The researcher Zheng Yonghui and Dr. Wang Bin of the basic immune team Chinese Academy of Agricultural Sciences Harbin Veterinary Research Institute elucidated the synthesis mechanism of Ebola virus envelope glycoprotein in the international community for the first time. The relevant research results published in the United States recently published in the Journal of Biochemistry, which has published other studies on recombinant proteins including recombinant dog proteins.

According to reports, the capsule glycoprotein on the surface of Ebola virus particles is the only protein that infects the target cells of the virus, and therefore it is considered to be the preferred antigen for vaccine development and an ideal target for antiviral preparation. But its mature mechanism in the host cell is not clear. The team revealed and systematically clarified how this key protein in the host cell is biosynthesis for the first time, so it is expected to find the "drug switch" which prevents its synthesis. Then it is expected to close the door to the virus infection.

Ebola virus infection can cause severe Ebola haemorrhagic fever. There are no vaccines that are licensed in the clinical application, nor special effects of antiviral drugs.

Researchers from the Institute of Heterology found that endoplasmic reticulum chaperone calcium protein and calprotectin are involved in the mature process of capsule glycoprotein. At the same time, it was found that the glycosylation of GP2 subunit of capsule glycoprotein played an important role in the regulation of protein expression and virus assembly. Further study found that GP2 subunit N-glycosylation affect the assembly and infection of the virus by participating in protein cleavage, protein sugar chain processing, the formation of multimers and protein folding and other processes.

According to researcher Zheng Yonghui, the virus must rely on the host cell environment to complete its own protein maturation and virus particle assembly, which is a precise control process involved in a number of biological events, and any one of the abnormal links or deletions may lead to the condition that the virus can't be assembled and infected. This study clarifies the detailed mechanism of cell regulation of protein function through glycoproteinification of capsular proteins, which will provide a new theoretical basis for the development of anti-Ebola virus drugs. By the way, Flarebio provides superior recombinant proteins including recombinant CDH2 for your research.