In terms of etiology, Parkinson's disease is associated with α-synuclein (αSyn) aggregation into toxic particles, thereby causing the brain to be responsible for motor control and release of dopamine-induced cell damage. According to studies using recombinant human proteins, the main way to deal with Parkinson's disease is to raise brain dopamine levels. However, the drawbacks are obvious: it can cause serious adverse reactions, and over time, the effect is often getting worse.

In order to find safer and more effective treatment, Mazmanian and Timothy Sampson, the first author of this article, also from the California Institute of Technology and others looked to the intestinal flora. In order to explore the possibility of the two, the researchers took mice as a model animal and conducted a series of experiments. But to remind everyone that the mice used in this study have been passive hands and feet - they are modified by the gene, the body will produce α-synuclein overexpression. The result is that this bad guy got a disease like Parkinson's disease. Next, they are placed in an ordinary and non-sterile environment or in a sterile environment to see what performance will be. The results show that for mice grown in sterile environments, the frequency of dysmotility is lower. And in the brain area associated with the control movement, the phenomenon of misfolding proteins is also improved. In fact in many ways, these mice behaved almost the same as normal mice and were full of vitality.

For mice showing Parkinson's disease symptoms due to human intervention, antibiotics can also be used as a treatment to improve motor function. In contrast, if the mice live in a sterile environment receive short-chain fatty acids (metabolites of intestinal microbes), or in their bodies implanted from patients with human Parkinson's disease Flora, their motor function will be seriously deteriorated. In a word, studies have revealed that intestinal flora in some cases or promote misfolding of protein aggregates, thereby impairing motor function. Thus, in addition to genetic factors, intestinal flora may play a very important role in the formation of Parkinson's disease. So it gave people a revelation that taking probiotics therapy amy help to relieve symptoms of Parkinson's disease.

However, Sampson warned, "The researchers used a large dose of antibiotics in mice. But for humans, this may be a huge risk for the immune system and it also brings about normal metabolic function. On the other hand, it is well known that intestinal flora is important to the human body and has important physiological functions. It is realistic that in the case of Parkinson's disease alone, we can't tell which bacteria are friends and which ones are enemies.

Although this study is far from the distance that humans are completely conquering Parkinson's disease, it brings new ideas for finding the appropriate treatment devices to develop potential new drugs. Flarebio provides you with recombinant proteins of good quality such as recombinant PIGR.