi: runner-up. Defeated. A spider seemingly defeated by a parasitic fungus. Credit: Roberto García-Roa João Araújo said: “Zombie-ant fungi are found in forests all over the world, however, the forests they inhabit are also shared with fungi that can parasitize, consume, and even castrate them. Scientists have only recently started to catalog and describe these fascinating fungi that can kill other fungi.” Paleoecology: best in category. A peek inside a hadrosaur egg. Credit: Submitted by Jordan Mallon. Restoration by Wenyu Ren The Paleoecology category winner was submitted by Jordan Mallon from the Canadian Museum of Nature, Canada, and was created by Wenyu Ren from Beijing, China. The image depicts an embryonic hadrosauroid — a dinosaur with a duck-like beak — developing within an egg from China’s Upper Cretaceous red beds, which date to between 72 and 66 million years ago. Paleoecology: runner-up. Paradoxical preservation. Microscopy reveals an extracted diplodocid dinosaur blood vessel. Credit: Dr. Jasmina Wiemann Jordan Mallon said: “The relatively small size of the egg and the unspecialized nature of the dinosaur embryo developing within it suggests that the earliest hadrosaurs were born immature and helpless. Over time, hadrosaurs began to lay larger eggs, indicating that their young may have been born at more advanced stages of development and required less parental care than earlier hadrosaurs.” Celebrating the Intersection of Art and Science Now in its third year, the BMC Ecology and Evolution Image Competition was created to give ecologists, evolutionary biologists, and paleontologists the opportunity to use their creativity to celebrate their research and the intersection between art and science. The winning images are selected by the Editor of BMC Ecology and Evolution and senior members of the journal’s editorial board. Editor Jennifer Harman said: “Judging the many remarkable images submitted to this year’s competition was a rewarding and challenging experience. The winning images were selected by our senior Editorial Board Members as much for the scientific stories behind them as for their artistic qualities. We thank all those who took part in this year’s competition and congratulate our winning entrants. We hope our readers enjoy viewing these images and exploring the stories behind them as much as we did.”

Researchers at the Earlham Institute have engineered tobacco plants to produce moth sex pheromones using sunlight and water, offering a sustainable and cost-effective alternative to chemical synthesis. By fine-tuning gene expression with copper sulfate, the team successfully regulated pheromone production without impacting the plants’ normal growth and development. Engineered tobacco plants produce moth pheromones, offering a sustainable alternative to chemical synthesis. Researchers at the Earlham Institute in Norwich have utilized precision gene engineering methods to transform tobacco plants into solar-powered factories that produce moth sex pheromones. Importantly, they have demonstrated the ability to effectively control the production of these molecules without negatively impacting normal plant growth. Pheromones are complex chemicals produced and released by an organism as a means of communication. They allow members of the same species to send signals, which includes letting others know they’re looking for love. Farmers can hang pheromone dispersers among their crops to mimic the signals of female insects, trapping or distracting the males from finding a mate. Some of these molecules can be produced by chemical processes but chemical synthesis is often expensive and creates toxic byproducts. Synthetic Biology as a Tool for Green Manufacturing Dr. Nicola Patron, who led this new research and heads the Synthetic Biology Group at the Earlham Institute, uses cutting-edge science to get plants to produce these valuable natural products. Synthetic biology applies engineering principles to the building blocks of life, DNA. By creating genetic modules with the instructions to build new molecules, Dr. Patron and her group can turn a plant such as tobacco into a factory that only needs sunlight and water. “Synthetic biology can allow us to engineer plants to make a lot more of something they already produced, or we can provide the genetic instructions that allow them to build new biological molecules, such as medicines or these pheromones,” said Dr. Patron. In this latest work, the team worked with scientists at the Plant Molecular and Cell Biology Institute in Valencia to engineer a species of tobacco, Nicotiana benthamiana, to produce moth sex pheromones. The same plant has previously been engineered to produce ebola antibodies and even coronavirus-like particles for use in Covid vaccines. The group built new sequences of DNA in the lab to mimic the moth genes and introduced a few molecular switches to precisely regulate their expression, which effectively turns the manufacturing process on and off. An important component of the new research was the ability to fine-tune the production of the pheromones, as coercing plants to continuously build these molecules has its drawbacks. “As we increase the efficiency, too much energy is diverted away from normal growth and development,” explained Dr. Patron. “The plants are producing a lot of pheromones but they’re not able to grow very large, which essentially reduces the capacity of our production line. Our new research provides a way to regulate gene expression with much more subtlety.” In the lab, the team set about testing and refining the control of genes responsible for producing the mix of specific molecules that mimic the sex pheromones of moth species, including navel orangeworm and cotton bollworm moths. Regulating Gene Expression with Copper Sulfate They showed that copper sulfate could be used to finely tune the activity of the genes, allowing them to control both the timing and level of gene expression. This is particularly important as copper sulfate is a cheap and readily-available compound already approved for use in agriculture. They were even able to carefully control the production of different pheromone components, allowing them to tweak the cocktail to better suit specific moth species. “We’ve shown we can control the levels of expression of each gene relative to the others,” said Dr. Patron. “This allows us to control the ratio of products that are made. Getting that recipe right is particularly important for moth pheromones as they’re often a blend of two or three molecules in specific ratios. Our collaborators in Spain are now extracting the plant-made pheromones and testing them in dispensers to see how well they compare to female moths.” The team hopes their work will pave the way to routinely using plants to produce a wide range of valuable natural products. “A major advantage of using plants is that it can be far more expensive to build complex molecules using chemical processes,” said Dr. Patron. “Plants produce an array of useful molecules already so we’re able to use the latest techniques to adapt and refine the existing machinery. “In the future, we may see greenhouses full of plant factories – providing a greener, cheaper, and more sustainable way to manufacture complex molecules.” Reference: “Tunable control of insect pheromone biosynthesis in Nicotiana benthamiana” by Kalyani Kallam, Elena Moreno-Giménez, Ruben Mateos-Fernández, Connor Tansley, Silvia Gianoglio, Diego Orzaez and Nicola Patron, 9 April 2023, Plant Biotechnology. DOI: 10.1111/pbi.14048 The research is part of the SUSPHIRE project, which received support from ERACoBiotech funded by the Horizon 2020 research and innovation program and the UKRI Biotechnology and Biological Sciences Research Council (BBSRC).

The researchers took this image of a tumor using immunofluorescence, a technique that allows them to stain tissue sections with fluorescently-labeled antibodies or dyes. Blue indicates the cell nuclei, green signifies tumor regions, and red is a marker for T cells. Credit: Elen Torres-Mejia Researchers decipher when and why immune cells fail to respond to immunotherapy, suggesting that T cells need a different kind of prodding to re-engage the immune response. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer in humans. Some patients with NSCLC receive a therapy called immune checkpoint blockade (ICB) that helps kill cancer cells by reinvigorating a subset of immune cells called T cells, which are “exhausted” and have stopped working. However, only about 35% of NSCLC patients respond to ICB therapy. Stefani Spranger’s lab at the MIT Department of Biology explores the mechanisms behind this resistance, with the goal of inspiring new therapies to better treat NSCLC patients. In a new study published on October 29 in Science Immunology, a team led by Spranger lab postdoc Brendan Horton revealed what causes T cells to be non-responsive to ICB — and suggests a possible solution. Scientists have long thought that the conditions within a tumor were responsible for determining when T cells stop working and become exhausted after being overstimulated or working for too long to fight a tumor. That’s why physicians prescribe ICB to treat cancer — ICB can invigorate the exhausted T cells within a tumor. However, Horton’s new experiments show that some ICB-resistant T cells stop working before they even enter the tumor. These T cells are not actually exhausted, but rather they become dysfunctional due to changes in gene expression that arise early during the activation of a T cell, which occurs in lymph nodes. Once activated, T cells differentiate into certain functional states, which are distinguishable by their unique gene expression patterns. The notion that the dysfunctional state that leads to ICB resistance arises before T cells enter the tumor is quite novel, says Spranger, the Howard S. and Linda B. Stern Career Development Professor, a member of the Koch Institute for Integrative Cancer Research, and the study’s senior author. “We show that this state is actually a preset condition, and that the T cells are already non-responsive to therapy before they enter the tumor,” she says. As a result, she explains, ICB therapies that work by reinvigorating exhausted T cells within the tumor are less likely to be effective. This suggests that combining ICB with other forms of immunotherapy that target T cells differently might be a more effective approach to help the immune system combat this subset of lung cancer. In order to determine why some tumors are resistant to ICB, Horton and the research team studied T cells in murine models of NSCLC. The researchers sequenced messenger RNA from the responsive and non-responsive T cells in order to identify any differences between the T cells. Supported in part by the Koch Institute Frontier Research Program, they used a technique called Seq-Well, developed in the lab of fellow Koch Institute member J. Christopher Love, the Raymond A. (1921) and Helen E. St. Laurent Professor of Chemical Engineering and a co-author of the study. The technique allows for the rapid gene expression profiling of single cells, which permitted Spranger and Horton to get a very granular look at the gene expression patterns of the T cells they were studying. Seq-Well revealed distinct patterns of gene expression between the responsive and non-responsive T cells. These differences, which are determined when the T cells assume their specialized functional states, may be the underlying cause of ICB resistance. Now that Horton and his colleagues had a possible explanation for why some T cells did not respond to ICB, they decided to see if they could help the ICB-resistant T cells kill the tumor cells. When analyzing the gene expression patterns of the non-responsive T cells, the researchers had noticed that these T cells had a lower expression of receptors for certain cytokines, small proteins that control immune system activity. To counteract this, the researchers treated lung tumors in murine models with extra cytokines. As a result, the previously non-responsive T cells were then able to fight the tumors — meaning that the cytokine therapy prevented, and potentially even reversed, the dysfunctionality. Administering cytokine therapy to human patients is not currently safe, because cytokines can cause serious side effects as well as a reaction called a “cytokine storm,” which can produce severe fevers, inflammation, fatigue, and nausea. However, there are ongoing efforts to figure out how to safely administer cytokines to specific tumors. In the future, Spranger and Horton suspect that cytokine therapy could be used in combination with ICB. “This is potentially something that could be translated into a therapeutic that could increase the therapy response rate in non-small cell lung cancer,” Horton says. Spranger agrees that this work will help researchers develop more innovative cancer therapies, especially because researchers have historically focused on T cell exhaustion rather than the earlier role that T cell functional states might play in cancer. “If T cells are rendered dysfunctional early on, ICB is not going to be effective, and we need to think outside the box,” she says. “There’s more evidence, and other labs are now showing this as well, that the functional state of the T cell actually matters quite substantially in cancer therapies.” To Spranger, this means that cytokine therapy “might be a therapeutic avenue” for NSCLC patients beyond ICB. Jeffrey Bluestone, the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology at the University of California-San Francisco, who was not involved with the paper, agrees. “The study provides a potential opportunity to ‘rescue’ immunity in the NSCLC non-responder patients with appropriate combination therapies,” he says. This research was funded by the Pew-Stewart Scholars for Cancer Research, the Ludwig Center for Molecular Oncology, the Koch Institute Frontier Research Program through the Kathy and Curt Mable Cancer Research Fund, and the National Cancer Institute.

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