謝耀元醫師於實驗室照片- 謝耀元，張其真 - 383dd1e2 的部落格

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謝耀元醫師於實驗室照片- 謝耀元，張其真

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謝耀元,張其真 SCI論文發表

Hsieh YY (謝耀元), Chang CC(張其真) (*Correspondence; **Equal contribution as first author)

(上圖為: 謝耀元醫師於實驗室照片)

1. Chang CC, Hsieh YY**, Lin WH, Lin CS*. Leiomyoma and vascular endothelial growth factor gene polymorphisms: a systematic review. Taiwan J Obstet Gynecol. 2010 Sep;49(3):247-53. (SCI).

2. Chang CC, Hsieh YY**, Hsu KH**, Lin CS*. Effects of alpha and beta recombinant FSH (Gonal-F, Puregon) and progesterone upon human endometrial cell proliferation in-vitro: a preliminary study. Gynecol Endocrinol. 2011 Feb;27(2):110-6 (SCI).

3. Chang CC, Hsieh YY**, Hsu KH, Tsai HD, Lin CS*. Deleterious effects of arsenic, benomyl, and carbendazim upon human endometrial cell proliferation in-vitro. Taiwan J Obstet Gynecol. 2010 Dec;49(4):449-54. (SCI).

4. Chang CC, Hsieh YY**, Hsu KH, Lin CS*. Effects of gonadotrophins (Gonal-F, Puregon) upon human endometrial cell proliferation in-vitro. Taiwan J Obstet Gynecol 2010, Mar;50(1):42-7. (SCI).

5. Tsai HD, Hsieh YY**, Hsieh JN, Chang CC, Yang CY, Yang JG, Cheng WL, Tsai FJ, Liu CS. Mitochondria DNA deletion and copy numbers of cumulus cells are associated with IVF outcomes. J Reprod Med. 2010 Nov-Dec;55(11-12):491-7. (SCI).

6. Hsieh YY, Chang CC, Wang YK, Hsu KH, Chen CP, Hsu CM, Tsai FJ. Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma. Anticancer Res. 2010 Jun;30(6):2203-8. (SCI).

7. Hsieh YY, Lin YJ, Chang CC, Chen DY, Hsu CM, Lo MM, Hsu KH, Tsai FJ. Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. J Clin Lab Anal. 2010;24(4):262-8. (SCI).

8. Chang CC, Hsieh YY**, Wang YK, Hsu KH, Tsai HD, Tsai FJ, Lin CS*. Identification of novel peptides specifically binding to endometriosis by screening phage-displaying peptide libraries. Fertil Steril. 2009;Dec;92(6):1850-5 (SCI).

9. Hsieh YY, Wan L, Chang CC, Tsai CH, Tsai FJ*. STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. Int J Biol Sci. 2009;5(1):74-81. (SCI)

10. Chen CL, Chang CC, Tsai HD, Hsieh YY*. Puerperal infection of methicillin-resistant Staphylococcus aureus.Taiwan J Obstet Gynecol. 2008 Sep;47(3):357-9. (SCI).

11. Hsu KH, Chang CC, Tsai HD, Tsai FJ, Hsieh YY*. Effects of yam and diosgenin on calpain systems in skeletal muscle of ovariectomized rats.Taiwan J Obstet Gynecol. 2008 Jun;47(2):180-6. (SCI).

12. Hsieh YY, Chang CC, Hsu KH, Tsai FJ, Chen CP, Tsai HD*. Effect of exercise training on calpain systems in lean and obese Zucker rats. Int J Biol Sci. 2008 Sep 9;4(5):300-8. (SCI).

13. Bau DT, Hsieh YY**, Wan L, Wang RF, Liao CC, Lee CC, Lin CC, Tsai CH, Tsai FJ*. Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis.Chin J Physiol. 2007 Dec 31;50(6):326-9. (SCI).

14. Hsieh YY, Chang CC, Tsai FJ*, Lin CC, Tsai CH. T allele for VEGF-460 Gene Polymorphism at 5'-Untranslated Region is Associated with Higher Susceptibility of Leiomyoma. Biochem Genet. 2008 Jun;46(5-6):356-61.(SCI).

15. Hsieh YY, Chang CC, Tsai HD*. Comparisons of different dosages of gonadotropin-releasing hormone (GnRH) antagonist, short-acting form and single, half-dose, long-acting form of GnRH agonist during controlled ovarian hyperstimulation and in vitro fertilization. Taiwan J Obstet Gynecol. 2008 Mar;47(1):66-74. (SCI)

16. Hsieh YY, Bau DT, Chang CC, Tsai CH, Chen CP, Tsai FJ*. XRCC4 codon 247*A and XRCC4 promoter -1394*T related genotypes but not XRCC4 intron 3 gene polymorphism are associated with higher susceptibility for endometriosis. Mol Reprod Dev. 2008 May;75(5):946-51. (SCI).

17. Hsieh YY, Chang CC, Bau DT, Yeh LS, Tsai FJ*, Tsai CH. X-ray repair cross-complementing group 4 (XRCC4) promoter -1394( *)T-related genotype, but not XRCC4 codon 247/intron 3 or xeroderma pigmentosum group D codon 312, 751/promoter -114, polymorphisms are correlated with higher susceptibility to myoma. Fertil Steril. 2008 Oct;90(4 Suppl):1417-23.(SCI).

18. Hsieh YY, Chang CC, Bau DT, Tsai FJ*, Tsai CH, Chen CP. The p21 codon 31*C- and DRD2 codon 313*T-related genotypes/alleles, but not XRCC1 codon 399, hOGG1 codon 326, and DRD1-48 polymorphisms, are correlated with the presence of leiomyoma. Fertil Steril. 2009 Mar;91(3):869-77. Epub 2009 Jan 26. (SCI).

19. Wan L, Chen WC, Tsai Y, Kao YT, Hsieh YY, Lee CC, Tsai CH, Chen CP, Tsai FJ. Growth Hormone (GH) Receptor C.1319 G>T Polymorphism, But Not Exon 3, Retention or Deletion Is Associated With Better First-Year Growth Response to GH Therapy in Patients With GH Deficiency. Pediatr Res. 2007 Dec;62(6):735-40 (SCI).

20. Lin JC, Chen YO, Chang CC, Hsieh YY*. Novel adjunctive treatment for cervical adhesion with cross-type nelaton catheter: a preliminary report and literature review. Taiwan J Obstet Gynecol. 2007 Mar;46(1):38-42. (SCI)

21. Hsieh YY, Lee CC, Chang CC, Wang YK, Yeh LS, Lin CS. Angiotensin I-converting enzyme insertion-related genotypes and allele are associated with higher susceptibility of endometriosis and leiomyoma. Mol Reprod Dev. 2007 Jul;74(7):808-14. (SCI)

22. Chang YL, Hsieh YY**, Tsai HD*. Preliminary report on the effect of a lower dose of gonadotropin-releasing hormone antagonist (cetrorelix) on ovarian hyperstimulation in lower-weight Asian women. Taiwan J Obstet Gynecol. 2006 Dec;45(4):317-20. (SCI)

23. Hsieh YY, Wang JP, Lin CS. Four novel single nucleotide polymorphisms within the promoter region of p53 gene and their associations with uterine leiomyoma. Mol Reprod Dev. 2007 Jul;74(7):815-20. (SCI)

24. Yeh LS, Hsieh YY**, Chang JG, Chang WW, Chang CC, Tsai FJ*. Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. Int J Gynecol Cancer. 2007 Jul-Aug;17(4):868-71. (SCI).

25. Hsieh YY, Chang CC, Tsai CH, Lin CC, Tsai FJ. Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma. Fertil Steril. 2007 Apr;87(4):886-95. (SCI)

26. Hsieh YY, Wang YK, Chang CC, Lin CS. Estrogen receptor alpha-351 XbaI*G and -397 PvuII*C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. Mol Hum Reprod. 2007 Feb;13(2):117-22. (SCI)

27. Lin CC, Hsieh YY**, Wang CH, Li YC, Hsieh LJ, Lee CC, Tsai CH, Tsai FJ*. Prenatal detection and characterization of a small supernumerary marker chromosome (sSMC) derived from chromosome 22 with apparently normal phenotype. Prenat Diagn. 2006 Aug 17;26(10):898-902 (SCI)

28. Hsieh YY, Lin CS. P53 codon 11, 72, and 248 gene polymorphisms in endometriosis. Int J Biol Sci. 2006;2(4):188-93. Epub 2006 Jul 12. (SCI)

29. Hsieh YY, Chang CC, Lin CS*. Seminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motility. Int J Biol Sci 2006; 2:23-29. (SCI)

30. Hsieh YY, Chang CC, Tsai HD, Lin CS*. Leukemia inhibitory factor in follicular fluid is not related to the number and quality of embryos as well as implantation and pregnancy rates. Biochem Genet. 2005 Oct;43(9-10):501-6 (SCI)

31. Hsieh YY, Chang CC, Tsai FJ*, Hsu CM, Lin CC, Tsai CH. The C-related genotype and allele for E-cadherin 3’-UTR Pml I polymorphism are associated with higher susceptibility to endometriosis. Genet Mol Biol 2005;28:661-4. (SCI)

32. Hsieh YY, Chang CC, Tsai FJ*, Peng CT, Yeh LS, Lin CC. Polymorphism for transforming growth factor beta 1-509 (TGF-B1-509): association with endometriosis. Biochem Genet. 2005 Jun;43(5-6):203-10. (SCI)

33. Hsieh YY, Chang CC, Tsai FJ*, Hsu CM, Lin CC, Tsai CH. Interleukin-2 receptor beta (IL-2Rbeta)-627*C homozygote but not IL-12Rbeta1 codon 378 or IL-18 105 polymorphism is associated with higher susceptibility to endometriosis. Fertil Steril. 2005 Aug;84(2):510-2. (SCI)

34. Hsieh YY, Chang CC, Tsai FJ*, Lin CC, Yeh LS, Peng CT. Androgen receptor trinucleotide polymorphism in leiomyoma. J Assist Reprod Genet. 2004 Dec;21(12):453-7. (SCI)

35. Lin HC, Tsai FJ*, Tsai CH, Hsieh YY, Hsu CM. Cytokine polymorphisms and chronic lung disease in small preterm infants. Arch Dis Child Fetal Neonatal Ed. 2005 Jan;90(1):F93-4. (SCI)

36. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Tsai CH. T homozygote and allele of epidermal growth factor receptor 2073 gene polymorphism are associated with higher susceptibility to endometriosis and leiomyomas. Fertil Steril. 2005 Mar;83(3):796-9. (SCI)

37. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Tsai CH. Estrogen receptor alpha dinucleotide repeat and cytochrome P450c17alpha gene polymorphisms are associated with susceptibility to endometriosis. Fertil Steril. 2005 Mar;83(3):567-72. (SCI)

38. Hsieh YY, Chen IP, Wang HI, Chang CC, Huang CW, Lin CS*. PROGINS Alu sequence insertion is associated with hyperprolactinemia but not leiomyoma susceptibility. Clin Endocrinol 2005;62:492-7 (SCI)

39. Hsieh YY, Chang CC, Tsai FJ*, Lin CC, Tsai CH. Cytochrome P450c17alpha 5'-untranslated region *T/C polymorphism in endometriosis. J Genet. 2004 Aug;83(2):189-92. (SCI)

40. Hsieh YY, Chang CC, Tsai FJ*, Hsu CM, Lin CC, Tsai CH. Angiotensin I-converting enzyme ACE 2350*G and ACE-240*T-related genotypes and alleles are associated with higher susceptibility to endometriosis. Mol Hum Reprod. 2005 Jan;11(1):11-14. (SCI)

41. Lin JC, Chen YO, Hsieh YY*. Incomplete uterine perforation after Intrauterine device Insertion: diagnosis and retrieval by flexible hysterofibroscopy in three very rare cases. Taiwanese J Obstet Gynecol 2004;43(4):243–245.

42. Hsieh YY, Chang CC, Tsai FJ*, Lin CC, Yeh LS, Tsai CH. Tumor necrosis factor-alpha-308 promoter and p53 codon 72 gene polymorphisms in women with leiomyomas. Fertil Steril. 2004 Oct;82(Suppl 3):1177-1181.(SCI)

43. Hsieh YY, Chang CC, Tsai FJ, Lin CC, Chen JM, Tsai CH*. Glutathione S-transferase M1*null genotype but not myeloperoxidase promoter G-463A polymorphism is associated with higher susceptibility to endometriosis. Mol Hum Reprod. 2004 Oct;10(10):713-717. (SCI)

44. Hsieh YY, Chang CC, Tsai FJ*, Yeh LS, Lin CC, Peng CT. T allele for VEGF gene-460 polymorphism at the 5'-untranslated region: association with a higher susceptibility to endometriosis. J Reprod Med. 2004 Jun;49(6):468-72. (SCI)

45. Hsieh YY, Chang CC, Hsu CW, Lin CS*. Gene transfections with p53 and p21 inhibit cell proliferation, collagen type I, leukemia inhibitory factor, and tumor necrosis factor-alpha expression in leiomyoma cells. Fertil Steril. 2004 Jun;81(6):1665-70. (SCI) (NSC 90-2314-B-039-025-)

46. Hsieh YY, Chang CC, Tsai FJ, Peng CT, Yeh LS, Lin CC. Insulin-like growth factor II gene ApaI polymorphism is not associated with endometriosis susceptibility. Genet Mol Biol 2004; 27:165-6

47. Chou IC, Tsai CH, Hsieh YY, Peng CT, Tsai FJ*. Association between polymorphism of interleukin-1beta-511 promoter and susceptibility to febrile convulsions in Taiwanese children. Acta Paediatr. 2003 Nov; 92(11): 1356. (SCI)

48. Hsieh YY, Chang CC, Tsai FJ*, Lin CC, Tai CT, Ho M. Association of an A allele for interleukin-10 -627 gene promoter polymorphism with higher susceptibility to endometriosis. J Reprod Med. 2003 Sep;48(9):735-8. (SCI)

49. Hsieh YY, Chang CC, Tsai FJ, Tsai HD, Yeh LS, Lin CC, Tsai CH. Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma. Fertil Steril. 2003 Jan;79(1):96-9. (SCI) (NSC 91-2314-B-039-028-)

50. Hsieh YY, Tsai FJ, Chang CC, Tsai CH. Lin CC, Yeh LS. Cytochrome P450c17α (CYP17) gene polymorphism is not associated with leiomyoma susceptibility. Genet Mol Biol 2002;25:361-4.

51. Tsai FJ, Chou IC, Hsieh YY, Lee CC, Lin CC, Tsai CH. Interleukin-4 intron 3 polymorphism is not related to susceptibility to febrile seizures. Pediatr Neurol. 2002 Oct;27(4):271-4. (SCI)

52. Hsieh YY, Lin WC, Chang CC, Tsai FJ, Yu MT, Tsai HD, Tsai CH. Turner syndrome with pseudodicentric Y chromosome mosaicism. J Assist Reprod Genet. 2002 Jun;19(6):302-3. (SCI)

53. Hsieh YY, Huang CC, Cheng TC, Chang CC, Tsai HD, Lee MS. Laser-assisted hatching of embryos is better than the chemical method for enhancing the pregnancy rate in women with advanced age. Fertil Steril. 2002 Jul;78(1):179-82. (SCI)

54. Tsai FJ, Hsieh YY, Chang CC, Lin CC, Tsai CH. Polymorphisms for interleukin 1 beta exon 5 and interleukin 1 receptor antagonist in Taiwanese children with febrile convulsions. Arch Pediatr Adolesc Med. 2002 Jun;156(6):545-8. (SCI)

55. Hsieh YY, Sun YL, Chang CC, Lee YS, Tsai HD, Lin CS. Superoxide dismutase activities of spermatozoa and seminal plasma are not correlated with male infertility. J Clin Lab Anal. 2002;16(3):127-131. (SCI) (NSC 92-2320-B-039-052-)

56. Hsieh YY, Chang CC, Tsai FJ, Hsu Y, Tsai HD, Tsai CH. Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: Non-association with endometriosis. J Clin Lab Anal. 2002;16(3):121-6. (SCI)

57. Hsieh YY, Lin CS, Sun YL, Chang CC, Tsai HD, Wu JC. In vivo gene transfer of leukemia inhibitory factor (LIF) into mouse endometrium. J Assist Reprod Genet. 2002 Feb;19(2):79-83. (SCI)

58. Chang CC, Hsieh YY, Tsai HD, Lin CC. Tubo-ovarian abscess presenting as pneumoperitoneum. J Assist Reprod Genet. 2002 Jan;19(1):42-3. (SCI)

59. Chang CC, Hsieh YY, Chung JG, Tsai HD, Tsai CH. Leukemia inhibitory factor decreases the arylamine N-acetyltransferase activity in human cumulus granulosa cells. J Assist Reprod Genet. 2001 Dec;18(12):660-4. (SCI)

60. Tsai MH, Lin CD, Hsieh YY, Chang FC, Tsai FJ, Chen WC, Tsai CH. Prognostic Significance of the Proline Form of p53 Codon 72 Polymorphism in Nasopharyngeal Carcinoma. Laryngoscope. 2002 Jan;112(1):116-9. (SCI)

61. Chang CC, Hsieh YY, Tsai FJ, Tsai CH, Tsai HD, Lin CC. The proline form of p53 codon 72 polymorphism is associated with endometriosis. Fertil Steril. 2002 Jan;77(1):43-5. (SCI) (NSC 91-2314-B-039-028-)

62. Hsieh YY, Chang CC, Tsai HD. Zona-free oocyte fertilized with intracytoplasmic sperm injection and underwent further division: case report and literature review. Chang Gung Med J. 2001 Sep;24(9):599-602. (MI)

63. Chang CC, Hsieh YY, Chung JG, Tsai HD, Tsai CH. Kinetics of acetyl coenzyme A: arylamine N-acetyltransferase from human cumulus cells. J Assist Reprod Genet. 2001 Sep;18(9):512-8. (SCI)

64. Hsieh YY, Chang CC, Tsai FJ, Wu JY, Shi YR, Tsai HD, Tsai CH. Polymorphisms for interleukin-1 beta (IL-1 beta)-511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist: nonassociation with endometriosis. J Assist Reprod Genet. 2001 Sep;18(9):506-11. (SCI)

65. Chang CC, Hsieh YY, Tsai HD. Doppler study of the fetal middle cerebral artery at three locations: preliminary report. Chang Gung Med J 2001 Jul;24(7):418-22 (MI)

66. Hsieh YY, Chang CC, Tsai HD. Antral follicle counting in predicting the retrieved oocyte number after ovarian hyperstimulation. J Assist Reprod Genet. 2001 Jun;18(6):320-4. (SCI)

67. Hsieh YY, Chang CC, Tsai FJ, Wu JY, Tsai CC, Tsai HD. Androgen receptor trinucleotide polymorphism in endometriosis. Fertil Steril. 2001 Aug;76(2):412-3. (SCI)

68. Hsieh YY, Tsai FJ, Chang CC, Chen WC, Tsai CH, Tsai HD, Lin CC. p21 gene codon 31 arginine/serine polymorphism: Non-association with endometriosis. J Clin Lab Anal 2001;15(4):184-7. (SCI)

69. Chang WC, Hsieh YY, Cheng TC, Chang CC, Tsai HD, Lee MS. Effect of methylglyoxal on mouse embryogenesis. Chang Gung Med J. 2001 Apr;24(4):251-7 (MI).

70. Hsieh YY, Wu JY, Chang CC, Tsai FJ, Lee CC, Tsai HD, Tsai CH. Prenatal diagnosis of oculocutaneous albinism two mutations located at the same allele. Prenat Diagn. 2001 Mar;21(3):200-1. (SCI)

71. Hsieh YY, Chang CC, Tsai HD, Tsai CH. Longitudinal survey of blood flow at three different locations in the middle cerebral artery in normal fetuses. Ultrasound Obstet Gynecol. 2001 Feb;17(2):125-8. (SCI)

72. Hsieh YY, Tsai FJ, Lin CC, Chang FC, Tsai CH. Breech deformation complex in neonates. J Reprod Med. 2000 Nov;45(11):933-5. (SCI)

73. Hsieh YY, Chang FC, Tsai HD. Doppler evaluation of the uterine and spiral arteries from different sampling sites and phases of the menstrual cycle during controlled ovarian hyperstimulation. Ultrasound Obstet Gynecol. 2000 Aug;16(2):192-6. (SCI)

74. Hsieh YY, Chang FC, Tsai HD, Tsai CH. Longitudinal survey of fetal ventricular ejection and shortening fraction throughout pregnancy. Ultrasound Obstet Gynecol. 2000 Jul;16(1):46-8. (SCI)

75. Hsieh YY, Chang FC, Tsai HD, Hsu TY, Yang TC. Accuracy of sonography in predicting the outcome of fetal congenital diaphragmatic hernia. Chung Hua I Hsueh Tsa Chih (Taipei). 2000 Oct;63(10):751-7. (MI)

76. Tsai HD, Chang CC, Hsieh YY, Lo HY. Leukemia inhibitory factor expression in different endometrial locations between fertile and infertile women throughout different menstrual phases. J Assist Reprod Genet. 2000 Sep;17(8):415-8. (SCI)

77. Hsieh YY, Tsai HD, Chang FC. Routine blastocyst culture and transfer: 201 patients' experience. J Assist Reprod Genet. 2000 Sep;17(8):405-8. (SCI)

78. Tsai HD, Chang CC, Hsieh YY, Hsu LW, Chang SC, Lo HY. Effect of different concentrations of recombinant leukemia inhibitory factor on different development stage of mouse embryo in vitro. J Assist Reprod Genet. 2000 Jul;17(6):352-5. (SCI)

79. Hsieh YY, Chang FC, Tsai HD, Hsu TY, Yang TC, Yeh LS, Chang WC. Gender prevalence in twin-twin transfusion syndrome. Chang Keng I Hsueh Tsa Chih. 2000 Aug;23(8):476-9. (MI)

80. Hsieh YY, Chang CC, Li PC, Tsai HD, Tsai CH. Successful application of extracorporeal membrane oxygenation and intra-aortic balloon counterpulsation as lifesaving therapy for a patient with amniotic fluid embolism. Am J Obstet Gynecol. 2000 Aug;183(2):496-7. (SCI)

81. Hsieh YY, Tsai HD, Chang CC, Lo HY, Chen CL. Low-dose aspirin for infertile women with thin endometrium receiving intrauterine insemination: a prospective, randomized study. J Assist Reprod Genet. 2000 Mar;17(3):174-7. (SCI)

82. Hsieh YY, Tsai HD, Chang CC, Hsu LW, Chang SC, Lo HY. Prolonged culture of human cryopreserved embryos with recombinant human leukemia inhibitory factor. J Assist Reprod Genet. 2000 Mar;17(3):131-4. (SCI)

83. Hsieh YY, Tsai HD, Chang CC, Lo HY. Sperm cryopreservation with empty human or mouse zona pellucidae. A comparison. J Reprod Med. 2000 May;45(5):383-6. (SCI)

84. Hsieh Y, Tsai H, Chang C, Lo H. Comparison of a single half-dose, long-acting form of gonadotropin-releasing hormone analog (GnRH-a) and a short-acting form of GnRH-a for pituitary suppression in a controlled ovarian hyperstimulation program. Fertil Steril. 2000 Apr;73(4):817-20. (SCI)

85. Hsieh Y, Tsai H, Chang C, Lo H. Cryopreservation of human spermatozoa within human or mouse empty zona pellucidae. Fertil Steril. 2000 Apr;73(4):694-8. (SCI)

86. Tsai HD, Chang CC, Hsieh YY, Lee CC, Lo HY. Artificial insemination. Role of endometrial thickness and pattern, of vascular impedance of the spiral and uterine arteries, and of the dominant follicle. J Reprod Med. 2000 Mar;45(3):195-200. (SCI)

87. Hsieh YY, Chang CC, Lee CC, Tsai HD. Fetal renal volume assessment by three-dimensional ultrasonography. Am J Obstet Gynecol. 2000 Feb;182(2):377-9. (SCI)

88. Hsieh YY, Tsai HD, Chang CC, Yeh LS, Yang TC, Hsu TY. Precipitate delivery and postpartum hemorrhage after term induction with 200 micrograms misoprostol. Chung Hua I Hsueh Tsa Chih (Taipei). 2000 Jan;63(1):58-61. (MI)

89. Hsieh YY, Chang CC, Tsai HD, Lee CC, Tsai CH. Longitudinal doppler sonographic measurements of vascular impedance in the central and peripheral spiral arteries throughout pregnancy. J Clin Ultrasound. 2000 Feb;28(2):78-82. (SCI)

90. Hsieh YY, Chang JG, Liu SC, Chang CC, Tsai HD. Microdeletions of azoospermic factor Genes in Taiwanese with azoospermia or severe oligozoospermia. Mid-Taiwan Journal of Medicine 2000 Dec;5(6):216-20

91. Hsieh YY, Hsu TY, Lee CC, Chang CC, Tsai HD, Tsai CH. Prenatal diagnosis of thoracopelvic dysplasia. A case report. J Reprod Med. 1999 Aug;44(8):737-40. (SCI)

92. Hsieh YY, Chang CC, Tsai HD, Yang TC, Lee CC, Tsai CH. Twin vs. singleton pregnancy. Clinical characteristics and latency periods in preterm premature rupture of membranes. J Reprod Med. 1999 Jul;44(7):616-20. (SCI)

93. Hsieh YY, Tsai HD, Chang CC, Chang CC, Lo HY, Lai AC. Ultrarapid cryopreservation of human embryos: experience with 1,582 embryos. Fertil Steril. 1999 Aug;72(2):253-6. (SCI)

94. Hsieh YY, Chang CC, Tsai HD, Yang TC, Lee CC, Tsai CH. The prenatal diagnosis of Pierre-Robin sequence. Prenat Diagn. 1999 Jun;19(6):567-9. (SCI)

95. Tsai HD, Chang CC, Hsieh YY, Lo HY, Hsu LW, Chang SC. Recombinant human leukemia inhibitory factor enhances the development of preimplantation mouse embryo in vitro. Fertil Steril. 1999 Apr;71(4):722-5. (SCI)

96. Hsieh YY, Chang CC, Tsai HD, Lee CC, Tsai FJ, Tsai CH. Prenatal diagnosis of dyssegmental dysplasia. A case report. J Reprod Med. 1999 Mar;44(3):303-5. (SCI)

97. Hsieh YY, Chang CC, Tsai HD, Yang TC, Chiu TH, Tsai CH. Primary hyperparathyroidism in pregnancy--report of 3 cases. Arch Gynecol Obstet. 1998;261(4):209-14. (SCI)

98. Hsieh YY, Lee CC, Chang CC, Tsai HD, Hsu TY, Tsai CH. Prenatal sonographic diagnosis of Cantrell's pentalogy with cystic hygroma in the first trimester. J Clin Ultrasound. 1998 Oct;26(8):409-12. (SCI)

99. Hsieh YY, Lee CC, Chang CC, Tsai HD, Yeh LS, Tsai CH. Successful prenatal digoxin therapy for Ebstein's anomaly with hydrops fetalis. A case report. J Reprod Med. 1998 Aug;43(8):710-2. (SCI)

100. Hsieh YY, Lin WC, Chang CC, Yeh LS, Hsu TY, Tsai HD. Laparoscopic radical hysterectomy with low paraaortic, subaortic and pelvic lymphadenectomy. Results of short-term follow-up. J Reprod Med. 1998 Jun;43(6):528-34. (SCI)

101. Hsieh YY, Chang CC, Lee CC, Tsai HD, Lin CC, Tsai CH. Conjoined twin's cephalothoracopagus janiceps monoymmetros: a case report. Arch Gynecol Obstet. 1998;261(3):163-6. (SCI)

102. Chang CC, Tsai FJ, Tsai HD, Tsai CH, Hseih YY, Lee CC, Yang TC, Wu JY. Prenatal diagnosis of Apert syndrome. Prenat Diagn. 1998 Jun;18(6):621-5.

103. Hsieh YY, Chang CC, Tsai HD, Chiu TH, Yang TC, Hsu TY. Rupture of rudimentary horn pregnancy: a case report. Chung Hua I Hsueh Tsa Chih (Taipei). 1998 May;61(5):289-94. (MI)

104. Hsieh YY, Chang CC, Tsai HD, Yeh LS, Hsu TY, Yang TC. Intramural pregnancy with negative maternal serum beta-hCG. A case report. J Reprod Med. 1998 May;43(5):468-70. (SCI)

105. Chang CC, Hsieh YY, Tsai HD, Yang TC, Yeh LS, Hsu TY. Acute pancreatitis in pregnancy. Chung Hua I Hsueh Tsa Chih (Taipei). 1998 Feb;61(2):85-92. (MI)

106. Tsai HD, Chang CC, Hsieh YY, Chang CC, Yang TC, Chen CM. Sonographic diagnosis of triplet tubal pregnancy after in vitro fertilization and embryo transfer. J Clin Ultrasound. 1998 Mar-Apr;26(3):159-62. (SCI)

國科會執行計劃

姓名	計畫名稱	計畫內擔任工作	起訖年月	補助機構
謝耀元	子宮肌瘤細胞之基因療法：以p53, p21, retinoblastoma蛋白施行基因轉移，並偵測細胞週期與cytokine之變化 (NSC 90-2314-B-039-025-)	主持人	90.8.1-91.7.31	NSC
謝耀元	子宮內膜異位與子宮肌瘤病患與cytokines，癌症抑制基因，荷爾蒙接受體基因多形體及環境因子之關聯性 (NSC 91-2314-B-039-028-)	主持人	91.8.1-92.7.31	NSC
謝耀元	以Two-dimensional polyacrylamide gel electrophoresis分析人類精液與精子細胞蛋白質體之分布及其與精液品質 (NSC 92-2320-B-039-052-)	主持人	92.8.1-93.7.31	NSC
謝耀元	應用RNA interference(RNAi)技術探討alpha及beta雌激素接受體，黃體素接受體與血管內皮生長激素表現抑制對子宮內膜異位與子宮肌瘤細胞之影響 (NSC 94-2314-B-039-014-)	主持人	94.8.1-95.7.31	NSC
謝耀元	使用噬菌體胜㵽庫應用於偵測子宮內膜異位瘤與子宮肌瘤細胞之特定標的胜㵽(NSC 95-2314-B-039-029-)	主持人	95.8.1-96.7.31	NS

【健康醫療網／記者王冠廷報導】台灣氣候不穩定，經常夏季濕熱、冬季乾冷，很容易使異位性皮膚炎的症狀惡化。尤其皮膚搔癢是異位性皮膚炎中最為擾人的症狀之一，讓大多患者非常困擾。食藥署提醒，過度抓癢將導致皮膚損傷並惡化發炎反應，使用抗組織胺與類固醇藥品能迅速舒緩不適，但後續應注意是否有藥品過度使用的情形。

「異位性皮膚炎」搔癢抓破皮易引起惡性循環

異位性皮膚炎是一種過敏性的慢性皮膚疾病，會伴隨表皮增厚，形成搔癢性濕疹的皮膚損害。當搔癢感產生時，很容易抓破皮膚組織、影響皮膚的屏障功能，使得外來的刺激物與過敏原進入體內，引發發炎反應；當發炎反應所釋放的組織胺又進一步引起搔癢感，患者再度抓癢，造成惡性循環。

治療三階段嚴重惡化可使用類固醇、免疫調節劑

針對異位性皮膚炎的治療，主要分為三個階段：

一、初期階段：

應多給予保濕劑，並間歇性搭配抗組織胺藥品與塗抹類固醇藥品。保濕劑可分成乳液、凝膠、乳膏及軟膏類，在較為濕熱的夏季可塗抹乳液，而乾冷的冬天可改用乳霜或油膏等產品。常見的抗組織胺藥品分別有塗抹用的Diphenylpyraline HCL，及口服的Cetirizine；塗抹用的類固醇藥品Betamethasone Dipropionate 或 Fluocinolone Acetonide。

二、惡化階段：

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謝耀元-張其真，張其真婦產科，，謝耀元，張其真試管嬰兒

搭配口服或是注射類固醇藥品，如短期使用的藥品Prednisolone；以及塗抹外用局部免疫調節劑藥品，例如：適用於成人的0.1% Tacrolimus軟膏（Ointment）和適用於兒童的0.03% Tacrolimus軟膏，1% Pimecrolimus乳膏（Cream），及較新的外用PDE-4抑制劑藥品：2% Crisaborole軟膏。

三、嚴重階段：

使用口服或注射免疫調節劑藥品，進而降低過敏反應，常使用的藥品如Cyclosporine、Methotrexate、Azathioprine及Mycophenolate等；亦有注射用的生物製劑Dupilumab；另有口服的標靶小分子藥品，如Abrocitinib、Baricitinib及Upadacitinib。

謝耀元婦產科，謝耀元，謝耀元試管嬰兒

謝耀元-張其真，張其真婦產科，，謝耀元，張其真試管嬰兒