If you are currently being treated with any of the following medications, you should not use alpha-lipoic acid without first talking to your healthcare provider.

Amikacin and Gentamicin

In an animal study, alpha-lipoic acid supplements reduced side effects, particularly toxicity to the ear, associated with these antibiotics. Additional studies are needed to confirm these effects in people.

Cisplatin and Cyclophosphamide

The use of alpha-lipoic acid supplements in animals protected against toxic side effects associated with these medications.

Thyroid-regulating Medications, Levothyroxine

Rats given alpha-lipoic acid supplements had altered thyroid hormone function, but improved cholesterol levels. Blood hormone levels and thyroid function tests should be monitored closely in people taking thyroid hormones who are also taking alpha-lipoic acid.